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dims.dev
Adios @AWSOpen @awscloud #EKS !
July 11, 2025 at 11:22 AM
nixos.org
NixOS is strong. Nearly 2B requests and almost 1 petabyte of bandwidth every week - the scale behind cache.nixos.org and releases.nixos.org.
@AWSOpen is extending its support for the 4th year!

discourse.nixos.org/t/aws-nixos-...

Big ♥️ to AWS and the Nix Infra team. ❄️
AWS & NixOS S3 Partnership Continues - Year 4!
Happy Monday, and hopefully a good 4 weeks before NixCon week to everyone! Some very good news for us today. ❄ AWS has committed the next chapter of its support for the NixOS Foundation &…
discourse.nixos.org
August 25, 2026 at 7:14 AM
dims.dev
Since #Anthropic is a hot topic today, see how they use #EKS for a whole bunch of their stuff :)

youtu.be/c9NJ6GSeNDM?...

#AWSOpen #awscloud
November 22, 2024 at 4:10 PM
wikipathways.fosstodon.org.ap.brid.gy
September 2025 WikiPathways update: 261 edits by 6 contributors and 13 new pathways in the last month. Accessible via #webservices, #rstats, #PathVisio and #Cytoscape. Supported by #AWSOpen. https://www.wikipathways.org/index.php/Download_Pathways

#bioinformatics #openscience #opensource
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September 12, 2025 at 6:59 PM
wikipathways.fosstodon.org.ap.brid.gy
February 2026 WikiPathways update: 95 edits by 9 contributorsin the last month. More news at https://github.com/wikipathways/wikipathways-help/discussions/221 Accessible via #webservices, #rstats, #PathVisio and #Cytoscape. Supported by #AWSOpen […]
Original post on fosstodon.org
fosstodon.org
February 12, 2026 at 5:59 AM
wikipathways.fosstodon.org.ap.brid.gy
October 2025 WikiPathways update: 129 edits by 10 contributors and 5 new pathways in the last month. Accessible via #webservices, #rstats, #PathVisio and #Cytoscape. Supported by #AWSOpen. https://www.wikipathways.org/index.php/Download_Pathways

#bioinformatics #openscience #opensource
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October 11, 2025 at 2:44 PM
wikipathways.fosstodon.org.ap.brid.gy
March 2026 WikiPathways update: 45 edits by 5 contributors in the last month. More news at https://github.com/wikipathways/wikipathways-help/discussions/227

Accessible via #webservices, #rstats, #PathVisio and #Cytoscape. Supported by #AWSOpen […]
Original post on fosstodon.org
fosstodon.org
March 10, 2026 at 9:31 PM
wikipathways.fosstodon.org.ap.brid.gy
November 2025 WikiPathways update: 686 edits by 6 contributors and 10 new pathways in the last month. Accessible via #webservices, #rstats, #PathVisio and #Cytoscape.

