Tag yourself.
I'm "FATIGUABILITY"
I'm "FATIGUABILITY"
someone accidently stumbled on an insanely ominious cdc government page, it’s a massive list of random words that looks like this. anyone know whats going on here?
ftp.cdc.gov/pub/health_S...
ftp.cdc.gov/pub/health_S...
December 19, 2025 at 2:16 AM
Tag yourself.
I'm "FATIGUABILITY"
I'm "FATIGUABILITY"
#MedTwitter #MedSky, do you know what postexertional malaise (PEM) is? It may be profound & can follow even minor physical or cognitive exertion hrs to days later. See 📸 for mechanisms. PEM is common in ppl w/ #LongCovid & #MECFS & isn’t just fatiguability. #MedEd
link.springer.com/content/pdf/...
link.springer.com/content/pdf/...
November 10, 2024 at 12:31 PM
#MedTwitter #MedSky, do you know what postexertional malaise (PEM) is? It may be profound & can follow even minor physical or cognitive exertion hrs to days later. See 📸 for mechanisms. PEM is common in ppl w/ #LongCovid & #MECFS & isn’t just fatiguability. #MedEd
link.springer.com/content/pdf/...
link.springer.com/content/pdf/...
1) Interesting experiment on fatiguability of arm muscles that might be useful as an objective test.
During repeated handgrip tasks, researchers found that "the neuromuscular system experienced changes earlier than the actual behavior"
During repeated handgrip tasks, researchers found that "the neuromuscular system experienced changes earlier than the actual behavior"
August 17, 2025 at 11:38 AM
1) Interesting experiment on fatiguability of arm muscles that might be useful as an objective test.
During repeated handgrip tasks, researchers found that "the neuromuscular system experienced changes earlier than the actual behavior"
During repeated handgrip tasks, researchers found that "the neuromuscular system experienced changes earlier than the actual behavior"
6) To digg deeper into PEM manifestations, I think we need better questions than those from the DePaul symptom questionnaire - these focus too much on fatigue after exertion and fatiguability, not on becoming sicker much later after the (over)exertion.
March 2, 2026 at 8:50 AM
6) To digg deeper into PEM manifestations, I think we need better questions than those from the DePaul symptom questionnaire - these focus too much on fatigue after exertion and fatiguability, not on becoming sicker much later after the (over)exertion.
#MedSky, do you know what postexertional malaise (PEM) is? It’s common in people w/ #LongCovid & #MECFS & isn’t just fatiguability. It may be profound & can follow even minor physical/cognitive exertion hrs to days later. See 📸 for mechanisms. #MedEd #MedTwitter
link.springer.com/content/pdf/...
link.springer.com/content/pdf/...
November 16, 2024 at 3:47 PM
#MedSky, do you know what postexertional malaise (PEM) is? It’s common in people w/ #LongCovid & #MECFS & isn’t just fatiguability. It may be profound & can follow even minor physical/cognitive exertion hrs to days later. See 📸 for mechanisms. #MedEd #MedTwitter
link.springer.com/content/pdf/...
link.springer.com/content/pdf/...
We have little trust in these NIH researchers because of their problematic effort preference theory.
This experimental setup, however, might help to show if muscle fatiguability in ME/CFS has a central (brain) or a peripheral (muscle) origin or both.
This experimental setup, however, might help to show if muscle fatiguability in ME/CFS has a central (brain) or a peripheral (muscle) origin or both.
1) Interesting experiment on fatiguability of arm muscles that might be useful as an objective test.
During repeated handgrip tasks, researchers found that "the neuromuscular system experienced changes earlier than the actual behavior"
During repeated handgrip tasks, researchers found that "the neuromuscular system experienced changes earlier than the actual behavior"
August 17, 2025 at 12:09 PM
We have little trust in these NIH researchers because of their problematic effort preference theory.
This experimental setup, however, might help to show if muscle fatiguability in ME/CFS has a central (brain) or a peripheral (muscle) origin or both.
This experimental setup, however, might help to show if muscle fatiguability in ME/CFS has a central (brain) or a peripheral (muscle) origin or both.
Got diagnosed with occult #TetheredCordSyndrome today after a loooong while of progression and am urged to have surgery for it next year >"< it’s said that my leg fatiguability is likely too far gone to be really fixed with surgery but the other symptoms should be reduced yayay!
September 25, 2026 at 12:02 AM
Got diagnosed with occult #TetheredCordSyndrome today after a loooong while of progression and am urged to have surgery for it next year >"< it’s said that my leg fatiguability is likely too far gone to be really fixed with surgery but the other symptoms should be reduced yayay!
