8/ Beyond DSS, we found similar results in chronic colitis models. Consistent with our findings in mice, inflamed intestinal tissues from IBD patients showed fewer IGF1+ fibroblasts, higher CXCL10 expression in ILC3s, and increased pDC accumulation.
September 24, 2026 at 6:49 PM
8/ Beyond DSS, we found similar results in chronic colitis models. Consistent with our findings in mice, inflamed intestinal tissues from IBD patients showed fewer IGF1+ fibroblasts, higher CXCL10 expression in ILC3s, and increased pDC accumulation.
6/ Surprisingly, loss of IGF1R did not alter ILC3 abundance or IL-22 production. Instead, IGF1 restrained IFNγ-induced CXCL10 production by ILC3s. Deleting Cxcl10 in ILC3s rescued the worsened colitis caused by IGF1R loss, revealing an IL-22-independent mechanism.
September 24, 2026 at 6:49 PM
6/ Surprisingly, loss of IGF1R did not alter ILC3 abundance or IL-22 production. Instead, IGF1 restrained IFNγ-induced CXCL10 production by ILC3s. Deleting Cxcl10 in ILC3s rescued the worsened colitis caused by IGF1R loss, revealing an IL-22-independent mechanism.
5/ We identified fibroblasts as the main source of intestinal IGF1 and found that IGF1R was highly expressed by ILC3s among intestinal immune cells.
September 24, 2026 at 6:49 PM
5/ We identified fibroblasts as the main source of intestinal IGF1 and found that IGF1R was highly expressed by ILC3s among intestinal immune cells.
4/ Anti-IGF1R therapies have been reported to induce de novo IBD and exacerbate pre-existing IBD. These observations prompted us to investigate the role of IGF1–IGF1R signaling in intestinal inflammation.
September 24, 2026 at 6:49 PM
4/ Anti-IGF1R therapies have been reported to induce de novo IBD and exacerbate pre-existing IBD. These observations prompted us to investigate the role of IGF1–IGF1R signaling in intestinal inflammation.
3/ The illustration was first generated with ChatGPT, then reimagined by an artist.
IGF1+ #fibroblasts support the ILC3 lighthouse. When IGF1–IGF1R signaling is disrupted, the lighthouse sends out excessive CXCL10 signals, drawing IFNα-producing pDC “ships” into the gut and worsening #inflammation.
IGF1+ #fibroblasts support the ILC3 lighthouse. When IGF1–IGF1R signaling is disrupted, the lighthouse sends out excessive CXCL10 signals, drawing IFNα-producing pDC “ships” into the gut and worsening #inflammation.
September 24, 2026 at 6:49 PM
3/ The illustration was first generated with ChatGPT, then reimagined by an artist.
IGF1+ #fibroblasts support the ILC3 lighthouse. When IGF1–IGF1R signaling is disrupted, the lighthouse sends out excessive CXCL10 signals, drawing IFNα-producing pDC “ships” into the gut and worsening #inflammation.
IGF1+ #fibroblasts support the ILC3 lighthouse. When IGF1–IGF1R signaling is disrupted, the lighthouse sends out excessive CXCL10 signals, drawing IFNα-producing pDC “ships” into the gut and worsening #inflammation.
New visualization: Rewiring of nutrient-sensing phospho-signaling across the murine lifespan
I am sharing a figure summarizing how phosphorylation status across the insulin/IGF1–AKT–mTORC1.
#MTORC1 #AMPK #Phosphoproteomics #InsulinSignaling #IGF1 #NutrientSensing #HepaticMetabolism
I am sharing a figure summarizing how phosphorylation status across the insulin/IGF1–AKT–mTORC1.
#MTORC1 #AMPK #Phosphoproteomics #InsulinSignaling #IGF1 #NutrientSensing #HepaticMetabolism
September 24, 2026 at 5:02 PM
New visualization: Rewiring of nutrient-sensing phospho-signaling across the murine lifespan
I am sharing a figure summarizing how phosphorylation status across the insulin/IGF1–AKT–mTORC1.
#MTORC1 #AMPK #Phosphoproteomics #InsulinSignaling #IGF1 #NutrientSensing #HepaticMetabolism
I am sharing a figure summarizing how phosphorylation status across the insulin/IGF1–AKT–mTORC1.
