#CDifficile
LightNews LightNews
robfagan.bsky.social
We have 2 fully funded PhD studentships available through the new Yorkshire Biosciences DTP (starting Oct 25) - please share! Both projects are focussed on #phage that infect #Cdifficile

#microsky #phage #evolution #cryoEM #AFM

www.whiterose-mechanisticbiology-dtp.ac.uk/yorkshire-bi...
A figure showing the structure of phage phiCD508 in extended and contracted forms, determined by cryo-EM by @jasonwils.bsky.social. Figure 1 (modified) from https://www.biorxiv.org/content/10.1101/2023.08.04.551987v1
November 30, 2024 at 10:14 AM
plosbiology.org
Bacterial ncRNAs influence various cellular functions & often have complex 3ry structures. ModT is a conserved #ncRNA found in 2,500 bacterial spp, shown here to regulate growth transition & sporulation in #Cdifficile via changes in c-di-GMP @helmholtz-hiri.bsky.social #PLOSBiology plos.io/4iIpgYm
This shows the C. difficile ModT locus, the genes regulated by ModT, and the conserved tertiary structures of ModT RNAs from 5 bacterial species.
December 17, 2024 at 1:31 PM
tinalence.bsky.social
Happy to share our work on #ncRNA #ModT in #Cdifficile from my postdoc, with the co-first author Johannes Sulzer!! It was an exciting time in @ffaber.bsky.social Franzi Faber`s Lab at UniWürzburg and @helmholtz-hiri.bsky.social.
plosbiology.org PLOS Biology @plosbiology.org · Dec 18
Bacterial ncRNAs influence various cellular functions & have complex 3ry structures. @tinalence.bsky.social @ffaberlab.bsky.social &co show that the #ncRNA ModT is conserved in 2,500 bacterial spp and regulates growth transition & sporulation in #Cdifficile via c-di-GMP #PLOSBiology plos.io/4iIpgYm
This shows the C. difficile ModT locus, the genes regulated by ModT, and the conserved tertiary structures of ModT RNAs from 5 bacterial species.
December 18, 2024 at 10:21 AM
pssalgado.bsky.social
🧫 #AMR #PhD open @newcastleuni.bsky.social!

How does #Cdifficile protein "armour" help it resist antimicrobials? Join me and @henrikstrahl.bsky.social to find out using:

🔬 #Structuralbiology, #microbiology #microscopy #genetics

📅 Deadline 20 May 2026

#PhD #PhDLife

Pls share!

(UK home only)
C. difficile S-layer’s role in antimicrobial resistance at Newcastle University on FindAPhD.com
PhD Project - C. difficile S-layer’s role in antimicrobial resistance at Newcastle University, listed on FindAPhD.com
findaphd.com
April 29, 2026 at 7:30 PM
plosbiology.org
Bacterial ncRNAs influence various cellular functions & have complex 3ry structures. @tinalence.bsky.social @ffaberlab.bsky.social &co show that the #ncRNA ModT is conserved in 2,500 bacterial spp and regulates growth transition & sporulation in #Cdifficile via c-di-GMP #PLOSBiology plos.io/4iIpgYm
This shows the C. difficile ModT locus, the genes regulated by ModT, and the conserved tertiary structures of ModT RNAs from 5 bacterial species.
December 18, 2024 at 9:48 AM
c-metamorphosis.bsky.social
Hi guys first post on bluesky kinda nervous #shybacteria #cdifficile
April 25, 2026 at 11:20 PM
robfagan.bsky.social
Just a few days left to apply for a fully funded PhD studentship with us - Jan 6th deadline. Funded through the new Yorkshire Biosciences DTP (starting Oct 25) - please share! Both projects are focussed on
#phage that infect #Cdifficile

