Only 58.5% of addiction facilities offered women-specific programs, leaving 23 states below 10 sites per 10,000 women.

Only 58.5% of addiction facilities offered women-specific programs, leaving 23 states below 10 sites per 10,000 women.

Background: Alcohol use disorder (AUD) involves an impaired ability to stop or control alcohol use despite adverse consequences and represents a major public health problem. While AUD is most prevalent among college students, integrated evidence-based treatments for this population are lacking. Objective: The objectives of our study were to test the #feasibility and acceptability of a newly developed behavioral intervention, problem-solving therapy and Apple Watch (PST-APPLE), and to preliminarily investigate the effectiveness of PST-APPLE among college students with symptoms of AUD. Methods: Participants were recruited through online advertising and on campus at universities in the Chicago area between May and September 2024. They were randomized in a 1:1 ratio using block randomization to the intervention group (PST-APPLE: n=12 individuals) or the control group (education-only: n=14 individuals), with the data analyst blinded to treatment assignment. Participants in the intervention group completed 12 weeks of the PST-APPLE intervention, delivered remotely via Zoom videoconferencing and interactions with the Apple Watch. Participants in the control group were asked to watch a 20-minute abstinence-motivation video and then participate in a 30-minute group discussion via Zoom. All participants completed follow-up assessments at 3 months. Outcomes included alcohol-related problems (Alcohol Use Disorders Identification Test [AUDIT] and Rutgers Alcohol Problem Index [RAPI]) and drinking motivation (Drinking Motives Questionnaire Revised [DMQR]). Results: We enrolled 26 participants aged 18‐25 years. The mean age was 22.5 (SD 2.20) years. We found reduced scores between preintervention and postintervention measures in the intervention group using 2-tailed paired tests and baseline-adjusted analysis of covariance, including reduced alcohol misuse and problems (AUDIT and RAPI scores) and reduced DMQR social and coping motivation scores. Baseline-adjusted mean differences comparing the intervention with the control group showed reductions in alcohol use (AUDIT; mean difference −4.70, 95% CI −8.69 to −0.70) and in DMQR social motivation (mean difference −0.85, 95% CI −1.51 to −0.18) and enhancement motivation scores (mean difference −0.75, 95% CI −1.47 to −0.04). Conclusions: Our study findings indicate that the PST-APPLE intervention is feasible, acceptable, and hypothesis generating among college students with AUD. While findings are promising, this pilot study was not powered for definitive efficacy testing. A fully powered randomized controlled trial is needed to confirm these effects. Future studies could adapt PST-APPLE to other wrist-worn electronic devices/watches that capture physiological data (eg, Fitbit, Samsung Galaxy Watch) to increase reach and scalability, particularly among younger adults and digitally literate populations. Trial Registration: ClinicalTrials.gov NCT06333288; https://clinicaltrials.gov/study/NCT06333288

Molecular Psychiatry - Probing the neurochemical mechanisms of rTMS for alcohol use disorder: Results from a randomized, sham-controlled, double-blind, crossover, proton MR Spectroscopy study

A study published in Molecular Psychiatry reveals that mice experiencing forced abstinence from alcohol showed heightened activity in the bed nucleus of the stria terminalis (BNST), a brain region linked to stress and addiction. This increased neural activity occurred before relapse behavior, suggesting potential for early detection of relapse risk in humans. Researchers observed that abstinent mice drank more bitter alcohol despite its unpleasant taste, indicating physiological challenges during abstinence. The BNST's role in anxiety and depression related to alcohol use disorder was further explored, with findings implying that screening BNST activity could identify individuals at higher relapse risk. The study highlights the complexity of addiction recovery, noting that while abstinence improves health outcomes, brain changes during withdrawal may paradoxically increase relapse likelihood. With over 30 million Americans affected by alcohol use disorder, identifying biomarkers like BNST activity could enhance treatment strategies. However, further research is needed to clarify the exact mechanisms and specific cell populations involved in this neural response.

In addition to reducing your desire for food, the GLP-1 RA drug, semaglutide, known as Wegovy, appears to also cut the craving for alcohol.

In addition to reducing your desire for food, the GLP-1 RA drug, semaglutide, known as Wegovy, appears to also cut the craving for alcohol.

Chronic alcohol intake leads to neuroinflammation and cell injury, proposed to result in alterations that perpetuate alcohol intake and cued relapse. Studies show that brain oxidative stress is consistently associated with alcohol-induced neuroinflammation, and literature implies that oxidative stre …

The emotion dysregulation and impulsivity are highly associated with alcohol use disorder (AUD). This study explored the role of impulsivity and emoti…