Our work out today in @nature.com!
We identified a previously unknown function for WEE1 in cell cycle control that could explain some of the inhibitor side-effects.
We found WEE1 inhibits APC/C(Cdh1) to promote S-phase and cell cycle entry. Inhibit Wee1 , block or impair cell cycle entry.
We identified a previously unknown function for WEE1 in cell cycle control that could explain some of the inhibitor side-effects.
We found WEE1 inhibits APC/C(Cdh1) to promote S-phase and cell cycle entry. Inhibit Wee1 , block or impair cell cycle entry.
Promising cancer drugs called Wee1 inhibitors have been limited by serious side effects.
Researchers have discovered a previously unknown role for Wee1 that could explain why.
The findings could help identify patients most likely to benefit & support development of safer, more targeted treatments.
Researchers have discovered a previously unknown role for Wee1 that could explain why.
The findings could help identify patients most likely to benefit & support development of safer, more targeted treatments.
Hidden role of a cancer treatment target could explain toxic side effects
Wee1 inhibitors are a promising new cancer treatment, but serious side effects threaten their adoption in the clinic. Now, researchers from the MRC Laboratory of Medical Sciences (LMS), the University...
lms.mrc.ac.uk
October 21, 2026 at 4:21 PM
Our work out today in @nature.com!
We identified a previously unknown function for WEE1 in cell cycle control that could explain some of the inhibitor side-effects.
We found WEE1 inhibits APC/C(Cdh1) to promote S-phase and cell cycle entry. Inhibit Wee1 , block or impair cell cycle entry.
We identified a previously unknown function for WEE1 in cell cycle control that could explain some of the inhibitor side-effects.
We found WEE1 inhibits APC/C(Cdh1) to promote S-phase and cell cycle entry. Inhibit Wee1 , block or impair cell cycle entry.
Koebbe et al. (Eur J Hum Genet 2026) found loss-of-function variants in ATM and CDH1 enriched in gastric cancer. In Helix, CDH1 variants are strongly enriched in cases; ATM has too few cases with the variant to call (OR 1.85, 95% CI 0.51–6.7; published 3.94). #HelixReplicates
October 23, 2026 at 5:56 PM
Koebbe et al. (Eur J Hum Genet 2026) found loss-of-function variants in ATM and CDH1 enriched in gastric cancer. In Helix, CDH1 variants are strongly enriched in cases; ATM has too few cases with the variant to call (OR 1.85, 95% CI 0.51–6.7; published 3.94). #HelixReplicates
Gisteren waren we met @borstkanker.bsky.social bij de (erfelijke) Maagkanker Challenge georganiseerd door @umcutrecht.bsky.social en @mdlfonds.bsky.social. Met 600 studenten. Zit er in je familie Diffuus Maagkanker en Lobulaire borstkanker? Misschien komt dat door een #CDH1-mutatie. /1
CDH1-mutatie: risico op maagkanker - Erfelijke maagkanker
Heb je een afwijking in het CDH1-gen? Dan heb je erfelijke aanleg voor maagkanker. Dit betekent dat je meer risico hebt om deze vorm van maagkanker te krijgen dan mensen die deze gen niet hebben. Vrou...
www.erfelijkemaagkanker.nl
October 17, 2026 at 6:58 AM
Gisteren waren we met @borstkanker.bsky.social bij de (erfelijke) Maagkanker Challenge georganiseerd door @umcutrecht.bsky.social en @mdlfonds.bsky.social. Met 600 studenten. Zit er in je familie Diffuus Maagkanker en Lobulaire borstkanker? Misschien komt dat door een #CDH1-mutatie. /1
I hate that the biggest story from Jack Smith's testimony yesterday was that kerfuffle with that Senator looking like an idiot for confusing the Iowa Hawkeyes w/the Atlanta Hawks.
It's obscured the important story of the crimes of which Jack Smith was investigating DJT + the evidence uncovered.
It's obscured the important story of the crimes of which Jack Smith was investigating DJT + the evidence uncovered.
October 1, 2026 at 7:21 AM
After losing her mother and sister to stomach cancer, Ashley Zaldivar made the decision to have a total gastrectomy.
Now, she's paying it forward by sharing her story and advocating for genetic testing. #OncSky #EndCancer
Now, she's paying it forward by sharing her story and advocating for genetic testing. #OncSky #EndCancer
Stomach cancer previvor: Why I promote genetic testing
Ashley Zaldivar resisted getting a gastrectomy until her mother died of a stomach cancer linked to the genetic mutation they shared. Today, she promotes genetic testing to boost awareness of CDH1.
spr.ly
September 30, 2026 at 3:32 PM
After losing her mother and sister to stomach cancer, Ashley Zaldivar made the decision to have a total gastrectomy.
