#CircAHA
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haoyin.bsky.social
#HutchinsonGilfordProgeriaSyndrome

#SmoothMuscleCell Progerin transgene drives #EndMT #Atherosclerosis🐭

⏫Aortic Endothelial Cell permeability
⏫Lesional EC infiltr▶️ColIV- & TGFβ1-rich plaque😮

Paracrine of progeroid aortic SMC?😆

#CircAHA 2024
www.ahajournals.org/doi/10.1161/...
December 4, 2025 at 11:55 AM
tomkaier.com
Renal denervation sham controlled trial published in CircAHA doi.org/10.1161/CIRCUL… - how intriguing! Great effort by the investigators - but I have questions.
November 12, 2024 at 10:47 AM
ahajournals.bsky.social
A new collaboration between the New England Journal of Medicine (NEJM) & the American Heart Association's flagship journal Circulation was just announced. Starting in early 2025, research authors can select a seamless transfer of their manuscript between @NEJM & @CircAHA #AHA24
November 17, 2024 at 9:15 PM
haoyin.bsky.social
🫀 #Lymphangiogenesis
#BranchedChainAminoAcid Catabolism
#HeartFailure

Prox1+ #LymphaticEndothelialCell BCKDK (kinase ⏬BCAA degradation) KO➡️
⏫Lymphangiogenesis
⏫Diastolic function
🐭HFpEF (L-NAME+HFD 12 wk)

Src-VEGFR3 axis

#CircAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/full/10....
May 24, 2025 at 7:25 PM
haoyin.bsky.social
Lineage tracing of Smooth Muscle Cells of different origins using integrated Dre(ER)-rox-CreER-loxp systems🐭

Second heart field▶️Isl1-Dre::Myh11-RSR-CreER
Cardiac neural crest▶️Wnt1-Dre
Somite▶️Meox1-DreER
Mesothelial/Visceral▶️Upk3b-Dre

Bin Zhou lab @CircAHA 2025
www.ahajournals.org/doi/10.1161/...
January 6, 2026 at 12:25 PM
haoyin.bsky.social
Higher #FattyAcidOxidation (likely +OXPHOS Adipogenesis mTPRC1) in non-failing ♀️Heart/Cardiomyocyte than ♂️heart

Integrative re-analysis of GTEx bulk RNAseq, snRNAseq, metabolomics

#CircAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
May 6, 2025 at 12:52 PM
haoyin.bsky.social
#CRISPR #RNAEditing #HypertrophicCardioMyopathy

AAV9-hpCas13d/gRNA
⏬30% RQ mutant mRNA
Partially rescue cardiac hypercontractility, LV hypertrophy & cardiomyocyte loss in early onset HCM of 2-mo Myh6 p.R872H/p.R404Q🐭

Resolve multiple🧍MYH7 variants

#CircAHA 2024
www.ahajournals.org/doi/10.1161/...
April 1, 2025 at 12:01 PM
ahajournals.bsky.social
Submitting your #cardiology manuscript to NEJM?

Learn more about seamlessly transferring your manuscript between @NEJM and @CircAHA #AHA25

https://www.ahajournals.org/circ/nejm-circulation-collaboration
November 6, 2025 at 10:13 PM
haoyin.bsky.social
Histone Variants
#SmoothMuscleCell

1⃣H2A.Z
⬇️in #Atherosclerosis
⏫SMC contractile gene
#CircAHA 2018
www.ahajournals.org/doi/10.1161/...
#BMCGenom 2025
bmcgenomics.biomedcentral.com/articles/10....

2⃣H3.3B
⬆️in #AorticDissection
⏫SMC synthetic genes
#Genomics 2023
www.sciencedirect.com/science/arti...
October 15, 2025 at 9:16 PM
thaiscoutinho.bsky.social
1/ Thrilled to see our work featured in the Go Red edition of @CircAHA !!! This was a labor of ❤️ - conceptualized by @brainheartnexus.bsky.social & I 6+ years ago while sipping ☕️ in my office, then brilliantly executed by @amydjohn who worked diligently and obtained her PhD for this work.
February 19, 2025 at 3:00 AM
haoyin.bsky.social
CDK4/6
Endothelial Cell Cycle
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia

Evidence from
👉Fucci2🐭 (fluorescent cell cycle reporter) Retina +BMP9/10 blocking Ab
+Palbociclib CDK4/6i

👉🐭EC ALK1 KO👁️🧠
+Palbociclib
👉👤HHT2 Skin biopsy

#CircAHA 2024
www.ahajournals.org/doi/full/10....
June 11, 2026 at 12:08 PM
haoyin.bsky.social
#AllograftVasculopathy

TET2 #DNADemethylase #MethylcytosineDioxygenase, an epigenomic defender of #SmoothMuscleCell contractile phenotype
⏬Interferon IFNγ in SMC

Ascorbic acid
⏫TET2 activity
⏬🐭aortic #GraftArteriopathy

#CircAHA 2021 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
September 6, 2025 at 1:32 PM
haoyin.bsky.social
Activating #HexosamineBiosynthesisPathway to treat #PeripheralArteryDisease

Glucosamine i.p. ⏫Reperfusion #Angiogenesis but not #Arteriogenesis in🐭#LimbIschemia (BALB/c, eNOS-/- C57BL/6)

Distinct pathways from VEGFA

ATF4 as a signaling mediator

#CircAHA 2024
www.ahajournals.org/doi/10.1161/...
November 14, 2024 at 1:04 PM
katherine-maki1.bsky.social
Join Editors of @CircAHA, @CircRes, and @JAHA_AHA and learn more about the publication process. #AHA24

Publishing Without Perishing: A Discussion With Leading Journal Editors

Friday, Nov 15 @ 3-4pm CT

Room: S105ABC

Program link: eppro01.ativ.me/appinfo.php?...
AHA24
eppro01.ativ.me
November 15, 2024 at 5:04 PM
ahajournals.bsky.social
Submitting your #cardiology manuscript to NEJM?

