#IGF2
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ijosjournal.bsky.social
Check out our video!🥳PLAGL1-IGF2 axis regulates osteogenesis of postnatal condyle development
#PLAGL1 #IGF2 #osteogenesis
@ijosjournal.bsky.social
www.nature.com/articles/s41...
October 22, 2025 at 5:15 AM
ijosjournal.bsky.social
Research reveals PLAGL1, a key gene, boosts jawbone growth via the IGF2 pathway, aiding bone-forming cells. Vital clues for treating craniofacial issues!👍
#PLAGL1 #IGF2 #jawbone #gene
@ijosjournal.bsky.social
www.nature.com/articles/s41...
October 13, 2025 at 8:14 AM
albertvilella.bsky.social
Unborn babies use genes from dad to remote control mothers for extra food #Igf2 #imprinting scitechdaily.com/unborn-babie...
Unborn Babies Use Genes From Dad to “Remote-Control” Mothers for Extra Food
Scientists at Cambridge have unveiled a fascinating mechanism where fetuses use a paternal gene to control the mother's nutrient release during pregnancy. This "remote control" system involves hormona...
scitechdaily.com
January 6, 2025 at 8:03 AM
cp-cellstemcell.bsky.social
Online Now! IGF2 acts downstream of Hippo signaling to regulate organ growth and restore liver regeneration in aging #stemcells
IGF2 acts downstream of Hippo signaling to regulate organ growth and restore liver regeneration in aging
Zhong and colleagues reveal a mechanism behind organ size control in development and regeneration. High IGF2 levels drive and coordinate rapid fetal and neonatal growth, while IGF2 silencing—upon postnatal Hippo signaling activation—limits growth and determines organ size. Restoring IGF2 expression enhances tissue repair and reverses age-related regenerative defects.
dlvr.it
September 8, 2026 at 11:36 PM
ento-ea.bsky.social
Co-phylogeny and biogeography of the myrmecophilous beetle Paussus favieri (Carabidae, Paussinae) and its host ant Pheidole pallidula (Hymenoptera, Myrmicinae)
onlinelibrary.wiley.com/doi/10.1111/...
Gonadulin and Insulin‐Like Growth Factor Involved in Rhipicephalus microplus Reproduction
Insulin-like growth factor (IGF2) in ovaries of Rhipicephalus microplus partially engorged females. Ovaries from females at different feeding stages were used to detect IGF2.
onlinelibrary.wiley.com
February 5, 2026 at 3:54 AM
cuendocrinology.bsky.social
Our fellows gave outstanding presentations at their posters at #ENDO2025. Dr Eugene Looi (just graduated) discussed PBH. Dr Pranitha Chekka discussed IGF2 mediated hypoglycemia. And Dr Swecha Potharaj presented on supplements causing adrenal function interference.
@cudeptofmedicine.bsky.social
July 14, 2025 at 3:48 PM
cellsdev.bsky.social
A very curious paper from the De Robertis lab shows how Cerberus - a growth factor that inhibits Wnt signalling, and IGF - a growth factor that activates MAPK signalling, can synergistically induce a new head (aka ectopic archencephalic differentiation) in Xenopus embryos.
doi.org/10.1016/j.cd...
Fig. 1. IGF2 and Cerberus mRNAs cooperate in ectopic head induction in Xenopus embryos. Embryos were microinjected into the ventral marginal zone of a single blastomere at the 4- to 8-cell stage. (A) Uninjected control sibling at early tailbud stage (n = 81). (B) A single ventral injection of IGF2 mRNA caused a small ectopic head protrusion with a pigmented cement gland on the belly (n = 86, 68 % with ectopic structures). (C) Cerberus mRNA induced a secondary head-like structure (n = 78, 94 % with ectopic heads). (D) Co-injection of IGF2 and Cerberus mRNAs induced a large ectopic head with an expanded cement gland (n = 90, 98 % with ectopic heads). (E–H) Panoramic views of control and injected embryos. Injected mRNA doses per embryo were: Cerberus, 100 pg; IGF2, 2 ng. Results from two experiments. Scale bars are 500 μm (A-D) and 2 mm (E-H). Fig. 6. Dominant-negative IGF receptor 1 blocked ectopic head formation by Cerberus mRNA in single ventral injections. (A) Control embryo at stage 24 injected with LacZ (100 pg) mRNA but not stained for β-galactosidase (n = 50). (B) DN-IGFR (600 pg) and LacZ injected embryos (n = 20, all normal). (C) Cerberus (100 pg) injected embryos with ectopic heads (n = 56, 96 % ectopic heads). (D) DN-IGFR blocked Cerberus ectopic heads (n = 33, 88 % with no ectopic structures, 12 % with small cement glands). (E–F) LacZ staining for (A–D). Scale bar, 500 μm.
January 17, 2026 at 1:03 AM
helmholtzmunich.bsky.social
🔬 Researchers led by Dr. Siegfried Ussar have identified insulin-like growth factor 2 (IGF2) as a central driver of fat tissue expansion during early postnatal development.

