www.nature.com/articles/s41...
New paper out!!
New paper out!!
A plasmid-chromosome crosstalk in multidrug resistant enterobacteria - Nature Communications
The authors describe a new crosstalk between a globally disseminated carbapenem resistance plasmid and clinical enterobacteria clones. This crosstalk provides a fitness advantage to the plasmid-carryi...
www.nature.com
December 30, 2024 at 6:33 PM
www.nature.com/articles/s41...
New paper out!!
New paper out!!
new very interesting paper about plasmid-chromosome crosstalk in Enterobacteriaceae
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A plasmid-chromosome crosstalk in multidrug resistant enterobacteria - Nature Communications
The authors describe a new crosstalk between a globally disseminated carbapenem resistance plasmid and clinical enterobacteria clones. This crosstalk provides a fitness advantage to the plasmid-carryi...
www.nature.com
December 31, 2024 at 10:23 AM
new very interesting paper about plasmid-chromosome crosstalk in Enterobacteriaceae
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Very happy to see this work published! We unveil a plasmid-chromosome crosstalk by showing that pOXA-48 encodes for a regulator that mediates the transcription of an enterobacterial chromosomal operon, resulting in a growth benefit for the plasmid-carrying bacteria!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A plasmid-chromosome crosstalk in multidrug resistant enterobacteria - Nature Communications
The authors describe a new crosstalk between a globally disseminated carbapenem resistance plasmid and clinical enterobacteria clones. This crosstalk provides a fitness advantage to the plasmid-carryi...
www.nature.com
January 2, 2025 at 11:20 AM
Very happy to see this work published! We unveil a plasmid-chromosome crosstalk by showing that pOXA-48 encodes for a regulator that mediates the transcription of an enterobacterial chromosomal operon, resulting in a growth benefit for the plasmid-carrying bacteria!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A plasmid-chromosome crosstalk in multidrug resistant enterobacteria
by Laura Toribio-Celestino, @sanmillan.bsky.social et al., in @naturecomms.bsky.social
www.nature.com/articles/s41...
by Laura Toribio-Celestino, @sanmillan.bsky.social et al., in @naturecomms.bsky.social
www.nature.com/articles/s41...
A plasmid-chromosome crosstalk in multidrug resistant enterobacteria - Nature Communications
The authors describe a new crosstalk between a globally disseminated carbapenem resistance plasmid and clinical enterobacteria clones. This crosstalk provides a fitness advantage to the plasmid-carryi...
www.nature.com
January 29, 2025 at 12:41 PM
A plasmid-chromosome crosstalk in multidrug resistant enterobacteria
by Laura Toribio-Celestino, @sanmillan.bsky.social et al., in @naturecomms.bsky.social
www.nature.com/articles/s41...
by Laura Toribio-Celestino, @sanmillan.bsky.social et al., in @naturecomms.bsky.social
www.nature.com/articles/s41...
March 17, 2025 at 10:41 AM
This work is finally published! 🥳🧬
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens
Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...
rdcu.be
August 20, 2025 at 1:25 PM
This work is finally published! 🥳🧬
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
New preprint in collaboration with @asantoslopez.bsky.social lab and led by Jorge Sastre. Combining experimental evolution and analyses of longitudinal samples from hospitalised patients, we unveiled a new mechanism of plasmid-mediated evolution beyond HGT 1/8
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Plasmid-encoded insertion sequences promote rapid adaptation in clinical enterobacteria
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
March 2, 2024 at 7:53 PM
New preprint in collaboration with @asantoslopez.bsky.social lab and led by Jorge Sastre. Combining experimental evolution and analyses of longitudinal samples from hospitalised patients, we unveiled a new mechanism of plasmid-mediated evolution beyond HGT 1/8
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
3′UTR-derived small RNA couples acid resistance to metabolic reprogramming of Salmonella within macrophages url: academic.oup.com/nar/article/...
3′UTR-derived small RNA couples acid resistance to metabolic reprogramming of Salmonella within macrophages
Abstract. Acid resistance is crucial for enterobacteria to withstand host acidic environments during infection, including the gastrointestinal tract and ma
academic.oup.com
January 7, 2026 at 8:19 AM
3′UTR-derived small RNA couples acid resistance to metabolic reprogramming of Salmonella within macrophages url: academic.oup.com/nar/article/...
