Nature research paper: Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1
go.nature.com/4oF4v2G
go.nature.com/4oF4v2G
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 - Nature
Microglia-derived IGF1 promotes the proliferation of GABAergic progenitors and neuroblasts in the human medial ganglionic eminence, contributing to the extended production of GABAergic neurons and an expanded cognitive capacity in the human brain.
go.nature.com
August 12, 2025 at 10:36 AM
Nature research paper: Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1
go.nature.com/4oF4v2G
go.nature.com/4oF4v2G
3/ The illustration was first generated with ChatGPT, then reimagined by an artist.
IGF1+ #fibroblasts support the ILC3 lighthouse. When IGF1–IGF1R signaling is disrupted, the lighthouse sends out excessive CXCL10 signals, drawing IFNα-producing pDC “ships” into the gut and worsening #inflammation.
IGF1+ #fibroblasts support the ILC3 lighthouse. When IGF1–IGF1R signaling is disrupted, the lighthouse sends out excessive CXCL10 signals, drawing IFNα-producing pDC “ships” into the gut and worsening #inflammation.
September 24, 2026 at 6:49 PM
3/ The illustration was first generated with ChatGPT, then reimagined by an artist.
IGF1+ #fibroblasts support the ILC3 lighthouse. When IGF1–IGF1R signaling is disrupted, the lighthouse sends out excessive CXCL10 signals, drawing IFNα-producing pDC “ships” into the gut and worsening #inflammation.
IGF1+ #fibroblasts support the ILC3 lighthouse. When IGF1–IGF1R signaling is disrupted, the lighthouse sends out excessive CXCL10 signals, drawing IFNα-producing pDC “ships” into the gut and worsening #inflammation.
New visualization: Rewiring of nutrient-sensing phospho-signaling across the murine lifespan
I am sharing a figure summarizing how phosphorylation status across the insulin/IGF1–AKT–mTORC1.
#MTORC1 #AMPK #Phosphoproteomics #InsulinSignaling #IGF1 #NutrientSensing #HepaticMetabolism
I am sharing a figure summarizing how phosphorylation status across the insulin/IGF1–AKT–mTORC1.
#MTORC1 #AMPK #Phosphoproteomics #InsulinSignaling #IGF1 #NutrientSensing #HepaticMetabolism
September 24, 2026 at 5:02 PM
New visualization: Rewiring of nutrient-sensing phospho-signaling across the murine lifespan
I am sharing a figure summarizing how phosphorylation status across the insulin/IGF1–AKT–mTORC1.
#MTORC1 #AMPK #Phosphoproteomics #InsulinSignaling #IGF1 #NutrientSensing #HepaticMetabolism
I am sharing a figure summarizing how phosphorylation status across the insulin/IGF1–AKT–mTORC1.
#MTORC1 #AMPK #Phosphoproteomics #InsulinSignaling #IGF1 #NutrientSensing #HepaticMetabolism
Proud to lead this awesome team @UniversityofFloridaCOM #onestepcloser www.nature.com/articles/s41...
Placental nanoparticle-mediated IGF1 gene therapy corrects fetal growth restriction in a guinea pig model - Gene Therapy
Gene Therapy - Placental nanoparticle-mediated IGF1 gene therapy corrects fetal growth restriction in a guinea pig model
www.nature.com
December 4, 2024 at 2:30 PM
Proud to lead this awesome team @UniversityofFloridaCOM #onestepcloser www.nature.com/articles/s41...
Animal vs Plant-Based Serum
The stuff that you see in the serum after the fatty animal meal actually causes the blood vessels to stiffen, increases inflammation, increases IGF1 and activates mTOR, and has other substances that have negative physiological responses." - Dr Garth Davis
The stuff that you see in the serum after the fatty animal meal actually causes the blood vessels to stiffen, increases inflammation, increases IGF1 and activates mTOR, and has other substances that have negative physiological responses." - Dr Garth Davis
March 7, 2026 at 8:04 PM
Animal vs Plant-Based Serum
The stuff that you see in the serum after the fatty animal meal actually causes the blood vessels to stiffen, increases inflammation, increases IGF1 and activates mTOR, and has other substances that have negative physiological responses." - Dr Garth Davis
The stuff that you see in the serum after the fatty animal meal actually causes the blood vessels to stiffen, increases inflammation, increases IGF1 and activates mTOR, and has other substances that have negative physiological responses." - Dr Garth Davis
4/ Anti-IGF1R therapies have been reported to induce de novo IBD and exacerbate pre-existing IBD. These observations prompted us to investigate the role of IGF1–IGF1R signaling in intestinal inflammation.
