smCRISPRa is a compact platform for high-efficiency multiplexed gene activation in mouse models.

Compact engineered Cas12m enables multiplexed CRISPR gene activation in mice  Bioengineer.org

smCRISPRa is a compact platform for high-efficiency multiplexed gene activation in mouse models.

smCRISPRa is a compact platform for high-efficiency multiplexed gene activation in mouse models.

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The authors identified and engineered a miniature, innate nuclease-dead xCas12m enabling effective epigenome editing. xCas12m–CRISPRoff achieved durable epigenetic silencing and inhibition of hepatitis B virus infection through single-AAV delivery.

Nature Structural & Molecular Biology, Published online: 16 September 2026; doi:10.1038/s41594-026-01890-9The authors identified and engineered a miniature, innate nuclease-dead xCas12m enabling effective epigenome editing. xCas12m–CRISPRoff achieved durable epigenetic silencing and inhibition of hepatitis B virus infection through single-AAV delivery.

Nature Structural & Molecular Biology, Published online: 16 September 2026; doi:10.1038/s41594-026-01890-9The authors identified and engineered a miniature, innate nuclease-dead xCas12m enabling effective epigenome editing. xCas12m–CRISPRoff achieved durable epigenetic silencing and inhibition of hepatitis B virus infection through single-AAV delivery.

The authors identified and engineered a miniature, innate nuclease-dead xCas12m enabling effective epigenome editing. xCas12m–CRISPRoff achieved durable epigenetic silencing and inhibition of hepatiti...

CRISPR-based epigenome editing represents a programmable strategy to precisely modulate gene expression, holding immense promise for therapeutic applications. However, the large size of the dCas prote...