#EpigeneticReprogramming
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robertlufkinmd.bsky.social
Read the full breakdown: robertlufkinmd.substack.com/p/human-age-...

Full episode on the Health Longevity Secrets podcast: youtu.be/twjyPvSsX8w

#Longevity #AgeReversal #EpigeneticReprogramming #HealthLongevitySecrets #ExponentialMedicine (7/7)
August 25, 2026 at 2:33 PM
robertlufkinmd.bsky.social
Full episode of Health Longevity Secrets -- youtu.be/twjyPvSsX8w
Full breakdown coming on the Health Longevity Secrets podcast www.youtube.com/@RobertLufkinMD

#Longevity #EpigeneticReprogramming #LifeBiosciences #ER100 #MetabolicHealth #HealthLongevitySecrets (5/5)
August 25, 2026 at 12:24 PM
alicefrolov.bsky.social
Transient OSKM induction dynamics in aged fibroblasts: relative transcript abundance over a 6-day doxycycline pulse-chase.

#PartialReprogramming #YamanakaFactors #CellularRejuvenation #EpigeneticReprogramming #OSKM #AgingBiology #TranscriptionalDynamics #SystemsBiology
Transient OSKM induction dynamics in aged fibroblasts: relative transcript abundance over a 6-day doxycycline pulse-chase Sharing a visualization developed in the context of our ongoing methodological work on partial reprogramming protocols. The figure depicts the temporal kinetics of the four Yamanaka factors (Oct4, Sox2, Klf4, c-Myc) at the transcript level across a 6-day window encompassing a doxycycline-inducible pulse followed by withdrawal, in a Tet-On system expressed in late-passage murine dermal fibroblasts. The multiline plot tracks normalized mRNA abundance (relative to Gapdh, log2 fold change over uninduced baseline) sampled at 12-hour intervals. Several features are worth highlighting for discussion: - Asynchronous induction onset: c-Myc and Klf4 transcripts rise with shorter latency than Oct4 and Sox2, consistent with reported differences in transactivator binding kinetics and endogenous chromatin accessibility at the respective loci. - Plateau asymmetry: Klf4 reaches the highest steady-state amplitude during the induction phase, while Sox2 exhibits the most attenuated response, in line with stoichiometric imbalances repeatedly documented in polycistronic OSKM cassettes. - Decay kinetics post-dox withdrawal: exogenous transcript clearance follows approximately first-order decay, with c-Myc displaying the shortest apparent half-life and Oct4 the longest residual signal, reflecting both mRNA stability and 3'UTR-dependent turnover. - The chosen 48-hour induction window is intended to remain below the somatic identity loss threshold reported by Ocampo et al. (2016) and subsequent studies, while still being sufficient to engage early epigenetic remodeling. Important caveat: the data plotted here are simulated and serve an illustrative purpose. #PartialReprogramming #YamanakaFactors #CellularRejuvenation #EpigeneticReprogramming #OSKM #AgingBiology #TranscriptionalDynamics #SystemsBiology
June 26, 2026 at 5:01 PM
longevitytech.bsky.social
First patient dosed in Phase 1 trial testing epigenetic restoration approach for progressive age-related vision loss.

Link as first comment.

#longevity #geroscience #epigeneticreprogramming #visionloss #biotech
Illustration of two people observing a large eye-like structure. The image depicts an advancement in OSK therapy by Life Bio, conveying a sense of progress and innovation.
June 10, 2026 at 9:17 AM
singulism.bsky.social
Sinclair Plans to Enter XPrize with Oral Rejuvenation Drug

#LongevityScience #EpigeneticReprogramming #DrugDiscovery
https://singulism.com/en/2026-06-09-david-sinclair-oral-rejuvenation-xprize
Sinclair Plans to Enter XPrize with Oral Rejuvenation Drug
Dr. David Sinclair of Harvard University is planning a human trial of an oral "reprogramming" drug, SL-100, within the framework of the XPrize competition. The attempt at whole-body rejuvenation spark
singulism.com
June 9, 2026 at 5:32 PM
alicefrolov.bsky.social
Epigenetic age reversal kinetics under partial versus complete Yamanaka factor-mediated reprogramming

Transient induction of OCT4, SOX2, and KLF4 (OSK) or the complete OSKM cassette.