Supported by #AWSOpen. https://www.wikipathways.org/index.php/Download_Pathways

#bioinformatics #openscience #opensource
New pathway, Caffeine in blood vessels (WP5601). In vascular smooth muscle, caffeine promotes relaxation by inhibiting myosin light-chain kinase (MLCK) through cAMP elevation and activating myosin light-chain phosphatase (MLCP), reducing myosin–actin interaction. As a nonselective adenosine receptor antagonist, caffeine blocks A₁/A₃ receptors (which normally lower cAMP) and A₂A/A₂B receptors (which normally raise cAMP), thereby altering adenylate cyclase activity. In endothelial cells, caffeine increases intracellular Ca²⁺, activating eNOS to produce nitric oxide (NO), which diffuses to smooth muscle and stimulates cGMP signaling, further promoting vasodilation. Inspired by Figure 1 in Kumar and Lipshultz, 2019. New pathway, KCNQ2 and KCNQ3-related epilepsy (WP5599): Processes involved in KCNQ2 and KCNQ3-related epilepsies. New pathways, GABA and glutamate signalling in epileptogenesis (WP5600): This pathway depicts the epileptogenic mechanisms involving GABA and glutamate signaling. It focuses on transporters and channel proteins that modulate action potential dynamics and their interacting partners, highlighting functional alterations that contribute to epilepsy pathogenesis.
November 12, 2025 at 6:21 AM
mikael.barbero.tech
Yet another OSS @OpenJDK distribution from Amazon @AWSOpen https://t.co/2ubRrvQ25B Along with with @adoptopenjdk and @AzulSystems/@ZuluCommunity and all Linux distribution builds, future is bright for #freeasinspeach @java
Introducing Amazon Corretto, a No-Cost Distribution of OpenJDK with Long-Term Support | Amazon Web Services
Update! Amazon Corretto became Generally Available on January 31st, 2019. Java is one of the most popular languages in use by AWS customers, and we are committed to supporting Java and keeping it free. Many of our customers have become concerned that they would have to pay for a long-term supported version of Java to […]
aws.amazon.com
November 20, 2024 at 5:46 PM
wikipathways.fosstodon.org.ap.brid.gy
Februari 2025 WikiPathways update: 313 edits by 10 contributors and 4 new pathways in the last month. Accessible via #webservices, #rstats, Pathvisio, and Cytoscape. Supported by AWSOpen https://www.wikipathways.org/download.html

#biology #bioinformatics #openscience
New pathway "Mitochondrial carrier deficiency associated with shuttle disturbances (WP5507)" https://www.wikipathways.org/pathways/WP5507 "Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s guide to the diagnosis, treatment, and follow-up of inherited metabolic diseases" New pathway "GIP and GLP-1 function by tissue (WP5509)" https://www.wikipathways.org/pathways/WP5509 "Functions of GIP and GLP-1, two agonists of which are found in the weight-loss drug tirzepatide (a.k.a. Mounjaro). "Pancreatic and exopancreatic function of glucose‐dependent insulinotropic polypepide (GIP) and glucagon‐like peptide (GLP)‐1. GIP acts directly on the endocrine pancreas, bone, fat, gastrointestinal (GI) tract and brain. GLP‐1 acts directly on the endocrine pancreas, gastrointestinal tract, heart and brain." From Figure 2 in https://pmc.ncbi.nlm.nih.gov/articles/PMC4020673/." New pathway: "Vedolizumab therapy for irritable bowel syndrome (WP5512)" https://www.wikipathways.org/pathways/WP5512 "Vedolizumab is a humanized monoclonal antibody with a predominantly gastrointestinal effect. It specifically inhibits leucocyte integrin α4β7, thus preventing its interaction with mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1), which is involved in the migration of lymphocytes from the blood stream to the intestinal tissue. Vedolizumab is indicated in the treatment of moderate to severe active Crohn's disease and ulcerative colitis in adult patients with poor response, loss of response, or intolerance to conventional treatment or to tumour necrosis factor alpha (TNF-α) antagonists." Inspired by Figure 1 in https://pubmed.ncbi.nlm.nih.gov/31470005/. Vedolizumab is also known by its trade name, Entyvio. New pathway: "NSAIDs mechanism of action (WP5513)" https://www.wikipathways.org/pathways/WP5513 "Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the cyclooxygenase isoenzymes COX1 and COX2 with varying degrees of specificity for the COX2 isoform. As a result, the conversion of arachidonic acid to prostaglandins (PGs) is inhibited. The main effects of PGs throughout the body are listed." Inspired by Figure 1 in PMID:32322101.
February 11, 2025 at 6:38 AM
chrisshort.net
Come hang out with me on Mastodon: hachyderm.io/@ChrisS...
Chris "Not So" Short 🇺🇦 (@ChrisShort@hachyderm.io)
1.76K Posts, 811 Following, 3.73K Followers · Open Source Diplomat | Kubernetes Contributor | Developer Advocate | r/devopsish | Disabled Veteran | Detroit | Work @AWSOpen | He/Him/His | Views solely mine | Toots auto-delete after 3 months | Resident Engineer/Scientist/Physicist for Max, age 8
hachyderm.io
August 13, 2024 at 1:02 PM
wikipathways.fosstodon.org.ap.brid.gy
January 2026 WikiPathways update: 134 edits by 3 contributorsin the last month. More news at https://github.com/wikipathways/wikipathways-help/discussions/213 Accessible via #webservices, #rstats, #PathVisio and #Cytoscape. Supported by #AWSOpen […]
Original post on fosstodon.org
fosstodon.org
January 11, 2026 at 12:14 PM
wikipathways.fosstodon.org.ap.brid.gy
:mega: April 2025 WikiPathways release: 454 edits by 10 contributors and 9 new pathways.

