🔬 A yeast model allows the separation of two key functions in #EwingSarcoma. 

✍️ #IRBBarcelona-@sjdhospitalbarcelona.org/profile/did:plc:yk2ko4up2gdxxmv3ubwj3kbg" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@sjdhospitalbarcelona.org

📰 Published in @pnasnexus.org

📌 DOI: 10.1093/pnasnexus/pgag329 

#IRBScience

Researchers describe how a protein linked to #cancer activates silent regions of DNA.

➡️ shorturl.at/k1Eec

***
📌 G3: Genes|Genomes|Genetics (2026) DOI: 10.1093/g3journal/jkag265

#IRBScience #IRBBarcelona #CancerResearch @sjdhospitalbarcelona.org

🔬 Researchers at #IRBBarcelona led by @swculek.bsky.social have found that a widely used mouse model resists weight gain due to unintended genetic effects of the experimental tool itself. 

📰 @eurjimmunol.bsky.social 

➡️ https://shorturl.at/5G0QP

📌 DOI: 10.1002/eji.70271

#IRBScience #Obesity

An international consortium led by #IRBBarcelona has produced the first comprehensive atlas showing how the #DNA sequence determines its shape, flexibility, and movements at the hexamer level.

📌 @natcomms.nature.com: DOI 10.1038/s41467-026-74390-5

#IRBScience

(2/2) They investigated mitofusin 1 and mitofusin 2 proteins ( #UniProt #Q8IWA4 and #O95140) and their role in interorganelle communication and autophagy. Congratulations to the first author, Isabel Gordaliza, and the whole team behind this outstanding job. #IRBScience

(1/2) Our friends from the Complex Metabolic Diseases and #Mitochondria @irbbarcelona.org group lead by Antonio Zorzano have recently published a #Paper in #Autophagy Journal ( s.mtrbio.com/lnbugdbrhi ). #IRBScience

A new study led by @milanlab.bsky.social's team at  #IRBBarcelona shows that tumours with chromosomal instability can promote their own growth by damaging the surrounding healthy tissues.

➡️ https://shorturl.at/s4xr5
📌 @emboreports.org DOI: 10.1038/s44319-026-00811-7

#IRBScience #CancerResearch

📢 A study by #IRBBarcelona & @ciccancer.bsky.social demonstrates that eliminating mutated #KRAS protein using #PROTACs induces rapid tumour regression in mouse models.

▶️ https://youtu.be/qZG4rTb4EIQ?si=Hn4jR5DRKj1FNmVt

📌 DOI: 10.1158/0008-5472.CAN-25-5172

#IRBScience #CancerResearch

🧬 Mutations in the "translators" of the human cell alter the reading of the genetic code in #cancer and #aging.

✍️ Lluís Ribas (#IRBBarcelona) et al.

📰 @genomeresearch.bsky.social

Read more ➡️ https://shorturl.at/5pk2P

📌 DOI: 10.1101/gr.281022.125

#IRBScience #AgeingResearch #AgingResearch

🧪

🔬 #Mitochondria identified as key player in a #RareDisease causing #microcephaly.

Published in 📰 @natcomms.nature.com

➡️ https://bit.ly/4sMO85i

📌 DOI: s41467-026-70521-0

#IRBScience @milanlab.bsky.social @icreacommunity.bsky.social @cerca.cat @bist.eu @sommalliance.bsky.social @www.pcb.ub.edu 

🧪

📌 Check the full article here:

"Proteostasis failure and mitochondrial dysfunction contribute to chromosomal instability-induced microcephaly."
Amanda González-Blanco, Adrián Acuña-Higaki, David Boettger, Jery Joy, and Marco Milán
@natcomms.nature.com 2026
DOI: s41467-026-70521-0

#IRBScience

🔬 #Mitochondria identified as key player in a #RareDisease causing #microcephaly.