#microsky #phage #evolution #cryoEM #AFM
A figure showing the structure of phage phiCD508 in extended and contracted forms, determined by cryo-EM by @jasonwils.bsky.social. Figure 1 (modified) from https://www.biorxiv.org/content/10.1101/2023.08.04.551987v1
January 2, 2025 at 11:17 AM
ffitzp.bsky.social
Brilliant & packed #cdifficile session @escmid.bsky.social
today - well done to all 5 presenters 👏👏 #escmidglobal @taescmid.bsky.social
April 12, 2025 at 1:42 PM
infect-net.bsky.social
👩‍⚕️👩🏾‍⚕️ Frauen in #Medizin & #Pharma: Connect & Collaborate! 🤝
Tillotts Pharma GmbH veranstaltet ein Netzwerk-Event speziell für euch:
📅 Mittwoch, 26. November 2025
🕟 18:30 Uhr
📍 Courtyard by Marriott Düsseldorf Hafen
Speditionstraße 11, 40221 Düsseldorf
#CDifficile #Vernetzung #Frauenkarrieren #Tillotts
October 28, 2025 at 10:46 AM
contagionlive.bsky.social
Dr. Joseph Zackular, from CHOP and UPenn discusses his mRNA vaccine research for #Cdifficile. The vaccine has shown promise in reducing mortality in animal models, with plans to move to human trials. #IDsky #MEDsky

Stay tuned for part 2 tomorrow: www.contagionlive.com/view/mrna-va...
mRNA Vaccine Shows Potential for C difficile Infections
Joseph Zackular, PhD, shares insights on his team’s mRNA vaccine research for C difficile, highlighting progress in animal models and future plans for human trials.
www.contagionlive.com
December 16, 2024 at 7:47 PM
reverseproject.bsky.social
🎬 #ESCMIDGlobal that's a wrap!
Today, we presented an oral abstract on the impact of cohorting interventions on #CDifficile infection, and two more posters - coming soon to the website.
📩 Sign-up for our newsletter to keep up-to-date with all the exciting developments and results 👉🏼 bit.ly/3KU3Zem
April 15, 2025 at 2:03 PM
simonthelwall.bsky.social
Good write up of an outbreak of #cdifficile ribotype 955 here.
#hcai

www.gov.uk/government/p...
Emergence and outbreak of Clostridioides difficile ribotype 955 in England
www.gov.uk
December 5, 2025 at 5:31 PM
contagionlive.bsky.social
Dr. @joeyzacks.bsky.social discussed how current antibiotics disrupt the microbiome, but targeted vaccines may help break the cycle of recurrent #Cdifficile infections.
#mRNAVaccine #IDsky #MEDsky

Listen here for more insights and stay tuned for part 3 tmr: www.contagionlive.com/view/targeti...
Targeting the C Diff Pathogen and Its Immune-Suppressing Toxins
Joseph Zackular, PhD suggests that mRNA vaccines and monoclonal antibodies could offer more effective treatments for recurrent C difficile infections
www.contagionlive.com
December 17, 2024 at 2:22 PM
contagionlive.bsky.social
The final part of our conversation with Dr. @joeyzacks.bsky.social discussed the challenges of community-acquired #Cdifficile. #IDsky #MEDsky

Listen here for deeper insights on this complicated infection and hope for it's possible #mRNAvaccine: www.contagionlive.com/view/while-h...
While Hospital-Acquired C difficile Cases Have Decreased, Community-Acquired Cases Have Risen
Contagion® is a fully integrated news resource for practitioners and specialists to assist with the identification, diagnosis, treatment, and prevention of infectious diseases.
www.contagionlive.com
December 18, 2024 at 4:31 PM
plosbiology.org
Bacterial ncRNAs influence various cellular functions & often have complex 3ry structures. ModT is a conserved #ncRNA found in 2,500 bacterial spp, shown here to regulate growth transition & sporulation in #Cdifficile via changes in c-di-GMP @helmholtz-hiri.bsky.social #PLOSBiology plos.io/4iIpgYm
This shows the C. difficile ModT locus, the genes regulated by ModT, and the conserved tertiary structures of ModT RNAs from 5 bacterial species.
December 17, 2024 at 5:29 PM
contagionlive.bsky.social
A new study finds the most effective FMT strategy for C. difficile involves multiple-dose capsules or colonoscopy after extended antibiotic pretreatment, with repeated FMT for recurrences. @hcplivenews.bsky.social #IDsky #MEDsky #Cdifficile