👉 Read more: t1p.de/71yka

@diabresearch-dzd.bsky.social
@genesdev.bsky.social

#DiabetesResearch #IGF2
IGF2 Identified as a Critical Regulator of Early Adipose Tissue Development Featured PublicationDiabetes
September 17, 2025 at 12:33 PM
cuendocrinology.bsky.social
Endocrine grand rounds: 1st yr fellow Dr Pranitha Chekka presented on causes of #hypoglycemia with focus on rare IGF2 mediated hypoglycemia and differences with insulinoma.
@cudeptofmedicine.bsky.social
February 20, 2025 at 3:45 AM
stemcellpodcast.com
The Hippo–IGF2 signaling pathway was found to control organ growth and liver #regeneration, with IGF2 restoring impaired regenerative capacity in aged mice. 🐁

Read more: https://bit.ly/4iW1JW3
🎧 Tune into the discussion: https://bit.ly/4xGNSaO
September 21, 2026 at 4:58 PM
bishopjoey.bsky.social
@thetonearm.com Thank you for posting about Zu! Their gig last night in Amsterdam was *so* good.

www.youtube.com/watch?v=IGF2...
ZU @ OCCII amsterdam 11-2-2026
YouTube video by mauri d
www.youtube.com
February 12, 2026 at 11:08 AM
drtanakabluesky.bsky.social
🦷 #Gum health flags dementia risk!🧬 #Spinal NTRK1→IGF2 drives pain! 💉 #Migraine #Antibodies ease #Anxiety too!
Surprising clues link #Body & #Mind! @mdpiopenaccess.bsky.social #BrainHealth #PainResearch
👉 www.mdpi.com/2227-9059/13...
November 24, 2025 at 7:15 AM
nafnlaus.bsky.social
(no aberrant IGF2/H19 regulation affecting gonads), no mitotic recombination (no loss of heterozygosity in key genes), no nonsense-mediated decay of critical transcripts (no mRNA instability), no splicing defects in sex-determining genes (no exon skipping), no dominant-negative...
April 17, 2025 at 12:36 PM
diabresearch-dzd.bsky.social
🧬 New research from Helmholtz Munich and the DZD reveals that IGF2 plays a crucial role in early adipose tissue development. Led by Dr. Siegfried Ussar, the study shows how IGF2 drives preadipocyte proliferation in the first weeks of life — a key step for healthy metabolism later on. #Metabolism
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helmholtzmunich.bsky.social Helmholtz Munich @helmholtzmunich.bsky.social · Sep 17
🔬 Researchers led by Dr. Siegfried Ussar have identified insulin-like growth factor 2 (IGF2) as a central driver of fat tissue expansion during early postnatal development.

