#ImmunityCP
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bethstevenslab.bsky.social
Excited to dive into special issue on neuro-immune axis! Happy to share our review on microglia states and function by the Dynamic Microglia duo Constanze Depp and Jordan Doman
Thank you @KavithaSci @ImmunityCP for the opportunity

cell.com/immunity/libra…www.cell.com/immuni/newar...es
https://cell.com/immunity/libra…
May 6, 2025 at 1:24 PM
cellreprolab.bsky.social
📢 New in @ImmunityCP: We have mapped the transcription factor “routes” that program two dendritic cell subsets opening paths for personalized #cancer #immunotherapy. Read it here: doi.org/10.1016/j.im...
Here is a summary of what we discovered 🧵:
Illustration by @azuravesta.bsky.social
August 29, 2025 at 4:11 PM
mohamadelamki.bsky.social
Excited to share our new study showing that perivascular macrophages promote vascular function in the brain. A greater collaboration with the great Melanie Greter. Huge congratulations to everyone involved! @UZH_en @ImmunityCP
May 2, 2025 at 12:23 PM
da-mesquita.bsky.social
Exhilarated to share the first original study from my lab published online @ImmunityCP. A great team endeavor spearheaded by the fantastic Sofia P. das Neves 😁
“Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination”
www.cell.com/immunity/ful...
Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination
The neurophysiological processes regulated by meningeal lymphatic function remain unclear. das Neves et al. showed that meningeal lymphatic dysfunction leads to loss of mature oligodendrocytes and dem...
www.cell.com
November 14, 2024 at 12:57 PM
labwaggoner.bsky.social
C1q activates the mitochondrial enzyme SARM1, driving NAD⁺ cleavage into cADPR, which precipitates metabolic collapse and PANoptosis of homeostatic macrophages, amplifing autoimmune tissue inflammation @ImmunityCP @Stanford
www.cell.com/immunity/ful...
March 8, 2026 at 2:55 AM
labwaggoner.bsky.social
@ImmunityCP preview
Mitochondria and NLRP3: To die or inflame
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
January 14, 2025 at 8:47 PM
labwaggoner.bsky.social
@ImmunityCP preview:
Restimulation by macrophages exhausts T cells
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Restimulation by macrophages exhausts T cells
Inhibiting T cell exhaustion is an attractive cancer immunotherapy strategy. In this issue of Immunity, Waibl Polania et al. examine the microenvironmental signals regulating terminal T cell exhaustio...
www.cell.com
January 14, 2025 at 8:42 PM
castltrastondrs.medsky.network
#MedSky🧪PedSky In a previous opinion piece @ImmunityCP @BrodinPetter discussed the possibility that energy-metabolic trade-offs would favour disease tolerance in growing children, leading to increased likelihood of #viralpersistence from #COVID19
www.cell.com/immunity/ful...
Immune responses in mild and severe COVID-19
October 2, 2023 at 6:46 PM
openboxscience.bsky.social
📣 @dasNeves_SP's talk is now on YouTube!
"#Meningeal lymphatic function promotes #oligodendrocyte survival and brain #myelination"
@ImmunityCP
2024
@Da_Mesquita_S
Lab
@MayoClinic
👉 Link: youtu.be/Xt_8bMlWYPU
#openscience
#JoinUs
[Sofia das Neves] Meningeal lymphatic function promotes oligodendrocyte survival & brain myelination
YouTube video by Open Box Science
youtu.be
November 21, 2024 at 5:36 PM
haoyin.bsky.social
Are there aorta-resident macrophages?

