1/ 🧵 In our new paper, we show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2. www.cell.com/molecular-ce...
Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains
Some proteins mimic the repressive mark H3K27me3, but the physiological relevance
of this phenomenon was unclear. Agius et al. show that the PRC2 subunits JARID2 and
PALI1 mimic H3K27me3 to antagonize...
www.cell.com
March 4, 2026 at 11:59 PM
1/ 🧵 In our new paper, we show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2. www.cell.com/molecular-ce...
1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance?
We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
🧵
www.biorxiv.org/content/10.1...
We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
🧵
www.biorxiv.org/content/10.1...
March 15, 2025 at 12:12 AM
1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance?
We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
🧵
www.biorxiv.org/content/10.1...
We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
🧵
www.biorxiv.org/content/10.1...
Our latest publication is now out at Genome Biology!
link.springer.com/article/10.1...
We uncover a unique association between a H3K27me3 reader complex and active transcription.
A thread with our key findings: (1/8)
#TEsky #Polycomb #transcription #smallRNAs
link.springer.com/article/10.1...
We uncover a unique association between a H3K27me3 reader complex and active transcription.
A thread with our key findings: (1/8)
#TEsky #Polycomb #transcription #smallRNAs
A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium - Genome Biology
Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repres...
link.springer.com
April 8, 2026 at 12:21 PM
Our latest publication is now out at Genome Biology!
link.springer.com/article/10.1...
We uncover a unique association between a H3K27me3 reader complex and active transcription.
A thread with our key findings: (1/8)
#TEsky #Polycomb #transcription #smallRNAs
link.springer.com/article/10.1...
We uncover a unique association between a H3K27me3 reader complex and active transcription.
A thread with our key findings: (1/8)
#TEsky #Polycomb #transcription #smallRNAs
Epigenetics Update - Transgenerational inheritance of altered H3K27me3 in wild-type Caenorhabditis elegans u.epigenome.us/KFiE6Ejh
Florian A Steiner (biology-unige.bsky.social) in embojournal.org
#Epigenetics #H3K27me3 #Chromatin
---
Gain hi-res at epigenometech.com
Florian A Steiner (biology-unige.bsky.social) in embojournal.org
#Epigenetics #H3K27me3 #Chromatin
---
Gain hi-res at epigenometech.com
September 25, 2026 at 3:34 PM
Epigenetics Update - Transgenerational inheritance of altered H3K27me3 in wild-type Caenorhabditis elegans u.epigenome.us/KFiE6Ejh
Florian A Steiner (biology-unige.bsky.social) in embojournal.org
#Epigenetics #H3K27me3 #Chromatin
---
Gain hi-res at epigenometech.com
Florian A Steiner (biology-unige.bsky.social) in embojournal.org
#Epigenetics #H3K27me3 #Chromatin
---
Gain hi-res at epigenometech.com
Online Now: Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains Online now:
Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains
Some proteins mimic the repressive mark H3K27me3, but the physiological relevance of this phenomenon was unclear. Agius et al. show that the PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to antagonize PRC2-mediated H3K27me3 deposition, limit Polycomb domain spreading, and enable timely activation of developmental genes in vivo.
dlvr.it
March 4, 2026 at 11:58 PM
Online Now: Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains Online now:
January 28, 2026 at 11:35 AM
8/ We propose that H3K27me3 mimicry has repeatedly emerged through evolution to restrict the spread of Polycomb domains by breaking the PRC2-H3K27me3 positive feedback loop.
March 15, 2025 at 12:12 AM
8/ We propose that H3K27me3 mimicry has repeatedly emerged through evolution to restrict the spread of Polycomb domains by breaking the PRC2-H3K27me3 positive feedback loop.
Lovely new review on H3K27me3 dynamics and potential functions in #plantscience by @drosborneplantsci.bsky.social
nph.onlinelibrary.wiley.com/doi/10.1111/...
nph.onlinelibrary.wiley.com/doi/10.1111/...
Finding balance: the dynamic interplay between H3K27me3 writers and erasers in regulating environmental plasticity and memory
Subject to an ever-changing world, plants must respond to harmful conditions and environmental fluctuations. Their evolutionary success can be attributed to their plasticity in both perceiving and in...
nph.onlinelibrary.wiley.com
December 4, 2025 at 7:54 AM
Lovely new review on H3K27me3 dynamics and potential functions in #plantscience by @drosborneplantsci.bsky.social
nph.onlinelibrary.wiley.com/doi/10.1111/...
nph.onlinelibrary.wiley.com/doi/10.1111/...
