#ArterioVenousMalformation
Angiopoietin-2
In🐭AVM by induced #EndothelialCell BRAF V600E transgene➡️
Capillary #EndothelialCell Angpt2⏫
Pericyte coverage⏬ & gain α-SMA
Angpt2 Ab⏬AVM formation, vascular leakage, pericyte wrapping, EC junctions
#Angiogenesis 2024
link.springer.com/article/10.1...
Angiopoietin-2
In🐭AVM by induced #EndothelialCell BRAF V600E transgene➡️
Capillary #EndothelialCell Angpt2⏫
Pericyte coverage⏬ & gain α-SMA
Angpt2 Ab⏬AVM formation, vascular leakage, pericyte wrapping, EC junctions
#Angiogenesis 2024
link.springer.com/article/10.1...
February 5, 2025 at 8:18 PM
#ArterioVenousMalformation
Angiopoietin-2
In🐭AVM by induced #EndothelialCell BRAF V600E transgene➡️
Capillary #EndothelialCell Angpt2⏫
Pericyte coverage⏬ & gain α-SMA
Angpt2 Ab⏬AVM formation, vascular leakage, pericyte wrapping, EC junctions
#Angiogenesis 2024
link.springer.com/article/10.1...
Angiopoietin-2
In🐭AVM by induced #EndothelialCell BRAF V600E transgene➡️
Capillary #EndothelialCell Angpt2⏫
Pericyte coverage⏬ & gain α-SMA
Angpt2 Ab⏬AVM formation, vascular leakage, pericyte wrapping, EC junctions
#Angiogenesis 2024
link.springer.com/article/10.1...
#HereditaryHemorrhagicTelangiectasia #ArterioVenousMalformation
Bi-specific agonist antibody (DIAG100 DIAG723) clustering ALK1 + BMPRII
-> ⏫BMP-SMAD1/5/8 signal
-> ⏬retinal AVM, joint vascularization, cardiac hypertrophy in HHT🐭1⃣BMP9/10ib 2⃣Eng iECKO
bioRxiv 2025
www.biorxiv.org/content/10.1...
Bi-specific agonist antibody (DIAG100 DIAG723) clustering ALK1 + BMPRII
-> ⏫BMP-SMAD1/5/8 signal
-> ⏬retinal AVM, joint vascularization, cardiac hypertrophy in HHT🐭1⃣BMP9/10ib 2⃣Eng iECKO
bioRxiv 2025
www.biorxiv.org/content/10.1...
September 3, 2025 at 7:08 PM
#HereditaryHemorrhagicTelangiectasia #ArterioVenousMalformation
Bi-specific agonist antibody (DIAG100 DIAG723) clustering ALK1 + BMPRII
-> ⏫BMP-SMAD1/5/8 signal
-> ⏬retinal AVM, joint vascularization, cardiac hypertrophy in HHT🐭1⃣BMP9/10ib 2⃣Eng iECKO
bioRxiv 2025
www.biorxiv.org/content/10.1...
Bi-specific agonist antibody (DIAG100 DIAG723) clustering ALK1 + BMPRII
-> ⏫BMP-SMAD1/5/8 signal
-> ⏬retinal AVM, joint vascularization, cardiac hypertrophy in HHT🐭1⃣BMP9/10ib 2⃣Eng iECKO
bioRxiv 2025
www.biorxiv.org/content/10.1...
