#Epigenetic regulation shapes B-cell fate and antibody responses.
This review explores how DNA and histone modifications, chromatin remodeling, and RNA regulators influence #HumoralImmunity and disease #Pathogenesis. @tsinghuauniversity.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
This review explores how DNA and histone modifications, chromatin remodeling, and RNA regulators influence #HumoralImmunity and disease #Pathogenesis. @tsinghuauniversity.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
October 18, 2026 at 3:30 PM
#Epigenetic regulation shapes B-cell fate and antibody responses.
This review explores how DNA and histone modifications, chromatin remodeling, and RNA regulators influence #HumoralImmunity and disease #Pathogenesis. @tsinghuauniversity.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
This review explores how DNA and histone modifications, chromatin remodeling, and RNA regulators influence #HumoralImmunity and disease #Pathogenesis. @tsinghuauniversity.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
This article reviews short-lived IgG, autoreactive IgM & impaired B cell/germinal center responses in Orientia tsutsugamushi infection, outlining methods to study human #HumoralImmunity & guide vaccine development. #medsky #Immunology
#Zoonoses #OpenAccess: doi.org/10.15212/ZOO...
#Zoonoses #OpenAccess: doi.org/10.15212/ZOO...
October 1, 2026 at 11:18 AM
This article reviews short-lived IgG, autoreactive IgM & impaired B cell/germinal center responses in Orientia tsutsugamushi infection, outlining methods to study human #HumoralImmunity & guide vaccine development. #medsky #Immunology
#Zoonoses #OpenAccess: doi.org/10.15212/ZOO...
#Zoonoses #OpenAccess: doi.org/10.15212/ZOO...
Dr. Ana Martínez-Riaño and collaborators uncover the cellular basis of CD137-mediated suppression of #HumoralImmunity, providing insight into rational combinatorial immunotherapeutic strategies incorporating CD137 agonists under clinical development. 💊 @embojournal.org
https://bit.ly/45YrHke
https://bit.ly/45YrHke
August 28, 2026 at 4:56 PM
Dr. Ana Martínez-Riaño and collaborators uncover the cellular basis of CD137-mediated suppression of #HumoralImmunity, providing insight into rational combinatorial immunotherapeutic strategies incorporating CD137 agonists under clinical development. 💊 @embojournal.org
https://bit.ly/45YrHke
https://bit.ly/45YrHke
#Medsky🧪 #IDsky #Immunosky #publichealth
#Humoralimmunity induced by XEC monovalent vaccines against #SARSCoV2 sub variants XEC, LP.8.1, NB.1.8.1, XFG & BA.3.2 . The investigations, incl the recent one8, suggest that all 4 of the JN.1 subvariants-based vaccines
#Humoralimmunity induced by XEC monovalent vaccines against #SARSCoV2 sub variants XEC, LP.8.1, NB.1.8.1, XFG & BA.3.2 . The investigations, incl the recent one8, suggest that all 4 of the JN.1 subvariants-based vaccines
December 14, 2025 at 5:04 AM
#Medsky🧪 #IDsky #Immunosky #publichealth
#Humoralimmunity induced by XEC monovalent vaccines against #SARSCoV2 sub variants XEC, LP.8.1, NB.1.8.1, XFG & BA.3.2 . The investigations, incl the recent one8, suggest that all 4 of the JN.1 subvariants-based vaccines
#Humoralimmunity induced by XEC monovalent vaccines against #SARSCoV2 sub variants XEC, LP.8.1, NB.1.8.1, XFG & BA.3.2 . The investigations, incl the recent one8, suggest that all 4 of the JN.1 subvariants-based vaccines
While it was previously thought that γδ T cells primarily trigger inflammatory responses & directly kill infected cells, their contribution to #humoralimmunity during natural infection & vaccination has been a neglected area of research.
September 18, 2025 at 4:42 PM
While it was previously thought that γδ T cells primarily trigger inflammatory responses & directly kill infected cells, their contribution to #humoralimmunity during natural infection & vaccination has been a neglected area of research.
Importantly, the findings have implications for multidose vaccination schedules, highlighting ipsilateral immunization as an optimal strategy to rapidly maximize #humoralimmunity on a population level during the early phases of an infectious disease outbreak.
April 1, 2025 at 3:54 AM
Importantly, the findings have implications for multidose vaccination schedules, highlighting ipsilateral immunization as an optimal strategy to rapidly maximize #humoralimmunity on a population level during the early phases of an infectious disease outbreak.
