Delighted to speak on the important topic of replacement of mini-puberty in male infants with hypogonadotropic hypogonadism at a great symposium on hypothalamic- pituitary function #ENDO2025 #endosky @qmulwhri.bsky.social
July 14, 2025 at 9:52 PM
Delighted to speak on the important topic of replacement of mini-puberty in male infants with hypogonadotropic hypogonadism at a great symposium on hypothalamic- pituitary function #ENDO2025 #endosky @qmulwhri.bsky.social
I have Kallman Syndrome and that means me and people assigned AMAB would not look masculine because we don't have testosterone.
Is just recently that the psycological impact of that has been measured and recognized.
Is just recently that the psycological impact of that has been measured and recognized.
May 17, 2026 at 11:05 PM
I have Kallman Syndrome and that means me and people assigned AMAB would not look masculine because we don't have testosterone.
Is just recently that the psycological impact of that has been measured and recognized.
Is just recently that the psycological impact of that has been measured and recognized.
I was diagnosed with idiopathic hypogonadotropic hypogonadism at 27 because I did not go completely through puberty. I had delayed puberty and looked much like my younger sister who was bigger than me. I am now on masculinising hormone therapy and seeking voice training to allow me the (1/2)
June 14, 2024 at 4:07 PM
I was diagnosed with idiopathic hypogonadotropic hypogonadism at 27 because I did not go completely through puberty. I had delayed puberty and looked much like my younger sister who was bigger than me. I am now on masculinising hormone therapy and seeking voice training to allow me the (1/2)
XX, (no ovotestes), germ cells properly migrate in XY (no gonocyte maturation failure), germ cells enter meiosis in XX (no premature oocyte depletion), HPG axis activates normally in puberty (no hypogonadotropic hypogonadism), no aberrant epigenetic silencing (no methylation defects at key loci),..
April 17, 2025 at 12:36 PM
XX, (no ovotestes), germ cells properly migrate in XY (no gonocyte maturation failure), germ cells enter meiosis in XX (no premature oocyte depletion), HPG axis activates normally in puberty (no hypogonadotropic hypogonadism), no aberrant epigenetic silencing (no methylation defects at key loci),..
Contributions of common genetic variants to constitutional delay of #puberty and idiopathic hypogonadotropic #hypogonadism.
doi.org/10.1210/clin...
Featured study in #JCEM. #FreeToView
#genetics #KallmanSyndrome
@endocrinesociety.bsky.social
doi.org/10.1210/clin...
Featured study in #JCEM. #FreeToView
#genetics #KallmanSyndrome
@endocrinesociety.bsky.social
Contributions of Common Genetic Variants to Constitutional Delay of Puberty and Idiopathic Hypogonadotropic Hypogonadism
AbstractContext. Constitutional delay of puberty (CDP) is highly heritable, but the genetic basis for CDP is largely unknown. Idiopathic hypogonadotropic h
doi.org
January 13, 2025 at 1:27 PM
Contributions of common genetic variants to constitutional delay of #puberty and idiopathic hypogonadotropic #hypogonadism.
doi.org/10.1210/clin...
Featured study in #JCEM. #FreeToView
#genetics #KallmanSyndrome
@endocrinesociety.bsky.social
doi.org/10.1210/clin...
Featured study in #JCEM. #FreeToView
#genetics #KallmanSyndrome
@endocrinesociety.bsky.social
New Research Letter:
Reversal of #congenital #hypogonadotropic #hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation www.thelancet.com/journals/lan... #CHH #kisspeptin
#FREE to read
#MedSky #EndoSky #GeneticSky
Reversal of #congenital #hypogonadotropic #hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation www.thelancet.com/journals/lan... #CHH #kisspeptin
#FREE to read
#MedSky #EndoSky #GeneticSky
Reversal of congenital hypogonadotropic hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation
The identification and characterisation of kisspeptin represents a milestone in our
understanding of the mechanisms underlying gonadotropin-releasing hormone (GnRH) neurosecretion.1,2
Kisspeptin is th...