Learn more about seamlessly transferring your manuscript between @NEJM and @CircAHA #ACC26

https://www.ahajournals.org/circ/nejm-circulation-collaboration
March 29, 2026 at 9:43 PM
drwanpen.bsky.social
Delighted to share perspective piece @CircAHA on history of resistant HTN with @adinaturcu.bsky.social. In the US, it was 1st defined by JNC V report. Back then, RH need combination of diuretic+2 drugs: BB, vasodilator, CCB, or ACEI. We have come a long way! #Cardiosky #Nephsky
tinyurl.com/3tttvaye
The Journey of Resistant Hypertension: From the Fifth Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure to American Heart Association/American Colle...
tinyurl.com
March 10, 2025 at 8:43 PM
hvanspall.bsky.social
#GlobalRounds
@CircAHA
@AHAjournals.bsky.social

#Afghanistan faces a #health crisis: low life expectancy, few cardiologists, high #CVD ☠️ & political/economic forces that disproportionately impact women

Read about challenges our Afghan colleagues face
https://www.ahajournals.org/doi/10.1161/CIRCU…
January 21, 2025 at 11:13 PM
haoyin.bsky.social
#PeripheralArteryDisease
CLEAR Outcomes trial post-hoc

Bempedoic acid reduces Major Adverse Cardiovascular Events & Major Adverse Limb Events

In 1624 with baseline PAD, 282 MALEs in 41 mo f/up

Absolute risk reduction 2.5% 8.3%➡️5.8%

♂️♀️?🤓

#CircAHA 2026
www.ahajournals.org/doi/10.1161/...
August 20, 2026 at 12:36 PM
mfnavedo.bsky.social
💊Check this out! Using human iPSC-derived sinoatrial node cells & 3D organoids, new study @CircAHA reveals how GLP1 directly accelerates the heart’s pacemaker.

Collab with Lulu Ren (former @mcipucd.bsky.social) & Joe Wu's Lab

@ucdavis.bsky.social

www.ahajournals.org/doi/10.1161/...
Tirzepatide Regulates Pacemaker Function by Modulating cAMP and Calcium Dynamics in Human Sinoatrial Node Cells | Circulation
www.ahajournals.org
June 23, 2026 at 2:45 PM
haoyin.bsky.social
Quantify in vivo #EndothelialCell proliferation
#Aorta #InferiorVenaCava
CDH5-DreER::Ki67-CrexER::R26-GFP🐭

In 8-wk🐭, 8% aortic EC are proliferative over 12-wk period
⏬in YAP1 KO or VEGFR2 KO

#Piezo1 maintains aortic EC division orientation

#CircAHA 2024
www.ahajournals.org/doi/10.1161/...
November 9, 2024 at 1:05 PM
sonuabrahammd.bsky.social
🚨 New @CircAHA #ESC2025 SimPub alert!
🚨 HCM isn’t just driven by rare Mendelian mutations. This study highlights the role of intermediate-effect variants (IEVs)—variants with moderate effect & low penetrance—in shaping disease expression. #HCM #SoMeEditor

tinyurl.com/HCM-IEVs
Redefining the Genetic Architecture of Hypertrophic Cardiomyopathy: Role of Intermediate Effect Variants | Circulation
Background: Hypertrophic cardiomyopathy (HCM) is a genetically heterogeneous disorder primarily linked to rare variants in sarcomere genes, though recently certain non-sarcomeric genes have emerged as...
tinyurl.com
August 29, 2025 at 2:52 PM
haoyin.bsky.social
Selectively targeting IGF2R−HLA-DR+ inflammatory, not IGF2R+HLA-DR− phagocytic, IFNγ-stimulated #Macrophage subpopulation using a PLK1 inhibitor BI-2536 to treat #Atherosclerosis

Multiomics: scRNAsq, 242-CD Flow cytometry, proteomics😎

#CircAHA 2023
www.ahajournals.org/doi/10.1161/...
December 26, 2023 at 8:04 PM
haoyin.bsky.social
CRISPR transcription activation of Titin in Cardiomyocyte to normalize sarcomeric content & contractile deficits of #hiPSC-cardiomyocyte carrying TTN truncated variant + dCas9-VPR

Cell type specificity⬅️gRNA targeting cardiac-specific cis elements

#CircAHA 2024
www.ahajournals.org/doi/10.1161/...
August 2, 2024 at 11:27 AM
ahajournals.bsky.social
Submitting your #cardiology manuscript to NEJM?

Learn more about seamlessly transferring your manuscript between @nejm.org and #CircAHA

https://www.ahajournals.org/circ/nejm-circulation-collaboration

#TCT2025
October 25, 2025 at 9:00 PM
ahajournals.bsky.social
Submitting your #cardiology manuscript to NEJM?

Learn more about seamlessly transferring your manuscript between @nejm.org and #CircAHA

https://www.ahajournals.org/circ/nejm-circulation-collaboration

#TCT2025
October 27, 2025 at 4:31 PM