CD36 is identified as a key suppressor in triple-negative breast cancer (TNBC). It inhibits tumor metastasis by promoting ferroptosis via the CD36–CAV1–lipid peroxidation axis. Multiomics and metasta...

The Goding lab, working in collaboration with the University Rey Juan Carlos, have shown that fatty acid uptake activates an AXL-CAV1-β-catenin axis to drive melanoma invasiveness.

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This review considers the inactivation mechanisms of CaV1 and CaV2 voltage-gated calcium channels and their role in normal physiology and pathophysiology.

Cytotoxic CD8+ T lymphocytes (CTLs) efficiently eliminate infected and cancerous cells throughout the body. T cell receptor (TCR)-induced Hedgehog signalling contributes to CTL-mediated killing, but how the pathway is activated downstream of the TCR is unknown. Here, we show that extracellular calcium (Ca2+) flux through L-type voltage-gated Ca2+ (Cav1) channels at the plasma membrane downstream of the TCR drives induction of the Hedgehog transcription factor Gli1, which is important for CTL killing in vitro and in vivo. This previously unknown non-canonical Hedgehog pathway is independent of canonical signalling and represents a primary mechanism of Gli1 induction in naive CD8+ T cells, whereas CTLs can also activate Gli1 via MAPK. We further show that Cav1 channel-controlled Gli1 induction is functionally important for CTL killing in mice and humans and other cytotoxic lymphocytes. Notably, killing capacity can be amplified using a small molecule Cav1 agonist or by overexpressing a g

Pathological neovascularization is a leading cause of vision loss. In this study, the authors identify FRZB and its NTR domain as suppressors of ocular angiogenesis. FRZB prevents CAV1 phosphorylation at Tyr42 which enhances downstream TGFβ signaling via ALK5 retention.

Cell Death Discovery - Integrative insights into the role of CAV1 in ketogenic diet and ferroptosis in pancreatic cancer