Our new story on how FGF23 regulates the genome and how both FGF23 and PTH control #vitaminD in kidney is finally up after years of work. Available on #researchsquare preprint server while under review: www.researchsquare.com/article/rs-1...
@uwmadison.bsky.social @uwmadisonnutrisci.bsky.social
@uwmadison.bsky.social @uwmadisonnutrisci.bsky.social
ETV1 Couples Reciprocal FGF23 and PTH Signaling to Renal CYP24A1 Regulation
Active vitamin D [1,25(OH)2D3; 1,25D] synthesis is finely balanced in kidney proximal tubules by the catabolic enzyme CYP24A1 and anabolic CYP27B1. Fibroblast growth factor 23 (FGF23) and 1,25D lower ...
www.researchsquare.com
August 10, 2026 at 8:46 PM
Our new story on how FGF23 regulates the genome and how both FGF23 and PTH control #vitaminD in kidney is finally up after years of work. Available on #researchsquare preprint server while under review: www.researchsquare.com/article/rs-1...
@uwmadison.bsky.social @uwmadisonnutrisci.bsky.social
@uwmadison.bsky.social @uwmadisonnutrisci.bsky.social
supposedly the Derisomaltose causes less.
Pathophysiology is really interesting- Carboxymaltose inhibits FGF23 degradation.
Is Myles Wolf on here? @dukekidney.bsky.social
Pathophysiology is really interesting- Carboxymaltose inhibits FGF23 degradation.
Is Myles Wolf on here? @dukekidney.bsky.social
April 21, 2025 at 10:15 PM
supposedly the Derisomaltose causes less.
Pathophysiology is really interesting- Carboxymaltose inhibits FGF23 degradation.
Is Myles Wolf on here? @dukekidney.bsky.social
Pathophysiology is really interesting- Carboxymaltose inhibits FGF23 degradation.
Is Myles Wolf on here? @dukekidney.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC...
Good recent review but in CKD , it will increase intact FGF23 more but lower serum PO4
Good recent review but in CKD , it will increase intact FGF23 more but lower serum PO4
April 21, 2025 at 11:23 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
Good recent review but in CKD , it will increase intact FGF23 more but lower serum PO4
Good recent review but in CKD , it will increase intact FGF23 more but lower serum PO4
Hemophagocytic Lymphohistiocytosis and Fibroblast Growth Factor 23 (FGF23)–Induced Hypophosphatemia
#nephsky #nephrology
www.ajkd.org/article/S027...
#nephsky #nephrology
www.ajkd.org/article/S027...
Hemophagocytic Lymphohistiocytosis and Fibroblast Growth Factor 23 (FGF23)–Induced Hypophosphatemia
Hypophosphatemia is a frequent complication of chimeric antigen receptor T-cell therapy.
In this setting, hypophosphatemia has been previously associated with cytokine release
syndrome. The mechanisms...
www.ajkd.org
July 1, 2026 at 3:36 AM
Hemophagocytic Lymphohistiocytosis and Fibroblast Growth Factor 23 (FGF23)–Induced Hypophosphatemia
#nephsky #nephrology
www.ajkd.org/article/S027...
#nephsky #nephrology
www.ajkd.org/article/S027...
Blood and urine calciprotein particles may differ due to the effects of FGF23.
March 26, 2025 at 12:35 PM
Blood and urine calciprotein particles may differ due to the effects of FGF23.
My main work from Stockholm is online as a preprint: FGF23 promotes renal immune cell infiltration and proinflammatory signaling in kidney disease models. Thanks to Mikhail Burmakin, Hannes Olauson and all other co-authors! #nephrology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The renal response to FGF23 shifts from phosphaturia towards inflammation in murine kidney disease models
Background: FGF23 excess is associated with morbidity and mortality, but the role of excessive circulating FGF23 concentrations as a mere biomarker or causative factor of pathology is controversial. H...
www.biorxiv.org
March 6, 2025 at 5:18 AM
My main work from Stockholm is online as a preprint: FGF23 promotes renal immune cell infiltration and proinflammatory signaling in kidney disease models. Thanks to Mikhail Burmakin, Hannes Olauson and all other co-authors! #nephrology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
My continued biomedical education
Soft tissue calcifications in #ChronicKidneyDisease —beyond the vasculature, heart, skeletal muscle, kidney
TNAP ENPP1 NaPi-2b ABCC6 AHSG FGF23 Klotho PiT-1/2
Lung
GI
Skin
Adipose
Testis
Brain Neuron
Eye
#PflügersArchiv 2025
link.springer.com/article/10.1...