Now, she's paying it forward by sharing her story and advocating for genetic testing. #OncSky #EndCancer
Now, she's paying it forward by sharing her story and advocating for genetic testing. #OncSky #EndCancer
Keynote speaker Dr. Parry Guilford breaks down the similarities between #lobular #breastcancer and diffuse #gastriccancer via a hereditary #CDH1 mutation. #ILCSymposium. Good to know as we enter Hereditary Cancer Awareness Week! #bcsm @lobularbca.bsky.social
September 24, 2026 at 6:45 PM
Keynote speaker Dr. Parry Guilford breaks down the similarities between #lobular #breastcancer and diffuse #gastriccancer via a hereditary #CDH1 mutation. #ILCSymposium. Good to know as we enter Hereditary Cancer Awareness Week! #bcsm @lobularbca.bsky.social
Guilford proposes using the term hereditary diffuse gastric & #lobular #breastcancer syndrome for those w/ #CDH1 mutation since many people who survive #gastric #cancer will develop #lobularBC. #ILCSymposium @lobularbca.bsky.social @elbcc-2018.bsky.social #bcsm #lobmob
September 24, 2026 at 6:54 PM
Guilford proposes using the term hereditary diffuse gastric & #lobular #breastcancer syndrome for those w/ #CDH1 mutation since many people who survive #gastric #cancer will develop #lobularBC. #ILCSymposium @lobularbca.bsky.social @elbcc-2018.bsky.social #bcsm #lobmob
Cadherin 1 negatively regulates SARS-CoV-2 infection in the olfactory epithelium
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Cadherin 1 negatively regulates SARS-CoV-2 infection in the olfactory epithelium - EMBO Reports
Olfactory dysfunction is a major symptom of COVID-19 syndrome. The critical genes contributing to SARS-CoV-2 infection are not fully understood. Here, we identified Cadherin 1 (CDH1), a hub in the int...
link.springer.com
September 24, 2026 at 1:24 PM
Cadherin 1 negatively regulates SARS-CoV-2 infection in the olfactory epithelium
link.springer.com/article/10.1...
link.springer.com/article/10.1...
A new multicenter GASTRIC consortium study identify that the absence of unusual endoscopic findings may be reassuring; masses, thickened folds, and signet ring cell carcinoma indicate higher risk of advanced disease in CDH1 carriers.
@soniakupfer.bsky.social
https://pubmed.ncbi.nlm.nih.gov/42604658/
@soniakupfer.bsky.social
https://pubmed.ncbi.nlm.nih.gov/42604658/
August 31, 2026 at 6:06 PM
A new multicenter GASTRIC consortium study identify that the absence of unusual endoscopic findings may be reassuring; masses, thickened folds, and signet ring cell carcinoma indicate higher risk of advanced disease in CDH1 carriers.
@soniakupfer.bsky.social
https://pubmed.ncbi.nlm.nih.gov/42604658/
@soniakupfer.bsky.social
https://pubmed.ncbi.nlm.nih.gov/42604658/
ZWINT is identified as a potential biomarker for prognosis & a therapeutic target in breast cancer, alongside TP53/CDH1. @WHU_1893
#OpenAccess: doi.org/10.1007/s115...
#currentmedicalscience #Oncology #BreastCancer #TP53 #CDH1 #Biomarker #TranslationalOncology
#OpenAccess: doi.org/10.1007/s115...
#currentmedicalscience #Oncology #BreastCancer #TP53 #CDH1 #Biomarker #TranslationalOncology
August 24, 2026 at 2:02 PM
ZWINT is identified as a potential biomarker for prognosis & a therapeutic target in breast cancer, alongside TP53/CDH1. @WHU_1893
#OpenAccess: doi.org/10.1007/s115...
#currentmedicalscience #Oncology #BreastCancer #TP53 #CDH1 #Biomarker #TranslationalOncology
#OpenAccess: doi.org/10.1007/s115...
#currentmedicalscience #Oncology #BreastCancer #TP53 #CDH1 #Biomarker #TranslationalOncology
Hereditary diffuse gastric cancer is a rare, serious genetic condition that increases the risk of developing stomach cancer.
Because the disease usually doesn't present symptoms until it's advanced, it's important to understand the risk factors. Learn more: spr.ly/63323fpWqV
Because the disease usually doesn't present symptoms until it's advanced, it's important to understand the risk factors. Learn more: spr.ly/63323fpWqV
Is stomach cancer hereditary?
