"HA degradation or synthesis inhibition reduced migration, but HMW-HA supplementation produced the largest reduction, suppressing migration to levels at or below stage B cells, with the effect strengthening over treatment duration"
Hyaluronan Surface Architecture Dictates Colorectal Cancer Progression and Extracellular Vesicle Communication
Hyaluronan (HA) is a principal component of the tumor glycocalyx in colorectal cancer (CRC). However, how the disease progression is linked to HA abundance and its nanoscale organization remains uncle...
www.biorxiv.org
September 23, 2026 at 3:57 AM
"HA degradation or synthesis inhibition reduced migration, but HMW-HA supplementation produced the largest reduction, suppressing migration to levels at or below stage B cells, with the effect strengthening over treatment duration"
Hyaluronan Surface Architecture Dictates Colorectal Cancer Progression and Extracellular Vesicle Communication https://www.biorxiv.org/content/10.64898/2026.09.16.751988v1
September 22, 2026 at 8:46 PM
Hyaluronan Surface Architecture Dictates Colorectal Cancer Progression and Extracellular Vesicle Communication https://www.biorxiv.org/content/10.64898/2026.09.16.751988v1
Hyaluronan Surface Architecture Dictates Colorectal Cancer Progression and Extracellular Vesicle Communication https://www.biorxiv.org/content/10.64898/2026.09.16.751988v1
September 22, 2026 at 8:46 PM
Hyaluronan Surface Architecture Dictates Colorectal Cancer Progression and Extracellular Vesicle Communication https://www.biorxiv.org/content/10.64898/2026.09.16.751988v1
NEW from Steven Feldon & Collyn Woeller: Transcriptomic profiling of thyroid eye disease orbital fibroblasts identifies sorafenib as a novel therapeutic, published in Frontiers in Endocrinology. #URochesterResearch doi.org/10.3389/fend... @flaumeye.bsky.social
Frontiers | Transcriptomic profiling of thyroid eye disease orbital fibroblasts identifies sorafenib as a novel therapeutic
IntroductionThyroid eye disease (TED) is a debilitating condition characterized by orbital fibroblast (OF) activation and excessive hyaluronan (HA) accumulat...
doi.org
September 18, 2026 at 4:04 PM
NEW from Steven Feldon & Collyn Woeller: Transcriptomic profiling of thyroid eye disease orbital fibroblasts identifies sorafenib as a novel therapeutic, published in Frontiers in Endocrinology. #URochesterResearch doi.org/10.3389/fend... @flaumeye.bsky.social
(NB. we also describe a convenient approach for tracking HA degradation by solution 1H NMR, where labeling with 13C is not needed - compare to our recent work on 13C labeling HA)
#glycotime #hyaluronan
#glycotime #hyaluronan
September 18, 2026 at 10:37 AM
(NB. we also describe a convenient approach for tracking HA degradation by solution 1H NMR, where labeling with 13C is not needed - compare to our recent work on 13C labeling HA)
#glycotime #hyaluronan
#glycotime #hyaluronan
Would be interested in the impact of stretching on hyaluronan behaviour, though suspect hydration, managing inflammation, and regular (within range) movement would be variables with greater importance.
September 17, 2026 at 11:23 PM
Would be interested in the impact of stretching on hyaluronan behaviour, though suspect hydration, managing inflammation, and regular (within range) movement would be variables with greater importance.
🚨New GlycoPOST dataset - GPST000759🚨
A practical framework for label-free GAG disaccharide analysis by HILIC-MS/MS: detailed protocols for analysis of diverse biological sample types
PI: Douglas Dyer and David Knight
#glycotime #glycopost
A practical framework for label-free GAG disaccharide analysis by HILIC-MS/MS: detailed protocols for analysis of diverse biological sample types
PI: Douglas Dyer and David Knight
#glycotime #glycopost
A practical framework for label-free GAG disaccharide analysis by HILIC-MS/MS: detailed protocols for analysis of diverse biological sample types
PI: Douglas Dyer and David Knight (The University of Manchester)
Keywords: GAG disaccharide analysis, heparan sulphate, chondroitin sulphate, dermatan sulphate, hyaluronan
Proteoglycans, and their glycosaminoglycan (GAG) side chains, are critical components of the ECM and the glycocalyx. GAGs can bind to many different proteins, such as chemokines, and form hydrated bar...
glycopost.glycosmos.org
September 17, 2026 at 2:18 PM
🚨New GlycoPOST dataset - GPST000759🚨
A practical framework for label-free GAG disaccharide analysis by HILIC-MS/MS: detailed protocols for analysis of diverse biological sample types
PI: Douglas Dyer and David Knight
#glycotime #glycopost
A practical framework for label-free GAG disaccharide analysis by HILIC-MS/MS: detailed protocols for analysis of diverse biological sample types
PI: Douglas Dyer and David Knight
#glycotime #glycopost
"HA does not encode biological information through dense combinatorial carbohydrate modifications, but rather primarily through polymer length, hydrodynamic volume, and.."