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia
Endothelial Cell KLF4 hyperactivation➡️
⏫EC Proliferation
⏬EC PDGFB➡️
⏬NG2+PDGFRβ+ Pericyte investment on AVM lesion
Evidence from
1⃣🐭 Retina +BMP9/10 Ab +EC Alk1 or Smad4 KO
2⃣HHT2👤 Nasal mucosa
#THNO 2026
www.thno.org/v16p4905.htm
#HereditaryHemorrhagicTelangiectasia
Endothelial Cell KLF4 hyperactivation➡️
⏫EC Proliferation
⏬EC PDGFB➡️
⏬NG2+PDGFRβ+ Pericyte investment on AVM lesion
Evidence from
1⃣🐭 Retina +BMP9/10 Ab +EC Alk1 or Smad4 KO
2⃣HHT2👤 Nasal mucosa
#THNO 2026
www.thno.org/v16p4905.htm
June 9, 2026 at 12:30 PM
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia
Endothelial Cell KLF4 hyperactivation➡️
⏫EC Proliferation
⏬EC PDGFB➡️
⏬NG2+PDGFRβ+ Pericyte investment on AVM lesion
Evidence from
1⃣🐭 Retina +BMP9/10 Ab +EC Alk1 or Smad4 KO
2⃣HHT2👤 Nasal mucosa
#THNO 2026
www.thno.org/v16p4905.htm
#HereditaryHemorrhagicTelangiectasia
Endothelial Cell KLF4 hyperactivation➡️
⏫EC Proliferation
⏬EC PDGFB➡️
⏬NG2+PDGFRβ+ Pericyte investment on AVM lesion
Evidence from
1⃣🐭 Retina +BMP9/10 Ab +EC Alk1 or Smad4 KO
2⃣HHT2👤 Nasal mucosa
#THNO 2026
www.thno.org/v16p4905.htm
CDK4/6
Endothelial Cell Cycle
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia
Evidence from
👉🐭Retina +BMP9/10 blocking Ab +Palbociclib Ribociclib
👉🐭EC Eng KO Retina 🧠 +Palbociclib
👉🐭EC Cdk6 KO Retina +BMP9/10 Ab
👉👤HHT2 (ALK1) Skin
#NatureCVR 2024
www.nature.com/articles/s44...
Endothelial Cell Cycle
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia
Evidence from
👉🐭Retina +BMP9/10 blocking Ab +Palbociclib Ribociclib
👉🐭EC Eng KO Retina 🧠 +Palbociclib
👉🐭EC Cdk6 KO Retina +BMP9/10 Ab
👉👤HHT2 (ALK1) Skin
#NatureCVR 2024
www.nature.com/articles/s44...
June 8, 2026 at 6:08 PM
CDK4/6
Endothelial Cell Cycle
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia
Evidence from
👉🐭Retina +BMP9/10 blocking Ab +Palbociclib Ribociclib
👉🐭EC Eng KO Retina 🧠 +Palbociclib
👉🐭EC Cdk6 KO Retina +BMP9/10 Ab
👉👤HHT2 (ALK1) Skin
#NatureCVR 2024
www.nature.com/articles/s44...
Endothelial Cell Cycle
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia
Evidence from
👉🐭Retina +BMP9/10 blocking Ab +Palbociclib Ribociclib
👉🐭EC Eng KO Retina 🧠 +Palbociclib
👉🐭EC Cdk6 KO Retina +BMP9/10 Ab
👉👤HHT2 (ALK1) Skin
#NatureCVR 2024
www.nature.com/articles/s44...
CDK4/6
Endothelial Cell Cycle
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia
Evidence from
👉Fucci2🐭 (fluorescent cell cycle reporter) Retina +BMP9/10 blocking Ab
+Palbociclib CDK4/6i
👉🐭EC ALK1 KO👁️🧠
+Palbociclib
👉👤HHT2 Skin biopsy
#CircAHA 2024
www.ahajournals.org/doi/full/10....
Endothelial Cell Cycle
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia
Evidence from
👉Fucci2🐭 (fluorescent cell cycle reporter) Retina +BMP9/10 blocking Ab
+Palbociclib CDK4/6i
👉🐭EC ALK1 KO👁️🧠
+Palbociclib
👉👤HHT2 Skin biopsy
#CircAHA 2024
www.ahajournals.org/doi/full/10....
June 11, 2026 at 12:08 PM
CDK4/6
Endothelial Cell Cycle
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia
Evidence from
👉Fucci2🐭 (fluorescent cell cycle reporter) Retina +BMP9/10 blocking Ab
+Palbociclib CDK4/6i
👉🐭EC ALK1 KO👁️🧠
+Palbociclib
👉👤HHT2 Skin biopsy
#CircAHA 2024
www.ahajournals.org/doi/full/10....