Accessible via #webservices, #rstats, Pathvisio, and Cytoscape. Supported by AWSOpen https://www.wikipathways.org/download.html

#biology #bioinformatics #openscience
new pathway: "Age-related macular degeneration (WP5526)" "Age-related macular degeneration (AMD) is a leading cause of vision impairment in individuals aged 55 and older in the Western world. This diagram shows metabolic pathway crosstalk in AMD. In AMD, the upregulation of PARP2 expression leads to the downregulation of SIRT1. The depletion of SIRT1, a NAD+-dependent deacetylase, causes acetylation and inactivation of PGC-1α." new pathway: "Retinoid metabolism in retina: healthy vs. RLBP1-deficient (WP5532)" "RLBP1 encodes CRALBP, a cellular retinaldehyde-binding protein that functions as a soluble retinoid carrier in the visual cycle of the eye. Mutations in RLBP1 are linked to recessively inherited conditions, such as Bothnia dystrophy, retinitis pigmentosa, retinitis punctata albescens, fundus albipunctatus, and Newfoundland rod-cone dystrophy." new pathway: "Aspirin prevention of cancer metastasis (WP5518)" "Platelets generate TXA2, which binds to its receptor (TP) on T cells, initiating the activation of ARHGEF1, a guanine exchange factor that promotes the conversion of RhoA from its inactive GDP-bound state to its active GTP-bound form. This RhoA activation inhibits TCR-induced kinase pathways, T cell proliferation, and effector functions, ultimately suppressing anti-metastatic immunity. TXA2 production by platelets is COX1-dependent and can be blocked by aspirin or COX-1 selective inhibitors, which relieve T cells from TXA2-mediated suppression. Inspired by figure 14 in in Yang et al. (2025)."
April 10, 2025 at 6:26 PM
wikipathways.fosstodon.org.ap.brid.gy
March 2025 WikiPathways release: 1,297 edits by 6 contributors and 1 new pathway

Accessible via #webservices, #rstats, Pathvisio, and Cytoscape. Supported by AWSOpen https://www.wikipathways.org/download.html

#biology #crohn #bioinformatics #openscience
Human pathway for "IL23 inhibitors in inflammatory bowel disease" (WP5516): "IL23 inhibitor drugs decrease an intestinal immune response that contributes to inflammatory bowel disease (IBD), like Crohn’s disease and ulcerative colitis. IL23 inhibitors like risankizumab (Skyrizi), guselkumab (Tremfya), mirikizumab (Omvoh), and brazikumab (MEDI2070) bind to IL23p19 (a.k.a. p19), the protein product of gene IL23A. That in turn blocks IL23A protein from binding to its receptor in immune cells, preventing the production of downstream inflammatory interleukins, cytokines, and other factors that manifest as IBD. IL-23 plays a crucial role in immune responses, especially in the intestinal mucosa. It has a novel p19 protein subunit, which interacts with the p40 subunit. This interaction activates the STAT4-JAK2 pathway. "
March 10, 2025 at 9:00 PM
wikipathways.fosstodon.org.ap.brid.gy
January 2025 WikiPathways update: 154 edits by 11 contributors and 5 new pathways in the last month. Accessible via #webservices, #rstats, Pathvisio, and Cytoscape. Supported by AWSOpen https://wikipathways.org/index.php/Download_Pathways

