Neural technologies are adopting bio-inspired designs to enhance biointegration and functionality. This review maps the growing field of bio-inspired electronics and discusses recent developments in t...

Neural technologies are adopting bio-inspired designs to enhance biointegration and functionality. This review maps the growing field of bio-inspired electronics and discusses recent developments in t...

This study examined the complex interactions among differential gene expression, immune responses, therapy-associated genes in Alzheimer’s disease (AD), and cognitive impairment, with a distinct focus on the integration of music therapy.

Researchers have created free-floating, hexagonal nanolaser particles , just 30 μm² in area , that confine light to volumes comparable with cell organelles, paving the way for label-free nanoscale sensing within living cells!

Bioceramics and Hydroxyapatite Market growth is projected to reach USD 7.38 Billion, at a 7.30% CAGR by driving industry size, share, top company analysis, segments research, trends and forecast repor...

Quercetin, a bioactive flavonoid abundant in diverse plant species, has been extensively investigated for its neuroprotective properties against neurodegenerative diseases (NDDs), such as Alzheimer’s, Parkinson’s, and Huntington’s diseases.

Neural technologies are adopting bio-inspired designs to enhance biointegration and functionality. This review maps the growing field of bio-inspired electronics and discusses recent developments in t...

Announcing a new article publication for BIO Integration journal. Chronic respiratory diseases impose a substantial health burden globally with increasing prevalence and mortality rates, especially in...

Solid tumors are characterized by extensive extracellular matrix (ECM) remodeling prominently featuring massive collagen deposition.

Purpose: The purpose of this study was to characterize the morphological and immunological aspects of biointegration at the optic–cornea joint of a second-generation synthetic corneal device. Methods: The initial prototype, single-piece optic–skirt configuration, is constructed from compact and flexible perfluoroalkoxy alkane with porous expanded polytetrafluoroethylene (ePTFE) overlying the skirt to allow skirt–cornea biointegration. The second-generation version was modified to add ePTFE around the optic wall to allow optic–cornea biointegration. Initial and amended second-generation devices were implanted into healthy rabbit eyes. Clinical examination, anterior segment optical coherence tomography, light microscopy, and immunofluorescence studies were performed to assess structural integrity and determine molecular signatures indicative of inflammation and tissue remodeling between the 2 prototypes. Results: Recipient eyes with both device versions showed no epithelial defects or tissue retraction at 3 months postoperatively. Optical coherence tomography images demonstrated no appreciable perioptic space with either prototype. Histopathology of the initial device demonstrated lack of stromal adhesion at the optic–cornea joint with epithelium filling the perioptic space. Second-generation devices demonstrated full sealing of the recipient stroma along the optic stem. Although the routine histopathology did not demonstrate inflammatory cells in the recipient cornea with either device, immunohistochemistry stains demonstrated quiescent phenotype of stromal and epithelial cells only in the second-generation devices. Conclusions: Biointegration between the synthetic corneal device and recipient tissue at the optic–cornea joint seems to avert inflammation and may help prevent sterile tissue lysis and prolong retention.

Purpose: The purpose of this study was to characterize the morphological and immunological aspects of biointegration at the optic–cornea joint of a second-generation synthetic corneal device. Methods: The initial prototype, single-piece optic–skirt configuration, is constructed from compact and flexible perfluoroalkoxy alkane with porous expanded polytetrafluoroethylene (ePTFE) overlying the skirt to allow skirt–cornea biointegration. The second-generation version was modified to add ePTFE around the optic wall to allow optic–cornea biointegration. Initial and amended second-generation devices were implanted into healthy rabbit eyes. Clinical examination, anterior segment optical coherence tomography, light microscopy, and immunofluorescence studies were performed to assess structural integrity and determine molecular signatures indicative of inflammation and tissue remodeling between the 2 prototypes. Results: Recipient eyes with both device versions showed no epithelial defects or tissue retraction at 3 months postoperatively. Optical coherence tomography images demonstrated no appreciable perioptic space with either prototype. Histopathology of the initial device demonstrated lack of stromal adhesion at the optic–cornea joint with epithelium filling the perioptic space. Second-generation devices demonstrated full sealing of the recipient stroma along the optic stem. Although the routine histopathology did not demonstrate inflammatory cells in the recipient cornea with either device, immunohistochemistry stains demonstrated quiescent phenotype of stromal and epithelial cells only in the second-generation devices. Conclusions: Biointegration between the synthetic corneal device and recipient tissue at the optic–cornea joint seems to avert inflammation and may help prevent sterile tissue lysis and prolong retention.

