#NatureCVR
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haoyin.bsky.social
Adult🐭Lung Veins Branch & serve as cellular sources of general capillary #EndothelialCell & Aerocyte

Upon🫁injury Not postnatal development

#SciArt

Slc6a2-CreERT2 labels veinous endothelium in🐭🫁but not other organs

@vaughandy.bsky.social #NatureCVR 2024
www.nature.com/articles/s44...
December 28, 2024 at 12:52 PM
rkramann.bsky.social
Our new paper put today @natureCVR led by @sikandhayat.bsky.social Tore Bleckwehl in collab with NovoNordisk 👇👇 www.nature.com/articles/s44...
Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis - Nature Cardiovascular Research
Bleckwehl et al. present a spatial transcriptomic map of atherosclerotic plaques across disease stages, revealing cellular recruitment and migration patterns and intercellular communication dynamics a...
www.nature.com
December 23, 2024 at 10:29 AM
haoyin.bsky.social
CDK4/6
Endothelial Cell Cycle
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia

Evidence from
👉🐭Retina +BMP9/10 blocking Ab +Palbociclib Ribociclib
👉🐭EC Eng KO Retina 🧠 +Palbociclib
👉🐭EC Cdk6 KO Retina +BMP9/10 Ab
👉👤HHT2 (ALK1) Skin

#NatureCVR 2024
www.nature.com/articles/s44...
June 8, 2026 at 6:08 PM
haoyin.bsky.social
Are there aorta-resident macrophages?

1⃣LYVE1+MMP9+ resident Mφ engages #Hyaluronan to degrade collagen fibrils, in adventitia+media
#ImmunityCP 2018
www.sciencedirect.com/science/arti...
2⃣MacAIR: Flow-sensing, anti-thrombotic aortic intima-resident Mφ
#NatureCVR 2022
www.nature.com/articles/s44...
May 16, 2024 at 11:26 AM
roddywalsh.bsky.social
Our paper on "Exploring the complex spectrum of dominance and recessiveness in genetic cardiomyopathies" is published today in @NatureCVR www.nature.com/articles/s44... A brief thread on the main findings in the study:
Exploring the complex spectrum of dominance and recessiveness in genetic cardiomyopathies - Nature C...
Lipov et al. performed a meta-analysis of biallelic genotypes in cardiomyopathy patients and the UK Biobank. Using rare variant association analysis, they identified 18 genes with robust evidence for ...
www.nature.com
October 9, 2023 at 3:53 PM
haoyin.bsky.social
#CardiacFibroblast/#Cardiomyocyte-derived BMP4 alleviates T-cell-driven #AutoimmuneMyocarditis
TCR-M🐭

Inflammatory Cxcl9+Ccl9+H2-A2+ fibroblast subset

Grem1/2 (BMP inhibitor) blockade (Ab 14-D10-2)⏬Mortality
w/o changing cardiotoxic CD4+ T cells

#NatureCVR 2024
www.nature.com/articles/s44...
April 16, 2024 at 11:25 AM
haoyin.bsky.social
TREM2 as a positive regulator of Macrophage #FoamCell mitochondria, survival & efferocytosis under hypercholesterolemia

Hematopoietic TREM2 KO⏫#NecroticCore formation in early (8~12 wk) #Atherosclerosis in Ldlr-/-🐭
w/o altering lesion or Mφ burden

#NatureCVR 2024
www.nature.com/articles/s44...
April 18, 2024 at 7:23 PM
chromatowski.bsky.social
Ah, the corresponding author kindly shared an unpaywalled version of this new study: “CCL2-mediated endothelial injury drives cardiac dysfunction in long COVID”

rdcu.be/dWWnY
Tweet from Nazish Sayed MD, MS, PhD @Nazish_Sayed Our paper on endothelial - cardiomyocyte crosstalk in #LongCovid is now online @NatureCVR. It highlighting the importance of early vascular health monitoring in patients with #LongCovid. @iDilipThomas @StanfordCVI @StanfordSurgery@maryhawn @StanfordVasc CCL2-mediated endothelial injury drives cardiac dy... From nature.com 6:59 PM • Oct 14, 2024 • 2,185 Views
October 15, 2024 at 3:11 AM
haoyin.bsky.social
Mechanotransduction for High #ShearStress (40 dyn/cm2) in #EndothelialCell

Shear-KLF2-BMPER⬇️EC BMP-SMAD1/5 signaling➡️
⏫Carotid/Skeletal muscle arterial outward remodeling

BMP9/10 antibody⏫ischemic limb reperfusion in diabetic🐭

Martin Schwartz lab #NatureCVR 2024
www.nature.com/articles/s44...
July 10, 2024 at 6:58 PM
haoyin.bsky.social
MerTK+ Cardiac-resident Macrophages protect against🐭🫀#IschemiaReperfusionInjury