Subsequently, obesity-associated inflammatory insults are predicted to disturb cellular and #humoralimmunity by triggering abnormal cell differentiation and lymphocyte exhaustion….
t.co/tbprYyNLGG
t.co/tbprYyNLGG
Frontiers | Obesity-compromised immunity in post-COVID-19 condition: a critical control point of chronicity
Post-COVID-19 condition is recognized as a multifactorial disorder, with persistent presence of viral antigens, discordant immunity, delayed viral clearance,...
t.co
August 12, 2024 at 11:38 AM
Subsequently, obesity-associated inflammatory insults are predicted to disturb cellular and #humoralimmunity by triggering abnormal cell differentiation and lymphocyte exhaustion….
t.co/tbprYyNLGG
t.co/tbprYyNLGG
#MdSky🧪#ImmunoSky Overview #autophagy roles on #Bcell development, maturation & Their capacity to generate long lasting #humoralimmunity against microbial pathogens enables #Bcells to protect the host against repeated infections, provides for vaccine efficacy
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
Frontiers | Role of canonical and noncanonical autophagy pathways in shaping the life journey of B cells
Autophagy is a regulated intracellular catabolic process by which invading pathogens, damaged organelles, aggregated proteins, and other macromolecules are d...
www.frontiersin.org
August 1, 2024 at 12:01 PM
#MdSky🧪#ImmunoSky Overview #autophagy roles on #Bcell development, maturation & Their capacity to generate long lasting #humoralimmunity against microbial pathogens enables #Bcells to protect the host against repeated infections, provides for vaccine efficacy
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
MedSky 🧪 IDSky #Viralimmunology #Immunology #CovidIsNotOver @systemsvirology #Maskup😷 #Getboosted EG.5.1 has a characteristic amino acid substitution in the spike protein (S), S:F456L, which contributes to its escape from #humoralimmunity.
November 16, 2023 at 4:11 PM
MedSky 🧪 IDSky #Viralimmunology #Immunology #CovidIsNotOver @systemsvirology #Maskup😷 #Getboosted EG.5.1 has a characteristic amino acid substitution in the spike protein (S), S:F456L, which contributes to its escape from #humoralimmunity.
After antigens from infection or vaccine antigens have been cleared, long-lived plasma cells and memory B cells persist to maintain #humoralimmunity.
September 19, 2023 at 5:35 AM
After antigens from infection or vaccine antigens have been cleared, long-lived plasma cells and memory B cells persist to maintain #humoralimmunity.
MedSky🧪Analysis of the association between the new #SARSCoV2 variant EG.5 & XBB breakthrough infection, BTI of XBB subvariants cannot efficiently induce antiviral #humoralimmunity against the infecting variants vs the BTI of previous #omicron variants.
September 12, 2023 at 5:18 AM
MedSky🧪Analysis of the association between the new #SARSCoV2 variant EG.5 & XBB breakthrough infection, BTI of XBB subvariants cannot efficiently induce antiviral #humoralimmunity against the infecting variants vs the BTI of previous #omicron variants.
This commentary highlights major gaps in understanding #HumoralImmunity to #OrientiaTsutsugamushi, the cause of #Scrubtyphus, emphasizing the need for mechanistic studies of #Bcell responses to define deficiencies in acute & long-term immunity.
#OpenAccess: zoonoses-journal.org/index.php/20...
#OpenAccess: zoonoses-journal.org/index.php/20...
Humoral Immune Response to Orientia tsutsugamushi Infection: Recent Research Findings and Future Studies
This study reveals gaps in humoral immunity to Orientia tsutsugamushi, stressing the need to clarify B cell responses in scrub typhus infection.
zoonoses-journal.org
September 10, 2025 at 10:10 AM
This commentary highlights major gaps in understanding #HumoralImmunity to #OrientiaTsutsugamushi, the cause of #Scrubtyphus, emphasizing the need for mechanistic studies of #Bcell responses to define deficiencies in acute & long-term immunity.
#OpenAccess: zoonoses-journal.org/index.php/20...
#OpenAccess: zoonoses-journal.org/index.php/20...
The giant E3 ligase #RNF213 serves as a master regulator of B-cell biology while its deficiency impairs PIK3/PIP3-mediated AKT-mTOR signaling and #MitochondrialRemodeling to disrupt B-cell development and #HumoralImmunity.