Researchers exposed skeletal muscle to serum of ppl w/ #MECFS or #LongCovid
@48 hrs: contractile
profile severely compromised, shift to glycolysis
@ 96-144 hrs: high fatiguability, fragile tissue, fragmented mitochondria
Postexertional malaise is very real.
www.sciencedirect.com/science/arti...
@48 hrs: contractile
profile severely compromised, shift to glycolysis
@ 96-144 hrs: high fatiguability, fragile tissue, fragmented mitochondria
Postexertional malaise is very real.
www.sciencedirect.com/science/arti...
571P Muscular metabolic plasticity in 3D in vitro models against systemic stress factors in ME/CFS and long COVID-19
Myalgic encephalomyelities/ chronic fatigue syndrome and long COVID-19 are clinically challenging, multi-symptomatic conditions with multiple overlapp…
www.sciencedirect.com
November 16, 2024 at 3:44 PM
Researchers exposed skeletal muscle to serum of ppl w/ #MECFS or #LongCovid
@48 hrs: contractile
profile severely compromised, shift to glycolysis
@ 96-144 hrs: high fatiguability, fragile tissue, fragmented mitochondria
Postexertional malaise is very real.
www.sciencedirect.com/science/arti...
@48 hrs: contractile
profile severely compromised, shift to glycolysis
@ 96-144 hrs: high fatiguability, fragile tissue, fragmented mitochondria
Postexertional malaise is very real.
www.sciencedirect.com/science/arti...
6) The changes in fMRI (signs of central fatiguability) also occurred, but only later. The authors therefore conclude: "While we found evidence for fatigability of central and peripheral 60 origins, peripheral fatigue seems to occur first."
August 17, 2025 at 11:38 AM
6) The changes in fMRI (signs of central fatiguability) also occurred, but only later. The authors therefore conclude: "While we found evidence for fatigability of central and peripheral 60 origins, peripheral fatigue seems to occur first."
7) Fatiguability will be measured following tasks that induces cognitive fatigue (PASAT) or physical fatigue (25-min cycling). There's also a smartphone application for repeated symptom assessment during the day and a wearable for heart rate, activity level and skin temperature.
June 10, 2026 at 7:38 AM
7) Fatiguability will be measured following tasks that induces cognitive fatigue (PASAT) or physical fatigue (25-min cycling). There's also a smartphone application for repeated symptom assessment during the day and a wearable for heart rate, activity level and skin temperature.
10) Although we have questions about this group, these experiments seem quite useful in figuring out muscle fatiguability (a key symptom of Ramsay ME).
Link to the paper:
Bedard et al. 2025 Multimodal neuroimaging of fatigability development.
direct.mit.edu/imag/...
Link to the paper:
Bedard et al. 2025 Multimodal neuroimaging of fatigability development.
direct.mit.edu/imag/...
August 17, 2025 at 11:39 AM
10) Although we have questions about this group, these experiments seem quite useful in figuring out muscle fatiguability (a key symptom of Ramsay ME).
Link to the paper:
Bedard et al. 2025 Multimodal neuroimaging of fatigability development.
direct.mit.edu/imag/...
Link to the paper:
Bedard et al. 2025 Multimodal neuroimaging of fatigability development.
direct.mit.edu/imag/...
If you do write about PEM, please can you make sure it clarifies that PEM is not the same as PEF, DOMS, fatiguability, exertion intolerance, though pwME can also get these.
December 24, 2024 at 10:54 PM
If you do write about PEM, please can you make sure it clarifies that PEM is not the same as PEF, DOMS, fatiguability, exertion intolerance, though pwME can also get these.
New from Germany:
Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory
www.nature.com/articles/s41...
Image is from latest Science for ME weekly update
#LongCovid #COVIDBrain #NeuroPASC
Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory
www.nature.com/articles/s41...
Image is from latest Science for ME weekly update
#LongCovid #COVIDBrain #NeuroPASC
January 19, 2025 at 10:04 PM
New from Germany:
Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory
www.nature.com/articles/s41...
Image is from latest Science for ME weekly update
#LongCovid #COVIDBrain #NeuroPASC
Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory
www.nature.com/articles/s41...