#EpigeneticReprogramming #YamanakaFactors #PartialReprogramming #EpigeneticClock #OSK #Rejuvenation #AgingBiology
Epigenetic age reversal kinetics under partial versus complete Yamanaka factor-mediated reprogramming Transient induction of OCT4, SOX2, and KLF4 (OSK) — or the complete OSKM cassette — drives progressive erasure of age-associated epigenetic marks, quantifiable via Horvath-family methylation clocks as negative delta biological age. Partial reprogramming protocols, defined by abbreviated factor expression prior to loss of somatic identity, achieve significant epigenetic rejuvenation while preserving cell-type-specific transcriptional programs — a critical distinction from complete reprogramming, which traverses a pluripotent intermediate with associated risks of teratoma formation and epigenetic dysregulation. The dose-response relationship between reprogramming cycle number and clock-measured age reversal suggests saturable resetting of methylation at clock CpGs, with diminishing returns beyond a tissue-specific threshold. Mechanistically, OSK-mediated rejuvenation is proposed to operate through TET-dependent active demethylation at age-hypermethylated loci and restoration of H3K27me3 patterning at Polycomb targets — implicating chromatin remodeling upstream of transcriptional identity restoration. These findings position partial reprogramming as the most mechanistically proximate intervention to date for reversing the epigenetic component of cellular aging.
May 29, 2026 at 5:00 PM
aldesinaga.bsky.social
moving the world one step closer to systemic, whole-body age reversal.

#AgeReversal #Longevity #ReverseAging #AntiAgingBreakthrough
#YouthExtension #EpigeneticReprogramming #CellularReprogramming #GeneTherapy #YamanakaFactors #Biotech #LifeBiosciences #DavidSinclair #FDAApprova
May 17, 2026 at 2:59 PM
yolandamr.bsky.social
#EpigeneticReprogrammingAndMammalianDevelopmentTeam @maudborensztein.bsky.social #IGMM #Biolum #CNRS #X-chromosome #XCR #epigeneticreprogramming #primordialgermcells #womenreproduction
March 26, 2026 at 1:20 PM
medcomm.bsky.social
#Review in #MedComm
Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions doi.org/10.1002/mco2...

#DifferentiationTherapy #EpigeneticReprogramming #SpatiotemporalOmics #TherapyResistance #TumorEvolution #TME
Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions
Cell plasticity refers to a dynamic program through which cells reprogram their phenotype, acquiring new histologic and molecular characteristics. Recognized as a hallmark of cancer, cellular plastic...
doi.org
December 26, 2025 at 3:18 AM
genesndiseases.bsky.social
This new study reveals how C/G fusion drives #EpigeneticReprogramming via #DNMT3B in acute megakaryoblastic #Leukemia (AMKL), highlighting DNMT3B inhibition as a promising #therapeutic avenue for #AMKL. @uamshealth.bsky.social #medsky

#OpenAccess: www.sciencedirect.com/science/arti...
October 26, 2025 at 12:51 AM
jacky1986.bsky.social
Revolutionary Tech Promises To Extend Human Lifespan To 20,000 Years, Claims Scientist.

#Longevity #EpigeneticReprogramming #LifeExtension #AntiAging #YamanakaFactors #LongevityRevolution #ScienceNews #FutureOfHealth #Biotech #Breakthrough #Healthspan

medium.com/@jckapadia00...
Revolutionary Tech Promises To Extend Human Lifespan To 20,000 Years, Claims Scientist
In a claim that seems ripped from the pages of the most ambitious science fiction, a pioneering scientist has announced a revolutionary…
medium.com
September 19, 2025 at 4:17 AM