#InsulinSignaling
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alicefrolov.bsky.social
New visualization: Rewiring of nutrient-sensing phospho-signaling across the murine lifespan

I am sharing a figure summarizing how phosphorylation status across the insulin/IGF1–AKT–mTORC1.

#MTORC1 #AMPK #Phosphoproteomics #InsulinSignaling #IGF1 #NutrientSensing #HepaticMetabolism
New visualization: Rewiring of nutrient-sensing phospho-signaling across the murine lifespan I am sharing a figure summarizing how phosphorylation status across the insulin/IGF1–AKT–mTORC1 and AMPK axes remodels with hepatic aging. The subtitle reads: "Relative phosphorylation of key nodes in the insulin/IGF1-AKT-mTORC1 and AMPK axes in liver, young vs old." I want to emphasize at the outset that the underlying data are simulated; the visualization is constructed to illustrate a literature-grounded trend rather than to report primary measurements. The chart is a phospho-signaling connected dot matrix: nodes are arranged on a pathway lattice with node-link edges tracing canonical directional relationships (receptor engagement, PI3K–PDK1–AKT propagation, TSC1/2 regulation of RHEB, mTORC1 substrate phosphorylation, and the AMPK inhibitory arm). Each node is segmented into paired young-versus-old glyphs, encoding relative phosphostoichiometry at defined residues (e.g., AKT pT308/pS473, TSC2 pT1462, mTOR pS2448, S6K1 pT389, 4E-BP1, AMPKα pT172, ACC pS79, ULK1 pS757). The depicted trend reflects a recurrent motif in the literature: attenuated proximal insulin/IGF1 input coupled with paradoxical sustained or elevated distal mTORC1 substrate phosphorylation in aged liver, alongside blunted AMPK pT172 responsiveness. The connected-dot topology is intended to make the directionality of this dysregulation legible, foregrounding node-specific decoupling between receptor-proximal signaling and downstream effector output rather than uniform pathway suppression. Edge weighting and glyph saturation encode effect magnitude, so viewers can distinguish nodes exhibiting the strongest young-old divergence from those that remain comparatively stable. I would welcome methodological critique on residue selection, the choice of lattice layout, and whether the segmented-node encoding adequately conveys stoichiometric versus occupancy interpretations.
September 24, 2026 at 5:02 PM
arxivlens.bsky.social
The neuropeptide neuromedin U receptor nmur-1 buffers insulin receptor signaling in bacteria-dependent C. elegans survival
Alcedo, J., Ch'ng, Q. et al.
Paper
Details
#NeuromedinUR #InsulinSignaling #C_elegansResearch
August 31, 2025 at 4:01 PM
genesdev.bsky.social
RESEARCH COMMUNICATION: Igf2 regulates early postnatal DPP4+ preadipocyte pool expansion
By Altun et. al and Siegfried Ussar
➡️ https://genesdev.cshlp.org/content/39/23-24/1414.full

#adipose #stemcells #adipogenesis #insulinsignaling #celldifferentiation #IGF
December 2, 2025 at 7:45 PM
bionewscentral.com
Study shows that specialized cells involved in #InsulinSignaling are activated in the #brain after #exercise, suggesting that #PhysicalActivity may directly improve #BrainFunction.
#OlderAdults #InsulinSensitivity #Type2Diabetes #Dementia #DementiaRisk
Exercise improves brain function, possibly reducing dementia risk – BioNews Central
Study shows that specialized cells involved in insulin signaling are activated in the brain after exercise, suggesting that physical activity may directly improve brain function. ...
sbee.link
January 24, 2025 at 7:57 PM
trndgtr.bsky.social
Folate Deficiency: DNA Damage Risk - Rhonda Patrick on DOAC

#dnadamage #insulinsignaling #folate #longevity
August 3, 2025 at 2:22 AM
alicefrolov.bsky.social
The Insulin/IGF-1 pathway = master switch between growth & longevity 🔀

↓ IIS = longer life in worms, flies, mice (20-100% extension)
↑ IIS = growth, metabolism, but accelerated aging

Key mechanisms when IIS is reduced:
✅ FOXO activation → stress resistance

#Longevity #InsulinSignaling #Aging
April 1, 2026 at 5:09 PM
shihcheng.bsky.social
Temporal phosphoproteomics reveals insulin's signaling cascade in human primary myotubes by analyzing over 1,500 phosphosites. #InsulinSignaling PMID:39939313, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56335-6
February 21, 2025 at 11:10 AM