Our News&views with Germano @cecerelab.bsky.social about the role of H3K27me3 in epigenetic control of piRNA transcription in worms 🪱 and flies 🪰 is out in @natsmb.nature.com
rdcu.be/erkld
rdcu.be/erkld
H3K27me3 expands the epigenetic control of piRNA transcription
Nature Structural & Molecular Biology - Constitutive heterochromatin can promote piRNA transcription, a crucial step in genome defense. Two studies now show that piRNA transcription in...
rdcu.be
June 17, 2025 at 2:17 PM
Our News&views with Germano @cecerelab.bsky.social about the role of H3K27me3 in epigenetic control of piRNA transcription in worms 🪱 and flies 🪰 is out in @natsmb.nature.com
rdcu.be/erkld
rdcu.be/erkld
Our paper on Alternative epigenetic states of Arabidopsis Transposable Elements is finally out in Genome Biology !
rdcu.be/d6Yly
rdcu.be/d6Yly
Alternative silencing states of transposable elements in Arabidopsis associated with H3K27me3
rdcu.be
January 22, 2025 at 12:17 PM
Our paper on Alternative epigenetic states of Arabidopsis Transposable Elements is finally out in Genome Biology !
rdcu.be/d6Yly
rdcu.be/d6Yly
Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains
Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains
Some proteins mimic the repressive mark H3K27me3, but the physiological relevance of this phenomenon was unclear. Agius et al. show that the PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to antagonize PRC2-mediated H3K27me3 deposition, limit Polycomb domain spreading, and enable timely activation of developmental genes in vivo.
dlvr.it
March 21, 2026 at 3:20 PM
Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains
First first-author paper out! 🎉
We show that the classically repressive mark H3K27me3 can be linked to active transcription through a newly identified reader complex 🤯
Really grateful to everyone involved in this project during my PhD!
Thread below 👇
We show that the classically repressive mark H3K27me3 can be linked to active transcription through a newly identified reader complex 🤯
Really grateful to everyone involved in this project during my PhD!
Thread below 👇
Our latest publication is now out at Genome Biology!
link.springer.com/article/10.1...
We uncover a unique association between a H3K27me3 reader complex and active transcription.
A thread with our key findings: (1/8)
#TEsky #Polycomb #transcription #smallRNAs
link.springer.com/article/10.1...
We uncover a unique association between a H3K27me3 reader complex and active transcription.
A thread with our key findings: (1/8)
#TEsky #Polycomb #transcription #smallRNAs
A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium - Genome Biology
Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repres...
link.springer.com
April 8, 2026 at 1:36 PM
First first-author paper out! 🎉
We show that the classically repressive mark H3K27me3 can be linked to active transcription through a newly identified reader complex 🤯
Really grateful to everyone involved in this project during my PhD!
Thread below 👇
We show that the classically repressive mark H3K27me3 can be linked to active transcription through a newly identified reader complex 🤯
Really grateful to everyone involved in this project during my PhD!
Thread below 👇
How do cells tune PRC2 allostery? We find EZH2 Ser21-phos restrains PRC2 adoption of the compact active state. Loss of this restraint promotes H3K27me3, redistributes cPRC1, and impairs differentiation. New bioRxiv with @kasinath-lab.bsky.social & @garcialabms.bsky.social! tinyurl.com/4369kmh2
June 5, 2026 at 12:30 AM
How do cells tune PRC2 allostery? We find EZH2 Ser21-phos restrains PRC2 adoption of the compact active state. Loss of this restraint promotes H3K27me3, redistributes cPRC1, and impairs differentiation. New bioRxiv with @kasinath-lab.bsky.social & @garcialabms.bsky.social! tinyurl.com/4369kmh2
Epigenetics Update - Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains bit.ly/3NmLO5Q
Edwina McGlinn and Chen Davidovich (Monash University) reporting in Mol Cell
#Epigenetics #PRC2 #H3K27me3
---
Perfect for cancer, immunology, and aging; epigenometech.com
Edwina McGlinn and Chen Davidovich (Monash University) reporting in Mol Cell
#Epigenetics #PRC2 #H3K27me3
---
Perfect for cancer, immunology, and aging; epigenometech.com
March 10, 2026 at 12:24 PM
Epigenetics Update - Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains bit.ly/3NmLO5Q
Edwina McGlinn and Chen Davidovich (Monash University) reporting in Mol Cell
#Epigenetics #PRC2 #H3K27me3
---
Perfect for cancer, immunology, and aging; epigenometech.com
Edwina McGlinn and Chen Davidovich (Monash University) reporting in Mol Cell
#Epigenetics #PRC2 #H3K27me3
---
Perfect for cancer, immunology, and aging; epigenometech.com
Thrilled to share my PhD paper showing how SUMO regulates PRC1 clustering and 3D genome organisation independently of H3K27me3! Grateful to @djost-physbiol.bsky.social group and the Fabian Erdel group for this great collaboration. doi.org/10.1093/nar/...
Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3
Abstract. Polycomb repressive complex 1 (PRC1) forms nuclear condensates that organize target chromatin domains. SUMOylation modulates PRC1 clustering, but
doi.org
September 23, 2026 at 4:41 PM
Thrilled to share my PhD paper showing how SUMO regulates PRC1 clustering and 3D genome organisation independently of H3K27me3! Grateful to @djost-physbiol.bsky.social group and the Fabian Erdel group for this great collaboration. doi.org/10.1093/nar/...
So happy to see this work finally online!
In this Research Review, I discuss the emerging roles of H3K27me3 writers (the enzymes that lay it down) and erasers (the enzymes that remove it) in controlling plant adaptation 🌿🌡️❄️🦠
nph.onlinelibrary.wiley.com/doi/10.1111/...
In this Research Review, I discuss the emerging roles of H3K27me3 writers (the enzymes that lay it down) and erasers (the enzymes that remove it) in controlling plant adaptation 🌿🌡️❄️🦠
nph.onlinelibrary.wiley.com/doi/10.1111/...
Finding balance: the dynamic interplay between H3K27me3 writers and erasers in regulating environmental plasticity and memory
Subject to an ever-changing world, plants must respond to harmful conditions and environmental fluctuations. Their evolutionary success can be attributed to their plasticity in both perceiving and in...
nph.onlinelibrary.wiley.com
December 4, 2025 at 11:02 AM
So happy to see this work finally online!
In this Research Review, I discuss the emerging roles of H3K27me3 writers (the enzymes that lay it down) and erasers (the enzymes that remove it) in controlling plant adaptation 🌿🌡️❄️🦠
nph.onlinelibrary.wiley.com/doi/10.1111/...
In this Research Review, I discuss the emerging roles of H3K27me3 writers (the enzymes that lay it down) and erasers (the enzymes that remove it) in controlling plant adaptation 🌿🌡️❄️🦠
nph.onlinelibrary.wiley.com/doi/10.1111/...
Why do #StemCells have lower levels of facultative #heterochromatin, defined by H3K27me3, compared to differentiated cells? By artificially lengthening G1 phase, @4everbiochemist.bsky.social &co show that G1 length is an essential determinant of H3K27me3 landscape @plosbiology.org 🧪 plos.io/4lKfztO
April 24, 2025 at 8:03 AM
Why do #StemCells have lower levels of facultative #heterochromatin, defined by H3K27me3, compared to differentiated cells? By artificially lengthening G1 phase, @4everbiochemist.bsky.social &co show that G1 length is an essential determinant of H3K27me3 landscape @plosbiology.org 🧪 plos.io/4lKfztO
PRC2 silences genes by adding H3K27me3 at the right spots in the genome. Our model shows how the nucleic acid-binding domain (NBD) of SUZ12 keeps this activity under control, and what happens when you remove it.
August 13, 2025 at 9:54 PM
PRC2 silences genes by adding H3K27me3 at the right spots in the genome. Our model shows how the nucleic acid-binding domain (NBD) of SUZ12 keeps this activity under control, and what happens when you remove it.
What defines limits & regulation of epigenetic inheritance?
Florian Steiner et al show altered genomic distribution of histone modification H3K27me3 can be transmitted across C. elegans generations through successive SET-32 & MES-4 action that alters its deposition
link.springer.com/article/10.1...
Florian Steiner et al show altered genomic distribution of histone modification H3K27me3 can be transmitted across C. elegans generations through successive SET-32 & MES-4 action that alters its deposition
link.springer.com/article/10.1...
Transgenerational inheritance of altered H3K27me3 in wild-type Caenorhabditis elegans - The EMBO Journal
Epigenetic inheritance provides mutation-free mechanisms for phenotypic adaptation, including modifications to DNA or DNA-associated proteins that create patterns of heritable gene regulation. However...
link.springer.com
September 18, 2026 at 9:55 AM
What defines limits & regulation of epigenetic inheritance?
Florian Steiner et al show altered genomic distribution of histone modification H3K27me3 can be transmitted across C. elegans generations through successive SET-32 & MES-4 action that alters its deposition
link.springer.com/article/10.1...