Soft tissue calcifications in #ChronicKidneyDisease —beyond the vasculature, heart, skeletal muscle, kidney
TNAP ENPP1 NaPi-2b ABCC6 AHSG FGF23 Klotho PiT-1/2
Lung
GI
Skin
Adipose
Testis
Brain Neuron
Eye
#PflügersArchiv 2025
link.springer.com/article/10.1...
June 6, 2025 at 12:01 PM
My continued biomedical education
Soft tissue calcifications in #ChronicKidneyDisease —beyond the vasculature, heart, skeletal muscle, kidney
TNAP ENPP1 NaPi-2b ABCC6 AHSG FGF23 Klotho PiT-1/2
Lung
GI
Skin
Adipose
Testis
Brain Neuron
Eye
#PflügersArchiv 2025
link.springer.com/article/10.1...
Soft tissue calcifications in #ChronicKidneyDisease —beyond the vasculature, heart, skeletal muscle, kidney
TNAP ENPP1 NaPi-2b ABCC6 AHSG FGF23 Klotho PiT-1/2
Lung
GI
Skin
Adipose
Testis
Brain Neuron
Eye
#PflügersArchiv 2025
link.springer.com/article/10.1...
We advance the understanding and importance of Ca/PO4/FGF23 in Dent disease
journals.lww.com/cjasn/abstra...
journals.lww.com/cjasn/abstra...
journals.lww.com
February 28, 2026 at 6:40 PM
We advance the understanding and importance of Ca/PO4/FGF23 in Dent disease
journals.lww.com/cjasn/abstra...
journals.lww.com/cjasn/abstra...
Our new paper led by
@hkkimphd.bsky.social
published today in Circulation that highlights hypertension induced by dietary phosphate excess via FGF23-FGFR4-calcineurin activation of SNS in normal rats bit.ly/43H3cGB
@ahascience.bsky.social
#cardiosky
@hkkimphd.bsky.social
published today in Circulation that highlights hypertension induced by dietary phosphate excess via FGF23-FGFR4-calcineurin activation of SNS in normal rats bit.ly/43H3cGB
@ahascience.bsky.social
#cardiosky
June 5, 2025 at 1:02 PM
Our new paper led by
@hkkimphd.bsky.social
published today in Circulation that highlights hypertension induced by dietary phosphate excess via FGF23-FGFR4-calcineurin activation of SNS in normal rats bit.ly/43H3cGB
@ahascience.bsky.social
#cardiosky
@hkkimphd.bsky.social
published today in Circulation that highlights hypertension induced by dietary phosphate excess via FGF23-FGFR4-calcineurin activation of SNS in normal rats bit.ly/43H3cGB
@ahascience.bsky.social
#cardiosky
Phosphorus-independent role of FGF23 in erythropoiesis and iron homeostasis
#nephsky
journals.plos.org/plosone/arti...
#nephsky
journals.plos.org/plosone/arti...
Phosphorus-independent role of FGF23 in erythropoiesis and iron homeostasis
A number of studies have reported an association between phosphorus, red blood cell (RBC) production, and iron metabolism. However, it is difficult to distinguish whether the effect of phosphorus is d...
journals.plos.org
December 16, 2024 at 4:24 AM
Phosphorus-independent role of FGF23 in erythropoiesis and iron homeostasis
#nephsky
journals.plos.org/plosone/arti...
#nephsky
journals.plos.org/plosone/arti...
New manuscript!
Excess of 🦴 hormone FGF23 worsens atherosclerosis in male but not female mice.
Thanks to co-authors Karolina Lindberg, Olga Ovchinnikova, Daniel Ketelhuth, John Pirault, Hannes Olauson, Göran Hansson and Tobias Larsson. 👏
www.sciencedirect.com/science/arti...
Excess of 🦴 hormone FGF23 worsens atherosclerosis in male but not female mice.
Thanks to co-authors Karolina Lindberg, Olga Ovchinnikova, Daniel Ketelhuth, John Pirault, Hannes Olauson, Göran Hansson and Tobias Larsson. 👏
www.sciencedirect.com/science/arti...
Fgf23 expression increases atherosclerotic plaque burden in male ApoE deficient mice
Components of both the innate and adaptive immune system impact on arterial walls in atherosclerosis. Fibroblast growth factor-23 (FGF23) is a phospha…
www.sciencedirect.com
March 1, 2025 at 1:25 PM
New manuscript!