September 24, 2026 at 6:49 PM
4/ Anti-IGF1R therapies have been reported to induce de novo IBD and exacerbate pre-existing IBD. These observations prompted us to investigate the role of IGF1–IGF1R signaling in intestinal inflammation.
Vegan diets lack...
Cholesterol
IGF1
Saturated fat
Heme iron
Heterocyclic Amines
Polycyclic Aromatic Hydrocarbons
Thank goodness, because together they cause chronic diseases in humans proven to lead to early deaths.
Cholesterol
IGF1
Saturated fat
Heme iron
Heterocyclic Amines
Polycyclic Aromatic Hydrocarbons
Thank goodness, because together they cause chronic diseases in humans proven to lead to early deaths.
July 10, 2025 at 12:11 AM
Vegan diets lack...
Cholesterol
IGF1
Saturated fat
Heme iron
Heterocyclic Amines
Polycyclic Aromatic Hydrocarbons
Thank goodness, because together they cause chronic diseases in humans proven to lead to early deaths.
Cholesterol
IGF1
Saturated fat
Heme iron
Heterocyclic Amines
Polycyclic Aromatic Hydrocarbons
Thank goodness, because together they cause chronic diseases in humans proven to lead to early deaths.
Beautiful work by Yu et al from the Xianhua Piao lab in @nature.com demonstrating that microglia-derived IGF1 regulates GABAergic neurogenesis. Very elegant combination of primary human data and hPSC-derived neuroimmune hMGE organoids. Congrats to all the authors.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 - Nature
Microglia-derived IGF1 promotes the proliferation of GABAergic progenitors and neuroblasts in the human medial ganglionic eminence, contributing to the extended production of GABAergic neurons and an ...
www.nature.com
August 15, 2025 at 3:00 PM
Beautiful work by Yu et al from the Xianhua Piao lab in @nature.com demonstrating that microglia-derived IGF1 regulates GABAergic neurogenesis. Very elegant combination of primary human data and hPSC-derived neuroimmune hMGE organoids. Congrats to all the authors.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
IGF1 modulates lesional skin inflammation in checkpoint inhibitor-induced lichen planus https://www.biorxiv.org/content/10.64898/2026.05.27.726087v1
May 29, 2026 at 6:15 AM
IGF1 modulates lesional skin inflammation in checkpoint inhibitor-induced lichen planus https://www.biorxiv.org/content/10.64898/2026.05.27.726087v1
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 - Nature
Microglia-derived IGF1 promotes the proliferation of GABAergic progenitors and neuroblasts in the human medial ganglionic eminence, contributing to the extended production of GABAergic neurons and an ...
www.nature.com
August 6, 2025 at 5:27 PM
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
IGF1 modulates lesional skin inflammation in checkpoint inhibitor-induced lichen planus #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.05.27.726087v1
https://www.biorxiv.org/content/10.64898/2026.05.27.726087v1
May 29, 2026 at 7:00 AM
IGF1 modulates lesional skin inflammation in checkpoint inhibitor-induced lichen planus #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.05.27.726087v1
https://www.biorxiv.org/content/10.64898/2026.05.27.726087v1
pregaming with ozempic and exercise while not posting any selfies and then gorging and taking IGF1 and GH secretagogues in order to execute a frame perfect three month transition speedrun
August 24, 2025 at 8:13 AM
pregaming with ozempic and exercise while not posting any selfies and then gorging and taking IGF1 and GH secretagogues in order to execute a frame perfect three month transition speedrun
And peripheral IGF1 improves gut architecture.
June 27, 2025 at 9:11 AM
And peripheral IGF1 improves gut architecture.
5/ We identified fibroblasts as the main source of intestinal IGF1 and found that IGF1R was highly expressed by ILC3s among intestinal immune cells.
September 24, 2026 at 6:49 PM
5/ We identified fibroblasts as the main source of intestinal IGF1 and found that IGF1R was highly expressed by ILC3s among intestinal immune cells.
IGF1 modulates lesional skin inflammation in checkpoint inhibitor-induced lichen planus https://www.biorxiv.org/content/10.64898/2026.05.27.726087v1
May 29, 2026 at 6:15 AM
IGF1 modulates lesional skin inflammation in checkpoint inhibitor-induced lichen planus https://www.biorxiv.org/content/10.64898/2026.05.27.726087v1
How is this shit legal? Does the disclaimer shield them from lawsuits ? onyxresearch.shop/product/igf1...