Florian Steiner et al show altered genomic distribution of histone modification H3K27me3 can be transmitted across C. elegans generations through successive SET-32 & MES-4 action that alters its deposition
link.springer.com/article/10.1...
Very interesting paper by Philipp Voigt about nucleosomal asymmetry at bivalent domains. "Bivalency recruits H3K27me3 but not H3K4me3 readers, promoting a poised state" www.cell.com/molecular-ce...
Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains
Bivalent promoters are thought to poise developmental genes for expression. Bryan et al. show that asymmetric bivalent nucleosomes recruit repressive H3K27me3 but not activating H3K4me3 readers, thereby promoting poising. Bivalency further attracts specific factors, including the acetylase KAT6B, which is required for proper activation of bivalent genes during differentiation.
www.cell.com
December 29, 2024 at 3:58 AM
Very interesting paper by Philipp Voigt about nucleosomal asymmetry at bivalent domains. "Bivalency recruits H3K27me3 but not H3K4me3 readers, promoting a poised state" www.cell.com/molecular-ce...
Why do #StemCells have lower levels of facultative #heterochromatin, defined by H3K27me3, compared to differentiated cells? By artificially lengthening G1 phase, @4everbiochemist.bsky.social &co show that G1 length is an essential determinant of H3K27me3 landscape @plosbiology.org 🧪 plos.io/4lKfztO
April 23, 2025 at 5:21 PM
Why do #StemCells have lower levels of facultative #heterochromatin, defined by H3K27me3, compared to differentiated cells? By artificially lengthening G1 phase, @4everbiochemist.bsky.social &co show that G1 length is an essential determinant of H3K27me3 landscape @plosbiology.org 🧪 plos.io/4lKfztO
Excited to share our new preprint on EZH1-mediated H3K27me3 in the adult brain!
We show that postmitotic neurons accumulate high levels of H3K27me3 broadly across the genome. This is dependent on EZH1, but surprisingly not required for gene expression regulation:
www.biorxiv.org/content/10.6...
We show that postmitotic neurons accumulate high levels of H3K27me3 broadly across the genome. This is dependent on EZH1, but surprisingly not required for gene expression regulation:
www.biorxiv.org/content/10.6...
www.biorxiv.org
May 12, 2026 at 4:40 PM
Excited to share our new preprint on EZH1-mediated H3K27me3 in the adult brain!
We show that postmitotic neurons accumulate high levels of H3K27me3 broadly across the genome. This is dependent on EZH1, but surprisingly not required for gene expression regulation:
www.biorxiv.org/content/10.6...
We show that postmitotic neurons accumulate high levels of H3K27me3 broadly across the genome. This is dependent on EZH1, but surprisingly not required for gene expression regulation:
www.biorxiv.org/content/10.6...
New from our lab & @harrisonflylab.bsky.social: Drosophila models of H3 K27M & EZHIP reveal conserved chromatin regulators that buffer PRC2 inhibition. An in vivo screen highlights how developmental defects can be rescued despite global H3K27me3 loss.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
May 27, 2025 at 3:29 PM
New from our lab & @harrisonflylab.bsky.social: Drosophila models of H3 K27M & EZHIP reveal conserved chromatin regulators that buffer PRC2 inhibition. An in vivo screen highlights how developmental defects can be rescued despite global H3K27me3 loss.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
✍️ The @sandraduharcourt.bsky.social Lab published a new article
📖 Genome Biology
📃 A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium
🔗 link.springer.com/article/10.1...
📖 Genome Biology
📃 A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium
🔗 link.springer.com/article/10.1...
April 14, 2026 at 9:42 AM
✍️ The @sandraduharcourt.bsky.social Lab published a new article
📖 Genome Biology
📃 A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium
🔗 link.springer.com/article/10.1...
📖 Genome Biology
📃 A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium
🔗 link.springer.com/article/10.1...
Epigenetics Update - EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming bit.ly/47obbub
#Epigenetic #Chromatin #H3K27me3 #PRC2 #IntergenerationalInheritance
---
High-resolution insights without cell sorting; epigenometech.com
#Epigenetic #Chromatin #H3K27me3 #PRC2 #IntergenerationalInheritance
---
High-resolution insights without cell sorting; epigenometech.com
October 22, 2025 at 12:06 PM
Epigenetics Update - EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming bit.ly/47obbub
#Epigenetic #Chromatin #H3K27me3 #PRC2 #IntergenerationalInheritance
---
High-resolution insights without cell sorting; epigenometech.com
#Epigenetic #Chromatin #H3K27me3 #PRC2 #IntergenerationalInheritance
---
High-resolution insights without cell sorting; epigenometech.com