Endothelial Cell Cycle
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia
Evidence from
👉Fucci2🐭 (fluorescent cell cycle reporter) Retina +BMP9/10 blocking Ab
+Palbociclib CDK4/6i
👉🐭EC ALK1 KO👁️🧠
+Palbociclib
👉👤HHT2 Skin biopsy
#CircAHA 2024
www.ahajournals.org/doi/full/10....
Glenn-Fontan procedure➡️core management for infants with single ventricle
A rat model of Glenn shunt (left superior vena cava-left pulmonary artery anastomosis) recapitulates
🫁 #ArterioVenousMalformation
⏬Aerocyte Car4
⏫Capillary eNOS
#PhysiolRep 2024
physoc.onlinelibrary.wiley.com/doi/10.14814...
A rat model of Glenn shunt (left superior vena cava-left pulmonary artery anastomosis) recapitulates
🫁 #ArterioVenousMalformation
⏬Aerocyte Car4
⏫Capillary eNOS
#PhysiolRep 2024
physoc.onlinelibrary.wiley.com/doi/10.14814...
July 20, 2025 at 12:16 PM
Glenn-Fontan procedure➡️core management for infants with single ventricle
A rat model of Glenn shunt (left superior vena cava-left pulmonary artery anastomosis) recapitulates
🫁 #ArterioVenousMalformation
⏬Aerocyte Car4
⏫Capillary eNOS
#PhysiolRep 2024
physoc.onlinelibrary.wiley.com/doi/10.14814...
A rat model of Glenn shunt (left superior vena cava-left pulmonary artery anastomosis) recapitulates
🫁 #ArterioVenousMalformation
⏬Aerocyte Car4
⏫Capillary eNOS
#PhysiolRep 2024
physoc.onlinelibrary.wiley.com/doi/10.14814...
A complex role of #EndopthelialCell mTORC1 in 🐭retinal #ArterioVenousMalformation
inducible EC Endoglin KO
👉mTORC1⬆️in AVM only
👉Rapamycin⏬AVM
👉EC Raptor (mTORC1 adaptor) KO mildly⏬AVM
👉EC TSC1 (mTORC1 suppressor) KO⏬AVM induced by BMP9/10 Ab
#Angiogenesis 2024
link.springer.com/article/10.1...
inducible EC Endoglin KO
👉mTORC1⬆️in AVM only
👉Rapamycin⏬AVM
👉EC Raptor (mTORC1 adaptor) KO mildly⏬AVM
👉EC TSC1 (mTORC1 suppressor) KO⏬AVM induced by BMP9/10 Ab
#Angiogenesis 2024
link.springer.com/article/10.1...
January 30, 2025 at 8:25 PM
A complex role of #EndopthelialCell mTORC1 in 🐭retinal #ArterioVenousMalformation
inducible EC Endoglin KO
👉mTORC1⬆️in AVM only
👉Rapamycin⏬AVM
👉EC Raptor (mTORC1 adaptor) KO mildly⏬AVM
👉EC TSC1 (mTORC1 suppressor) KO⏬AVM induced by BMP9/10 Ab
#Angiogenesis 2024
link.springer.com/article/10.1...
inducible EC Endoglin KO
👉mTORC1⬆️in AVM only
👉Rapamycin⏬AVM
👉EC Raptor (mTORC1 adaptor) KO mildly⏬AVM
👉EC TSC1 (mTORC1 suppressor) KO⏬AVM induced by BMP9/10 Ab
#Angiogenesis 2024
link.springer.com/article/10.1...
BMP10 KO alone, but not BMP9 KO alone, induces #ArterioVenousMalformation in 🐭Retina Brain wounded Skin
ROSA26-CreER; Bmp10 f/f vs Bmp9-/- vs compound KO
B6/129 strain
Exogenous BMP10, not BMP9, rescues retinal vascularization in BMP9/10 dKO🐭
#Angiogenesis 2023
link.springer.com/article/10.1...