Hereditary diffuse gastric cancer is a condition caused by the inherited CDH1 gene mutation that increases the risk of stomach cancer. Paul Mansfield, M.D., explains how it develops, the importance of genetic testing and why preventive surgery is the most effective way to manage risk.
spr.ly
July 31, 2025 at 1:00 PM
Hereditary diffuse gastric cancer is a rare, serious genetic condition that increases the risk of developing stomach cancer.
Because the disease usually doesn't present symptoms until it's advanced, it's important to understand the risk factors. Learn more: spr.ly/63323fpWqV
Because the disease usually doesn't present symptoms until it's advanced, it's important to understand the risk factors. Learn more: spr.ly/63323fpWqV
Sarah Grace Beckham relied on our Dr. Paul Mansfield to face her fears when he preventatively removed her stomach. How she was able to return the favor on the dance floor at her wedding: http://spr.ly/63324Nxzlk #EndCancer
Young adult cancer pre-vivor: Why I had my stomach removed at age 25
Sarah Grace Beckham was only 25 when her oncologist recommended she get her stomach removed due to a genetic mutation called CDH1. Read on to find out how she overcame her fears to take the plunge — and how she returned the favor at her wedding four years later.
spr.ly
May 26, 2025 at 4:24 PM
Sarah Grace Beckham relied on our Dr. Paul Mansfield to face her fears when he preventatively removed her stomach. How she was able to return the favor on the dance floor at her wedding: http://spr.ly/63324Nxzlk #EndCancer
Our main results are that (1) key driver mutations that are commonly considered truncal (PIK3CA and CDH1) exhibit complex clonal dynamics in paired biopsies, (2) bilateral biopsies from MBC patients were phylogenetically unrelated but had shared driver mutations and CNVs, and (3) ...
April 16, 2026 at 4:11 PM
Our main results are that (1) key driver mutations that are commonly considered truncal (PIK3CA and CDH1) exhibit complex clonal dynamics in paired biopsies, (2) bilateral biopsies from MBC patients were phylogenetically unrelated but had shared driver mutations and CNVs, and (3) ...
CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.06.20.660633v1
https://www.biorxiv.org/content/10.1101/2025.06.20.660633v1
June 23, 2025 at 7:00 AM
CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.06.20.660633v1
https://www.biorxiv.org/content/10.1101/2025.06.20.660633v1
From MBoC
Faithful meiosis requires more than APC/C activity—it also requires degradation of the APC/C activator Cdh1. Yeast studies reveal how nutrient sensing regulates this process and supports accurate chromosome segregation.
https://www.molbiolcell.org/doi/10.1091/mbc.E24-07-0286
Faithful meiosis requires more than APC/C activity—it also requires degradation of the APC/C activator Cdh1. Yeast studies reveal how nutrient sensing regulates this process and supports accurate chromosome segregation.
https://www.molbiolcell.org/doi/10.1091/mbc.E24-07-0286
June 24, 2026 at 8:35 PM
From MBoC
Faithful meiosis requires more than APC/C activity—it also requires degradation of the APC/C activator Cdh1. Yeast studies reveal how nutrient sensing regulates this process and supports accurate chromosome segregation.
https://www.molbiolcell.org/doi/10.1091/mbc.E24-07-0286
Faithful meiosis requires more than APC/C activity—it also requires degradation of the APC/C activator Cdh1. Yeast studies reveal how nutrient sensing regulates this process and supports accurate chromosome segregation.
https://www.molbiolcell.org/doi/10.1091/mbc.E24-07-0286
Hereditary diffuse gastric cancer with germline CDH1 variants carries a high risk of signet ring cell carcinoma (SRCC), with limited data to choose between endoscopic surveillance and prophylactic total gastrectomy.
#genomics #HereditaryCancer #ClinicalGenetics
#genomics #HereditaryCancer #ClinicalGenetics
Predictors of early cancer burden in CDH1 pathogenic variant carriers: a UK single-centre cohort study.
Hereditary diffuse gastric cancer (HDGC) · EClinicalMedicine 2026
www.genox-veille.fr
July 21, 2026 at 1:00 PM
Hereditary diffuse gastric cancer with germline CDH1 variants carries a high risk of signet ring cell carcinoma (SRCC), with limited data to choose between endoscopic surveillance and prophylactic total gastrectomy.