1⃣LYVE1+MMP9+ resident Mφ engages #Hyaluronan to degrade collagen fibrils, in adventitia+media
#ImmunityCP 2018
www.sciencedirect.com/science/arti...
2⃣MacAIR: Flow-sensing, anti-thrombotic aortic intima-resident Mφ
#NatureCVR 2022
www.nature.com/articles/s44...
May 16, 2024 at 11:26 AM
openboxscience.bsky.social
youtu.be/ArQgwaqwpW4
Verena Van Der Heide talk is now on Youtube!
Prolonged but finite antigen presentation promotes reversible defects of ‘‘helpless’’ memory CD8+ T cells. @ ImmunityCP @SinaiImmunol @LCMVlab
"[Verena Van Der Heide] Finite antigen exposure drives reversible defects in ‘helpless’ CD8+ T cells
Verena Van Der Heide, (Icahn School of Medicine at Mount Sinai ) Prolonged but finite antigen presentation promotes reversible defects of ‘‘helpless’’ memory CD8+ T cells (Immunity 2025)
youtu.be
October 3, 2025 at 2:31 PM
dom-somma.genomic.social.ap.brid.gy
Finally, our paper studying synovial tissue # DC #dendtriticcells in joint health and #rheumatoidarthritis is out in Immunity!
#scrnaseq #spatialtranscriptomic
From: @ImmunityCP
https://mstdn.science/@ImmunityCP/113557582489769767
November 28, 2024 at 11:34 AM
castltrastondrs.medsky.network
#MedSky🧪 #ImmunoSky #IDSky Summary of the extensive immune system changes in #LongCovid
www.openread.academy/en/paper/rea...
@ImmunityCP
www.cell.com/immunity/abs...
Challenges and opportunities in long COVID research
Long COVID (LC) has become a major public health concern, necessitating multi-pronged research efforts to understand the pathophysiologic mechanisms of this condition and aid in patient diagnosis and ...
www.cell.com
June 11, 2024 at 3:21 PM
bocklab.bsky.social
🧬[1/7] Vaccines educate our adaptive immune system, but some also boost innate immunity. We investigated who profits from this “wake-up call” to the immune system, in a prospective clinical study with 323 volunteers. Check out our new paper in @ImmunityCP doi.org/10.1016/j.im...
January 9, 2024 at 4:11 PM
troubleshooter.bsky.social
twitter.com/EricTopol/st... 3/3
Eric Topol on X: "Two new studies @ImmunityCP delve into the issue of #SARSCoV2 immune imprinting after infections and vaccinations https://t.co/h34J7ykPxA @SCOTTeHENSLEY @timsjohnston @EJohnWherry @markmpainter https://t.co/EdFtd3zfX4 @veeslerlab https://t.co/gXunIc2LTA" / X
Two new studies @ImmunityCP delve into the issue of #SARSCoV2 immune imprinting after infections and vaccinations https://t.co/h34J7ykPxA @SCOTTeHENSLEY @timsjohnston @EJohnWherry @markmpainter https://t.co/EdFtd3zfX4 @veeslerlab https://t.co/gXunIc2LTA
twitter.com
March 15, 2024 at 1:03 AM
garvaninstitute.bsky.social
New Garvan research reveals how hepatitis C triggers autoimmunity through B cell mutations – not molecular mimicry as previously thought.

Published in @ImmunityCP, this could transform treatment approaches for a range of autoimmune diseases.

ow.ly/UlzN50UHio7
Scientists working in a lab.
January 15, 2025 at 10:43 PM
beatricezitti.bsky.social
Celebrating milestones @ImmunityCP and the great team behind it that made it possible 🍾 Thanks #YenanBryceson @liveidsmo #WenningZheng #HeinrichSchlums and @EliTheScientist 💪🏼
December 6, 2024 at 5:32 PM
marcveld.bsky.social
Opposing effects of pre-existing antibody and memory T cell help on the dynamics of recall germinal centers

This nice paper is now out @immunityCP. The pre-print was highlighted here: x.com/Marc_Veld/stat...

