I’m going through proofs and discovered a reference to ‘Fa imids’. Having fun now picturing a dynasty of cockney caliphs in Cairo.
January 29, 2026 at 8:58 AM
I’m going through proofs and discovered a reference to ‘Fa imids’. Having fun now picturing a dynasty of cockney caliphs in Cairo.
Resistance to less-potent IMiDs in myeloma can be rescued with more-potent IMiDs. IMiD resistance represents both a problem and opportunity, Vidyasgar Koduri, MD, PhD, said, who spoke abt CRBN mutation-driven IMiD resistance mechanisms. #IMS26
September 25, 2026 at 2:54 PM
Resistance to less-potent IMiDs in myeloma can be rescued with more-potent IMiDs. IMiD resistance represents both a problem and opportunity, Vidyasgar Koduri, MD, PhD, said, who spoke abt CRBN mutation-driven IMiD resistance mechanisms. #IMS26
Amazing @led3hub.bsky.social Lecture by @thewoolab.bsky.social! She talked about her group's exciting work on protein C-terminal cyclic imids as natural ligands of cereblon for protein degradation. (1/3)
www.nature.com/articles/s41...
#TPD #DrugDiscovery #ChemBio #ChemSky #Degron
www.nature.com/articles/s41...
#TPD #DrugDiscovery #ChemBio #ChemSky #Degron
February 26, 2026 at 3:52 PM
Amazing @led3hub.bsky.social Lecture by @thewoolab.bsky.social! She talked about her group's exciting work on protein C-terminal cyclic imids as natural ligands of cereblon for protein degradation. (1/3)
www.nature.com/articles/s41...
#TPD #DrugDiscovery #ChemBio #ChemSky #Degron
www.nature.com/articles/s41...
#TPD #DrugDiscovery #ChemBio #ChemSky #Degron
Not me
Well, technically they're both IMIDs
Well, technically they're both IMIDs
July 4, 2026 at 5:39 PM
Not me
Well, technically they're both IMIDs
Well, technically they're both IMIDs
Mañana Update en IMIDS @sefhfarmahosp.bsky.social
November 20, 2024 at 4:44 PM
Mañana Update en IMIDS @sefhfarmahosp.bsky.social
Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells | ACS Chemical Biology pubs.acs.org/doi/10.1021/...
Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells
Immunomodulatory imide drugs (IMiDs), including thalidomide, lenalidomide, and pomalidomide, can be used to induce degradation of a protein of interest that is fused to a short degron motif, which often comprises a zinc finger (ZF). These IMiDs, however, also induce the degradation of endogenous ZF-containing neosubstrates, including IKZF1, IKZF3, and SALL4. To improve degradation selectivity, we took a bump-and-hole approach to design and screen bumped IMiD analogues against 8380 ZF mutants. This yielded a bumped IMiD analogue that induces efficient degradation of a mutant ZF degron, while not affecting other cellular proteins, including IKZF1, IKZF3, and SALL4. In proof-of-concept studies, this system was applied to induce degradation of the optimum degron fused to CDK9, HPRT1, NanoLuc, or TRIM28. We anticipate that this system will be a valuable addition to the current arsenal of degron systems for use in target validation.
pubs.acs.org
November 3, 2025 at 8:00 PM
Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells | ACS Chemical Biology pubs.acs.org/doi/10.1021/...
To B or Not to B - CAR-T Cells Enter the Treatment Arena of IMIDS | VuMedi https://buff.ly/40DQwQY
To B or Not to B - CAR-T Cells Enter the Treatment Arena of IMIDS
A video from William Rigby, posted on Aug 29, 2024.
buff.ly
November 10, 2024 at 2:53 PM
To B or Not to B - CAR-T Cells Enter the Treatment Arena of IMIDS | VuMedi https://buff.ly/40DQwQY
This is very interesting, and suggests access to nature opportunities should come on parent packs india.mongabay.com/2026/09/redu...
Reduced exposure to nature is linked to immune system diseases [Commentary]
Cases of immune-mediated inflammatory diseases (IMIDs) such as type 1 diabetes and asthma, have been rising in the last two decades.
india.mongabay.com
September 6, 2026 at 6:33 AM
This is very interesting, and suggests access to nature opportunities should come on parent packs india.mongabay.com/2026/09/redu...
Good simple explanation on how IMIDs like lenalidomide/Revlimid, thalidomide, pomalidomide, and others work. These discoveries have lead to many other degrader drugs that are changing cancer therapy, all due to the myeloma field and pioneering trials lead by Bart Barlogie at UAMS
Lenalidomide is a medication used to treat multiple myeloma, myelodysplastic syndromes (MDS), and more.
How does it work?
[1/5]
How does it work?