Excess of 🦴 hormone FGF23 worsens atherosclerosis in male but not female mice.
Thanks to co-authors Karolina Lindberg, Olga Ovchinnikova, Daniel Ketelhuth, John Pirault, Hannes Olauson, Göran Hansson and Tobias Larsson. 👏
www.sciencedirect.com/science/arti...
Excess of 🦴 hormone FGF23 worsens atherosclerosis in male but not female mice.
Thanks to co-authors Karolina Lindberg, Olga Ovchinnikova, Daniel Ketelhuth, John Pirault, Hannes Olauson, Göran Hansson and Tobias Larsson. 👏
www.sciencedirect.com/science/arti...
What do the findings of a new #ASNCJASN study suggest about the role of FGF23 in Dent disease type 1? kidney.pub/CJASN0978 David S. Goldfarb MD
March 24, 2026 at 6:00 PM
What do the findings of a new #ASNCJASN study suggest about the role of FGF23 in Dent disease type 1? kidney.pub/CJASN0978 David S. Goldfarb MD
Interesting FGF23 research, not specific to #XLH, but makes me glad I'm female! I have enough heart-disease issues from other causes. #MedSky #ChronicHypophos
New manuscript!
Excess of 🦴 hormone FGF23 worsens atherosclerosis in male but not female mice.
Thanks to co-authors Karolina Lindberg, Olga Ovchinnikova, Daniel Ketelhuth, John Pirault, Hannes Olauson, Göran Hansson and Tobias Larsson. 👏
www.sciencedirect.com/science/arti...
Excess of 🦴 hormone FGF23 worsens atherosclerosis in male but not female mice.
Thanks to co-authors Karolina Lindberg, Olga Ovchinnikova, Daniel Ketelhuth, John Pirault, Hannes Olauson, Göran Hansson and Tobias Larsson. 👏
www.sciencedirect.com/science/arti...
Fgf23 expression increases atherosclerotic plaque burden in male ApoE deficient mice
Components of both the innate and adaptive immune system impact on arterial walls in atherosclerosis. Fibroblast growth factor-23 (FGF23) is a phospha…
www.sciencedirect.com
March 1, 2025 at 5:37 PM
Interesting FGF23 research, not specific to #XLH, but makes me glad I'm female! I have enough heart-disease issues from other causes. #MedSky #ChronicHypophos
Dr. Makota Kuro-O kicks off the 2025 Renal Week conference with a fascinating journey on the toxicity of phosphate in CKD.
March 26, 2025 at 12:21 PM
Dr. Makota Kuro-O kicks off the 2025 Renal Week conference with a fascinating journey on the toxicity of phosphate in CKD.
journals.physiology.org/doi/epdf/10....
Did you know that the glycolytic pathway in kidney proximal tubule cells can function as a "sensor" of phosphate levels? Read below to learn how this mechanism plays a role in FGF23 signaling and mineral metabolism during CKD.
Did you know that the glycolytic pathway in kidney proximal tubule cells can function as a "sensor" of phosphate levels? Read below to learn how this mechanism plays a role in FGF23 signaling and mineral metabolism during CKD.
Glycerol-3-phosphate contributes to the increase in FGF23 production in chronic kidney disease
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journals.physiology.org
April 14, 2025 at 5:57 PM
journals.physiology.org/doi/epdf/10....
Did you know that the glycolytic pathway in kidney proximal tubule cells can function as a "sensor" of phosphate levels? Read below to learn how this mechanism plays a role in FGF23 signaling and mineral metabolism during CKD.
Did you know that the glycolytic pathway in kidney proximal tubule cells can function as a "sensor" of phosphate levels? Read below to learn how this mechanism plays a role in FGF23 signaling and mineral metabolism during CKD.
Targeted deletion of fibroblast growth factor 23 rescues metabolic dysregulation of diet-induced #obesity in female mice. Featured research article in #Endocrinology #FreeToView
#FGF23 #metabolism #diet
doi.org/10.1210/endo...
@endocrinesociety.bsky.social
#FGF23 #metabolism #diet
doi.org/10.1210/endo...
@endocrinesociety.bsky.social
Targeted Deletion of Fibroblast Growth Factor 23 Rescues Metabolic Dysregulation of Diet-induced Obesity in Female Mice
Abstract. Fibroblast growth factor 23 (FGF23) is a bone-secreted protein widely recognized as a critical regulator of skeletal and mineral metabolism. Howe
doi.org
January 15, 2025 at 8:18 PM
Targeted deletion of fibroblast growth factor 23 rescues metabolic dysregulation of diet-induced #obesity in female mice. Featured research article in #Endocrinology #FreeToView
#FGF23 #metabolism #diet
doi.org/10.1210/endo...