Image is from latest Science for ME weekly update
#LongCovid #COVIDBrain #NeuroPASC
What?! Publikation aus *1990*:
"...indicate attentional deficits in some patients and slower speed of information processing in others. The prolonged latencies observed in these patients have not been observed in patients with depression in many other studies."
pubmed.ncbi.nlm.nih.gov/2324756/
"...indicate attentional deficits in some patients and slower speed of information processing in others. The prolonged latencies observed in these patients have not been observed in patients with depression in many other studies."
pubmed.ncbi.nlm.nih.gov/2324756/
Sensory and cognitive event-related potentials in myalgic encephalomyelitis - PubMed
Myalgic Encephalomyelitis (ME) is a form of post viral fatigue syndrome resulting in myalgia and fluctuating fatiguability. Symptoms reflecting central nervous system dysfunction are common and include muscle weakness, headache, sensory disturbances, poor short term memory and impairment of concentr …
pubmed.ncbi.nlm.nih.gov
March 19, 2026 at 1:26 PM
What?! Publikation aus *1990*:
"...indicate attentional deficits in some patients and slower speed of information processing in others. The prolonged latencies observed in these patients have not been observed in patients with depression in many other studies."
pubmed.ncbi.nlm.nih.gov/2324756/
"...indicate attentional deficits in some patients and slower speed of information processing in others. The prolonged latencies observed in these patients have not been observed in patients with depression in many other studies."
pubmed.ncbi.nlm.nih.gov/2324756/
I agree. As a long term ME patient I can say almost 100% of doctors do not really know what PEM is, even if they have heard of the concept. They still think “fatigue” not “fatiguability”, nor “neuro-endocrine-immune flare” nor anaerobic thresholds, brain-body shutdown etc.
April 7, 2026 at 9:48 AM
I agree. As a long term ME patient I can say almost 100% of doctors do not really know what PEM is, even if they have heard of the concept. They still think “fatigue” not “fatiguability”, nor “neuro-endocrine-immune flare” nor anaerobic thresholds, brain-body shutdown etc.
I got a gym routine from the physio to cope with muscle fatiguability on the field a couple of years ago and I’m so angry that it works. I have to do meta exercise now
March 21, 2025 at 7:10 PM
I got a gym routine from the physio to cope with muscle fatiguability on the field a couple of years ago and I’m so angry that it works. I have to do meta exercise now
... but then it went bad:
"Prolonging the exposure to 96 and 144 hours induced high fatiguability, and fragility in tissues. The mitochondria, at longer exposures, appeared to be fragmented". Paper by Mughal et al : www.nmd-journal.com/article/S096... 3/3 #mecfs
"Prolonging the exposure to 96 and 144 hours induced high fatiguability, and fragility in tissues. The mitochondria, at longer exposures, appeared to be fragmented". Paper by Mughal et al : www.nmd-journal.com/article/S096... 3/3 #mecfs
571P Muscular metabolic plasticity in 3D in vitro models against systemic stress factors in ME/CFS and long COVID-19
Myalgic encephalomyelities/ chronic fatigue syndrome and long COVID-19 are clinically
challenging, multi-symptomatic conditions with multiple overlapping symptoms. Unfortunately,
contemporary research...
www.nmd-journal.com
October 10, 2024 at 3:59 AM
... but then it went bad:
"Prolonging the exposure to 96 and 144 hours induced high fatiguability, and fragility in tissues. The mitochondria, at longer exposures, appeared to be fragmented". Paper by Mughal et al : www.nmd-journal.com/article/S096... 3/3 #mecfs
"Prolonging the exposure to 96 and 144 hours induced high fatiguability, and fragility in tissues. The mitochondria, at longer exposures, appeared to be fragmented". Paper by Mughal et al : www.nmd-journal.com/article/S096... 3/3 #mecfs
New word of the day - “Fatiguability”
June 10, 2026 at 10:21 AM
New word of the day - “Fatiguability”
(5/6)
Dass ein tatsächlicher Experte, @neurostingl.bsky.social,
einen gewohnt fundierten Beitrag liefert, ist wichtig!
Es bleibt zu hoffen, dass seine Klarheit durch die weiteren Beiträge nicht derart verwässert wird,
dass das alte Narrativ weitestgehend bestehen bleibt:
#MECFS als Müdigkeit
Dass ein tatsächlicher Experte, @neurostingl.bsky.social,
einen gewohnt fundierten Beitrag liefert, ist wichtig!
Es bleibt zu hoffen, dass seine Klarheit durch die weiteren Beiträge nicht derart verwässert wird,
dass das alte Narrativ weitestgehend bestehen bleibt:
#MECFS als Müdigkeit
October 24, 2025 at 11:24 AM
(5/6)
Dass ein tatsächlicher Experte, @neurostingl.bsky.social,
einen gewohnt fundierten Beitrag liefert, ist wichtig!
Es bleibt zu hoffen, dass seine Klarheit durch die weiteren Beiträge nicht derart verwässert wird,
dass das alte Narrativ weitestgehend bestehen bleibt:
#MECFS als Müdigkeit
Dass ein tatsächlicher Experte, @neurostingl.bsky.social,
einen gewohnt fundierten Beitrag liefert, ist wichtig!