[1/5]
November 9, 2024 at 6:17 PM
Good simple explanation on how IMIDs like lenalidomide/Revlimid, thalidomide, pomalidomide, and others work. These discoveries have lead to many other degrader drugs that are changing cancer therapy, all due to the myeloma field and pioneering trials lead by Bart Barlogie at UAMS
Thank you British Association of Dermatologists for highlighting our editorial on living guidelines in IMIDs with a reflection on the first published Behcet’s living guideline in @RheumJnl and @BrJDermatol
https://www.instagram.com/p/C_2rI_Lt5Wf/?igsh=MTJmc3Zud3ZqcXFoMw==
https://www.instagram.com/p/C_2rI_Lt5Wf/?igsh=MTJmc3Zud3ZqcXFoMw==
September 16, 2024 at 11:09 AM
Thank you British Association of Dermatologists for highlighting our editorial on living guidelines in IMIDs with a reflection on the first published Behcet’s living guideline in @RheumJnl and @BrJDermatol
https://www.instagram.com/p/C_2rI_Lt5Wf/?igsh=MTJmc3Zud3ZqcXFoMw==
https://www.instagram.com/p/C_2rI_Lt5Wf/?igsh=MTJmc3Zud3ZqcXFoMw==
Study: 15% of people with IMIDs got COVID-19 over a year. Higher levels of vaccine-induced antibodies = lower infection risk. Boosters may help maintain protection.
🔗 rimuhc.ca/en/-/new-stu...
@cusm-muhc.bsky.social @healthsciences.mcgill.ca @mcgill.ca
🔗 rimuhc.ca/en/-/new-stu...
@cusm-muhc.bsky.social @healthsciences.mcgill.ca @mcgill.ca
April 10, 2025 at 3:18 PM
Study: 15% of people with IMIDs got COVID-19 over a year. Higher levels of vaccine-induced antibodies = lower infection risk. Boosters may help maintain protection.
🔗 rimuhc.ca/en/-/new-stu...
@cusm-muhc.bsky.social @healthsciences.mcgill.ca @mcgill.ca
🔗 rimuhc.ca/en/-/new-stu...
@cusm-muhc.bsky.social @healthsciences.mcgill.ca @mcgill.ca
Really enjoying @cpkotanidis.bsky.social’s fascinating presentation on his interesting work at @brighamandwomens.bsky.social on identifying risk markers of CVD in patients with IMIDs 🤩👏👏👏
May 6, 2025 at 8:30 PM
Really enjoying @cpkotanidis.bsky.social’s fascinating presentation on his interesting work at @brighamandwomens.bsky.social on identifying risk markers of CVD in patients with IMIDs 🤩👏👏👏
Warmest congratulations to Dr. Evangelin Shaloom Vitus who successfully defended her PhD thesis today. The thesis consists of four highly clinically relevant studies, investigating the association between COVID-19 and immune-mediated inflammatory diseases (IMIDs) such as IBD.
@dg.dk @aau.dk
@dg.dk @aau.dk
March 10, 2026 at 4:12 PM
this is a great point, Quinn! I'd argue that IMiDs are also efficacious through non cancer cell-autonomous mechanisms, thereby reducing selective pressure.
November 28, 2024 at 4:45 PM
this is a great point, Quinn! I'd argue that IMiDs are also efficacious through non cancer cell-autonomous mechanisms, thereby reducing selective pressure.
This poignant clip shows IMIDs’ toll on health, family wellbeing & young people’s future hopes.
Excited by The MRC's investment in restorative immunology and research towards cures for individually rare, collectively common conditions:
www.ukri.org/news/new-50m...
@arthritisuk.bsky.social
Excited by The MRC's investment in restorative immunology and research towards cures for individually rare, collectively common conditions:
www.ukri.org/news/new-50m...
@arthritisuk.bsky.social
September 23, 2026 at 4:35 PM
This poignant clip shows IMIDs’ toll on health, family wellbeing & young people’s future hopes.
Excited by The MRC's investment in restorative immunology and research towards cures for individually rare, collectively common conditions:
www.ukri.org/news/new-50m...
@arthritisuk.bsky.social
Excited by The MRC's investment in restorative immunology and research towards cures for individually rare, collectively common conditions:
www.ukri.org/news/new-50m...
@arthritisuk.bsky.social
Targeting TNF cytokine axis in inflammatory diseases. Great success story of #immunotherapy
#immunosky #medsky #IDSky #rheumatology
rupress.org/jem/article/...
#immunosky #medsky #IDSky #rheumatology
rupress.org/jem/article/...
Targeting TNF/TNFR superfamilies in immune-mediated inflammatory diseases | Journal of Experimental Medicine | Rockefeller University Press
Following over two decades of clinical success for anti-TNF drugs, antagonists against multiple TNF/TNFR superfamily proteins are in development for IMIDs.
rupress.org
September 25, 2024 at 5:37 PM
Targeting TNF cytokine axis in inflammatory diseases. Great success story of #immunotherapy
#immunosky #medsky #IDSky #rheumatology
rupress.org/jem/article/...
#immunosky #medsky #IDSky #rheumatology
rupress.org/jem/article/...
