New work deciphers how disruptions to #lymphatic drainage drive fibrosis in transplanted lungs and hearts through the accumulation of hyaluronan—and identifies potential therapeutic targets to prevent lung fibrosis in mice. #ScienceTranslationalMedicine https://scim.ag/3ONyh7H
Lymphatic disruption drives lung transplant fibrosis through interleukin-1–mediated hyaluronan accumulation
Interleukin-1–mediated hyaluronan synthesis in transplanted grafts promotes fibrotic remodeling because of lymphatic disruption.
scim.ag
March 2, 2026 at 7:05 PM
New work deciphers how disruptions to #lymphatic drainage drive fibrosis in transplanted lungs and hearts through the accumulation of hyaluronan—and identifies potential therapeutic targets to prevent lung fibrosis in mice. #ScienceTranslationalMedicine https://scim.ag/3ONyh7H
#ImmuneRepair! @becky-dodd.bsky.social @drtesutherland.bsky.social @profjudiallen.bsky.social show that #lung tissue damage caused by a nematode requires hyaluronan (HA) deposition to repair & that type 2 immunity & IL13 are fundamental for HA deposition! onlinelibrary.wiley.com/doi/10.1002/...
Injury From Nematode Lung Migration Induces an IL‐13‐Dependent Hyaluronan Matrix
A consistent feature of lung injury is a rapid and sustained accumulation of hyaluronan (HA). The rodent gut-dwelling nematode Nippostrongylus brasiliensis (Nb) induces tissue damage as it migrates t....
onlinelibrary.wiley.com
November 26, 2024 at 4:42 PM
#ImmuneRepair! @becky-dodd.bsky.social @drtesutherland.bsky.social @profjudiallen.bsky.social show that #lung tissue damage caused by a nematode requires hyaluronan (HA) deposition to repair & that type 2 immunity & IL13 are fundamental for HA deposition! onlinelibrary.wiley.com/doi/10.1002/...
🎉 the 1st paper from my post-doc is published 🎉 We found that #lunginjury caused by migration of N.brasiliensis induces an #IL-13 dependent #hyaluronan matrix. onlinelibrary.wiley.com/doi/full/10....
Injury From Nematode Lung Migration Induces an IL‐13‐Dependent Hyaluronan Matrix
A consistent feature of lung injury is a rapid and sustained accumulation of hyaluronan (HA). The rodent gut-dwelling nematode Nippostrongylus brasiliensis (Nb) induces tissue damage as it migrates t....
onlinelibrary.wiley.com
November 26, 2024 at 8:58 PM
🎉 the 1st paper from my post-doc is published 🎉 We found that #lunginjury caused by migration of N.brasiliensis induces an #IL-13 dependent #hyaluronan matrix. onlinelibrary.wiley.com/doi/full/10....
My lab in Aberdeen, in the stunning North East of Scotland, will soon be recruiting for a post-doc to studying immune-ECM interactions in the lung. If you love IL-13, Hyaluronan, ECM biology, pulmonary immune responses....Get in touch and keep an eye out for the position.
November 13, 2024 at 8:30 AM
My lab in Aberdeen, in the stunning North East of Scotland, will soon be recruiting for a post-doc to studying immune-ECM interactions in the lung. If you love IL-13, Hyaluronan, ECM biology, pulmonary immune responses....Get in touch and keep an eye out for the position.
Very excited to announce the VOR release of our manuscript titled "Insights into substrate binding and utilization by hyaluronan synthase" with eLife!
elifesciences.org/articles/109...
elifesciences.org/articles/109...
Insights into substrate binding and utilization by hyaluronan synthase
Complementary biochemical and structural findings reveal molecular principles underlying substrate selectivity by a model hyaluronan synthase.
elifesciences.org
March 21, 2026 at 9:45 PM
Very excited to announce the VOR release of our manuscript titled "Insights into substrate binding and utilization by hyaluronan synthase" with eLife!
elifesciences.org/articles/109...
elifesciences.org/articles/109...
Becky's paper is out! Watch our joyful collaborative team across Manchester, Aberdeen & Virginia unravel how the IL-13-induced HA matrix contributes to pathology vs repair in the lung (Thank you Wellcome) @becky-dodd.bsky.social @drtesutherland.bsky.social onlinelibrary.wiley.com/doi/10.1002/...