Read more: www.contagionlive.com/view/study-e...
Study Explores Therapeutic Approaches to Enhance FMT Success in C difficile Treatment
The most successful FMT approach involved administering multiple-dose capsules or colonoscopy following an extended course of antibiotic pretreatment.
www.contagionlive.com
July 22, 2025 at 1:12 PM
femsjournals.bsky.social
Bile acids play a critical role in the germination of spores. Vinay et al. summarize the effects of #bile acids and their metabolites on #germination, receptor proteins, #germinants of clostridial species. #Cdifficile
@StanleyBrul
#FEMSMicrobiolRev
buff.ly/7Zh0ozL
March 7, 2025 at 10:00 AM
plosbiology.org
Unlike other #bacteria, C. difficile must detect both germinant & co-germinant signals to trigger #spore #germination. This study finds that the CspC:CspA complex is a key signaling node that integrates environmental cues to regulate #Cdifficile spore germination @plosbiology.org 🧪 plos.io/4rtCKdZ
Model for Clostridioides difficile germination. Top: Model of the C. difficile proteins required for germination during sporulation. From left to right: interdomain processing of the CspBA fusion protein by the protease YabG occurs in the spore coat layer; heterodimerization of CspC and CspA and homodimerization of CspB; and loading of key germination proteins into the cortex region of the mature spore. Bottom right: Model of a C. difficile spore undergoing germination. Sensing of germinant and co-germinant signals (either directly or indirectly) by the CspC:CspA heterodimer (1) leads to the heterodimer adopting an active conformation (2). Bottom left: CspC:CspA heterodimer space-filling model. Residues at the center of the CspC:CspA heterodimer binding interface (I.) play important roles in transducing germinant and co-germinant signals, while residues at the periphery of the binding interface (II.) help stabilize the complex. Signal transduction by the CspC:CspA heterodimer initiates the activation of CspB (either directly or indirectly) (3). Active CspB then proteolytically activates the cortex-lytic enzyme SleC (4), which will go on to degrade the spore cortex (5), allowing for rehydration of the spore core and resumption of metabolic activity.
February 3, 2026 at 5:25 PM
gmj-georgia.bsky.social
Breakthrough: Manufactured 15-strain biotherapeutic achieves 85-90% success rate matching traditional fecal transplant for recurrent C. diff infections. Phase 1b…

#Biotherapeutic #Cdifficile #Clinicaltrial #FMT #Microbiome

#Biotherapeutic #Cdifficile #Clinicaltrial #FMT #Microbiome

https://new…
New biotherapeutic matches FMT for C. diff treatment
Breakthrough: Manufactured 15-strain biotherapeutic achieves 85-90% success rate matching traditional fecal transplant for recurrent C. diff infections. Phase 1b… #Biotherapeutic #Cdifficile #Clinicaltrial #FMT #Microbiome
news.gmj.ge
June 6, 2026 at 12:51 AM
plosbiology.org
Unlike other #bacteria, C. difficile must detect both germinant & co-germinant signals to trigger #spore #germination. This study finds that the CspC:CspA complex is a key signaling node that integrates environmental cues to regulate #Cdifficile spore germination @plosbiology.org 🧪 plos.io/4rtCKdZ
Model for Clostridioides difficile germination. Top: Model of the C. difficile proteins required for germination during sporulation. From left to right: interdomain processing of the CspBA fusion protein by the protease YabG occurs in the spore coat layer; heterodimerization of CspC and CspA and homodimerization of CspB; and loading of key germination proteins into the cortex region of the mature spore. Bottom right: Model of a C. difficile spore undergoing germination. Sensing of germinant and co-germinant signals (either directly or indirectly) by the CspC:CspA heterodimer (1) leads to the heterodimer adopting an active conformation (2). Bottom left: CspC:CspA heterodimer space-filling model. Residues at the center of the CspC:CspA heterodimer binding interface (I.) play important roles in transducing germinant and co-germinant signals, while residues at the periphery of the binding interface (II.) help stabilize the complex. Signal transduction by the CspC:CspA heterodimer initiates the activation of CspB (either directly or indirectly) (3). Active CspB then proteolytically activates the cortex-lytic enzyme SleC (4), which will go on to degrade the spore cortex (5), allowing for rehydration of the spore core and resumption of metabolic activity.
February 3, 2026 at 9:20 AM
contagionlive.bsky.social
ICYMI: Hidden pathways of #Cdifficile transmission in hospitals; environmental contamination plays a key role in spreading the infection, suggesting a need for updated #infectioncontrol strategies focused on surface cleaning & hand hygiene. #IDsky #MEDsky