IGF1-LR3 1mg
IGF-1 LR3 1mg lyophilized peptide. Not for human use.
onyxresearch.shop
August 23, 2025 at 7:07 PM
How is this shit legal? Does the disclaimer shield them from lawsuits ? onyxresearch.shop/product/igf1...
#SpatialTranscriptomics #Visium
Human Healthy Skin Wound Healing (This is a Human Trial!🥸 N=7)
D0/1/7/30
Angiogenic niche comprising #EndothelialCell Fibroblast Mφ
Mφ secretome
D1 (inflam) IL1A/B CCL7
D7 (prolif) TGFB C1QB
D30 (remodeling) IGF1 C1QB
#CellStemCell 2024
www.cell.com/cell-stem-ce...
Human Healthy Skin Wound Healing (This is a Human Trial!🥸 N=7)
D0/1/7/30
Angiogenic niche comprising #EndothelialCell Fibroblast Mφ
Mφ secretome
D1 (inflam) IL1A/B CCL7
D7 (prolif) TGFB C1QB
D30 (remodeling) IGF1 C1QB
#CellStemCell 2024
www.cell.com/cell-stem-ce...
December 27, 2024 at 12:09 PM
#SpatialTranscriptomics #Visium
Human Healthy Skin Wound Healing (This is a Human Trial!🥸 N=7)
D0/1/7/30
Angiogenic niche comprising #EndothelialCell Fibroblast Mφ
Mφ secretome
D1 (inflam) IL1A/B CCL7
D7 (prolif) TGFB C1QB
D30 (remodeling) IGF1 C1QB
#CellStemCell 2024
www.cell.com/cell-stem-ce...
Human Healthy Skin Wound Healing (This is a Human Trial!🥸 N=7)
D0/1/7/30
Angiogenic niche comprising #EndothelialCell Fibroblast Mφ
Mφ secretome
D1 (inflam) IL1A/B CCL7
D7 (prolif) TGFB C1QB
D30 (remodeling) IGF1 C1QB
#CellStemCell 2024
www.cell.com/cell-stem-ce...
#apaperaday IGF1 themed as Alper Yavas, a PhD student who work on IGF1, its many isoforms and binding proteins, will get his PhD later today. The paper is from scientific reports by Preethy et al on the use of beta-glucan to ameliorate muscle pathology in mdx mice. DOI: 10.1038/s41598-025-92258-4
March 26, 2025 at 8:31 AM
#apaperaday IGF1 themed as Alper Yavas, a PhD student who work on IGF1, its many isoforms and binding proteins, will get his PhD later today. The paper is from scientific reports by Preethy et al on the use of beta-glucan to ameliorate muscle pathology in mdx mice. DOI: 10.1038/s41598-025-92258-4
New paper out: Kupffer cells control neonatal hepatic metabolism via Igf1 signaling.: Makdissi, Nikola; Hirschmann, Daria J; Frolov, Aleksej; et al.
Development Vol. 153, no. 2, p. dev204962 | Thanks for sharing #dzne #papers
Development Vol. 153, no. 2, p. dev204962 | Thanks for sharing #dzne #papers
Kupffer cells control neonatal hepatic metabolism via Igf1 signaling.
Makdissi, Nikola; Hirschmann, Daria J; Frolov, Aleksej; et al.
Development Vol. 153, no. 2, p. dev204962
dlvr.it
February 14, 2026 at 10:53 AM
Additive effect of ALXN2420, a GH receptor antagonist, and octreotide on IGF1 suppression in vivo by Guillaume Ravel et al
EJE Volume 192, Issue 3, March 2025
Open access paper 👉 doi.org/10.1093/ejen...
#endocrinology #acromegaly #ALXN2420
EJE Volume 192, Issue 3, March 2025
Open access paper 👉 doi.org/10.1093/ejen...
#endocrinology #acromegaly #ALXN2420
May 29, 2025 at 9:07 AM
Additive effect of ALXN2420, a GH receptor antagonist, and octreotide on IGF1 suppression in vivo by Guillaume Ravel et al
EJE Volume 192, Issue 3, March 2025
Open access paper 👉 doi.org/10.1093/ejen...
#endocrinology #acromegaly #ALXN2420
EJE Volume 192, Issue 3, March 2025
Open access paper 👉 doi.org/10.1093/ejen...