👉 Read more: t1p.de/71yka

@diabresearch-dzd.bsky.social
@genesdev.bsky.social

#DiabetesResearch #IGF2
IGF2 Identified as a Critical Regulator of Early Adipose Tissue Development Featured PublicationDiabetes
September 18, 2025 at 8:26 AM
lehtinenlab.bsky.social
Apocrine secretion changes the composition of the CSF in minutes. We found a surge of key developmental signals including IGF2, Sonic Hedgehog (SHH), insulin, & transthyretin (TTR). Each of these proteins is known to shape how neural progenitors divide and differentiate.
May 28, 2025 at 12:56 PM
eahellerphd.bsky.social
Department of Mother Nature:
CpG demethylation of the paternal H19-DMR allele decreases Igf2 expression and increases H19 expression through imprinted epigenetic regulation of CTCF binding.
www.nature.com/articles/nco...
July 28, 2025 at 3:23 PM
itmat.bsky.social
Igf2/H19 locus as instructive model to study how allele-specific #GenomeArchitecture facilitates enhancer-promoter interaction that dictate tissue-specific #GeneExpression in #SkeletalMuscle doi.org/10.1371/jour... @Marisa_S_B #TranslationalScience
Igf2 adult-specific skeletal muscle enhancer activity revealed in mice with intergenic CTCF boundary deletion
Author summary All mammals have a unique class of genes that are crucial for normal growth, known as “imprinted genes,” where only one gene copy inherited from a parent is active. Imprinted genes are ...
doi.org
September 2, 2025 at 6:22 PM
biorxiv-devbio.bsky.social
Igf2 regulates early postnatal DPP4+ preadipocyte pool expansion https://www.biorxiv.org/content/10.1101/2025.02.08.637214v1
February 8, 2025 at 9:30 PM
mendell-lab.bsky.social
Interestingly, Plagl1 encodes a transcription factor that promotes embryonic growth by transactivating Igf2 expression. This function likely synergizes with the noncoding function of this mRNA in removing the growth suppressing miRNA miR-322 through TDMD.
July 2, 2025 at 4:17 PM
cfgtedinburgh.bsky.social
Yes. It's not my field, but to me the experimental results seem compelling -- the proposed role of paternal Igf2 expression in the mouse placenta is well supported, particularly by the deletion data.

There's a nice non-sensational Research Highlight piece here: www.nature.com/articles/s41...
Fetal orchestration of maternal metabolism via IGF2 - Nature Reviews Endocrinology
Nature Reviews Endocrinology - Fetal orchestration of maternal metabolism via IGF2
www.nature.com
January 6, 2025 at 10:40 AM
drtanakabluesky.bsky.social
‪Think chronic postsurgical #Pain is inevitable? 🔥 We just uncovered a spinal NTRK1→IGF2→ER #Stress cascade fueling CPSP Block NTRK1 or silence IGF2 to reverse pain 🚀💥⚡️💉🧠 @mdpiopenaccess.bsky.social
#ChronicPain #Neuroscience #PainResearch #NonOpioid #PrecisionMedicine
doi.org/10.3390/biom...
July 29, 2025 at 5:58 AM
rridrobot.bsky.social
The authors included RRIDs in their in Science Advances paper! We value the author's support of reproducibility. #ReproducibleResearch #RRID #STMpublishing
Single-cell protein activity analysis reveals aberrant myogenesis and IGF2-PI3K pathway dependencies in MYOD1-mutant rhabdomyosarcoma
Read the full paper: Single-cell protein activity analysis reveals aberrant myogenesis and IGF2-PI3K pathway dependencies in MYOD1-mutant rhabdomyosarcoma
doi.org
March 4, 2026 at 8:03 AM
biorxiv-cancer.bsky.social
Integrated Proteomic and Epigenomic Analysis Reveals IGF2 as a Vulnerability in PRC2-Deficient Malignant Peripheral Nerve Sheath Tumors https://www.biorxiv.org/content/10.1101/2025.11.05.686792v1
November 6, 2025 at 11:48 PM
rridrobot.bsky.social
A paper using RRID:AB_2923704 from @proteintech.bsky.social was just published in iScience. Thanks for making your methods matter! #reproducibility #ReproducibleResearch #BetterScience
ZBED6–IGF2–PIK3C3 autophagy axis drives ccRCC progression: A multi-omics integration study
Read the full paper: ZBED6–IGF2–PIK3C3 autophagy axis drives ccRCC progression: A multi-omics integration study
doi.org
March 22, 2026 at 7:00 AM