www.thelancet.com
June 3, 2025 at 10:38 PM
New Research Letter:
Reversal of #congenital #hypogonadotropic #hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation www.thelancet.com/journals/lan... #CHH #kisspeptin
#FREE to read
#MedSky #EndoSky #GeneticSky
Reversal of #congenital #hypogonadotropic #hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation www.thelancet.com/journals/lan... #CHH #kisspeptin
#FREE to read
#MedSky #EndoSky #GeneticSky
Read our July Issue, featuring thyroid eye disease, type 2 diabetes remission, IcoSema, adrenal incidentalomas, CGM, gestational diabetes, congenital hypogonadotropic hypogonadism, junk food and soda taxes, childhood obesity, Prader-Willi syndrome, and more bit.ly/2LArJXX
#MedSky #EndoSky #OncSky
#MedSky #EndoSky #OncSky
June 17, 2025 at 10:33 PM
Read our July Issue, featuring thyroid eye disease, type 2 diabetes remission, IcoSema, adrenal incidentalomas, CGM, gestational diabetes, congenital hypogonadotropic hypogonadism, junk food and soda taxes, childhood obesity, Prader-Willi syndrome, and more bit.ly/2LArJXX
#MedSky #EndoSky #OncSky
#MedSky #EndoSky #OncSky
Reversal of congenital hypogonadotropic hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation - The Lancet Diabetes & Endocrinology www.thelancet.com/journals/lan...
Reversal of congenital hypogonadotropic hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation
The identification and characterisation of kisspeptin represents a milestone in our
understanding of the mechanisms underlying gonadotropin-releasing hormone (GnRH) neurosecretion.1,2
Kisspeptin is th...
www.thelancet.com
June 4, 2025 at 5:25 PM
Reversal of congenital hypogonadotropic hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation - The Lancet Diabetes & Endocrinology www.thelancet.com/journals/lan...
Kallmann syndrome - a form of hypogonadotropic hypogonadism.
Rare hormone condition that prevents normal puberty and fertility.
#rarediseaseday #rarediseaseday2025 #kallmannsyndrome #kallmann #hypogonadism #hypogonadotropichypogonadism #puberty #anosmia #hormonereplacementtherapy #endocrinology
Rare hormone condition that prevents normal puberty and fertility.
#rarediseaseday #rarediseaseday2025 #kallmannsyndrome #kallmann #hypogonadism #hypogonadotropichypogonadism #puberty #anosmia #hormonereplacementtherapy #endocrinology
February 19, 2025 at 11:15 PM
Kallmann syndrome - a form of hypogonadotropic hypogonadism.
Rare hormone condition that prevents normal puberty and fertility.
#rarediseaseday #rarediseaseday2025 #kallmannsyndrome #kallmann #hypogonadism #hypogonadotropichypogonadism #puberty #anosmia #hormonereplacementtherapy #endocrinology
Rare hormone condition that prevents normal puberty and fertility.
#rarediseaseday #rarediseaseday2025 #kallmannsyndrome #kallmann #hypogonadism #hypogonadotropichypogonadism #puberty #anosmia #hormonereplacementtherapy #endocrinology
I have had the penetrative sex, how many times in total.
Twice when in 2011. Once in 2012. Once in 2014. I think that's it.
The hormone disorder i have is likely to blame. Recently diagnosed with: adult onset idiopathic hypogonadotropic hypogonadism.
Twice when in 2011. Once in 2012. Once in 2014. I think that's it.
The hormone disorder i have is likely to blame. Recently diagnosed with: adult onset idiopathic hypogonadotropic hypogonadism.
August 28, 2026 at 6:59 AM
I have had the penetrative sex, how many times in total.
Twice when in 2011. Once in 2012. Once in 2014. I think that's it.
The hormone disorder i have is likely to blame. Recently diagnosed with: adult onset idiopathic hypogonadotropic hypogonadism.
Twice when in 2011. Once in 2012. Once in 2014. I think that's it.
The hormone disorder i have is likely to blame. Recently diagnosed with: adult onset idiopathic hypogonadotropic hypogonadism.
Gonadotropin therapy for mini-puberty induction in male infants with hypogonadotropic #hypogonadism. #pediatrics #DSD Featured study in #JCEM #FreeToView
doi.org/10.1210/clin...