www.cell.com/immunit...
June 4, 2024 at 10:00 PM
troubleshooter.bsky.social
#Servicepost #Gesundheit #SARSCoV2 #Impfung 🧵
"Zwei neue Studien @ImmunityCP befassen sich mit der Frage der #SARSCoV2-Immunprägung nach Infektionen und Impfungen
cell.com/immunity/ful...
@SCOTTeHENSLEY @timsjohnston
@EJohnWherry @markmpainter
1/3
Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans
Immune imprinting occurs after repeated Wuhan-Hu-1 spike exposures, but it is unclear whether it can be overcome. Tortorici et al. show that the updated XBB.1.5 mRNA COVID-19 booster elicits neutraliz...
cell.com
March 15, 2024 at 1:01 AM
castltrastondrs.medsky.network
Review the current understanding of CD8+ T cell differentiation and function in cancer, discussing recent advances within a four-signal framework that incorporates #Tcellmetabolism &the impact of the #tumormicroenvironment @ImmunityCP

www.sciencedirect.com/science/arti...
October 11, 2023 at 11:11 AM
castltrastondrs.medsky.network
MedSky🧪 #Drugsdelivery #Drugsdevelopment #IDsky RNA Vaccines .A step at the time in educating the immune system @ImmunityCP

www.cell.com/immunity/ful...
RNA is in vitro transcribed with nucleoside bases that include N-1-methylpseudouridine, which substitutes for unmodified uridine. The synthesized mRNA is capped, purified, and encapsulated into a lipid nanoparticle (LNP), which includes an ionizable lipid. Upon intramuscular injection, the LNP enters the endosomes of cells, and the RNA is released into the cytoplasm where it is translated into protein. The inclusion of the N-1-methylpseudouridine, 5′ cap, sequence optimization, and purification reduce innate immune activation and translational inhibition. The LNP has adjuvant activity that includes induction of IL-1β and IL-6. Transfected cells translate the mRNA into protein, which is subsequently processed and loaded on major histocompatibility molecules and presented to T cells or presented on the cell surface for recognition by B cells. Figure created with BioRender.com, generated by A. Amabile (Mount Sinai).
December 16, 2023 at 10:52 PM
bcmfromthelabs.bsky.social
Researchers reveal a mechanism that allows triple negative #BreastCancer (#TNBC) to become #resistant to #therapy.
#XiangZhangLab, L. Yu et al #ImmunityCP #fattyAcids #ImmuneSuppression #BreastCancerAwarenessMonth @bcmhouston.bsky.social blogs.bcm.edu/2025/04/22/f...
Fatty acids promote immune suppression and therapy resistance in triple negative breast cancer
The researchers show that disrupting lipid formulation reverses treatment resistance and the immunosuppressive microenvironment.
blogs.bcm.edu
October 6, 2025 at 3:47 PM
wolfgangvivas.bsky.social
Check out our full preview in
@ImmunityCP
to see how this redefines our view of immune senescence and disease tolerance!
Massive congrats to the authors on a beautiful paper.
authors.elsevier.com/a/1nE%7EB3qN...
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June 17, 2026 at 1:03 PM
delafuentelab.bsky.social
(1/3) New in @ImmunityCP @CellPressNews: A single protein inside mitochondria, NDUFA4, keeps some immune cells in tumors “asleep.” Cutting its levels wakes them up, so they start attacking the cancer
Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity
Clark et al. reveal that tumor-derived cues induce a functional switch in tumor-associated macrophages (TAMs) through decreased expression of NDUFA4, a mitochondrial complex IV subunit. This promotes ...
www.cell.com
July 3, 2025 at 12:17 PM
iatlas-cri.bsky.social
The Germline Analysis module is based on the manuscript by Sayaman, @MohSaad2012 et al, co-led by @ziv_elad and @DBedognetti published @ImmunityCP @UCSF @UCSFCancer, @QatarComputing, @SidraMedicine https://www.cell.com/immunity/fulltext/S1074-7613(21)00034-0
iatlas-cri.bsky.social CRI iAtlas @iatlas-cri.bsky.social · Jun 28
Explore in http://cri-iatlas.org the germline genetic contribution to the immune landscape of cancer with results of heritability analysis, GWAS, and rare variant analysis across 30 cancer types characterized by the TCGA #immunoOncology #cancerGenomics
November 26, 2024 at 11:35 PM