Great two days at our Wnt SFB 1324 meeting @heidelberg ! 🧬
Fantastic science, fresh ideas, new tools & lots of exciting collaborations. Great to have Lizzy, Gemma & Jess presenting their work and getting inspired.
Now back @lsiexeter.bsky.social to try it all out! 🔬🐟 #Wnt #Cytonemes
Fantastic science, fresh ideas, new tools & lots of exciting collaborations. Great to have Lizzy, Gemma & Jess presenting their work and getting inspired.
Now back @lsiexeter.bsky.social to try it all out! 🔬🐟 #Wnt #Cytonemes
October 9, 2026 at 7:52 AM
Great two days at our Wnt SFB 1324 meeting @heidelberg ! 🧬
Fantastic science, fresh ideas, new tools & lots of exciting collaborations. Great to have Lizzy, Gemma & Jess presenting their work and getting inspired.
Now back @lsiexeter.bsky.social to try it all out! 🔬🐟 #Wnt #Cytonemes
Fantastic science, fresh ideas, new tools & lots of exciting collaborations. Great to have Lizzy, Gemma & Jess presenting their work and getting inspired.
Now back @lsiexeter.bsky.social to try it all out! 🔬🐟 #Wnt #Cytonemes
How does a Wnt cytoneme contact become a productive signalling site?
Emma Cooper and colleagues find focal Ca²⁺ transients at cytoneme contacts and link Ca²⁺ availability to contact stability and Wnt/β-catenin signalling.
www.biorxiv.org/content/10.6...
#Wnt #Cytonemes #CellBiology
Emma Cooper and colleagues find focal Ca²⁺ transients at cytoneme contacts and link Ca²⁺ availability to contact stability and Wnt/β-catenin signalling.
www.biorxiv.org/content/10.6...
#Wnt #Cytonemes #CellBiology
September 17, 2026 at 2:59 PM
How does a Wnt cytoneme contact become a productive signalling site?
Emma Cooper and colleagues find focal Ca²⁺ transients at cytoneme contacts and link Ca²⁺ availability to contact stability and Wnt/β-catenin signalling.
www.biorxiv.org/content/10.6...
#Wnt #Cytonemes #CellBiology
Emma Cooper and colleagues find focal Ca²⁺ transients at cytoneme contacts and link Ca²⁺ availability to contact stability and Wnt/β-catenin signalling.
www.biorxiv.org/content/10.6...
#Wnt #Cytonemes #CellBiology
What if we didn’t use genetics (says the fly scientist) but used other, physical, manipulations? What if we could put up molecular jersey barriers to keep cytonemes from interacting or moving normally? Would it lead to tissue perturbations?
September 15, 2026 at 12:56 PM
What if we didn’t use genetics (says the fly scientist) but used other, physical, manipulations? What if we could put up molecular jersey barriers to keep cytonemes from interacting or moving normally? Would it lead to tissue perturbations?
One of the more annoying things about this system is that genetic disruptions of actin cytoskeleton that mess with cytonemes also disrupts events across the whole cell - which is you know, not great if your signaling system requires say, actin-dependent endocytosis (Notch)
September 15, 2026 at 12:54 PM
One of the more annoying things about this system is that genetic disruptions of actin cytoskeleton that mess with cytonemes also disrupts events across the whole cell - which is you know, not great if your signaling system requires say, actin-dependent endocytosis (Notch)
Wouldn’t it be cool if we had a more specific way to disrupt cytonemes? (flies don’t have MyoX 🙃 )
September 15, 2026 at 12:55 PM
Wouldn’t it be cool if we had a more specific way to disrupt cytonemes? (flies don’t have MyoX 🙃 )
So we embedded dissected patterning tissues into a calcium-inducible nanofiber gel and asked what happened to their cytonemes, and what happened to their patterning.
September 15, 2026 at 12:57 PM
So we embedded dissected patterning tissues into a calcium-inducible nanofiber gel and asked what happened to their cytonemes, and what happened to their patterning.
Our lab is interested in cell shape, differentiation and tissue patterning. We have been using cytonemes and Notch signaling in the patterning peripheral nervous system of the fly as a model system. We have a lot of questions, here’s one of my favorite addressed in this paper:
September 15, 2026 at 12:54 PM
Our lab is interested in cell shape, differentiation and tissue patterning. We have been using cytonemes and Notch signaling in the patterning peripheral nervous system of the fly as a model system. We have a lot of questions, here’s one of my favorite addressed in this paper:
First, their cytonemes get messed up. And they don’t move very well. This was possibly one of the most difficult experiments I’ve ever asked someone to do and my PhD student did a stellar job.
September 15, 2026 at 12:59 PM
First, their cytonemes get messed up. And they don’t move very well. This was possibly one of the most difficult experiments I’ve ever asked someone to do and my PhD student did a stellar job.
Faisal Mahdi's review made the cover🎉 what a great end to a long first week of the semester!
Interested in how cytonemes may be regulating how cancers and TME communicate? Check out the review! www.mdpi.com/1422-0067/27...
Interested in how cytonemes may be regulating how cancers and TME communicate? Check out the review! www.mdpi.com/1422-0067/27...
September 11, 2026 at 3:25 PM
Faisal Mahdi's review made the cover🎉 what a great end to a long first week of the semester!
Interested in how cytonemes may be regulating how cancers and TME communicate? Check out the review! www.mdpi.com/1422-0067/27...
Interested in how cytonemes may be regulating how cancers and TME communicate? Check out the review! www.mdpi.com/1422-0067/27...
Aiyana Lopez, a NERSC USRA recipient, did some incredible work investigating how the Notch protein regulates cytonemes and, conversely, how cytonemes regulate Notch signaling!
August 28, 2026 at 4:21 PM
Aiyana Lopez, a NERSC USRA recipient, did some incredible work investigating how the Notch protein regulates cytonemes and, conversely, how cytonemes regulate Notch signaling!
Last, but definitely not least, is our fantastic returning co-op student, Christina Bernados. She investigated the role of cytonemes in lung health and developed machine-learning pipelines to automate cytoneme quantification, something we will be using in the lab for years to come!
August 28, 2026 at 4:21 PM
Last, but definitely not least, is our fantastic returning co-op student, Christina Bernados. She investigated the role of cytonemes in lung health and developed machine-learning pipelines to automate cytoneme quantification, something we will be using in the lab for years to come!
The authors included RRIDs in their in bioRxiv paper! RRIDs improve reproducibility in scientific research. #accelerateopenscience #BetterScience #OpenScience
Adult Clock Neuron Somatic Neuropeptide Release and Cytonemes Regulate Sleep
Read the full paper: Adult Clock Neuron Somatic Neuropeptide Release and Cytonemes Regulate Sleep
doi.org
August 28, 2026 at 7:02 AM
The authors included RRIDs in their in bioRxiv paper! RRIDs improve reproducibility in scientific research. #accelerateopenscience #BetterScience #OpenScience
New review out!🎉🧪🔬 Cancer cells don't just broadcast signals, but deliver them directly. TNTs and TMs get most of the hype, but our review explores how cytonemes are reshaping our understanding of tumor communication and the TME.
www.mdpi.com/4048006
www.mdpi.com/4048006
August 25, 2026 at 5:31 PM
New review out!🎉🧪🔬 Cancer cells don't just broadcast signals, but deliver them directly. TNTs and TMs get most of the hype, but our review explores how cytonemes are reshaping our understanding of tumor communication and the TME.
www.mdpi.com/4048006
www.mdpi.com/4048006
Happy #MicroscopyMonday! Here's some #SciArt of a confocal micrograph stylized using the Ps emboss filter. See the thin projections extending between the 2 cells? They're #cytonemes! 🔬 How do they find each other? Follow postdoc @itsscientistsam.bsky.social to learn more 🧪 👩🔬
August 24, 2026 at 4:11 PM
Happy #MicroscopyMonday! Here's some #SciArt of a confocal micrograph stylized using the Ps emboss filter. See the thin projections extending between the 2 cells? They're #cytonemes! 🔬 How do they find each other? Follow postdoc @itsscientistsam.bsky.social to learn more 🧪 👩🔬
Adult Clock Neuron Somatic Neuropeptide Release and Cytonemes Regulate Sleep
#Drosophila
#Drosophila
Adult Clock Neuron Somatic Neuropeptide Release and Cytonemes Regulate Sleep
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
August 20, 2026 at 4:23 PM
Adult Clock Neuron Somatic Neuropeptide Release and Cytonemes Regulate Sleep
#Drosophila
#Drosophila
Rambaud, B., Joseph, M., Tsai, F. C., ...., Bassereau, P., Hipfner, D. R., Carreno, S. (2025). Slik sculpts the plasma membrane into cytonemes to control cell-cell communication.. Embo j, 44(8):2186-2210 link.springer.com/article/10.1...
Slik sculpts the plasma membrane into cytonemes to control cell-cell communication - The EMBO Journal
Cytonemes are signaling filopodia that facilitate long-range cell–cell communication by forming synapses between cells. Initially discovered in Drosophila for transporting morphogens during embryogene...
link.springer.com
August 19, 2026 at 10:34 PM
Rambaud, B., Joseph, M., Tsai, F. C., ...., Bassereau, P., Hipfner, D. R., Carreno, S. (2025). Slik sculpts the plasma membrane into cytonemes to control cell-cell communication.. Embo j, 44(8):2186-2210 link.springer.com/article/10.1...
Rambaud, B., Joseph, M., Tsai, F. C., ..., Bassereau, P., Hipfner, D. R., Carreno, S. (2025). Slik sculpts the plasma membrane into cytonemes to control cell-cell communication.. Embo j, 44(8):2186-2210 link.springer.com/article/10.1...