@endocrinesociety.bsky.social
doi.org/10.1210/clin...
@endocrinesociety.bsky.social
Gonadotropin Therapy for Mini-Puberty Induction in Male Infants With Hypogonadotropic Hypogonadism
AbstractContext. Congenital hypogonadotropic hypogonadism (CHH) is defined as an isolated deficiency of gonadotropin hormones. Mini-puberty, a transient po
doi.org
May 8, 2025 at 4:05 PM
Gonadotropin therapy for mini-puberty induction in male infants with hypogonadotropic #hypogonadism. #pediatrics #DSD Featured study in #JCEM #FreeToView
doi.org/10.1210/clin...
@endocrinesociety.bsky.social
doi.org/10.1210/clin...
@endocrinesociety.bsky.social
Ovarian reserve markers are widely used in fertility assessment, yet no systematic review has evaluated them specifically for WHO type 1 (hypogonadotropic hypogonadism) anovulation. This new review is the first to examine this relationship,
doi.org/10.1016/j.rb...
doi.org/10.1016/j.rb...
July 13, 2026 at 7:00 PM
Ovarian reserve markers are widely used in fertility assessment, yet no systematic review has evaluated them specifically for WHO type 1 (hypogonadotropic hypogonadism) anovulation. This new review is the first to examine this relationship,
doi.org/10.1016/j.rb...
doi.org/10.1016/j.rb...
Boy did they misread that article.
A) Kallmann syndrome is not intersex but it is form of hypogonadotropic hypogonadism.
B) A single quote regarding “highly unusual and almost complete devotion to politics in his life” does not mention evil.
my.clevelandclinic.org/health/disea...
A) Kallmann syndrome is not intersex but it is form of hypogonadotropic hypogonadism.
B) A single quote regarding “highly unusual and almost complete devotion to politics in his life” does not mention evil.
my.clevelandclinic.org/health/disea...
What Is Kallmann Syndrome?
Kallmann syndrome can cause late puberty or prevent puberty from happening. It may affect your sense of smell.
my.clevelandclinic.org
November 13, 2025 at 6:16 PM
Boy did they misread that article.
A) Kallmann syndrome is not intersex but it is form of hypogonadotropic hypogonadism.
B) A single quote regarding “highly unusual and almost complete devotion to politics in his life” does not mention evil.
my.clevelandclinic.org/health/disea...
A) Kallmann syndrome is not intersex but it is form of hypogonadotropic hypogonadism.
B) A single quote regarding “highly unusual and almost complete devotion to politics in his life” does not mention evil.
my.clevelandclinic.org/health/disea...
More than 20 genes have been linked to Kallmann syndrome (KS) or isolated GnRH deficiency (which includes KS). Some sources even suggest the number is around 30 to 40 genes associated with hypogonadotropic hypogonadism, including KS.
November 13, 2025 at 9:58 PM
More than 20 genes have been linked to Kallmann syndrome (KS) or isolated GnRH deficiency (which includes KS). Some sources even suggest the number is around 30 to 40 genes associated with hypogonadotropic hypogonadism, including KS.
RRIDs were included in this in Genetics in Medicine paper. RRIDs improve reproducibility in scientific research. #methodsmatter #BetterScience #OpenResearch
De novo rare EMX2 variants lead to idiopathic hypogonadotropic hypogonadism
Read the full paper: De novo rare EMX2 variants lead to idiopathic hypogonadotropic hypogonadism
doi.org
March 5, 2026 at 8:00 AM
RRIDs were included in this in Genetics in Medicine paper. RRIDs improve reproducibility in scientific research. #methodsmatter #BetterScience #OpenResearch
I mentioned the mental health part because there is an study of how men with KS, even when they were diagnosed and received proper HRT for a long time, have psychosexual problems:
70% have difficulty with intimate relationships
26% have never been sexually active
academic.oup.com/smoa/article...
70% have difficulty with intimate relationships
26% have never been sexually active
academic.oup.com/smoa/article...