Living Hydrogels: Ultra-High Molecular Weight Hyaluronan and the Emergence of Adaptive Regenerative Macromolecules
Living Hydrogels: Ultra-High Molecular Weight Hyaluronan and the Emergence of Adaptive Regenerative Macromolecules
www.preprints.org
September 4, 2026 at 10:54 PM
"HA does not encode biological information through dense combinatorial carbohydrate modifications, but rather primarily through polymer length, hydrodynamic volume, and.."
Living Hydrogels: Ultra-High Molecular Weight Hyaluronan and the Emergence of Adaptive Regenerative Macromolecules
Living Hydrogels: Ultra-High Molecular Weight Hyaluronan and the Emergence of Adaptive Regenerative Macromolecules
A behind-the-scenes look at my most recent animation of hyaluronan heavy chain formation! #sciart
There is a part 2 coming up of this animation, as we have to have those heavy chains degraded! (This refraction process was foundational to my PhD research!
Made in procreate.
There is a part 2 coming up of this animation, as we have to have those heavy chains degraded! (This refraction process was foundational to my PhD research!
Made in procreate.
September 4, 2026 at 3:54 PM
A behind-the-scenes look at my most recent animation of hyaluronan heavy chain formation! #sciart
There is a part 2 coming up of this animation, as we have to have those heavy chains degraded! (This refraction process was foundational to my PhD research!
Made in procreate.
There is a part 2 coming up of this animation, as we have to have those heavy chains degraded! (This refraction process was foundational to my PhD research!
Made in procreate.
Another #scienceanimation, this time on the molecule I studied for my PhD! Hyaluronan (HA) is a sugar on the outside of your cells that can, during inflammation, form heavy chains that reach out into the bloodstream. These heavy chains can act as landing sites for infiltrating immune cells! #science
September 2, 2026 at 10:57 PM
Another #scienceanimation, this time on the molecule I studied for my PhD! Hyaluronan (HA) is a sugar on the outside of your cells that can, during inflammation, form heavy chains that reach out into the bloodstream. These heavy chains can act as landing sites for infiltrating immune cells! #science
@thermofishersci.bsky.social's resource, RRID:AB_2534079, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #OpenScience #accelerateopenscience #reproducibility
Frontiers | Dipeptidyl peptidase-4 inhibitors suppress myofibroblastic differentiation and hyaluronan synthesis in Graves’ orbitopathy fibroblasts
Graves’ orbitopathy (GO) is characterized by inflammation, hyaluronan accumulation, tissue expansion, and fibrosis of orbital tissues, while effective antifi...
doi.org
September 2, 2026 at 7:01 AM
@thermofishersci.bsky.social's resource, RRID:AB_2534079, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #OpenScience #accelerateopenscience #reproducibility
“Piezo1 activation during the course of TED leads not only to diminished de novo adipogenesis but also the inhibition of HA production under adipogenic stimuli. Based on the results in non-TED OFs, this HA-modulating effect of Piezo1 is independent of whether adipogenesis actually occurs.”
PIEZO1 receptor activation in orbital fibroblasts during adipogenic induction diminishes the accumulation of hyaluronan | ETA2026 | 47th Annual Meeting of the European Thyroid Association (ETA) 2026 |...
www.endocrine-abstracts.org
September 1, 2026 at 8:10 AM
“Piezo1 activation during the course of TED leads not only to diminished de novo adipogenesis but also the inhibition of HA production under adipogenic stimuli. Based on the results in non-TED OFs, this HA-modulating effect of Piezo1 is independent of whether adipogenesis actually occurs.”
BioDrop MD® Plus goes beyond standard artificial tears with two premium ingredients: trehalose + hyaluronan.