ROSA26-CreER; Bmp10 f/f vs Bmp9-/- vs compound KO
B6/129 strain
Exogenous BMP10, not BMP9, rescues retinal vascularization in BMP9/10 dKO🐭
#Angiogenesis 2023
link.springer.com/article/10.1...
May 31, 2026 at 12:46 PM
BMP10 KO alone, but not BMP9 KO alone, induces #ArterioVenousMalformation in 🐭Retina Brain wounded Skin
ROSA26-CreER; Bmp10 f/f vs Bmp9-/- vs compound KO
B6/129 strain
Exogenous BMP10, not BMP9, rescues retinal vascularization in BMP9/10 dKO🐭
#Angiogenesis 2023
link.springer.com/article/10.1...
ROSA26-CreER; Bmp10 f/f vs Bmp9-/- vs compound KO
B6/129 strain
Exogenous BMP10, not BMP9, rescues retinal vascularization in BMP9/10 dKO🐭
#Angiogenesis 2023
link.springer.com/article/10.1...
Microvascular dysmorphogenesis in BMP9 KO 129/Ola🐭
👉Liver 25~30 wk
⬆️Proliferation of hepatocytes & non-parenchymal cells
👉Kidney 17 wk
⬆️Glomerular capillary size
⬆️Renal fibrosis
⬇️Podocyte
👉 #ArterioVenousMalformation in Liver/Intestine/Uterus
#CardiovascRes 2024
academic.oup.com/cardiovascre...
👉Liver 25~30 wk
⬆️Proliferation of hepatocytes & non-parenchymal cells
👉Kidney 17 wk
⬆️Glomerular capillary size
⬆️Renal fibrosis
⬇️Podocyte
👉 #ArterioVenousMalformation in Liver/Intestine/Uterus
#CardiovascRes 2024
academic.oup.com/cardiovascre...
June 1, 2026 at 11:06 AM
Microvascular dysmorphogenesis in BMP9 KO 129/Ola🐭
👉Liver 25~30 wk
⬆️Proliferation of hepatocytes & non-parenchymal cells
👉Kidney 17 wk
⬆️Glomerular capillary size
⬆️Renal fibrosis
⬇️Podocyte
👉 #ArterioVenousMalformation in Liver/Intestine/Uterus
#CardiovascRes 2024
academic.oup.com/cardiovascre...
👉Liver 25~30 wk
⬆️Proliferation of hepatocytes & non-parenchymal cells
👉Kidney 17 wk
⬆️Glomerular capillary size
⬆️Renal fibrosis
⬇️Podocyte
👉 #ArterioVenousMalformation in Liver/Intestine/Uterus
#CardiovascRes 2024
academic.oup.com/cardiovascre...
#Zebrafish #ArterioVenousMalformation
rasa1a/rasa1b crispant->
AVM at #CaudalVascularPlexus
+⏫#EndothelialCell size &⏫Pillar->
Failed #IntussusceptiveAngiogenesis-based remodeling
Unaltered EC proliferation/apoptosis
Sarah Childs lab Development 2023
journals.biologists.com/dev/article/...
rasa1a/rasa1b crispant->
AVM at #CaudalVascularPlexus
+⏫#EndothelialCell size &⏫Pillar->
Failed #IntussusceptiveAngiogenesis-based remodeling
Unaltered EC proliferation/apoptosis
Sarah Childs lab Development 2023
journals.biologists.com/dev/article/...
September 16, 2023 at 11:46 AM
#Zebrafish #ArterioVenousMalformation
rasa1a/rasa1b crispant->
AVM at #CaudalVascularPlexus
+⏫#EndothelialCell size &⏫Pillar->
Failed #IntussusceptiveAngiogenesis-based remodeling
Unaltered EC proliferation/apoptosis
Sarah Childs lab Development 2023
journals.biologists.com/dev/article/...
rasa1a/rasa1b crispant->
AVM at #CaudalVascularPlexus
+⏫#EndothelialCell size &⏫Pillar->
Failed #IntussusceptiveAngiogenesis-based remodeling
Unaltered EC proliferation/apoptosis
Sarah Childs lab Development 2023
journals.biologists.com/dev/article/...
