#GapJunctions
LightNews LightNews
vitalylerner.bsky.social
#Intro #postdoc @urochester.bsky.social working on depth and motion #perception using #neuropixels #ephys in #nhp. Previously #gapjunctions with #patchclamp #optogenetics. 🧪🧠 Passionate about #figureskating ⛸️.
November 17, 2024 at 2:11 PM
drsilviapenuela.bsky.social
Thanks to Dr. Henrique Girao and team for a great sabbatical visit to the beautiful University of Coimbra #connexins #pannexins #gapjunctions
May 21, 2025 at 6:36 PM
plosbiology.org
Gap junctions allow transfer of small molecules between cells. @mirouse-lab.bsky.social &co show that #GapJunctions allow the exchange of metabolites between germ cells & somatic cells to promote germline growth during #Drosophila #oogenesis 🧪 @plosbiology.org plos.io/3CYrZwu
Top: Scheme of an ovariole, oriented from the anterior (A) to the posterior (P) end, as in all the subsequent images. The ovariole starts with the germarium from which young follicles bud before undergoing massive growth until the formation of an egg at the posterior end. In each follicle, somatic follicle cells (in purple) surround a germline cyst with the nurse cells (pink) and the oocyte (in blue). Bottom left: Somatic Inx2A mutant clones, marked by the absence of RFP expression, induce a germline growth defect when they cover the whole epithelium (arrow) compared with the wild-type younger follicle (n − 1) (arrowhead). Bottom right: Maximum intensity projection of immunostaining for Inx2 (green) and Inx4 (magenta) in follicles containing Inx4 RNAi-expressing germline clones visualized by Inx4 absence. Note the absence of Inx2 plaques at germline contacts at higher magnification and the growth defect of Inx4 RNAi follicles (arrow) compared with the wild-type younger follicle (arrowhead).
February 19, 2025 at 9:14 AM
fabmusacchio.bsky.social
🧠 New blog post on #GapJunctions: How #ElectricalSynapses synchronize #neurons & shape #NetworkDynamics. Includes a #modeling overview + small #PythonTutorial using #NESTsimulator. Feel free to share!

🌍 fabriziomusacchio.com/blog/2025-08-15-gap_junctions/

#Neuroscience #CompNeuro #OpenSource
On the role of gap junctions in neural modelling
Gap junctions are specialized intercellular connections that facilitate direct electrical and chemical communication between neurons. Unlike synaptic transmission, which involves neurotransmitter rele...
fabriziomusacchio.com
August 17, 2025 at 4:14 PM
plosbiology.org
Gap junctions allow transfer of small molecules between cells. @mirouse-lab.bsky.social &co show that #GapJunctions allow the exchange of metabolites between germ cells & somatic cells to promote germline growth during #Drosophila #oogenesis 🧪 @plosbiology.org plos.io/3CYrZwu
Top: Scheme of an ovariole, oriented from the anterior (A) to the posterior (P) end, as in all the subsequent images. The ovariole starts with the germarium from which young follicles bud before undergoing massive growth until the formation of an egg at the posterior end. In each follicle, somatic follicle cells (in purple) surround a germline cyst with the nurse cells (pink) and the oocyte (in blue). Bottom left: Somatic Inx2A mutant clones, marked by the absence of RFP expression, induce a germline growth defect when they cover the whole epithelium (arrow) compared with the wild-type younger follicle (n − 1) (arrowhead). Bottom right: Maximum intensity projection of immunostaining for Inx2 (green) and Inx4 (magenta) in follicles containing Inx4 RNAi-expressing germline clones visualized by Inx4 absence. Note the absence of Inx2 plaques at germline contacts at higher magnification and the growth defect of Inx4 RNAi follicles (arrow) compared with the wild-type younger follicle (arrowhead).
February 19, 2025 at 5:40 PM
jgp.org
Levitt, Benninger et al. @cuanschutz.bsky.social investigate how loss of #GapJunctions under diabetogenic environments and their protection influence subpopulations of #insulin-producing β-cells rupress.org/jgp/article/...

#Diabetes
March 31, 2026 at 4:45 PM
cp-trendsbiochem.bsky.social
Available now - the Review "The ins and outs of #connexins and #pannexins beyond the cell surface" from Henrique Girao and colleagues.