Published in 📰 @natcomms.nature.com

➡️ bit.ly/4sMO85i

📌 DOI: s41467-026-70521-0

#IRBScience @milanlab.bsky.social @icreacommunity.bsky.social @cerca.cat @bist.eu @sommalliance.bsky.social @www.pcb.ub.edu

🧵👇

The key to attacking “undruggable” proteins: #IRBBarcelona reveals a breakthrough drug mechanism.

📰 Science Advances

➡️ https://bit.ly/4u2xBvh

📌 DOI: 10.1126/sciadv.adz74

@xsalvatella1.bsky.social @mpi-cbg.de 

#IRBScience #NuageTx

🧪

🔬 The key to attacking “undruggable” proteins: #IRBBarcelona reveals a breakthrough drug mechanism.

📰 Published in Science Advances

➡️ bit.ly/4u2xBvh

📌 DOI: 10.1126/sciadv.adz74

@xsalvatella1.bsky.social @mpi-cbg.de

#IRBScience #NuageTx

🗣️ @ptck72.bsky.social: “Recognising protein degradation as part of kinase inhibitor mechanisms expands the possibilities for designing more effective therapies”.

#IRBScience #ProteinDegradation #TPD #DrugDiscovery
@cerca.cat @icreacommunity.bsky.social @bist.eu

Related article: "A dual TGF-β immunosuppressive barrier impedes T cell recruitment and expansion in metastatic colorectal cancer".

📰 @natgenet.nature.com

📌 doi.org/10.1038/s415...

#IRBScience #CancerResearch #ColorectalCancer #Immunotherapy

🧪

🔬 #ColorectalCancer evades #immunotherapy using a dual barrier:

A study by #IRBBarcelona & @cnag-eu.bsky.social reveals how metastatic colorectal tumours block the immune system through two complementary mechanisms.

📰 @natgenet.nature.com

➡️ bit.ly/49BJaC0

#IRBScience @batllelab.bsky.social

🧪

🧪 Out in @nature.com:  Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.

 ✍️ #IRBBarcelona & University of Washington

📌 DOI: 10.1038/s41586-025-09521-x

#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social

🧪 Out in @nature.com:  Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.

 ✍️ #IRBBarcelona & University of Washington

📌 DOI: 10.1038/s41586-025-09521-x

Video credits: 3CatInfo, Som3cat

#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.socialky.app/profile/did:plc:h4oarsknsugjli3piiechbzh" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@bbglab.bsky.social

Ferriol Calvet and Raquel Blanco (on the left), PhD students at the @bbglab.bsky.social at #IRBBarcelona, are the first authors of this study.

📝 @nature.com (2025)-DOI: 10.1038/s41586-025-09521-x

#IRBScience #CancerResearch

🧪

🧪 Out in @nature.com: Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.

✍️ #IRBBarcelona & University of Washington

➡️ bit.ly/42wcIN5

📌 DOI: 10.1038/s41586-025-09521-x

#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social

🧵👇

🔍 A fantastic session of #Descubre, led by Dr. Modesto Orozco, from the Molecular Modeling & Bioinformatics group.

🗣️Sharing #IRBscience with #IRBBarcelona's administrative & technical staff.

Thank you, Dr. Orozco 🙌

🔬An aggressive #ChildhoodCancer case opens new avenues for advanced cell therapies.

✍️ #IRBBarcelona, @cnag-eu.bsky.social, @sjdhospitalbarcelona.org

📰 Annals of Oncology

Read more here ➡️ bit.ly/40Ut5lC

📌 DOI: 10.1016/j.annonc.2025.05.530

#IRBScience

🧪

The study suggests that while current methods are useful for proposing potential molecular interactions, they are insufficient to reflect how the local microenvironment dictates actual cell-to-cell dialogue.

➡️ bit.ly/4lDSLeZ

📌 DOI: 10.1186/s13059-025-03677-5

#IRBScience

🔬 A new study by #IRBBarcelona reveals the limitations of current methods used to study cell communication.

📰 #GenomeBiology

✍️ @epareja10.bsky.social @ptck72.bsky.social

➡️ bit.ly/4kvcD2a

📌 DOI: 10.1186/s13059-025-03677-5

#IRBScience

🧪 🧵👇