#endocrinology #acromegaly #ALXN2420
Kupffer cells control neonatal hepatic metabolism via Igf1 signaling https://www.biorxiv.org/content/10.1101/2025.02.19.638983v1
February 24, 2025 at 2:31 PM
Kupffer cells control neonatal hepatic metabolism via Igf1 signaling https://www.biorxiv.org/content/10.1101/2025.02.19.638983v1
Understanding IGF1 LR3: A Comprehensive Guide
Insulin-Like Growth Factor 1 Long R3 (IGF1 LR3) is a synthetic protein known for its potent anabolic properties. With enhanced biological effects, it is crucial in muscle growth and cellular repair research. Unlike regular IGF-1, LR3 variant resists…
Insulin-Like Growth Factor 1 Long R3 (IGF1 LR3) is a synthetic protein known for its potent anabolic properties. With enhanced biological effects, it is crucial in muscle growth and cellular repair research. Unlike regular IGF-1, LR3 variant resists…
Understanding IGF1 LR3: A Comprehensive Guide
Insulin-Like Growth Factor 1 Long R3 (IGF1 LR3) is a synthetic protein known for its potent anabolic properties. With enhanced biological effects, it is crucial in muscle growth and cellular repair research. Unlike regular IGF-1, LR3 variant resists binding to inhibitory proteins, prolonging efficacy and facilitating more effective interaction with cell receptors. This modified protein supports muscle hypertrophy, strength, and potential anti-aging properties. However, its therapeutic uses remain under rigorous scientific evaluation.
24-7.is
May 27, 2026 at 10:33 PM
Understanding IGF1 LR3: A Comprehensive Guide
Insulin-Like Growth Factor 1 Long R3 (IGF1 LR3) is a synthetic protein known for its potent anabolic properties. With enhanced biological effects, it is crucial in muscle growth and cellular repair research. Unlike regular IGF-1, LR3 variant resists…
Insulin-Like Growth Factor 1 Long R3 (IGF1 LR3) is a synthetic protein known for its potent anabolic properties. With enhanced biological effects, it is crucial in muscle growth and cellular repair research. Unlike regular IGF-1, LR3 variant resists…
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 https://www.biorxiv.org/content/10.1101/2024.10.19.619180v1
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 https://www.biorxiv.org/content/10.1101/2024.10.19.619180v1
GABAergic neurons are an essential cellular component of neural circuits. Their abundance and divers
www.biorxiv.org
October 20, 2024 at 9:15 AM
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 https://www.biorxiv.org/content/10.1101/2024.10.19.619180v1
📣 Today: #POSTER TOP-203, congrats 🥳
A rising international star is A-TANGO #YoungInvestigator Wenting Tan, UCL
👉 Recombinant insulin-like growth factor-1 #IGF1: a novel therapy for #patients with #cirrhosis + #ACLF
👉 Topic: Cirrhosis & Complications
#LiverFailure #ACLF
@rajivjalan.bsky.social
A rising international star is A-TANGO #YoungInvestigator Wenting Tan, UCL
👉 Recombinant insulin-like growth factor-1 #IGF1: a novel therapy for #patients with #cirrhosis + #ACLF
👉 Topic: Cirrhosis & Complications
#LiverFailure #ACLF
@rajivjalan.bsky.social
May 8, 2025 at 11:17 AM
📣 Today: #POSTER TOP-203, congrats 🥳
A rising international star is A-TANGO #YoungInvestigator Wenting Tan, UCL
👉 Recombinant insulin-like growth factor-1 #IGF1: a novel therapy for #patients with #cirrhosis + #ACLF
👉 Topic: Cirrhosis & Complications
#LiverFailure #ACLF
@rajivjalan.bsky.social
A rising international star is A-TANGO #YoungInvestigator Wenting Tan, UCL
👉 Recombinant insulin-like growth factor-1 #IGF1: a novel therapy for #patients with #cirrhosis + #ACLF
👉 Topic: Cirrhosis & Complications
#LiverFailure #ACLF
@rajivjalan.bsky.social
One thing that's puzzling my endocrinologist and I is the high level of IGF1 hormone I've got due to the prolactinoma. Like, I can't see any abnormal bone growth? Especially not where it counts heh heh.
October 8, 2024 at 9:03 PM
One thing that's puzzling my endocrinologist and I is the high level of IGF1 hormone I've got due to the prolactinoma. Like, I can't see any abnormal bone growth? Especially not where it counts heh heh.