Check out our video!🥳PLAGL1-IGF2 axis regulates osteogenesis of postnatal condyle development
#PLAGL1 #IGF2 #osteogenesis
@ijosjournal.bsky.social
www.nature.com/articles/s41...
#PLAGL1 #IGF2 #osteogenesis
@ijosjournal.bsky.social
www.nature.com/articles/s41...
October 22, 2025 at 5:15 AM
Check out our video!🥳PLAGL1-IGF2 axis regulates osteogenesis of postnatal condyle development
#PLAGL1 #IGF2 #osteogenesis
@ijosjournal.bsky.social
www.nature.com/articles/s41...
#PLAGL1 #IGF2 #osteogenesis
@ijosjournal.bsky.social
www.nature.com/articles/s41...
Research reveals PLAGL1, a key gene, boosts jawbone growth via the IGF2 pathway, aiding bone-forming cells. Vital clues for treating craniofacial issues!👍
#PLAGL1 #IGF2 #jawbone #gene
@ijosjournal.bsky.social
www.nature.com/articles/s41...
#PLAGL1 #IGF2 #jawbone #gene
@ijosjournal.bsky.social
www.nature.com/articles/s41...
October 13, 2025 at 8:14 AM
Research reveals PLAGL1, a key gene, boosts jawbone growth via the IGF2 pathway, aiding bone-forming cells. Vital clues for treating craniofacial issues!👍
#PLAGL1 #IGF2 #jawbone #gene
@ijosjournal.bsky.social
www.nature.com/articles/s41...
#PLAGL1 #IGF2 #jawbone #gene
@ijosjournal.bsky.social
www.nature.com/articles/s41...
Regulated decay of microRNAs plays a critical role in controlling body size in mammals! Check out our new paper in @genesdev.bsky.social and see thread previously posted with our pre-print 👇 for more info. Congrats to Collette LaVigne, Jaeil Han, and all authors!
genesdev.cshlp.org/cgi/content/...
genesdev.cshlp.org/cgi/content/...
November 10, 2025 at 5:40 PM
Regulated decay of microRNAs plays a critical role in controlling body size in mammals! Check out our new paper in @genesdev.bsky.social and see thread previously posted with our pre-print 👇 for more info. Congrats to Collette LaVigne, Jaeil Han, and all authors!
genesdev.cshlp.org/cgi/content/...
genesdev.cshlp.org/cgi/content/...
I am pleased to present our latest pre-print describing our identification of the long-sought triggers for target-directed microRNA degradation (TDMD) of miR-322 and miR-503, work led by Collette LaVigne and Jaeil Han. For more info, read on! 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
Precise control of microRNA (miRNA) expression is critical during development. An important mechanism of miRNA regulation is target-directed microRNA degradation (TDMD), a pathway in which the binding...
www.biorxiv.org
July 2, 2025 at 4:17 PM
I am pleased to present our latest pre-print describing our identification of the long-sought triggers for target-directed microRNA degradation (TDMD) of miR-322 and miR-503, work led by Collette LaVigne and Jaeil Han. For more info, read on! 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Interestingly, Plagl1 encodes a transcription factor that promotes embryonic growth by transactivating Igf2 expression. This function likely synergizes with the noncoding function of this mRNA in removing the growth suppressing miRNA miR-322 through TDMD.
July 2, 2025 at 4:17 PM
Interestingly, Plagl1 encodes a transcription factor that promotes embryonic growth by transactivating Igf2 expression. This function likely synergizes with the noncoding function of this mRNA in removing the growth suppressing miRNA miR-322 through TDMD.