Injury From Nematode Lung Migration Induces an IL‐13‐Dependent Hyaluronan Matrix
A consistent feature of lung injury is a rapid and sustained accumulation of hyaluronan (HA). The rodent gut-dwelling nematode Nippostrongylus brasiliensis (Nb) induces tissue damage as it migrates t...
onlinelibrary.wiley.com
November 26, 2024 at 8:58 AM
Becky's paper is out! Watch our joyful collaborative team across Manchester, Aberdeen & Virginia unravel how the IL-13-induced HA matrix contributes to pathology vs repair in the lung (Thank you Wellcome) @becky-dodd.bsky.social @drtesutherland.bsky.social onlinelibrary.wiley.com/doi/10.1002/...
Want to tag the #ECM for live imaging?
Our AAV vector, pAAV-CMVie-NcanGFP (a genetically encoded fluorescent tag for hyaluronan) is now available at Addgene!
addgene.org/235983/
Our AAV vector, pAAV-CMVie-NcanGFP (a genetically encoded fluorescent tag for hyaluronan) is now available at Addgene!
addgene.org/235983/
June 19, 2025 at 10:34 AM
Want to tag the #ECM for live imaging?
Our AAV vector, pAAV-CMVie-NcanGFP (a genetically encoded fluorescent tag for hyaluronan) is now available at Addgene!
addgene.org/235983/
Our AAV vector, pAAV-CMVie-NcanGFP (a genetically encoded fluorescent tag for hyaluronan) is now available at Addgene!
addgene.org/235983/
Structure and unusual binding mechanism of the hyaluronan receptor LYVE-1 mediating leucocyte entry to lymphatics @NatureComms
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 21, 2025 at 6:47 PM
Structure and unusual binding mechanism of the hyaluronan receptor LYVE-1 mediating leucocyte entry to lymphatics @NatureComms
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Grateful to everyone who made the NEXT Symposium at the Laboratory of Gnotobiology a success! A stellar lineup of speakers from academia and industry! We now know oral hyaluronan supplementation works—it’s time to discover how! 💡🔬 #NEXTSymposium #ScientificDiscovery #Hyaluronan @mbuavcr.bsky.social
October 29, 2025 at 3:24 PM
Grateful to everyone who made the NEXT Symposium at the Laboratory of Gnotobiology a success! A stellar lineup of speakers from academia and industry! We now know oral hyaluronan supplementation works—it’s time to discover how! 💡🔬 #NEXTSymposium #ScientificDiscovery #Hyaluronan @mbuavcr.bsky.social
Nice discussion of ECM-mitochondrial communication here. Could mitochondrial dysfunction be at the root of ECM abnormalities frequently observed in ME/CFS? (I tend to think so.) #poorlittlebeans #mitochondriaNOThypochondria www.cell.com/cell/abstrac...
The extracellular matrix integrates mitochondrial homeostasis
Degradation of hyaluronan in the extracellular matrix leads to mitochondrial remodeling, activation of mitochondrial stress responses, and augmented immune signaling.
www.cell.com
January 5, 2025 at 12:58 PM
Nice discussion of ECM-mitochondrial communication here. Could mitochondrial dysfunction be at the root of ECM abnormalities frequently observed in ME/CFS? (I tend to think so.) #poorlittlebeans #mitochondriaNOThypochondria www.cell.com/cell/abstrac...
Happening right now. Our Center Director, Dr. Steven Jones, is presenting an online seminar for the International Society of Hyaluronan Sciences. This seminar focuses on his laboratory's most recent work on understanding the contribution of Hyaluronan in Ventricular Remodeling. #cardiosky
November 18, 2025 at 4:36 PM
Happening right now. Our Center Director, Dr. Steven Jones, is presenting an online seminar for the International Society of Hyaluronan Sciences. This seminar focuses on his laboratory's most recent work on understanding the contribution of Hyaluronan in Ventricular Remodeling. #cardiosky
If are a researcher who works on hyaluronan, please follow @ishas-org.bsky.social
April 14, 2025 at 2:23 AM
If are a researcher who works on hyaluronan, please follow @ishas-org.bsky.social
Do subterranean mammals have hyper-elastic skin thanks to super-sized hyaluronan (HA) polymers?
We challenge this popular idea in a new preprint, presenting the first skin elasticity measurements of burrowing rodents & HA size profiles for Ansell’s mole-rat (1/8) 🧪
www.biorxiv.org/content/10.6...
We challenge this popular idea in a new preprint, presenting the first skin elasticity measurements of burrowing rodents & HA size profiles for Ansell’s mole-rat (1/8) 🧪
www.biorxiv.org/content/10.6...
February 14, 2026 at 1:32 PM
Do subterranean mammals have hyper-elastic skin thanks to super-sized hyaluronan (HA) polymers?
We challenge this popular idea in a new preprint, presenting the first skin elasticity measurements of burrowing rodents & HA size profiles for Ansell’s mole-rat (1/8) 🧪
www.biorxiv.org/content/10.6...