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
March 10, 2026 at 4:01 PM
The giant E3 ligase #RNF213 serves as a master regulator of B-cell biology while its deficiency impairs PIK3/PIP3-mediated AKT-mTOR signaling and #MitochondrialRemodeling to disrupt B-cell development and #HumoralImmunity.
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
#RNF213, an IFN-inducible #E3Ligase, regulates B-cell development by degrading #SPIB; its loss disrupts AKT-mTOR signaling and antibody responses, while SPIB deletion or #PIK3C3 inhibition restores function. #HumoralImmunity
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
February 22, 2026 at 1:26 AM
#RNF213, an IFN-inducible #E3Ligase, regulates B-cell development by degrading #SPIB; its loss disrupts AKT-mTOR signaling and antibody responses, while SPIB deletion or #PIK3C3 inhibition restores function. #HumoralImmunity
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
Researchers develop a synthetic #ProteinCondensate #nanoadjuvant platform that boosts antigen cross-presentation, drives strong CTL and #HumoralImmunity, activates cGAS–STING signaling, and enables scalable, modular #CancerVaccine design.
#OpenAccess #STTT: doi.org/10.1038/s413...
#OpenAccess #STTT: doi.org/10.1038/s413...
January 10, 2026 at 8:01 PM
Researchers develop a synthetic #ProteinCondensate #nanoadjuvant platform that boosts antigen cross-presentation, drives strong CTL and #HumoralImmunity, activates cGAS–STING signaling, and enables scalable, modular #CancerVaccine design.
#OpenAccess #STTT: doi.org/10.1038/s413...
#OpenAccess #STTT: doi.org/10.1038/s413...
This study reports that #mRNAvaccines encoding full or partial #ChikungunyaVirus structural proteins, mCV-1 & mCV-2, induced strong cellular & #HumoralImmunity and provided broad cross-lineage protection in mice & #RhesusMacaques. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
September 19, 2025 at 8:45 AM
This study reports that #mRNAvaccines encoding full or partial #ChikungunyaVirus structural proteins, mCV-1 & mCV-2, induced strong cellular & #HumoralImmunity and provided broad cross-lineage protection in mice & #RhesusMacaques. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
🫒
Higher adherence to MedDiet, especially olive oil intake, is linked to stronger post-vaccine anti-Spike IgG responses, even after accounting for prior infection.
Diet & metabolic health may shape vaccine effectiveness more than we thought.
#MediterraneanDiet #HumoralImmunity
lnkd.in/dwWCCe7w
Higher adherence to MedDiet, especially olive oil intake, is linked to stronger post-vaccine anti-Spike IgG responses, even after accounting for prior infection.
Diet & metabolic health may shape vaccine effectiveness more than we thought.
#MediterraneanDiet #HumoralImmunity
lnkd.in/dwWCCe7w
January 24, 2026 at 6:11 PM
🫒
Higher adherence to MedDiet, especially olive oil intake, is linked to stronger post-vaccine anti-Spike IgG responses, even after accounting for prior infection.
Diet & metabolic health may shape vaccine effectiveness more than we thought.
#MediterraneanDiet #HumoralImmunity
lnkd.in/dwWCCe7w
Higher adherence to MedDiet, especially olive oil intake, is linked to stronger post-vaccine anti-Spike IgG responses, even after accounting for prior infection.
Diet & metabolic health may shape vaccine effectiveness more than we thought.
#MediterraneanDiet #HumoralImmunity
lnkd.in/dwWCCe7w
Dietary supplementation of #ArachidonicAcid promotes #HumoralImmunity
By. S. Feng, E. Ma, X. Na, Z. Wang, L. Zhao, A. Zhao, G. Cheng & colleagues at Tsinghua University
➡️ doi.org/10.1038/s443...
By. S. Feng, E. Ma, X. Na, Z. Wang, L. Zhao, A. Zhao, G. Cheng & colleagues at Tsinghua University
➡️ doi.org/10.1038/s443...
September 16, 2025 at 8:59 AM
Dietary supplementation of #ArachidonicAcid promotes #HumoralImmunity
By. S. Feng, E. Ma, X. Na, Z. Wang, L. Zhao, A. Zhao, G. Cheng & colleagues at Tsinghua University
➡️ doi.org/10.1038/s443...
By. S. Feng, E. Ma, X. Na, Z. Wang, L. Zhao, A. Zhao, G. Cheng & colleagues at Tsinghua University
➡️ doi.org/10.1038/s443...