#bioinformatics #openscience #opensource
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January 28, 2025 at 9:24 AM
wikipathways.fosstodon.org.ap.brid.gy
December 2024 WikiPathways update: 272 edits by 7 contributors and 11 new pathways in the last month. Accessible via #webservices, #rstats, Pathvisio, and Cytoscape. Supported by AWSOpen. https://wikipathways.org/index.php/Download_Pathways #bioinformatics #openscience #opensource
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December 21, 2024 at 12:58 PM
lizrice.com
Curious about @awscloud involvement in open source? Come along to this Open@Amazon virtual event (and you'll also see me doing a @ciliumproject demo!)

https://openatamazon.splashthat.com/ @AWSOpen
splashthat.com
openatamazon.splashthat.com
November 4, 2024 at 2:20 PM
loicmathieu.fr
Amazon fournit une distribution d'OpenJDK gratuite et compte supporter Java 8 jusqu'en 2023! https://twitter.com/AWSOpen/status/1062639394262315010
November 26, 2024 at 11:25 AM
thilozimmermann.bsky.social
As a born #Carpenter (German: #Zimmermann) I just have to like this "ROS #Carpentry: Hands-On #OpenSource Skills" proposed #RSS2020 Workshop by @kscottz & #MabelZhang of @OpenRoboticsOrg, @cambuscaron of @AWSOpen & #SteveMacenski of #SamsungResearch #goROS
https://t.co/vmPPu9QEQk
January 17, 2025 at 1:20 PM
trivikram.bsky.social
I don't use #rustlang, but am very interested in it as:

➡️ most loved programming language for 4+ years
➡️ both @firefox and @deno_land use it
➡️ @AWSOpen sponsors it!

That's why I took 2020 State of Rust Survey and you should too! https://t.co/xy47bJL1i7 https://t.co/Uxa2gxT8Re https://t.co/w...
November 12, 2024 at 3:34 AM
trivikram.bsky.social
And the important slide about fundraising - thanks to all "no hoodies" folks, individual contributors and sponsors #cjs19

@AWSOpen @FormidableLabs @eggheadio @heroku @mozilla @stripe @fbOpenSource @codezilla_it https://t.co/rFGr0BwYnJ
November 12, 2024 at 2:49 AM
trivikram.bsky.social
Thanks to the #OpenSource community in Seattle for helping organize #cjs19

And thanks to lead organizer Carter Rebasa

On stage we have @CascadiaJS @seattlejs @seattlereactjs @ngSeattle @AWSOpen and more!

#javascript #Nodejs https://t.co/NGP2g888TZ
November 12, 2024 at 2:49 AM
trivikram.bsky.social
Thank you @AWS @AWSOpen for sponsoring @CascadiaJS #cjs19

Speaking of AWS, I maintain AWS SDK for #javascript and #nodejs and my team is hiring! https://t.co/dmeYYV3X7G

Do DM me on Twitter if you're interested to join or have any questions! https://t.co/PLUPcw9c4R
November 12, 2024 at 2:48 AM
trivikram.bsky.social
Time to increase participation in JSRs (Java Spec Requests) https://jcp.org/en/jsr/overview https://twitter.com/AWSOpen/status/1186675527077240833
November 12, 2024 at 2:47 AM
trivikram.bsky.social
Too many developers like @rustlang
Both @firefox and @deno_land uses it, and @AWSOpen sponsors it.

So I planned to learn it over this weekend.
Creating this thread for sharing what I learn about Rust as a JavaScript developer.

https://doc.rust-lang.org/book/title-page.html
November 12, 2024 at 2:47 AM