Dissecting pOXA-48 fitness effects in clinical enterobacteria using plasmid-wide CRISPRi screens https://www.biorxiv.org/content/10.1101/2025.01.23.633114v1
January 24, 2025 at 12:16 PM
Dissecting pOXA-48 fitness effects in clinical enterobacteria using plasmid-wide CRISPRi screens https://www.biorxiv.org/content/10.1101/2025.01.23.633114v1
👏 Congrats to Frédéric Barras, elected Associate Member of the Royal Academy of Belgium (Science Class)!
He leads our unit on Stress Adaptation & Metabolism in Enterobacteria.
A proud recognition for Institut Pasteur.
He leads our unit on Stress Adaptation & Metabolism in Enterobacteria.
A proud recognition for Institut Pasteur.
January 8, 2026 at 1:58 PM
👏 Congrats to Frédéric Barras, elected Associate Member of the Royal Academy of Belgium (Science Class)!
He leads our unit on Stress Adaptation & Metabolism in Enterobacteria.
A proud recognition for Institut Pasteur.
He leads our unit on Stress Adaptation & Metabolism in Enterobacteria.
A proud recognition for Institut Pasteur.
Want to know if temocillin is non-inferior to meropenem in BSI by 3GCeph resistant enterobacteria?
We are presenting the results of ASTARTÉ trial at ESCMID Global Sunday 16:15 Hall 9.
#ESCMIDGlobal
We are presenting the results of ASTARTÉ trial at ESCMID Global Sunday 16:15 Hall 9.
#ESCMIDGlobal
April 12, 2025 at 3:24 PM
Want to know if temocillin is non-inferior to meropenem in BSI by 3GCeph resistant enterobacteria?
We are presenting the results of ASTARTÉ trial at ESCMID Global Sunday 16:15 Hall 9.
#ESCMIDGlobal
We are presenting the results of ASTARTÉ trial at ESCMID Global Sunday 16:15 Hall 9.
#ESCMIDGlobal
🚨 New preprint! We know that plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Dissecting pOXA-48 fitness effects in clinical enterobacteria using plasmid-wide CRISPRi screens
Conjugative plasmids are the main vehicle for the spread of antimicrobial resistance (AMR) genes in clinical bacteria. AMR plasmids allow bacteria to survive antibiotic treatments, but they also produ...
www.biorxiv.org
January 24, 2025 at 12:26 PM
🚨 New preprint! We know that plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Plasmid-chromosome transcriptional crosstalk in multidrug resistant clinical enterobacteria https://www.biorxiv.org/content/10.1101/2024.08.08.607126v1
Plasmid-chromosome transcriptional crosstalk in multidrug resistant clinical enterobacteria https://www.biorxiv.org/content/10.1101/2024.08.08.607126v1
Conjugative plasmids promote the dissemination and evolution of antimicrobial resistance in bacteria
www.biorxiv.org
August 9, 2024 at 5:15 AM
Plasmid-chromosome transcriptional crosstalk in multidrug resistant clinical enterobacteria https://www.biorxiv.org/content/10.1101/2024.08.08.607126v1
If you like plasmid-bacteria interactions, take a look at our new study!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Plasmid-chromosome transcriptional crosstalk in multidrug resistant clinical enterobacteria
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
August 10, 2024 at 7:13 AM
If you like plasmid-bacteria interactions, take a look at our new study!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Today I learned: The flagellar serotype "H" of enterobacteria stands for German "Hauch" ("breath") because swarming colonies on agar look like when you breathe at a glass slide... and the "O-antigen" was first seen with non-motile strains ("ohne Hauch"). I am stunned... 🤔🌬️🧫
October 30, 2023 at 1:45 PM
Today I learned: The flagellar serotype "H" of enterobacteria stands for German "Hauch" ("breath") because swarming colonies on agar look like when you breathe at a glass slide... and the "O-antigen" was first seen with non-motile strains ("ohne Hauch"). I am stunned... 🤔🌬️🧫
multicellular enterobacteria.
September 18, 2026 at 12:25 PM
multicellular enterobacteria.
Evolution at work! In just 640 generations, E. coli under competition lost its T6SS nanoweapon via adaptive mutations. A novel RfaH-dependent regulation was uncovered, hinting at a conserved control across enterobacteria. #T6SS #MicroSky
✍️ Cascales and coll.
www.biorxiv.org/content/10.1...
✍️ Cascales and coll.
www.biorxiv.org/content/10.1...