🌟 Dr. Linda’s Fact of the Week 🌟
"Electrosclerotherapy is a new treatment modality being used to explore a more effective treatment for both AVMs and other Vascular Malformations."
See our NEW Parent Package here: birthmark.org/npp-avm/
#VBF #ArteriovenousMalformation
"Electrosclerotherapy is a new treatment modality being used to explore a more effective treatment for both AVMs and other Vascular Malformations."
See our NEW Parent Package here: birthmark.org/npp-avm/
#VBF #ArteriovenousMalformation
June 21, 2025 at 1:18 AM
🌟 Dr. Linda’s Fact of the Week 🌟
"Electrosclerotherapy is a new treatment modality being used to explore a more effective treatment for both AVMs and other Vascular Malformations."
See our NEW Parent Package here: birthmark.org/npp-avm/
#VBF #ArteriovenousMalformation
"Electrosclerotherapy is a new treatment modality being used to explore a more effective treatment for both AVMs and other Vascular Malformations."
See our NEW Parent Package here: birthmark.org/npp-avm/
#VBF #ArteriovenousMalformation
🌟 Dr. Linda’s Fact of the Week 🌟
"Some individuals with extracranial AVMs may have an intercranial one as well and should get an MRI to rule it out"
See our NEW Parent Package here: birthmark.org/npp-avm/
#VBF #MedicalFacts #DrLindasFactOfTheWeek #ArteriovenousMalformation
"Some individuals with extracranial AVMs may have an intercranial one as well and should get an MRI to rule it out"
See our NEW Parent Package here: birthmark.org/npp-avm/
#VBF #MedicalFacts #DrLindasFactOfTheWeek #ArteriovenousMalformation
June 14, 2025 at 2:17 PM
🌟 Dr. Linda’s Fact of the Week 🌟
"Some individuals with extracranial AVMs may have an intercranial one as well and should get an MRI to rule it out"
See our NEW Parent Package here: birthmark.org/npp-avm/
#VBF #MedicalFacts #DrLindasFactOfTheWeek #ArteriovenousMalformation
"Some individuals with extracranial AVMs may have an intercranial one as well and should get an MRI to rule it out"
See our NEW Parent Package here: birthmark.org/npp-avm/
#VBF #MedicalFacts #DrLindasFactOfTheWeek #ArteriovenousMalformation
Presenting our #VBF Expert of the Week!
Dr. Giacomo Colletti
Contact or read more about this Expert by visiting one of the links below:
birthmark.org/vbf-experts
#ExpertOfTheWeek #VBFExperts #IndustryExpert #ExpertAdvice #VascularBirthmarksFoundation #ArteriovenousMalformation #VascularAnomalies
Dr. Giacomo Colletti
Contact or read more about this Expert by visiting one of the links below:
birthmark.org/vbf-experts
#ExpertOfTheWeek #VBFExperts #IndustryExpert #ExpertAdvice #VascularBirthmarksFoundation #ArteriovenousMalformation #VascularAnomalies
February 13, 2025 at 7:06 PM
Presenting our #VBF Expert of the Week!