@endocrinesociety.bsky.social
#FGF23 #metabolism #diet
doi.org/10.1210/endo...
@endocrinesociety.bsky.social
New in Stem Cell Reports🥳🎉: we chart the endothelial-to-hematopoietic transition from iPSCs. Persistent endothelial programs & FGF23 signaling limit HSPC output—blocking FGF boosts blood stem cell generation. Read more 👉 lnkd.in/gZAzeiEb
September 18, 2025 at 9:09 PM
New in Stem Cell Reports🥳🎉: we chart the endothelial-to-hematopoietic transition from iPSCs. Persistent endothelial programs & FGF23 signaling limit HSPC output—blocking FGF boosts blood stem cell generation. Read more 👉 lnkd.in/gZAzeiEb
Interesting FGF23 research, not directly applicable to #XLH, but suggests a possible basis for the known tendency of chronic hypophosphatemia patients to be overweight (beyond what lack of exercise accounts for). #medSky www.endocrine.org/journals/end...
Targeted Deletion of Fibroblast Growth Factor 23 Rescues Metabolic Dysregulation of Diet-induced Obesity in Female Mice
In the present study, we show for the first time that increased circulating FGF23 levels in obese humans correlate with increased expression of adipose Fgf23 and both positively correlate with BMI.
www.endocrine.org
January 15, 2025 at 5:32 PM
Interesting FGF23 research, not directly applicable to #XLH, but suggests a possible basis for the known tendency of chronic hypophosphatemia patients to be overweight (beyond what lack of exercise accounts for). #medSky www.endocrine.org/journals/end...
Dynamic single cell transcriptomics defines #kidney #FGF23/KL bioactivity and novel segment-specific inflammatory targets
doi.org/10.1016/j.kint.2024.12.014
#inflammation #mineralmetabolism #MedSky #NephSky
doi.org/10.1016/j.kint.2024.12.014
#inflammation #mineralmetabolism #MedSky #NephSky
January 22, 2025 at 5:32 PM
Dynamic single cell transcriptomics defines #kidney #FGF23/KL bioactivity and novel segment-specific inflammatory targets
doi.org/10.1016/j.kint.2024.12.014
#inflammation #mineralmetabolism #MedSky #NephSky
doi.org/10.1016/j.kint.2024.12.014
#inflammation #mineralmetabolism #MedSky #NephSky
a/g 0.77 나머지는 모두 보통의 상태. 아직 속이 안좋은지 밥을 좀 덜먹음. 복막염 치료하면서 환묘들 케이스 많이 듣게되면서 수혈가능성도 생각해보고 혹시나해서 혈액형검사 같이했는데 B형나옴😇 그리고 fgf23 의뢰함
April 27, 2026 at 9:07 AM
a/g 0.77 나머지는 모두 보통의 상태. 아직 속이 안좋은지 밥을 좀 덜먹음. 복막염 치료하면서 환묘들 케이스 많이 듣게되면서 수혈가능성도 생각해보고 혹시나해서 혈액형검사 같이했는데 B형나옴😇 그리고 fgf23 의뢰함
The renal response to FGF23 shifts from phosphaturia toward inflammation in kidney disease
The renal response to FGF23 shifts from phosphaturia toward inflammation in kidney disease - PubMed
FGF23 excess is associated with morbidity and mortality, but the role of excessive circulating FGF23 concentrations as a causative factor of pathology is controversial. Here, we investigated the consequences of FGF23 excess in kidney disease. This study used three disease models: anti-glomerular bas …
pubmed.ncbi.nlm.nih.gov
March 11, 2026 at 3:31 AM
The renal response to FGF23 shifts from phosphaturia toward inflammation in kidney disease
Factors associated with impaired physical functionality in x-linked hypophosphatemia #XLH
academic.oup.com/jbmrplus/adv...
academic.oup.com/jbmrplus/adv...
Factors associated with impaired physical functionality in x-linked hypophosphatemia
Abstract. X-linked hypophosphatemia (XLH) is a rare inherited disorder characterized by elevated levels of fibroblast growth factor-23 (FGF23), chronic hyp
academic.oup.com
February 8, 2025 at 7:01 AM
Factors associated with impaired physical functionality in x-linked hypophosphatemia #XLH
academic.oup.com/jbmrplus/adv...
academic.oup.com/jbmrplus/adv...