We challenge this popular idea in a new preprint, presenting the first skin elasticity measurements of burrowing rodents & HA size profiles for Ansell’s mole-rat (1/8) 🧪
www.biorxiv.org/content/10.6...
Time to read this comprehensive review by Tony Day, part of our IL-13-HA team. onlinelibrary.wiley.com/doi/full/10.... Watch this space for Becky’s paper on Il-13 and Hyaluronan in the lung after nematode migration. @becky-dodd.bsky.social @drtesutherland.bsky.social
Hyaluronan‐protein interactions: Lilliput revisited
Hyaluronan (HA) is a huge linear polysaccharide composed entirely of a simple repeating disaccharide that has been preserved unchanged since the evolution of vertebrates ~520 million years ago. It is...
onlinelibrary.wiley.com
November 22, 2024 at 7:24 PM
Time to read this comprehensive review by Tony Day, part of our IL-13-HA team. onlinelibrary.wiley.com/doi/full/10.... Watch this space for Becky’s paper on Il-13 and Hyaluronan in the lung after nematode migration. @becky-dodd.bsky.social @drtesutherland.bsky.social
Study implicates enzyme in neurodegenerative conditions
OHSU research finds a specific enzyme is involved in myelin breakdown that causes conditions such as MS, stroke, and Alzheimer’s
www.eurekalert.org/news-release...
OHSU research finds a specific enzyme is involved in myelin breakdown that causes conditions such as MS, stroke, and Alzheimer’s
www.eurekalert.org/news-release...
Study implicates enzyme in neurodegenerative conditions
Researchers at Oregon Health & Science University have identified a type of enzyme with a complicated name — cell migration inducing and hyaluronan-binding protein, or CEMIP — is assoc...
www.eurekalert.org
December 13, 2025 at 1:24 PM
Study implicates enzyme in neurodegenerative conditions
OHSU research finds a specific enzyme is involved in myelin breakdown that causes conditions such as MS, stroke, and Alzheimer’s
www.eurekalert.org/news-release...
OHSU research finds a specific enzyme is involved in myelin breakdown that causes conditions such as MS, stroke, and Alzheimer’s
www.eurekalert.org/news-release...
Viral-mediated fluorescent labeling of hyaluronan reveals extracellular matrix dynamics in the mouse brain in vivo https://www.biorxiv.org/content/10.1101/2025.01.31.635882v1
February 5, 2025 at 7:16 PM
Viral-mediated fluorescent labeling of hyaluronan reveals extracellular matrix dynamics in the mouse brain in vivo https://www.biorxiv.org/content/10.1101/2025.01.31.635882v1
📣 PhD project available 📣
Interested in immuno-matrix interactions and matrix regulation?
This project will investigate how hyaluronan is cleared from the lungs after infection. 🫁
@profjudiallen.bsky.social
@lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social
www.findaphd.com/phds/project...
Interested in immuno-matrix interactions and matrix regulation?
This project will investigate how hyaluronan is cleared from the lungs after infection. 🫁
@profjudiallen.bsky.social
@lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social
www.findaphd.com/phds/project...
(MCR DTP) Macrophage clearance of hyaluronan: mechanisms and consequences for lung disease at The University of Manchester on FindAPhD.com
PhD Project - (MCR DTP) Macrophage clearance of hyaluronan: mechanisms and consequences for lung disease at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
October 15, 2025 at 9:36 AM
📣 PhD project available 📣
Interested in immuno-matrix interactions and matrix regulation?
This project will investigate how hyaluronan is cleared from the lungs after infection. 🫁
@profjudiallen.bsky.social
@lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social
www.findaphd.com/phds/project...
Interested in immuno-matrix interactions and matrix regulation?
This project will investigate how hyaluronan is cleared from the lungs after infection. 🫁
@profjudiallen.bsky.social
@lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social
www.findaphd.com/phds/project...
Very intriguing #glycotime 🧪⤵️
Naive CD4+ T cells synthesize a hyaluronan-rich glycocalyx that is diminished following activation: iScience www.cell.com/iscience/ful...
Naive CD4+ T cells synthesize a hyaluronan-rich glycocalyx that is diminished following activation: iScience www.cell.com/iscience/ful...
Naive CD4+ T cells synthesize a hyaluronan-rich glycocalyx that is diminished following activation
Immunology; Cell biology; Developmental biology
www.cell.com
June 18, 2026 at 8:11 PM
Very intriguing #glycotime 🧪⤵️
Naive CD4+ T cells synthesize a hyaluronan-rich glycocalyx that is diminished following activation: iScience www.cell.com/iscience/ful...