GAS6-ATF3 cascade
⏫IFNα/β signaling
⏬apoptosis
⏫proliferation
in MerTK+ Mφ
Pro-angiogenic IGF1 paracrine of MerTTK+ Mφ😎

Plasma GAS6
➖corr MACEs
in👤#AcuteCoronarySyndrome

#NatureCVR 2024
www.nature.com/articles/s44...
April 23, 2024 at 11:23 AM
mannlab.bsky.social
For those wanting the key insights without the deep methods dive, we published a research briefing in
@NatureCVR
nature.com/articles/s44...
#SpatialProteomics #CardiovascularResearch
June 26, 2026 at 9:20 AM
haoyin.bsky.social
ApoB #AntiSenseOligo + low-fat diet for 12 wks alleviates #VascularInflammation in established🐭#Atherosclerosis

EC invagination+focal loss in regressing plaque😎 (#EndMT at sub-cap level)
⏫contractile #FibrousCap SMC; ⏬Fibromyocyte & Chondromyocyte

#NatureCVR 2024
www.nature.com/articles/s44...
January 19, 2024 at 8:10 PM
haoyin.bsky.social
SM α-actin can translocate into nuclei & promote transcription of #SmoothMuscleCell contractile genes😎
SM α-actin occupies the CArG boxes, also KLF4 gene👈

ACTA2 R179C
ACTA2 R179H #SmoothMuscleDysfunctionSyndrome
⏬SMC Contractile genes

#NatureCVR 2023
www.ncbi.nlm.nih.gov/pmc/articles...
August 20, 2024 at 11:23 AM
haoyin.bsky.social
B cell #Atherosclerosis

GPR55 deficiency in🐭B Cell->
IgG overproduction
⏫mitochondria biogenesis
⏬#PlasmaCell maturation (⏬CD23)
⏫#Atherotherosclerosis

Also GPR55 in T cell or SMC?😁
Sabine Steffens lab #NatureCVR 2022
www.nature.com/articles/s44...
October 4, 2023 at 7:22 PM
victorchang.edu.au
A major driver of FMD has been identified by a team of scientists incl our Director Prof @Kovacic_Jason. The @NatureCVR study could help lead to new treatments for the disease which effects ~5% of adults and can cause stroke, heart attack + kidney failure: https://www.victorchang.edu.au/news/caus...
January 29, 2025 at 5:40 AM
victorchang.edu.au
From developing a test for sudden cardiac arrest risk, to shedding light on FMD, and better understanding causes of heart defects + miscarriage, 2024 was another big year for our scientists w research published in @Circ_Gen @ScienceAdvances + @NatureCVR: https://eprints.victorchang.edu.au/view/ye...
January 29, 2025 at 5:39 AM
victorchang.edu.au
A major driver of FMD has been identified by a team of scientists incl our Director Prof @Kovacic_Jason. The @NatureCVR study could help lead to new treatments for the disease which effects ~5% of adults and can cause stroke, heart attack + kidney failure:

victorchang.edu.au/news/cause-fmd…
January 29, 2025 at 4:48 AM
victorchang.edu.au
A major driver of FMD has been identified by a team of scientists incl our Director Prof @Kovacic_Jason. The @NatureCVR study could help lead to new treatments for the disease which effects ~5% of adults and can cause stroke, heart attack + kidney failure:

victorchang.edu.au/news/cause-fmd…
December 10, 2024 at 4:04 AM
ruibenedito.bsky.social
Published @NatureCVR by the Kari Alitalo lab ! Hopefully will get as much impact and visibility as the initial study.

rdcu.be/dE5fX
February 11, 2025 at 7:35 AM
ruibenedito.bsky.social
Fantastic perspective by the endothelium/transcription factors experts @jmgsalinero and S. Raffi (@AnsaryStemCell) on our recent paper @NatureCVR. 👇

rdcu.be/deAYp
February 11, 2025 at 7:32 AM
ruibenedito.bsky.social
We got the hero image ! Yeah ! Congrats to @MFdezChacon and all the other lab heroes !

x.com/NatureCVR/stat…
February 11, 2025 at 7:32 AM
ruibenedito.bsky.social
A research briefing about the discovery and implications of our paper was also published @NatureCVR. 👉

x.com/RuiBenedito_/s… rdcu.be/ddH4z
ruibenedito.bsky.social Rui Benedito @ruibenedito.bsky.social · May 29
Our latest story on the incongruence between transcriptional states and vascular pathophysiology @NatureCVR🍾. Thanks to all authors and collaborators @CNIC_CARDIO, @mliarispe, @KGaengel.

nature.com/articles/s4416…
February 11, 2025 at 7:32 AM
ruibenedito.bsky.social
Our latest story on the incongruence between transcriptional states and vascular pathophysiology @NatureCVR🍾. Thanks to all authors and collaborators @CNIC_CARDIO, @mliarispe, @KGaengel.

nature.com/articles/s4416…
February 11, 2025 at 7:30 AM