Dr. Giacomo Colletti
Contact or read more about this Expert by visiting one of the links below:
birthmark.org/vbf-experts
#ExpertOfTheWeek #VBFExperts #IndustryExpert #ExpertAdvice #VascularBirthmarksFoundation #ArteriovenousMalformation #VascularAnomalies
Dr. Giacomo Colletti
Contact or read more about this Expert by visiting one of the links below:
birthmark.org/vbf-experts
#ExpertOfTheWeek #VBFExperts #IndustryExpert #ExpertAdvice #VascularBirthmarksFoundation #ArteriovenousMalformation #VascularAnomalies
Lucy Markovic death: Australia’s Next Top Model star dies, aged 27
#RIP
#LucyMarkovic
#ABrightShiningLight
#ArteriovenousMalformation
#AVM
#Independent
https://www.the-independent.com/life-style/lucy-markovic-australias-next-top-model-dead-b2731543.html
#RIP
#LucyMarkovic
#ABrightShiningLight
#ArteriovenousMalformation
#AVM
#Independent
https://www.the-independent.com/life-style/lucy-markovic-australias-next-top-model-dead-b2731543.html
April 11, 2025 at 2:34 PM
Lucy Markovic death: Australia’s Next Top Model star dies, aged 27
#RIP
#LucyMarkovic
#ABrightShiningLight
#ArteriovenousMalformation
#AVM
#Independent
https://www.the-independent.com/life-style/lucy-markovic-australias-next-top-model-dead-b2731543.html
#RIP
#LucyMarkovic
#ABrightShiningLight
#ArteriovenousMalformation
#AVM
#Independent
https://www.the-independent.com/life-style/lucy-markovic-australias-next-top-model-dead-b2731543.html
Transcriptomes of #LiverSinusoidalEndothelialCell & #GlomerularEndothelialCell of BMP9 KO🐭
#ArterioVenousMalformation/AV Shunting in liver intestine uterine
Arterial dilation/tortuosity in lung brain
#CardiovascRes 2024
academic.oup.com/cardiovascre...
#ArterioVenousMalformation/AV Shunting in liver intestine uterine
Arterial dilation/tortuosity in lung brain
#CardiovascRes 2024
academic.oup.com/cardiovascre...
July 17, 2024 at 11:08 AM
Transcriptomes of #LiverSinusoidalEndothelialCell & #GlomerularEndothelialCell of BMP9 KO🐭
#ArterioVenousMalformation/AV Shunting in liver intestine uterine
Arterial dilation/tortuosity in lung brain
#CardiovascRes 2024
academic.oup.com/cardiovascre...
#ArterioVenousMalformation/AV Shunting in liver intestine uterine
Arterial dilation/tortuosity in lung brain
#CardiovascRes 2024
academic.oup.com/cardiovascre...
Dysplastic cerebrovasculature in human #ArterioVenousMalformation
Vessel-enriched scRNAseq
Up to 8 #SmoothMuscleCell subclusters
2 MYOCD-LGALS3+ #Fibromyocyte subset😆
▶️A transition population b/w SMC & #PerivascularFibroblast?
#Science 2022
www.science.org/doi/10.1126/...
Vessel-enriched scRNAseq
Up to 8 #SmoothMuscleCell subclusters
2 MYOCD-LGALS3+ #Fibromyocyte subset😆
▶️A transition population b/w SMC & #PerivascularFibroblast?
#Science 2022
www.science.org/doi/10.1126/...
December 9, 2023 at 9:01 PM
Dysplastic cerebrovasculature in human #ArterioVenousMalformation
Vessel-enriched scRNAseq
Up to 8 #SmoothMuscleCell subclusters
2 MYOCD-LGALS3+ #Fibromyocyte subset😆
▶️A transition population b/w SMC & #PerivascularFibroblast?
#Science 2022
www.science.org/doi/10.1126/...
Vessel-enriched scRNAseq
Up to 8 #SmoothMuscleCell subclusters
2 MYOCD-LGALS3+ #Fibromyocyte subset😆
▶️A transition population b/w SMC & #PerivascularFibroblast?
#Science 2022
www.science.org/doi/10.1126/...
Have you heard of The #VascularBirthmarksFoundation ? Presenting our #VBF Expert of the Week! Contact or read more about this Expert by visiting: birthmark.org/vbf-experts/ #arteriovenousmalformation
January 2, 2025 at 3:45 PM
Have you heard of The #VascularBirthmarksFoundation ? Presenting our #VBF Expert of the Week! Contact or read more about this Expert by visiting: birthmark.org/vbf-experts/ #arteriovenousmalformation