Es bleibt zu hoffen, dass seine Klarheit durch die weiteren Beiträge nicht derart verwässert wird,
dass das alte Narrativ weitestgehend bestehen bleibt:
#MECFS als Müdigkeit
Full text of this German study has just been published
Pyridostigmine improves hand grip strength in patients with #myalgicencephalomyelitis / #CFS
Free fulltext:
www.frontiersin.org/journals/neu...
This drug, Mestinon, is being tested in the @openmedf.bsky.social LIFT trial
#MEcfs #PwME
Pyridostigmine improves hand grip strength in patients with #myalgicencephalomyelitis / #CFS
Free fulltext:
www.frontiersin.org/journals/neu...
This drug, Mestinon, is being tested in the @openmedf.bsky.social LIFT trial
#MEcfs #PwME
September 3, 2025 at 12:36 PM
Full text of this German study has just been published
Pyridostigmine improves hand grip strength in patients with #myalgicencephalomyelitis / #CFS
Free fulltext:
www.frontiersin.org/journals/neu...
This drug, Mestinon, is being tested in the @openmedf.bsky.social LIFT trial
#MEcfs #PwME
Pyridostigmine improves hand grip strength in patients with #myalgicencephalomyelitis / #CFS
Free fulltext:
www.frontiersin.org/journals/neu...
This drug, Mestinon, is being tested in the @openmedf.bsky.social LIFT trial
#MEcfs #PwME
Respectfully I disagree. The rule change reverts to the status quo before last fall. Pain, weakness, limitation of motion, fatiguability,flare-ups are still considered such as in 38 CFR 4.40, 4.45 and 4.59. This is just not using an examiner’s hypothetical estimations on an unmediated state
February 18, 2026 at 4:22 AM
Respectfully I disagree. The rule change reverts to the status quo before last fall. Pain, weakness, limitation of motion, fatiguability,flare-ups are still considered such as in 38 CFR 4.40, 4.45 and 4.59. This is just not using an examiner’s hypothetical estimations on an unmediated state
she’s plunked into not just an adult body, but an adult body with EXTREME agility and strength with no fatiguability. So she’s got zero impulse control or inhibition that comes with aging and experiencing, even with programming to simulate it. Leading to possible DEADLY trauma induced kid tantrums.
September 28, 2025 at 12:54 AM
she’s plunked into not just an adult body, but an adult body with EXTREME agility and strength with no fatiguability. So she’s got zero impulse control or inhibition that comes with aging and experiencing, even with programming to simulate it. Leading to possible DEADLY trauma induced kid tantrums.
Oh interesting. Well rapid muscle fatiguability is def an ME hallmark but yeah, not clear! Sorry I don’t have a better answer!
September 24, 2025 at 6:23 PM
Oh interesting. Well rapid muscle fatiguability is def an ME hallmark but yeah, not clear! Sorry I don’t have a better answer!
From @tmprowell.bsky.social on Twitter:
OP: threadreaderapp.com/thread/18441...
Direct link to the research:
571P Muscular metabolic plasticity in 3D in vitro models against systemic stress factors in ME/CFS and long COVID-19
www.sciencedirect.com/science/arti...
#LongCovid #MECFS
OP: threadreaderapp.com/thread/18441...
Direct link to the research:
571P Muscular metabolic plasticity in 3D in vitro models against systemic stress factors in ME/CFS and long COVID-19
www.sciencedirect.com/science/arti...
#LongCovid #MECFS
October 11, 2024 at 2:27 PM
From @tmprowell.bsky.social on Twitter:
OP: threadreaderapp.com/thread/18441...
Direct link to the research:
571P Muscular metabolic plasticity in 3D in vitro models against systemic stress factors in ME/CFS and long COVID-19
www.sciencedirect.com/science/arti...
#LongCovid #MECFS
OP: threadreaderapp.com/thread/18441...
Direct link to the research:
571P Muscular metabolic plasticity in 3D in vitro models against systemic stress factors in ME/CFS and long COVID-19
www.sciencedirect.com/science/arti...
#LongCovid #MECFS
🔬 We found that myosin behaves abnormally in relaxed muscle from human XLMTM patients and dog/mouse models, preferring a structurally disordered and highly energy-consuming biochemical state. This increase in energy usage could contribute to muscle fatiguability. (3/5)
December 29, 2025 at 2:15 PM
🔬 We found that myosin behaves abnormally in relaxed muscle from human XLMTM patients and dog/mouse models, preferring a structurally disordered and highly energy-consuming biochemical state. This increase in energy usage could contribute to muscle fatiguability. (3/5)