Though often co-studied, our latest study reveals that Crohn’s Disease and ulcerative colitis harbor distinct genealogical, genetic, and microbial associations with a broad spectrum of immune-mediated inflammatory diseases (IMIDs).
See all disease profiles in Nature Communications. Link in Comments
See all disease profiles in Nature Communications. Link in Comments
January 23, 2026 at 12:56 PM
Though often co-studied, our latest study reveals that Crohn’s Disease and ulcerative colitis harbor distinct genealogical, genetic, and microbial associations with a broad spectrum of immune-mediated inflammatory diseases (IMIDs).
See all disease profiles in Nature Communications. Link in Comments
See all disease profiles in Nature Communications. Link in Comments
imids her boice already i love herfrrrrr
March 17, 2025 at 12:11 PM
imids her boice already i love herfrrrrr
Oh yes, there's been a whole slew of research on it! The biggest recent study is this one out of Canada: pubmed.ncbi.nlm.nih.gov/39116084/
Mortality and major adverse cardiovascular events after glucagon-like peptide-1 receptor agonist initiation in patients with immune-mediated inflammatory diseases and type 2 diabetes: A population-bas...
In patients with IMIDs and type 2 diabetes, GLP-1-RA exposure is associated with a lower risk of all-cause mortality and MACE compared to a cardioneutral active comparator.
pubmed.ncbi.nlm.nih.gov
May 18, 2025 at 1:56 AM
Oh yes, there's been a whole slew of research on it! The biggest recent study is this one out of Canada: pubmed.ncbi.nlm.nih.gov/39116084/
Immunosuppressed individuals may be more susceptible to severe COVID including hospitalization, ICU admission, and mortality
Early studies suggested the benefit of vaccination in terms of preventing severe COVID in people with IMIDs .
Early studies suggested the benefit of vaccination in terms of preventing severe COVID in people with IMIDs .
August 22, 2025 at 6:33 AM
Immunosuppressed individuals may be more susceptible to severe COVID including hospitalization, ICU admission, and mortality
Early studies suggested the benefit of vaccination in terms of preventing severe COVID in people with IMIDs .
Early studies suggested the benefit of vaccination in terms of preventing severe COVID in people with IMIDs .
Fresh from #bioRxiv:
Longitudinal blood #microsampling and proteome monitoring facilitate timely intervention in experimental type 1 diabetes.
#Proteome #Diabetes #Prevention #teamscience
@scilifelab.bsky.social #KarolinskaInstitutet #KTH #TUM
www.biorxiv.org/content/10.1...
Longitudinal blood #microsampling and proteome monitoring facilitate timely intervention in experimental type 1 diabetes.
#Proteome #Diabetes #Prevention #teamscience
@scilifelab.bsky.social #KarolinskaInstitutet #KTH #TUM
www.biorxiv.org/content/10.1...
Longitudinal blood microsampling and proteome monitoring facilitate timely intervention in experimental type 1 diabetes
Symptoms of immune-mediated diseases (IMIDs) typically appear after irreversible tissue damage, making early interventions based on pre-symptomatic indicators crucial. Current efforts to identify mole...
www.biorxiv.org
November 22, 2024 at 6:41 AM
Fresh from #bioRxiv:
Longitudinal blood #microsampling and proteome monitoring facilitate timely intervention in experimental type 1 diabetes.
#Proteome #Diabetes #Prevention #teamscience
@scilifelab.bsky.social #KarolinskaInstitutet #KTH #TUM
www.biorxiv.org/content/10.1...
Longitudinal blood #microsampling and proteome monitoring facilitate timely intervention in experimental type 1 diabetes.
#Proteome #Diabetes #Prevention #teamscience
@scilifelab.bsky.social #KarolinskaInstitutet #KTH #TUM
www.biorxiv.org/content/10.1...
Cytokines drive disease
#ImmunoSky #IDSky #Rheumatology #gastroenterology 🩺
rupress.org/jem/article/...
#ImmunoSky #IDSky #Rheumatology #gastroenterology 🩺
rupress.org/jem/article/...
Targeting TNF/TNFR superfamilies in immune-mediated inflammatory diseases | Journal of Experimental Medicine | Rockefeller University Press
Following over two decades of clinical success for anti-TNF drugs, antagonists against multiple TNF/TNFR superfamily proteins are in development for IMIDs.
rupress.org
November 5, 2024 at 6:23 PM
Cytokines drive disease
#ImmunoSky #IDSky #Rheumatology #gastroenterology 🩺
rupress.org/jem/article/...
#ImmunoSky #IDSky #Rheumatology #gastroenterology 🩺
rupress.org/jem/article/...
Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells
Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells
Immunomodulatory imide drugs (IMiDs), including thalidomide, lenalidomide, and pomalidomide, can be used to induce degradation of a protein of interest that is fused to a short degron motif, which oft...
pubs.acs.org
November 14, 2025 at 2:35 PM
Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells