I also think conspiracy theories make it difficult to navigate actually having experienced a very rare side effect to drugs/vax (I had dapsone-induced methemglobenemia after being on the drug for 2.5 years, I am still very pro biomedicine)
March 16, 2026 at 7:28 PM
I also think conspiracy theories make it difficult to navigate actually having experienced a very rare side effect to drugs/vax (I had dapsone-induced methemglobenemia after being on the drug for 2.5 years, I am still very pro biomedicine)
I've also had methemeglobenemia from dapsone and liver issues from colchicine and go bonkers on prednisone, so I'm unlucky with meds side effects, so I'd like to be on fewer. But that would require me to be in remission.
November 29, 2025 at 12:17 AM
I've also had methemeglobenemia from dapsone and liver issues from colchicine and go bonkers on prednisone, so I'm unlucky with meds side effects, so I'd like to be on fewer. But that would require me to be in remission.
I had drug-induced methemoglobinemia from dapsone. It was terrifying!!! But I'm not questioning the efficiency of drug approvals.
December 20, 2024 at 2:29 PM
I had drug-induced methemoglobinemia from dapsone. It was terrifying!!! But I'm not questioning the efficiency of drug approvals.
Unless you take a regimen of dapsone, rifampicin and clofazimine for a year
Leprosy will take control and bring you to your Death 🔥
November 28, 2024 at 6:17 PM
Unless you take a regimen of dapsone, rifampicin and clofazimine for a year
Hey is there a #dermsky community here? (Or #IDSky #PharmSky)
If you had someone with pyoderma gangrenosa who responded well to dapsone but had other side effects, what would be your second drug of choice? Minocyline, steroids, cyclosporine?
@roxanadaneshjou.bsky.social
If you had someone with pyoderma gangrenosa who responded well to dapsone but had other side effects, what would be your second drug of choice? Minocyline, steroids, cyclosporine?
@roxanadaneshjou.bsky.social
December 19, 2024 at 9:25 PM
Hey is there a #dermsky community here? (Or #IDSky #PharmSky)
If you had someone with pyoderma gangrenosa who responded well to dapsone but had other side effects, what would be your second drug of choice? Minocyline, steroids, cyclosporine?
@roxanadaneshjou.bsky.social
If you had someone with pyoderma gangrenosa who responded well to dapsone but had other side effects, what would be your second drug of choice? Minocyline, steroids, cyclosporine?
@roxanadaneshjou.bsky.social
Complications related to medicine/vaccines do suck. But they are rare. Of course, for instance, I wish I didn't have dapsone-induced methemoglobinemia, but this drug is still very safe. I also had a weird out of range reaction.
There have always been ways to report vaccine complications!
There have always been ways to report vaccine complications!
January 29, 2025 at 5:09 PM
Complications related to medicine/vaccines do suck. But they are rare. Of course, for instance, I wish I didn't have dapsone-induced methemoglobinemia, but this drug is still very safe. I also had a weird out of range reaction.
There have always been ways to report vaccine complications!
There have always been ways to report vaccine complications!
3️⃣ Switching to 2nd-line prophylactic agents, e.g. atovaquone & dapsone are LESS EFFECTIVE than TMP/SMX at preventing PJP and opportunistic infections caused by Listeria monocytogenes, Toxoplasma gondii, and Nocardia spp. & can lead to breakthrough infections and significant morbidity and mortality.
June 4, 2025 at 2:13 PM
3️⃣ Switching to 2nd-line prophylactic agents, e.g. atovaquone & dapsone are LESS EFFECTIVE than TMP/SMX at preventing PJP and opportunistic infections caused by Listeria monocytogenes, Toxoplasma gondii, and Nocardia spp. & can lead to breakthrough infections and significant morbidity and mortality.
Leprosy is fully curable using a combination of antibiotics called multidrug therapy (MDT), which typically includes dapsone, rifampicin, and clofazimine. This treatment is highly effective, stops the disease from spreading within days of starting, and is provided free of charge by the WHO
July 31, 2026 at 3:26 PM
Leprosy is fully curable using a combination of antibiotics called multidrug therapy (MDT), which typically includes dapsone, rifampicin, and clofazimine. This treatment is highly effective, stops the disease from spreading within days of starting, and is provided free of charge by the WHO
The answer is: sulfhemoglobinemia.
Sulfhemoglobinemia is a *permanently* modified hemoglobin associated with exposure to TMP/SMX, dapsone, phenazopyridine, & other amino & nitro compounds.
It has an altered oxy-hemoglobin dissociation curve, but unlike metHb the curve is RIGHT-shifted.
2/
Sulfhemoglobinemia is a *permanently* modified hemoglobin associated with exposure to TMP/SMX, dapsone, phenazopyridine, & other amino & nitro compounds.
It has an altered oxy-hemoglobin dissociation curve, but unlike metHb the curve is RIGHT-shifted.
2/
November 18, 2024 at 1:27 AM
The answer is: sulfhemoglobinemia.
Sulfhemoglobinemia is a *permanently* modified hemoglobin associated with exposure to TMP/SMX, dapsone, phenazopyridine, & other amino & nitro compounds.
It has an altered oxy-hemoglobin dissociation curve, but unlike metHb the curve is RIGHT-shifted.
2/
Sulfhemoglobinemia is a *permanently* modified hemoglobin associated with exposure to TMP/SMX, dapsone, phenazopyridine, & other amino & nitro compounds.
It has an altered oxy-hemoglobin dissociation curve, but unlike metHb the curve is RIGHT-shifted.
2/
Just don't use poppers if you take
riociguat
avanafil
cabergoline
ergoloid mesylates
ergotamine
lofexidine
methylergonovine
sildenafil
tadalafil
vardenafil
arginine
benazepril
bretylium
bupivacaine implant
captopril
dapsone topical
nitroglycerin
tetracaine
And you *should* be fine 😅
riociguat
avanafil
cabergoline
ergoloid mesylates
ergotamine
lofexidine
methylergonovine
sildenafil
tadalafil
vardenafil
arginine
benazepril
bretylium
bupivacaine implant
captopril
dapsone topical
nitroglycerin
tetracaine
And you *should* be fine 😅
October 24, 2024 at 7:02 PM
Just don't use poppers if you take
riociguat
avanafil
cabergoline
ergoloid mesylates
ergotamine
lofexidine
methylergonovine
sildenafil
tadalafil
vardenafil
arginine
benazepril
bretylium
bupivacaine implant
captopril
dapsone topical
nitroglycerin
tetracaine
And you *should* be fine 😅
riociguat
avanafil
cabergoline
ergoloid mesylates
ergotamine
lofexidine
methylergonovine
sildenafil
tadalafil
vardenafil
arginine
benazepril
bretylium
bupivacaine implant
captopril
dapsone topical
nitroglycerin
tetracaine
And you *should* be fine 😅
Good morning. This is a #PhunQuiz Dose. Which one treats severe hypoglycemia?
A. Dapsone
B. Dasatinib
C. Dasiglucagon
D. Deferoxamine
See the thread
#PharmSky #Medicines #Pharmacy #MedSky #Pharmacology #FOAMed #NAPLEX #Pharmacists #NCLEX #PharmacyStudents #PharmacyTechnicians #PTCB
A. Dapsone
B. Dasatinib
C. Dasiglucagon
D. Deferoxamine
See the thread
#PharmSky #Medicines #Pharmacy #MedSky #Pharmacology #FOAMed #NAPLEX #Pharmacists #NCLEX #PharmacyStudents #PharmacyTechnicians #PTCB
April 20, 2025 at 3:00 PM
Good morning. This is a #PhunQuiz Dose. Which one treats severe hypoglycemia?
A. Dapsone
B. Dasatinib
C. Dasiglucagon
D. Deferoxamine
See the thread
#PharmSky #Medicines #Pharmacy #MedSky #Pharmacology #FOAMed #NAPLEX #Pharmacists #NCLEX #PharmacyStudents #PharmacyTechnicians #PTCB
A. Dapsone
B. Dasatinib
C. Dasiglucagon
D. Deferoxamine
See the thread
#PharmSky #Medicines #Pharmacy #MedSky #Pharmacology #FOAMed #NAPLEX #Pharmacists #NCLEX #PharmacyStudents #PharmacyTechnicians #PTCB
#idboardreview Person w/ borderline leprosy was started on rifampicin, dapsone, clofazimine 4 wks ago, now w/F 102F, diffuse exfoliative rash, cheilits, subconjuctival hemorrhage, b/l ulnar claw hand deformity, ALT 540, AST 250, bil 3.8, Hb 9. dx? #idsky #idmeded #meded
March 18, 2026 at 1:27 AM
#idboardreview Person w/ borderline leprosy was started on rifampicin, dapsone, clofazimine 4 wks ago, now w/F 102F, diffuse exfoliative rash, cheilits, subconjuctival hemorrhage, b/l ulnar claw hand deformity, ALT 540, AST 250, bil 3.8, Hb 9. dx? #idsky #idmeded #meded
I'm a very pro-biomedicine person who's been unlucky with a handful of drug side effects (psych issues on prednisone, methemoglobinemia on dapsone) so happy to explain my story to those residents.
September 14, 2026 at 1:59 AM
I'm a very pro-biomedicine person who's been unlucky with a handful of drug side effects (psych issues on prednisone, methemoglobinemia on dapsone) so happy to explain my story to those residents.
Limited data tovaquone and dapsone as alternatives to TMP-SMX for PJP prophylaxis
🆕️✨️ Single-center, retrospective cohort #TID
Alternative Pneumocystis Pneumonia Prophylaxis in Solid Organ Transplants #idsky #medsky #TxID
onlinelibrary.wiley.com/doi/full/10....
🆕️✨️ Single-center, retrospective cohort #TID
Alternative Pneumocystis Pneumonia Prophylaxis in Solid Organ Transplants #idsky #medsky #TxID
onlinelibrary.wiley.com/doi/full/10....
Alternative Pneumocystis Pneumonia Prophylaxis in Solid Organ Transplants
At our institution, 34.9% of solid organ transplant recipients over a 2-year period received alternative Pneumocystis jirovecii pneumonia prophylaxis due to trimethoprim-sulfamethoxazole (TMP-SMX) al...
onlinelibrary.wiley.com
November 28, 2024 at 9:14 PM
Limited data tovaquone and dapsone as alternatives to TMP-SMX for PJP prophylaxis
🆕️✨️ Single-center, retrospective cohort #TID
Alternative Pneumocystis Pneumonia Prophylaxis in Solid Organ Transplants #idsky #medsky #TxID
onlinelibrary.wiley.com/doi/full/10....
🆕️✨️ Single-center, retrospective cohort #TID
Alternative Pneumocystis Pneumonia Prophylaxis in Solid Organ Transplants #idsky #medsky #TxID
onlinelibrary.wiley.com/doi/full/10....
Personally, would do Ganciclovir/valgcv + gscf support intermittently to keep ANC >1000 if the issue is only agranulocytosis! Would switch PCP SXT proph to SS/day or switch to Dapsone to minimise other drug contributions to agranulocytosis.
January 24, 2025 at 2:25 AM
Personally, would do Ganciclovir/valgcv + gscf support intermittently to keep ANC >1000 if the issue is only agranulocytosis! Would switch PCP SXT proph to SS/day or switch to Dapsone to minimise other drug contributions to agranulocytosis.
I'm also on dapsone, which is mostly taken by AIDS patients to prevent opportunistic fungal infections in the lungs.
March 25, 2024 at 12:33 AM
I'm also on dapsone, which is mostly taken by AIDS patients to prevent opportunistic fungal infections in the lungs.
#ResearchHighlight from Marlous Grijsen, OUCRU
Challenges associated with #dapsone for #leprosy treatment in Indonesia - urgent need for access to alternative antimicrobial drugs
Read more 👉 www.ndm.ac/tropmed.res-hi
Full publication 👉 www.thelancet.com/journals/lan...
Challenges associated with #dapsone for #leprosy treatment in Indonesia - urgent need for access to alternative antimicrobial drugs
Read more 👉 www.ndm.ac/tropmed.res-hi
Full publication 👉 www.thelancet.com/journals/lan...
March 5, 2025 at 9:18 AM
#ResearchHighlight from Marlous Grijsen, OUCRU
Challenges associated with #dapsone for #leprosy treatment in Indonesia - urgent need for access to alternative antimicrobial drugs
Read more 👉 www.ndm.ac/tropmed.res-hi
Full publication 👉 www.thelancet.com/journals/lan...
Challenges associated with #dapsone for #leprosy treatment in Indonesia - urgent need for access to alternative antimicrobial drugs
Read more 👉 www.ndm.ac/tropmed.res-hi
Full publication 👉 www.thelancet.com/journals/lan...
I'm on dapsone full time.
May 18, 2024 at 11:07 PM
I'm on dapsone full time.
It can't be cured with yoga but as I've already noted in reply to another comment, there is a successful treatment regimen that consists of three medicines (dapsone, rifampicin and clofazimine) and is referred to as multi-drug therapy (MDT). Science trumps occult pseudo-science yet again!
July 27, 2025 at 10:36 AM
It can't be cured with yoga but as I've already noted in reply to another comment, there is a successful treatment regimen that consists of three medicines (dapsone, rifampicin and clofazimine) and is referred to as multi-drug therapy (MDT). Science trumps occult pseudo-science yet again!
I'm on Dapsone. (I don't do well on sulfa.)
March 30, 2025 at 7:16 AM
I'm on Dapsone. (I don't do well on sulfa.)
Looks like preferred regimen for Hansen’s is daily dapsone and rifampicin once per month for paucibacillary disease and if multibacillary you add clofazimine. Seems like thalidomide can be used for erythema nodosum leprosum
January 30, 2025 at 10:12 PM
Looks like preferred regimen for Hansen’s is daily dapsone and rifampicin once per month for paucibacillary disease and if multibacillary you add clofazimine. Seems like thalidomide can be used for erythema nodosum leprosum
Omg yes 😭😭😭 The only thing that (mostly) works for me is topical Dapsone, which my dermatologist prescribes. She also has me use retin-A. But even still I'll get big ass pimples on my chin a lot. Not as much as before though. Sometimes (like today) I'll actually have clear skin 🤯
1/
1/
July 27, 2025 at 8:15 PM
Omg yes 😭😭😭 The only thing that (mostly) works for me is topical Dapsone, which my dermatologist prescribes. She also has me use retin-A. But even still I'll get big ass pimples on my chin a lot. Not as much as before though. Sometimes (like today) I'll actually have clear skin 🤯
1/
1/
In Leprosy Review Vol 96/4
Dapsone Hypersensitivity Syndrome with multisystem involvement in a case of Borderline Tuberculoid Hansen’s disease by Alok Jindal, Rabia Alam, Shitij Goel, Azra Ferheen Chaudhary
https://leprosyreview.org/articles/96/4
#OpenAccess #Leprosy #Dapsone #GlobalHealth #IDsky
Dapsone Hypersensitivity Syndrome with multisystem involvement in a case of Borderline Tuberculoid Hansen’s disease by Alok Jindal, Rabia Alam, Shitij Goel, Azra Ferheen Chaudhary
https://leprosyreview.org/articles/96/4
#OpenAccess #Leprosy #Dapsone #GlobalHealth #IDsky
December 22, 2025 at 10:00 AM
In Leprosy Review Vol 96/4
Dapsone Hypersensitivity Syndrome with multisystem involvement in a case of Borderline Tuberculoid Hansen’s disease by Alok Jindal, Rabia Alam, Shitij Goel, Azra Ferheen Chaudhary
https://leprosyreview.org/articles/96/4
#OpenAccess #Leprosy #Dapsone #GlobalHealth #IDsky
Dapsone Hypersensitivity Syndrome with multisystem involvement in a case of Borderline Tuberculoid Hansen’s disease by Alok Jindal, Rabia Alam, Shitij Goel, Azra Ferheen Chaudhary
https://leprosyreview.org/articles/96/4
#OpenAccess #Leprosy #Dapsone #GlobalHealth #IDsky
New Review Article
The role of the HLA-B*13:01 allele in leprosy patients with dapsone hypersensitivity syndrome (DHS): A systematic review and meta-analysis by Sri Linuwih Menaldi et al.
Available in Leprosy Review Volume 96/3:
https://leprosyreview.org/article/96/3/20-25047
#IDSky #Leprosy
The role of the HLA-B*13:01 allele in leprosy patients with dapsone hypersensitivity syndrome (DHS): A systematic review and meta-analysis by Sri Linuwih Menaldi et al.
Available in Leprosy Review Volume 96/3:
https://leprosyreview.org/article/96/3/20-25047
#IDSky #Leprosy
December 4, 2025 at 4:00 PM
New Review Article
The role of the HLA-B*13:01 allele in leprosy patients with dapsone hypersensitivity syndrome (DHS): A systematic review and meta-analysis by Sri Linuwih Menaldi et al.
Available in Leprosy Review Volume 96/3:
https://leprosyreview.org/article/96/3/20-25047
#IDSky #Leprosy
The role of the HLA-B*13:01 allele in leprosy patients with dapsone hypersensitivity syndrome (DHS): A systematic review and meta-analysis by Sri Linuwih Menaldi et al.
Available in Leprosy Review Volume 96/3:
https://leprosyreview.org/article/96/3/20-25047
#IDSky #Leprosy