#CalorieRestriction #VascularAging #Progeroid🐭

CR (30%⏬, 7- to 22-wk) in ERCC1Δ/−🐭 rescues #AorticAging
⏬elastin breaks
⏬proteoglycan
⏬MMPSense680
⏬ssDNA-cGAS-STING1
⏬inflamm VCAM1+ or LGALS3+ #SmoothMuscleCell

+Aortic bulk RNAseq

#Aging_Cell 2025
onlinelibrary.wiley.com/doi/10.1111/...

80-mer DNA aptamer as a selective marker for #Senescence
Targeting EDA-Fibronectin Kd 500~1000 pM

Label senescent cells in naturally aged🐭🫁
Aptamer binding ⬇️in 21-mo INK-ATTAC🐭 with p16 cells eliminated

#Aging_Cell 2025
onlinelibrary.wiley.com/doi/10.1111/...

Interesting to hear the study, which received the 2023 Best Article Award in the Aging_Cell Journal.. Well done Dr. Chisaka Kuehnemann from @TuftsUniversity Boston, USA.

#AnatSoc #AnatSocWinter24 #AnatSocUCLan

#HutchinsonGilfordProgeriaSyndrome

HGPS hiPSC #EndothelialCell Secretome screening->
#Angiopoietin2 autocrine (⏫#Angiogenesis #NitricOxide) & paracrine (⏬ #SmoothMuscleCell death #Senescence)

#BaseEditing Progerin⏫Angpt2 & HGPS EC behaviors
#Aging_Cell 2024
onlinelibrary.wiley.com/doi/10.1111/...

In vivo & In vitro Causal evidence of #EndothelialCell #Senescence as a driver of #Aging-related Compromise of #BloodBrainBarrier

Old INK-ATTC🐭(p16-hi cell elimination)

Senescent+ Healthy EC co-culture

#Aging_Cell 2024
onlinelibrary.wiley.com/doi/full/10....

#Oocyte #Aging #Heterochromatin

Mouse 9- vs 2-mo
Human <35 vs >35 y/o

Aging▶️
⏬Heterochromatin
⏫DNA damage
⏫Retrotransposon transcription dsRNA Dicer

Overexpression of Sirt1 or EZH2 in aged oocytes to rescue

#Aging_Cell 2022
onlinelibrary.wiley.com/doi/10.1111/...

We are happy to announce our latest article in @Aging_Cell, exploring the senescent intracrine action of IL-6. Congratulations to the lead author, @flor_herbstein, our team at @IBioBA_MPSP, and our collaborators, @LucPontel and @AGTheoLab! �Ÿ”—https://onlinelibrary.wiley.com/doi/full/10.1111/acel.14...

Circulate Health Reveals Study Results on Therapeutic Plasma Exchange and Biological Age Reduction#United_States#Novato,_California#Circulate_Health#Therapeutic_Plasma#Aging_Cell