Naive CD4+ T cells synthesize a hyaluronan-rich glycocalyx that is diminished following activation: iScience www.cell.com/iscience/ful...
I'm not coming back yet, just didn't want anyone to worry about little old me. I'm just cleaning dog messes and researching sharpei fever and how hyaluronan works and doing dog training like 18 hours of the day and playing I Was a Teenage Exocolonist the other 6 hours.
June 22, 2024 at 2:52 AM
I'm not coming back yet, just didn't want anyone to worry about little old me. I'm just cleaning dog messes and researching sharpei fever and how hyaluronan works and doing dog training like 18 hours of the day and playing I Was a Teenage Exocolonist the other 6 hours.
Hyaluronan in COVID-19: a matrix for understanding lung disease journals.asm.org/doi/10.1128/...
Hyaluronan in COVID-19: a matrix for understanding lung disease | mBio
Hyaluronan (HA) is a polysaccharide of very high molecular weight (HMW) found ubiquitously
in the tissues of mammals. It is associated with the cell surface and acts as an essential
component of the e...
journals.asm.org
December 11, 2024 at 5:56 PM
Hyaluronan in COVID-19: a matrix for understanding lung disease journals.asm.org/doi/10.1128/...
Dedicating this #Fluorescencefriday to the #ECMatrix lovers. Was trialing some ECM staining methods on a scratch wound and love the HABP staining looking almost like flames 🔥🧪🔬
Lets see what you got, @ablanchasensio.bsky.social 😉
Lets see what you got, @ablanchasensio.bsky.social 😉
December 6, 2024 at 2:28 PM
Dedicating this #Fluorescencefriday to the #ECMatrix lovers. Was trialing some ECM staining methods on a scratch wound and love the HABP staining looking almost like flames 🔥🧪🔬
Lets see what you got, @ablanchasensio.bsky.social 😉
Lets see what you got, @ablanchasensio.bsky.social 😉
Join the Sutherland Lab in Aberdeen! We have a research fellow opening to explore IL-13 regulation of hyaluronan extracellular matrices drug lung injury, repair and chronic pathology with funding from @wellcometrust.bsky.social www.abdn.ac.uk/research/job...
Research Fellow, Medicine, Medical Sciences & Nutrition (IMS301R) | The University of Aberdeen
www.abdn.ac.uk
December 5, 2024 at 10:15 AM
Join the Sutherland Lab in Aberdeen! We have a research fellow opening to explore IL-13 regulation of hyaluronan extracellular matrices drug lung injury, repair and chronic pathology with funding from @wellcometrust.bsky.social www.abdn.ac.uk/research/job...
Hyaluronan-Collagen balance dictates regenerative vs non-regenerative fate of adult🐭digit regeneration🤠
Soft matrix confers a pro-regenerative, HA-building (HAPLN1+) Blastema Fibroblast state
Force mapping of wounded digits (stiffness fluidity)
#Science 2026
www.science.org/doi/10.1126/...
Soft matrix confers a pro-regenerative, HA-building (HAPLN1+) Blastema Fibroblast state
Force mapping of wounded digits (stiffness fluidity)
#Science 2026
www.science.org/doi/10.1126/...
May 14, 2026 at 11:38 AM
Hyaluronan-Collagen balance dictates regenerative vs non-regenerative fate of adult🐭digit regeneration🤠
Soft matrix confers a pro-regenerative, HA-building (HAPLN1+) Blastema Fibroblast state
Force mapping of wounded digits (stiffness fluidity)
#Science 2026
www.science.org/doi/10.1126/...
Soft matrix confers a pro-regenerative, HA-building (HAPLN1+) Blastema Fibroblast state
Force mapping of wounded digits (stiffness fluidity)
#Science 2026
www.science.org/doi/10.1126/...
Cool investigation of hyaluronan - a substance that has led to much discussion in our lab over the years - & skin biomechanics in subterranean & surface dwelling species 👇
Do subterranean mammals have hyper-elastic skin thanks to super-sized hyaluronan (HA) polymers?
We challenge this popular idea in a new preprint, presenting the first skin elasticity measurements of burrowing rodents & HA size profiles for Ansell’s mole-rat (1/8) 🧪
www.biorxiv.org/content/10.6...
We challenge this popular idea in a new preprint, presenting the first skin elasticity measurements of burrowing rodents & HA size profiles for Ansell’s mole-rat (1/8) 🧪
www.biorxiv.org/content/10.6...
February 14, 2026 at 4:12 PM
Cool investigation of hyaluronan - a substance that has led to much discussion in our lab over the years - & skin biomechanics in subterranean & surface dwelling species 👇