#GapJunctions #IntercellularCommunication #SubcellularTrafficking #ExtracellularVesicle #Mitochondria

authors.elsevier.com/a/1l6BQ3S6Gf...
May 22, 2025 at 3:44 PM
plosbiology.org
Gap junctions allow transfer of small molecules between cells. @mirouse-lab.bsky.social &co show that #GapJunctions allow the exchange of metabolites between germ cells & somatic cells to promote germline growth during #Drosophila #oogenesis 🧪 @plosbiology.org plos.io/3CYrZwu
Top: Scheme of an ovariole, oriented from the anterior (A) to the posterior (P) end, as in all the subsequent images. The ovariole starts with the germarium from which young follicles bud before undergoing massive growth until the formation of an egg at the posterior end. In each follicle, somatic follicle cells (in purple) surround a germline cyst with the nurse cells (pink) and the oocyte (in blue). Bottom left: Somatic Inx2A mutant clones, marked by the absence of RFP expression, induce a germline growth defect when they cover the whole epithelium (arrow) compared with the wild-type younger follicle (n − 1) (arrowhead). Bottom right: Maximum intensity projection of immunostaining for Inx2 (green) and Inx4 (magenta) in follicles containing Inx4 RNAi-expressing germline clones visualized by Inx4 absence. Note the absence of Inx2 plaques at germline contacts at higher magnification and the growth defect of Inx4 RNAi follicles (arrow) compared with the wild-type younger follicle (arrowhead).
February 19, 2025 at 2:15 PM
fabmusacchio.bsky.social
Direct follow-up post: This example shows how to simulate a network of 500 inhibitory #SNN neurons with #GapJunctions using #NESTsimulator, analyzing the effects on #synchrony and #oscillations:

🌍 www.fabriziomusacchio.com/blog/2025-09...

#CompNeuro #Neuroscience #PythonTutorial #Python
August 18, 2025 at 5:36 AM
broberger.bsky.social
At #FENS2026 ? Our new data on #electricalsynapses tomorrow: Olga Netsyk shows how #gapjunctions time spikes even in a ”slow” network (PS04-678) & Andriana Mantzafou reveals how removing electrical synapses alters the rules of engagement in a circuit and can even make rats better fathers (PS04-677).
July 7, 2026 at 10:21 AM
apspublications.bsky.social
Function 🔙 Throw Back Thursday. #Endothelial-adipocyte Cx43 Mediated #GapJunctions Can Regulate #Adiposity. 🐀 Read: https://ow.ly/cOFT50Zv9O1
August 5, 2026 at 1:30 PM
physrep.bsky.social
Mind the Gap? This study re-examines #gapjunctions in the Zona #glomerulosa of mouse #adrenal #cortex, reporting RNA and protein expression of #connexin 43 and 37. However, in adrenal slice cultures, only limited evidence for GJ function was obtained.
https://buff.ly/40FEt3V
#CellCommunication
buff.ly
February 3, 2025 at 11:02 AM
jgp.org
Coincidence detection supported by electrical synapses is shaped by the D-type K⁺ current. New study from Antonella Dapino and Sebastián Curti (Universidad de la República, Uruguay) rupress.org/jgp/article/...

#CellularPhysiology #IonChannels #GapJunctions
February 6, 2026 at 2:45 PM
rupress.org
In @jgp.org, Levitt, Benninger et al. @cuanschutz.bsky.social investigate how loss of #GapJunctions under diabetogenic environments and their protection influence subpopulations of #insulin-producing β-cells rupress.org/jgp/article/...

#Diabetes
March 31, 2026 at 6:15 PM
bellaxuying.bsky.social
We look at using Ca2+ loading and Ca2+ imaging for revealing #xenopus cell populations coupled by #gapjunctions. Although our cell type's limitations produced negative results, we thought it important to publish and encourage people to try in more amenable systems!

🔗 www.eneuro.org/content/13/5...
Simultaneous Whole-Cell Recording and Calcium Imaging Does Not Reveal Electrically Coupled Neurons in Xenopus Tadpoles
Neuronal populations connected by gap junctions can be revealed via dye coupling of small molecules like neurobiotin and Lucifer yellow. However, the extent of dye diffusion between neurons varies wit...
www.eneuro.org
June 4, 2026 at 9:14 AM