February 11, 2025 at 1:50 AM
Evolution at work! In just 640 generations, E. coli under competition lost its T6SS nanoweapon via adaptive mutations. A novel RfaH-dependent regulation was uncovered, hinting at a conserved control across enterobacteria. #T6SS #MicroSky
✍️ Cascales and coll.
www.biorxiv.org/content/10.1...
✍️ Cascales and coll.
www.biorxiv.org/content/10.1...
Não sei tirar foto, mas é uma enterobacteria que fiz coloração de gram
November 28, 2024 at 10:53 PM
Não sei tirar foto, mas é uma enterobacteria que fiz coloração de gram
Dissecting the fitness effects of a carbapenem resistance plasmid in clinical Enterobacterales using plasmid-wide CRISPRi screens
@aliciapcv.bsky.social @jorgesastred.bsky.social @sanmillan.bsky.social @cnb-csic.bsky.social
#bacteria #plasmids
@aliciapcv.bsky.social @jorgesastred.bsky.social @sanmillan.bsky.social @cnb-csic.bsky.social
#bacteria #plasmids
Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens - Nature Communications
This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the carbapenemase OXA-48 has a role in the plasmid-associated fitness costs.
bit.ly
October 17, 2025 at 4:56 PM
Dissecting the fitness effects of a carbapenem resistance plasmid in clinical Enterobacterales using plasmid-wide CRISPRi screens
@aliciapcv.bsky.social @jorgesastred.bsky.social @sanmillan.bsky.social @cnb-csic.bsky.social
#bacteria #plasmids
@aliciapcv.bsky.social @jorgesastred.bsky.social @sanmillan.bsky.social @cnb-csic.bsky.social
#bacteria #plasmids
A plasmid-chromosome crosstalk in multidrug resistant enterobacteria www.nature.com/articles/s41...
A plasmid-chromosome crosstalk in multidrug resistant enterobacteria - Nature Communications
The authors describe a new crosstalk between a globally disseminated carbapenem resistance plasmid and clinical enterobacteria clones. This crosstalk provides a fitness advantage to the plasmid-carryi...
www.nature.com
January 1, 2025 at 12:04 AM
A plasmid-chromosome crosstalk in multidrug resistant enterobacteria www.nature.com/articles/s41...
🚨 Preprint alert 🚨
β-lactamase production in enterobacteria induces collateral sensitivity to other antibiotics!
We believe that these findings expose the Achilles’ heel of β-lactamase producing bacteria!
With @sanmillan.bsky.social and many others (not on bsky).
Check it out! 👇
#MicroSky
β-lactamase production in enterobacteria induces collateral sensitivity to other antibiotics!
We believe that these findings expose the Achilles’ heel of β-lactamase producing bacteria!
With @sanmillan.bsky.social and many others (not on bsky).
Check it out! 👇
#MicroSky
β-lactamase expression induces collateral sensitivity in Escherichia coli
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
November 23, 2023 at 4:56 PM
🚨 Preprint alert 🚨
β-lactamase production in enterobacteria induces collateral sensitivity to other antibiotics!
We believe that these findings expose the Achilles’ heel of β-lactamase producing bacteria!
With @sanmillan.bsky.social and many others (not on bsky).
Check it out! 👇
#MicroSky
β-lactamase production in enterobacteria induces collateral sensitivity to other antibiotics!
We believe that these findings expose the Achilles’ heel of β-lactamase producing bacteria!
With @sanmillan.bsky.social and many others (not on bsky).
Check it out! 👇
#MicroSky
Yep they also carry enterobacteria such as salmonella for feeding it to any animal is not a good idea.
March 13, 2025 at 6:02 PM
Yep they also carry enterobacteria such as salmonella for feeding it to any animal is not a good idea.
All in all, our study highlights the role of different plasmid-encoded genes in the biology of pOXA-48 and opens new doors to explore alternative ways to fight AMR in enterobacteria. 13/14
August 20, 2025 at 1:25 PM
All in all, our study highlights the role of different plasmid-encoded genes in the biology of pOXA-48 and opens new doors to explore alternative ways to fight AMR in enterobacteria. 13/14
Interesting new findings about the role played by the ArcZ sRNA during Phage T2 infection - ArcZ is conserved in Salmonella, E. coli & other enterobacteria
June 20, 2026 at 8:43 AM
Interesting new findings about the role played by the ArcZ sRNA during Phage T2 infection - ArcZ is conserved in Salmonella, E. coli & other enterobacteria