www.contagionlive.com/view/new-gen...
New Genomic Study Reveals Hidden Pathways of C difficile Transmission in Hospitals
Environmental contamination plays a larger role than previously recognized, prompting calls for updated infection control strategies
www.contagionlive.com
April 9, 2025 at 4:13 PM
plosbiology.org
Unlike other #bacteria, C. difficile must detect both germinant & co-germinant signals to trigger #spore #germination. This study finds that the CspC:CspA complex is a key signaling node that integrates environmental cues to regulate #Cdifficile spore germination @plosbiology.org 🧪 plos.io/4rtCKdZ
Model for Clostridioides difficile germination. Top: Model of the C. difficile proteins required for germination during sporulation. From left to right: interdomain processing of the CspBA fusion protein by the protease YabG occurs in the spore coat layer; heterodimerization of CspC and CspA and homodimerization of CspB; and loading of key germination proteins into the cortex region of the mature spore. Bottom right: Model of a C. difficile spore undergoing germination. Sensing of germinant and co-germinant signals (either directly or indirectly) by the CspC:CspA heterodimer (1) leads to the heterodimer adopting an active conformation (2). Bottom left: CspC:CspA heterodimer space-filling model. Residues at the center of the CspC:CspA heterodimer binding interface (I.) play important roles in transducing germinant and co-germinant signals, while residues at the periphery of the binding interface (II.) help stabilize the complex. Signal transduction by the CspC:CspA heterodimer initiates the activation of CspB (either directly or indirectly) (3). Active CspB then proteolytically activates the cortex-lytic enzyme SleC (4), which will go on to degrade the spore cortex (5), allowing for rehydration of the spore core and resumption of metabolic activity.
February 3, 2026 at 1:55 PM
bitscopic.bsky.social
A new study found that people with alcohol use disorder are much more likely to get a C. difficile infection. PraediAlert helps find both the infection and people with a history of alcohol problems.

www.infectioncontroltoday.com/view/uncover...

#Cdifficile #alcoholdisorder #Clostridioidesdifficile
Uncovering a Hidden Risk: Alcohol Use Disorder Significantly Increases C difficile Infection Rates
A groundbreaking study reveals a strong connection between alcohol use disorder and increased risk for Clostridioides difficile infection, challenging traditional assumptions and calling for enhanced ...
www.infectioncontroltoday.com
April 11, 2025 at 11:51 AM
simonthelwall.bsky.social
Moving on to C. difficile infection, it's another story of years of success followed by a worrying rise in incidence in recent years.
#hcai #cdi #cdifficile
October 6, 2024 at 6:15 AM
smitslab.bsky.social
Our work focuses on ibezapolstat (for treatment of #Cdifficile infections #CDI) and a novel compound from a series that is intended to target other pathogens, such as #VRE and #MRSA. This representative compound, ACX-801, was selected on the basis of excellent inhibition of PolC in vitro. 4/9
November 6, 2025 at 10:32 AM