Slik sculpts the plasma membrane into cytonemes to control cell-cell communication - The EMBO Journal
Cytonemes are signaling filopodia that facilitate long-range cell–cell communication by forming synapses between cells. Initially discovered in Drosophila for transporting morphogens during embryogene...
link.springer.com
August 18, 2026 at 6:34 PM
Rambaud, B., Joseph, M., Tsai, F. C., ..., Bassereau, P., Hipfner, D. R., Carreno, S. (2025). Slik sculpts the plasma membrane into cytonemes to control cell-cell communication.. Embo j, 44(8):2186-2210 link.springer.com/article/10.1...
#TunnelingNanotubes and #cytonemes in cancer and development
Kenneth M. Yamada (@niaidnews.bsky.social), David A. Cruz Walma, and Wakako Endo:
rupress.org/jcb/article/...
#CellSignaling #Development #cancer
Kenneth M. Yamada (@niaidnews.bsky.social), David A. Cruz Walma, and Wakako Endo:
rupress.org/jcb/article/...
#CellSignaling #Development #cancer
August 6, 2026 at 8:15 PM
#TunnelingNanotubes and #cytonemes in cancer and development
Kenneth M. Yamada (@niaidnews.bsky.social), David A. Cruz Walma, and Wakako Endo:
rupress.org/jcb/article/...
#CellSignaling #Development #cancer
Kenneth M. Yamada (@niaidnews.bsky.social), David A. Cruz Walma, and Wakako Endo:
rupress.org/jcb/article/...
#CellSignaling #Development #cancer
Three Addresses, One Neuron: How a Fly's Sleep Signal Travels Without a Synapse
RT & follow.
https://1ban.news/drosophila-clock-neuron-cytonemes-sleep/
#1ban #drosophila #clock #sleep
RT & follow.
https://1ban.news/drosophila-clock-neuron-cytonemes-sleep/
#1ban #drosophila #clock #sleep
August 2, 2026 at 8:31 PM
Three Addresses, One Neuron: How a Fly's Sleep Signal Travels Without a Synapse
RT & follow.
https://1ban.news/drosophila-clock-neuron-cytonemes-sleep/
#1ban #drosophila #clock #sleep
RT & follow.
https://1ban.news/drosophila-clock-neuron-cytonemes-sleep/
#1ban #drosophila #clock #sleep
For #FluorescenceFriday we have, "TNTs, cytonemes, and migrasomes, oh my!"
July 31, 2026 at 2:44 PM
For #FluorescenceFriday we have, "TNTs, cytonemes, and migrasomes, oh my!"
New review: Yamada, Cruz Walma, and Endo discuss the long nanotubular interconnections termed #cytonemes, #TunnelingNanotubes or #TumorMicrotubes formed by cells to exchange regulatory proteins and organelles for regulating #development, adult homeostasis, and #cancer. rupress.org/jcb/article/...
July 30, 2026 at 7:00 PM
New review: Yamada, Cruz Walma, and Endo discuss the long nanotubular interconnections termed #cytonemes, #TunnelingNanotubes or #TumorMicrotubes formed by cells to exchange regulatory proteins and organelles for regulating #development, adult homeostasis, and #cancer. rupress.org/jcb/article/...
Adult Clock Neuron Somatic Neuropeptide Release and Cytonemes Regulate Sleep https://www.biorxiv.org/content/10.64898/2026.07.27.741016v1
July 30, 2026 at 5:16 PM
Adult Clock Neuron Somatic Neuropeptide Release and Cytonemes Regulate Sleep https://www.biorxiv.org/content/10.64898/2026.07.27.741016v1
Adult Clock Neuron Somatic Neuropeptide Release and Cytonemes Regulate Sleep https://www.biorxiv.org/content/10.64898/2026.07.27.741016v1
July 30, 2026 at 5:16 PM
Adult Clock Neuron Somatic Neuropeptide Release and Cytonemes Regulate Sleep https://www.biorxiv.org/content/10.64898/2026.07.27.741016v1
New @jcb.org review: Yamada, Cruz Walma & Endo discuss the long nanotubular interconnections termed #cytonemes, #TunnelingNanotubes or #TumorMicrotubes formed by cells to exchange regulatory proteins and organelles for regulating #development, adult homeostasis & #cancer. rupress.org/jcb/article/...
July 30, 2026 at 8:00 PM
New @jcb.org review: Yamada, Cruz Walma & Endo discuss the long nanotubular interconnections termed #cytonemes, #TunnelingNanotubes or #TumorMicrotubes formed by cells to exchange regulatory proteins and organelles for regulating #development, adult homeostasis & #cancer. rupress.org/jcb/article/...
Well - I’m not sure. It’s the mTmG lineage tracer, so the labeled cells expressed Shh at one point during development, but may not be expressing it at this stage. We’re trying to ID cell types that might make SHH cytonemes during development - currently in the “survey” stage. 🤓
July 24, 2026 at 7:25 PM
Well - I’m not sure. It’s the mTmG lineage tracer, so the labeled cells expressed Shh at one point during development, but may not be expressing it at this stage. We’re trying to ID cell types that might make SHH cytonemes during development - currently in the “survey” stage. 🤓