💧 Hydrates and protects
💧 Helps retain moisture
💧 Light, non-blurring comfort
Premium dry eye care from promedeyehealth.com
#BioDrop #DryEye #EyeCare
💧 Hydrates and protects
💧 Helps retain moisture
💧 Light, non-blurring comfort
Premium dry eye care from promedeyehealth.com
#BioDrop #DryEye #EyeCare
August 31, 2026 at 4:12 PM
BioDrop MD® Plus goes beyond standard artificial tears with two premium ingredients: trehalose + hyaluronan.
💧 Hydrates and protects
💧 Helps retain moisture
💧 Light, non-blurring comfort
Premium dry eye care from promedeyehealth.com
#BioDrop #DryEye #EyeCare
💧 Hydrates and protects
💧 Helps retain moisture
💧 Light, non-blurring comfort
Premium dry eye care from promedeyehealth.com
#BioDrop #DryEye #EyeCare
OUT NOW from Steve Feldon & Collyn Woeller: Lonigutamab Inhibits Hyaluronan Production by Reducing IGF-1R Levels in Thyroid Eye Disease Orbital Fibroblasts. #URochesterResearch doi.org/10.1210/clin... @flaumeye.bsky.social
Lonigutamab Inhibits Hyaluronan Production by Reducing IGF-1R Levels in Thyroid Eye Disease Orbital Fibroblasts
AbstractContext. In thyroid eye disease (TED), the connective tissue behind the eye becomes inflamed and expands, partly due to excessive deposition of hya
doi.org
August 26, 2026 at 4:04 PM
OUT NOW from Steve Feldon & Collyn Woeller: Lonigutamab Inhibits Hyaluronan Production by Reducing IGF-1R Levels in Thyroid Eye Disease Orbital Fibroblasts. #URochesterResearch doi.org/10.1210/clin... @flaumeye.bsky.social
Ny artikel på Lex
fasciacyt
En fasciacyt er en celle, der specifikt findes i de bånd eller hinder, som omgiver muskler og muskelsener (fascier). Fasciacytter udskiller en ekstracellulær matrix, der er rig på hyaluronan.
lex.dk
August 21, 2026 at 7:14 PM
Ny artikel på Lex
Alterations in this "connectivome” could link the brain, immune system, gut, sensory systems and musculoskeletal abnormalities seen in autism.
From 2022, no mention of hyaluronan.
From 2022, no mention of hyaluronan.
The “Connectivome Theory”: A New Model to Understand Autism Spectrum Disorders
The classical approach to autism spectrum disorders (ASD) is often limited to considering their neuro-functional aspects. However, recent scientific literature has shown that ASDs also affect many bod...
pmc.ncbi.nlm.nih.gov
August 17, 2026 at 9:07 PM
Alterations in this "connectivome” could link the brain, immune system, gut, sensory systems and musculoskeletal abnormalities seen in autism.
From 2022, no mention of hyaluronan.
From 2022, no mention of hyaluronan.
Improved diagnostic identification of urothelial carcinoma through solid-state nanopore determination of urinary hyaluronan size distribution https://www.medrxiv.org/content/10.64898/2026.08.12.26360208v1
August 13, 2026 at 7:11 PM
Improved diagnostic identification of urothelial carcinoma through solid-state nanopore determination of urinary hyaluronan size distribution https://www.medrxiv.org/content/10.64898/2026.08.12.26360208v1
Dr Djihane Bouzid, Ferhat Abbas University Setif
Microbial hyaluronan production from a locally isolated bacterial strain: preliminary characterization and in vivo wound-healing potential
Microbial hyaluronan production from a locally isolated bacterial strain: preliminary characterization and in vivo wound-healing potential
August 9, 2026 at 3:25 PM
Dr Djihane Bouzid, Ferhat Abbas University Setif
Microbial hyaluronan production from a locally isolated bacterial strain: preliminary characterization and in vivo wound-healing potential
Microbial hyaluronan production from a locally isolated bacterial strain: preliminary characterization and in vivo wound-healing potential
#Proteomics showed that 3BTMs progressively mature, moving closer to juvenile human brain than to organoids. Synapse proteins, astrocyte maturation markers and brain ECM components (hyaluronan, CSPGs) increased over time. This maturation was highly reproducible across iPSC lines. 4/11
August 5, 2026 at 7:25 AM
#Proteomics showed that 3BTMs progressively mature, moving closer to juvenile human brain than to organoids. Synapse proteins, astrocyte maturation markers and brain ECM components (hyaluronan, CSPGs) increased over time. This maturation was highly reproducible across iPSC lines. 4/11