Altogether, this study provides a valuable dataset that will facilitate identification of additional mammalian TDMD triggers and establishes the existence of a Plagl1/Lrrc58-mediated TDMD pathway that plays a major role in regulating mammalian body size. /end
July 2, 2025 at 4:17 PM
Altogether, this study provides a valuable dataset that will facilitate identification of additional mammalian TDMD triggers and establishes the existence of a Plagl1/Lrrc58-mediated TDMD pathway that plays a major role in regulating mammalian body size. /end
PLAGL1, KLF4, and IRX5 drive osteogenesis in periosteal progenitors for mandible rege… PMID:42168182, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-73058-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
The PLAGL1-KLF4-IRX5 axis promotes the osteogenesis of periosteal progenitors during mandible regeneration | Nature Communications
Transcription factor (TF) networks are pivotal regulators of stem/progenitor cell fate. However, the regulatory mechanisms mediated by key TFs in adult periosteal stem/progenitor cells (PSPCs) remain poorly understood, impeding targeted therapies development for craniofacial bone regeneration. By integrating an analysis of regeneration-related, tissue-specific TF networks with insights from embryonic development, we demonstrate that the imprinted TF PLAGL1 is critical for the osteoblast differentiation of PSPCs and that the loss of Plagl1 compromises mandibular bone regeneration. Mechanistically, PLAGL1 transcriptionally activates TF Irx5 synergistically with TF KLF4, thereby inducing the expression of downstream osteogenic genes. Using the CRISPR-dCas9-Tet1-CD/sgRNA system, we develop a differentially methylated region-targeted therapeutic strategy to reactivate the maternal allele of Plagl1, leveraging its imprinted function to promote mandibular bone regeneration. This study delinea
doi.org
May 30, 2026 at 3:00 PM
The authors included RRIDs in their None paper! We value the author's support of reproducibility. #reproducibility #OpenScience #accelerateopenscience
Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
doi.org
July 23, 2025 at 7:02 AM
The authors included RRIDs in their None paper! We value the author's support of reproducibility. #reproducibility #OpenScience #accelerateopenscience
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.353138.125.abstract
Josh Mendell HHMI
RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.353138.125.abstract
Josh Mendell HHMI
January 26, 2026 at 7:00 PM
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.353138.125.abstract
Josh Mendell HHMI
RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.353138.125.abstract
Josh Mendell HHMI
Check out related work by the Mendell lab (@mendell-lab.bsky.social) and the Xie lab: www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1... (3/3)
Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
Precise control of microRNA (miRNA) expression is critical during development. An important mechanism of miRNA regulation is target-directed microRNA degradation (TDMD), a pathway in which the binding...
www.biorxiv.org
November 7, 2025 at 6:33 PM
Check out related work by the Mendell lab (@mendell-lab.bsky.social) and the Xie lab: www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1... (3/3)
RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/40/3-4/215.full
Josh Mendell HHMI
#TDMD #RNAdecay #miRNA #triggerRNA #development
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/40/3-4/215.full
Josh Mendell HHMI
#TDMD #RNAdecay #miRNA #triggerRNA #development
February 9, 2026 at 7:00 PM
RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/40/3-4/215.full
Josh Mendell HHMI
#TDMD #RNAdecay #miRNA #triggerRNA #development
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/40/3-4/215.full
Josh Mendell HHMI
#TDMD #RNAdecay #miRNA #triggerRNA #development
But the presumptive triggers that induce TDMD of miR-322/503 have remained elusive until now. We show here that Plagl1 and Lrrc58 are the long-sought trigger RNAs for TDMD of miR-322 and miR-503, respectively.
July 2, 2025 at 4:17 PM
But the presumptive triggers that induce TDMD of miR-322/503 have remained elusive until now. We show here that Plagl1 and Lrrc58 are the long-sought trigger RNAs for TDMD of miR-322 and miR-503, respectively.
いじったのは、もともと報告のあったIgf2r, Kcnq1, Snrpn, Grb10, Peg3, Nespas, Gnasに、Peg10, Impact, Mest。それに加えて、Jade1, Gab1, Sfmbt2, Smoc1, Xist, Igf2, Plagl1, Peg13, Peg3。ESでK27me3が剥がれているであろう非典型インプリンティングも含めてます。
February 4, 2025 at 7:54 AM
いじったのは、もともと報告のあったIgf2r, Kcnq1, Snrpn, Grb10, Peg3, Nespas, Gnasに、Peg10, Impact, Mest。それに加えて、Jade1, Gab1, Sfmbt2, Smoc1, Xist, Igf2, Plagl1, Peg13, Peg3。ESでK27me3が剥がれているであろう非典型インプリンティングも含めてます。
Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503 https://www.biorxiv.org/content/10.1101/2025.06.30.662380v1
July 2, 2025 at 4:18 AM
Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503 https://www.biorxiv.org/content/10.1101/2025.06.30.662380v1
Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503 https://www.biorxiv.org/content/10.1101/2025.06.30.662380v1
July 2, 2025 at 4:18 AM
Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503 https://www.biorxiv.org/content/10.1101/2025.06.30.662380v1
"We present the most comprehensive MRI data series on ET, PLAGL, a rare embryonal tumor in children and adolescents. It is not possible to distinguish between PLAGL1- and PLAGL2-amplified tumors on the basis of imaging, nor can ET, PLAGL be differentiated from other embryonal CNS tumors."
April 1, 2025 at 3:47 PM
"We present the most comprehensive MRI data series on ET, PLAGL, a rare embryonal tumor in children and adolescents. It is not possible to distinguish between PLAGL1- and PLAGL2-amplified tumors on the basis of imaging, nor can ET, PLAGL be differentiated from other embryonal CNS tumors."