#genomics #HereditaryCancer #ClinicalGenetics
#genomics #HereditaryCancer #ClinicalGenetics
"Detection of bowel cancer marker in wastewater may offer new early warning system" @eurekalert.bsky.social via www.eurekalert.org/news-release... #water
Detection of bowel cancer marker in wastewater may offer new early warning system
Detection of a bowel cancer marker (CDH1) in wastewater may offer a new community level early warning system for the disease, suggests a proof of concept study published online in the Journal of Epide...
www.eurekalert.org
March 18, 2026 at 12:09 AM
"Detection of bowel cancer marker in wastewater may offer new early warning system" @eurekalert.bsky.social via www.eurekalert.org/news-release... #water
#gerontology #ecology #publichealth #exposome
CA4 and CAT suppression;
SPP1, CDH1, and TIMP1 elevation
Unraveling the molecular mechanisms of
air pollution-induced
lung adenocarcinoma
through machine learning,
network toxicology,
and molecular docking
.
www.sciencedirect.com/science/arti...
CA4 and CAT suppression;
SPP1, CDH1, and TIMP1 elevation
Unraveling the molecular mechanisms of
air pollution-induced
lung adenocarcinoma
through machine learning,
network toxicology,
and molecular docking
.
www.sciencedirect.com/science/arti...
January 12, 2026 at 9:02 AM
#gerontology #ecology #publichealth #exposome
CA4 and CAT suppression;
SPP1, CDH1, and TIMP1 elevation
Unraveling the molecular mechanisms of
air pollution-induced
lung adenocarcinoma
through machine learning,
network toxicology,
and molecular docking
.
www.sciencedirect.com/science/arti...
CA4 and CAT suppression;
SPP1, CDH1, and TIMP1 elevation
Unraveling the molecular mechanisms of
air pollution-induced
lung adenocarcinoma
through machine learning,
network toxicology,
and molecular docking
.
www.sciencedirect.com/science/arti...
New lab preprint!
We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry
A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook
www.biorxiv.org/cgi/content/...
We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry
A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook
www.biorxiv.org/cgi/content/...
Wee1 opposes APC/C(Cdh1) activity to promote S-phase entry
Wee1 phosphorylates and inhibits CDK activity to inhibit mitotic entry and establish a G2 DNA damage checkpoint. Consequently, Wee1 inhibitors are in clinical trials, developed to be synthetically let...
www.biorxiv.org
December 3, 2025 at 4:03 PM
New lab preprint!
We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry
A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook
www.biorxiv.org/cgi/content/...
We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry
A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook
www.biorxiv.org/cgi/content/...
Vandaag spreek ik bij de lotgenotencontactdag van de Stichting CDH1 en CTNNA1. Dat is voor mensen met erfelijk maag en borstkanker.
Vandaag hebben ze bekend gemaakt dat ze een andere, veel mooiere en passender naam: Stamverwanten.
Ik krijg helemaal zin om er bij te horen!
Vandaag hebben ze bekend gemaakt dat ze een andere, veel mooiere en passender naam: Stamverwanten.
Ik krijg helemaal zin om er bij te horen!
November 9, 2024 at 10:11 AM
Vandaag spreek ik bij de lotgenotencontactdag van de Stichting CDH1 en CTNNA1. Dat is voor mensen met erfelijk maag en borstkanker.
Vandaag hebben ze bekend gemaakt dat ze een andere, veel mooiere en passender naam: Stamverwanten.
Ik krijg helemaal zin om er bij te horen!
Vandaag hebben ze bekend gemaakt dat ze een andere, veel mooiere en passender naam: Stamverwanten.
Ik krijg helemaal zin om er bij te horen!
Now I am concerned for you, have you been checked to see if you carry
BRCA1, BRCA2, PTEN, TP53, CDH1, and STK11 genes? Because that could be serious. My aunt got breast cancer from HRT.
BRCA1, BRCA2, PTEN, TP53, CDH1, and STK11 genes? Because that could be serious. My aunt got breast cancer from HRT.
February 24, 2025 at 4:27 PM
Now I am concerned for you, have you been checked to see if you carry
BRCA1, BRCA2, PTEN, TP53, CDH1, and STK11 genes? Because that could be serious. My aunt got breast cancer from HRT.
BRCA1, BRCA2, PTEN, TP53, CDH1, and STK11 genes? Because that could be serious. My aunt got breast cancer from HRT.
Interesting. Her2 mutant responders show co-occurrence with CDH1 mutations. www.nature.com/articles/s41...
Tucatinib and trastuzumab in HER2-mutated metastatic breast cancer: a phase 2 basket trial - Nature Medicine
In this phase 2 basket trial, patients with heavily pretreated HER2-mutated metastatic breast cancer received the small-molecule HER2 inhibitor tucatinib and anti-HER2 trastuzumab, leading to encourag...
www.nature.com
January 18, 2025 at 9:36 AM
Interesting. Her2 mutant responders show co-occurrence with CDH1 mutations. www.nature.com/articles/s41...
