#CCRdownunder
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marionkcampbell.bsky.social
The stepped wedge design came up in the #CCRDownUnder meeting last week so it seemed a good time to revisit the pros and cons of this design 1/6
#MethodologyMonday #128
December 15, 2025 at 8:05 AM
whizzfizzlizz.bsky.social
Had a great time sitting on the panels for #RSI and #CLIPII at #CCRDownunder and it was great to see my Monash statto pals on stage @jesskasza.bsky.social @criticalcarereviews.com
December 10, 2025 at 10:16 PM
criticalcarereviews.com
Co-Chief Investigators Carol Hodgson and Lisa Higgins share an overview of the #ECMORehab trial and the key takeaways for clinicians after presenting the results at #CCRdownunder

@jama.com
December 10, 2025 at 7:21 AM
criticalcarereviews.com
Chief Investigator Angelique de Man and Senior Investigator Sander Rozemeijer share the results from the #VITaCCA trial and what it means for clinicians after presenting at #CCRdownunder

Livestream -> www.criticalcarereviews.com

@jama.com
December 10, 2025 at 5:52 AM
criticalcarereviews.com
Co-Chief Investigators Jonathan Casey and Matthew Semler share their insights from the #RSI trial after presenting at #CCRdownunder

Livestream -> www.criticalcarereviews.com

@jama.com
December 10, 2025 at 5:40 AM
criticalcarereviews.com
Chief Investigator Arthur Kwizera shares an overview of the #ARISEAFRICA trial after presenting at #CCRdownunder and highlights what clinicians can take away from the results.

Livestream -> www.criticalcarereviews.com

@jama.com
December 10, 2025 at 4:40 AM
icunutrition.bsky.social
Ascorbate is its ionised (deprotonated) form, which predominates in the body at physiological pH. Ascorbate is the focus of new Vitamin C research #ccrdownunder
December 10, 2025 at 3:21 AM
icunutrition.bsky.social
The preparation is important- Mark Plummer nicely outlining the importance of understanding what is studied in Vit C trials
Ascorbic acid is the acidic, protonated form of Vit C (used in many trials and may explain the harm 1/2 #ccrdownunder #VITACCtrial
December 10, 2025 at 3:21 AM
criticalcarereviews.com
Many thanks for facilitating the publication of the RSI trial with #CCRdownunder
December 10, 2025 at 3:04 AM
icunutrition.bsky.social
Next up VITaCC results session (Early high-dose vitamin C in post-cardiac arrest syndrome) up next at #CCRdownunder #VITACCtrial
December 10, 2025 at 2:36 AM
icunutrition.bsky.social
Congratulations to the RSI trial team #CCRdownunder
nejm.org NEJM.org @nejm.org · Dec 10
In a randomized trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. Full trial results: nej.md/44EOlxB

@criticalcarereviews.com
CCR Down Under 2025 Original Article | Dec. 9, 2025 | NEJM.org Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults Figure 1. In-Hospital Death, According to Trial Group. The NEJM identity sits at the bottom.
December 10, 2025 at 12:34 AM
criticalcarereviews.com
RSI trial now starting

➡️ Etomidate vs Ketamine for RSI

➡️ Jonathan Casey & Matthew Semler presenting
➡️ Chris Nickson editorialising

➡️ Join the livestream - criticalcarereviews.com

#ccrdownunder
December 10, 2025 at 12:14 AM
icunutrition.bsky.social
Next up RSI results session (Etomidate vs Ketamine for intubation) up next at #CCRdownunder #RSItrial
December 10, 2025 at 12:12 AM
icunutrition.bsky.social
#ARISEAFRICAtrial is a stepped wedge cluster- this design is useful for interventions delivered at the ICU/hospital level and individual randomisation is difficult. Clusters transition from control to intervention at different times www.bmj.com/content/350/... #ccrdownunder @criticalcarereviews.com
The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting
#### Summary points
www.bmj.com
December 9, 2025 at 10:14 PM
icunutrition.bsky.social
And here is the protocol publication for #ARISEAFRICAtrial: pmc.ncbi.nlm.nih.gov/articles/PMC... #ccrdownunder
Respiratory support with standard low-flow oxygen therapy, high-flow oxygen therapy or continuous positive airway pressure in adults with acute hypoxaemic respiratory failure in a resource-limited setting: protocol for a randomised, open-label, clinical trial – the Acute Respiratory Intervention StudiEs in Africa (ARISE-AFRICA) study
Acute hypoxaemic respiratory failure (AHRF) is associated with high mortality in sub-Saharan Africa. This is at least in part due to critical care-related resource constraints including limited access to invasive mechanical ventilation and/or highly ...
pmc.ncbi.nlm.nih.gov
December 9, 2025 at 10:09 PM
icunutrition.bsky.social
First up on Day 2 of #CCRdownunder is #ARISEAFRICAtrial. Post your questions using the hash tags and follow the live stream here: criticalcarereviews.com
@criticalcarereviews.com
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December 9, 2025 at 9:52 PM
criticalcarereviews.com
Chief Investigator Ary Serpa Neto shares an overview of the #ACTiVE trial after presenting the results at #CCRdownunder

@jama.com
December 9, 2025 at 7:41 AM
criticalcarereviews.com
Chief Investigator Michael Reade provides an overview of the #CLIP-II trial at #CCRdownunder and what it means for clinicians.

@jama.com
December 9, 2025 at 7:34 AM
criticalcarereviews.com
Co-Chief Investigators Brenda O'Neill and Danny McAuley share the results of the #iRehab trial after presenting at #CCRdownunder

Livestream -> www.criticalcarereviews.com

@jama.com
December 9, 2025 at 7:17 AM
criticalcarereviews.com
Chief Investigator, Evangelos Giamarellos-Bourboulis shares the findings from the #ImmunoSep trial and what it means for clinicians at #CCRdownunder

Livestream -> www.criticalcarereviews.com

@jama.com
December 9, 2025 at 7:13 AM
jama.com
Editorial: Sinnige et al demonstrate that closed-loop ventilation did not improve ventilator-free days compared to conventional care.

Questions remain regarding how best to integrate adaptive ventilation systems into real-world practice. #CCRdownunder ja.ma/4pXyYJb
An editorial from JAMA, published December 8, 2025, titled "Automated Modes to Improve Mechanical Ventilation Outcomes—The Ghost in the Machine" by Michael C. Sklar, MD, MSc; Niall D. Ferguson, MD, MSc.
December 9, 2025 at 5:30 AM
jama.com
Research Summary: Early use of automated closed-loop ventilation did not increase ventilator-free days at day 28 compared with protocolized conventional ventilation. #CCRdownunder ja.ma/48AgJCj
JAMA Research Summary: Effect of Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation on Ventilator-Free Days in Critically Ill Adults. Closed-loop ventilation: 16.7 days. Conventional ventilation: 16.3 days.
December 9, 2025 at 5:15 AM
jama.com
RCT: Among critically ill adults receiving invasive mechanical ventilation, early use of an automated closed-loop ventilation system did not increase ventilator-free days at day 28 compared with protocolized conventional ventilation. #CCRdownunder ja.ma/4oHW9Gj
JAMA study graph: Cumulative distribution of ventilator-free days for critically ill adults. Compares closed-loop (blue) vs. conventional ventilation (red). X-axis: Ventilator-free days. Y-axis: Cumulative patients, %.
December 9, 2025 at 5:00 AM
icunutrition.bsky.social
Last session of the day- ACTiVE Trial #ACTIVEtrial #ccrdownunder
December 9, 2025 at 4:31 AM