Purpose: The purpose of this study was to characterize the morphological and immunological aspects of biointegration at the optic–cornea joint of a second-generation synthetic corneal device. Methods: The initial prototype, single-piece optic–skirt configuration, is constructed from compact and flexible perfluoroalkoxy alkane with porous expanded polytetrafluoroethylene (ePTFE) overlying the skirt to allow skirt–cornea biointegration. The second-generation version was modified to add ePTFE around the optic wall to allow optic–cornea biointegration. Initial and amended second-generation devices were implanted into healthy rabbit eyes. Clinical examination, anterior segment optical coherence tomography, light microscopy, and immunofluorescence studies were performed to assess structural integrity and determine molecular signatures indicative of inflammation and tissue remodeling between the 2 prototypes. Results: Recipient eyes with both device versions showed no epithelial defects or tissue retraction at 3 months postoperatively. Optical coherence tomography images demonstrated no appreciable perioptic space with either prototype. Histopathology of the initial device demonstrated lack of stromal adhesion at the optic–cornea joint with epithelium filling the perioptic space. Second-generation devices demonstrated full sealing of the recipient stroma along the optic stem. Although the routine histopathology did not demonstrate inflammatory cells in the recipient cornea with either device, immunohistochemistry stains demonstrated quiescent phenotype of stromal and epithelial cells only in the second-generation devices. Conclusions: Biointegration between the synthetic corneal device and recipient tissue at the optic–cornea joint seems to avert inflammation and may help prevent sterile tissue lysis and prolong retention.

Purpose: The purpose of this study was to characterize the morphological and immunological aspects of biointegration at the optic–cornea joint of a second-generation synthetic corneal device. Methods: The initial prototype, single-piece optic–skirt…

Purpose: The purpose of this study was to characterize the morphological and immunological aspects of biointegration at the optic–cornea joint of a second-generation synthetic corneal device. Methods: The initial prototype, single-piece optic–skirt…

What are the most important technologies? SATW’s Technology Outlook provides an overview of what universities and industry are working on in 2024 and 2025.

**Abstract:** Decellularized Extracellular Matrix (dECM) scaffolds hold immense promise for tissue engineering and regenerative medicine due to their inherent biocompatibility and bioactivity. However, a critical limitation lies in their relatively fixed porosity, which can hinder cell infiltration, vascularization, and nutrient transport, impeding successful scaffold biointegration. This paper proposes a novel, scalable methodology for dynamically modulating dECM scaffold porosity *post-decellularization* using machine learning (ML)-guided microfluidic devices, resulting in enhanced cell infiltration and accelerated tissue regeneration.

**Abstract:** This paper introduces a novel framework for optimizing the design of branched vascular networks generated via 3D bio-printing, leveraging the synergistic combination of Generative Adversarial Networks (GANs) and Multi-Objective Evolutionary Algorithms (MOEAs). Our approach aims to maximize both vascular network patency and biomaterial biointegration, critical factors for successful tissue engineering and regenerative medicine applications. The framework automates the design process, iteratively refining network morphology and material composition to achieve superior performance compared to traditional manual design and stochastic bio-printing methods.

**Abstract:** This research details a novel system for enhancing vascular graft biointegration following implantation for ischemic cardiac repair, leveraging multi-modal data analysis and a closed-loop adaptive growth factor delivery system. Utilizing a proprietary 'HyperScore' evaluation framework, real-time physiological data (blood flow, oxygenation, graft mechanical properties) are analyzed to dynamically adjust growth factor delivery, promoting robust neovascularization and minimizing long-term graft failure.