Psychosexual Development in Men with Congenital Hypogonadotropic Hypogonadism on Long-Term Treatment: A Mixed Methods Study
AbstractIntroduction. Congenital hypogonadotropic hypogonadism (CHH) is a rare, genetic, reproductive endocrine disorder characterized by absent puberty an
academic.oup.com
December 29, 2024 at 2:15 AM
I mentioned the mental health part because there is an study of how men with KS, even when they were diagnosed and received proper HRT for a long time, have psychosexual problems:
70% have difficulty with intimate relationships
26% have never been sexually active
academic.oup.com/smoa/article...
70% have difficulty with intimate relationships
26% have never been sexually active
academic.oup.com/smoa/article...
nyaspubs.onlinelibrary.wiley.com/share/H6CMMN...
Kallmann syndrome / hypogonadotropic hypogonadism affects normal puberty and fertility in both males & females.
Fertility treatments are available in the form of gonadotropin therapy.
#kallmann #hypogonadotropic #infertility #puberty #gonadotropin
Kallmann syndrome / hypogonadotropic hypogonadism affects normal puberty and fertility in both males & females.
Fertility treatments are available in the form of gonadotropin therapy.
#kallmann #hypogonadotropic #infertility #puberty #gonadotropin
Current landscape of fertility induction in males with congenital hypogonadotropic hypogonadism
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nyaspubs.onlinelibrary.wiley.com
February 16, 2025 at 6:36 PM
nyaspubs.onlinelibrary.wiley.com/share/H6CMMN...
Kallmann syndrome / hypogonadotropic hypogonadism affects normal puberty and fertility in both males & females.
Fertility treatments are available in the form of gonadotropin therapy.
#kallmann #hypogonadotropic #infertility #puberty #gonadotropin
Kallmann syndrome / hypogonadotropic hypogonadism affects normal puberty and fertility in both males & females.
Fertility treatments are available in the form of gonadotropin therapy.
#kallmann #hypogonadotropic #infertility #puberty #gonadotropin
Is this what's bothering you, son? A micropenis can be caused by a number of conditions, including hypogonadotropic hypogonadism,
There is no cure for micropenis, but a doctor can help manage the condition and improve symptoms. Treatment often involves a short course of testosterone therapy
There is no cure for micropenis, but a doctor can help manage the condition and improve symptoms. Treatment often involves a short course of testosterone therapy
January 14, 2025 at 12:42 AM
Is this what's bothering you, son? A micropenis can be caused by a number of conditions, including hypogonadotropic hypogonadism,
There is no cure for micropenis, but a doctor can help manage the condition and improve symptoms. Treatment often involves a short course of testosterone therapy
There is no cure for micropenis, but a doctor can help manage the condition and improve symptoms. Treatment often involves a short course of testosterone therapy
www.tiktok.com/@neilsmith38...
I was still labelled as a "late bloomer" at the age of 20. I did not get the correct diagnosis of having #Kallmann syndrome until I was 23.
Kallmann syndrome is a form of #hypogonadotropic hypogonadism that prevents puberty from occurring correctly.
I was still labelled as a "late bloomer" at the age of 20. I did not get the correct diagnosis of having #Kallmann syndrome until I was 23.
Kallmann syndrome is a form of #hypogonadotropic hypogonadism that prevents puberty from occurring correctly.
TikTok - Make Your Day
www.tiktok.com
April 6, 2025 at 6:18 AM
www.tiktok.com/@neilsmith38...
I was still labelled as a "late bloomer" at the age of 20. I did not get the correct diagnosis of having #Kallmann syndrome until I was 23.
Kallmann syndrome is a form of #hypogonadotropic hypogonadism that prevents puberty from occurring correctly.
I was still labelled as a "late bloomer" at the age of 20. I did not get the correct diagnosis of having #Kallmann syndrome until I was 23.
Kallmann syndrome is a form of #hypogonadotropic hypogonadism that prevents puberty from occurring correctly.
Genetics of infertility: Rare de novo EMX2 variants cause hypogonadotropic hypogonadism, developmental delay and hearing loss. bit.ly/3MV47P5 #GeneticsInFertility #exome
December 26, 2025 at 7:07 PM
Genetics of infertility: Rare de novo EMX2 variants cause hypogonadotropic hypogonadism, developmental delay and hearing loss. bit.ly/3MV47P5 #GeneticsInFertility #exome