Proximal Ascending aorta is made of #SmoothMuscleCell of dual lineage origins
Luminal side: Wnt1+ #CardiacNeuralCrest
Abluminal side: Mef2c+ #SecondHeartField

Their transcript profiles by scRNAseq + snATACseq👇

#AortaEd
#ATVB 2024 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...

#CoarctationOfAorta
A developmental problem of #SmoothMuscleCell #BoundaryFormation?😃

"a border is formed at the interface b/w #CardiacNeuralCrest- derived SMCs in the 6th #PharyngealArchArtery & #ParaxialMesoderm -derived SMCs in the dorsal aorta"

#JDBMDPI 2025
www.mdpi.com/2221-3759/13...