#MTORC1 #AMPK #Phosphoproteomics #InsulinSignaling #IGF1 #NutrientSensing #HepaticMetabolism
Novel human neutralizing monoclonal antibodies against Pregnancy-Associated Plasma Protein A for the treatment of Autosomal Dominant Polycystic Kidney Disease
#nephsky #nephrology
www.kidney-international.org/article/S008...
#nephsky #nephrology
www.kidney-international.org/article/S008...
Novel human neutralizing monoclonal antibodies against Pregnancy-Associated Plasma Protein A for the treatment of Autosomal Dominant Polycystic Kidney Disease
Pregnancy-associated plasma protein A (PAPPA) cleaves insulin-like growth factor (IGF)
binding proteins (IGFBP) 2, 4, 5, releasing IGF1. PAPPA is overexpressed in polycystic
kidneys and its genetic el...
www.kidney-international.org
September 23, 2026 at 11:38 AM
Novel human neutralizing monoclonal antibodies against Pregnancy-Associated Plasma Protein A for the treatment of Autosomal Dominant Polycystic Kidney Disease
#nephsky #nephrology
www.kidney-international.org/article/S008...
#nephsky #nephrology
www.kidney-international.org/article/S008...
Aşırı fibronektin, integrinler ve FAK enzimi üzerinden zararlı sinyaller gönderir. Bu durum, damar sağlığını koruyan VEGF, HBEGF ve IGF1 büyüme faktörlerinin zincirini bozarak astrositler ile kan damarı hücreleri arasındaki iletişimi keser.
September 15, 2026 at 5:36 PM
Aşırı fibronektin, integrinler ve FAK enzimi üzerinden zararlı sinyaller gönderir. Bu durum, damar sağlığını koruyan VEGF, HBEGF ve IGF1 büyüme faktörlerinin zincirini bozarak astrositler ile kan damarı hücreleri arasındaki iletişimi keser.
Investigation of Stress Granule-Associated Biomarkers (IGF1 and CDK2) and Their Regulatory Mechanisms in Alzheimer’s Disease: A Combined Transcriptomic, Bioinformatic and Experimental Study #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-10579672/latest
https://www.researchsquare.com/article/rs-10579672/latest
September 10, 2026 at 4:03 PM
Investigation of Stress Granule-Associated Biomarkers (IGF1 and CDK2) and Their Regulatory Mechanisms in Alzheimer’s Disease: A Combined Transcriptomic, Bioinformatic and Experimental Study #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-10579672/latest
https://www.researchsquare.com/article/rs-10579672/latest
Il y a 6 ans : Les coureurs du Tour de France 2020 sont tous dopés, au moins à l'insu de leur plein gré www.cyclisme-dopage.com/actualite/20... #cyclisme #dopage #médecins #argon #TDF2020 #EPO #Quartz #salbutamol #IGF1
Les coureurs du Tour de France 2020 sont tous dop�s, au moins � l'insu de leur plein gr�
A Nice, les m�decins d'�quipes sont l�, mais pas pour le conoravirus. Ce sont des m�decins de la performance. Ils pr�parent les athl�tes selon des r�sultats d'analyses allant jusqu'� plus de 30…
www.cyclisme-dopage.com
September 8, 2026 at 2:58 PM
Il y a 6 ans : Les coureurs du Tour de France 2020 sont tous dopés, au moins à l'insu de leur plein gré www.cyclisme-dopage.com/actualite/20... #cyclisme #dopage #médecins #argon #TDF2020 #EPO #Quartz #salbutamol #IGF1
Constitutive PDGFRb activation drives connective tissue overgrowth through STAT5-IGF1 signaling https://www.biorxiv.org/content/10.64898/2026.08.27.747555v1
August 29, 2026 at 3:36 PM
Constitutive PDGFRb activation drives connective tissue overgrowth through STAT5-IGF1 signaling https://www.biorxiv.org/content/10.64898/2026.08.27.747555v1
Constitutive PDGFRb activation drives connective tissue overgrowth through STAT5-IGF1 signaling https://www.biorxiv.org/content/10.64898/2026.08.27.747555v1
August 29, 2026 at 3:36 PM
Constitutive PDGFRb activation drives connective tissue overgrowth through STAT5-IGF1 signaling https://www.biorxiv.org/content/10.64898/2026.08.27.747555v1
🧫 Hormones such as insulin and insulin-like growth factors do far more than regulate blood sugar.
Through closely related receptors, they help coordinate metabolism, growth, development, neuronal survival, and repair... 🧵
#IOCB #IOCBPrague #insulin #IGF1 #neuroprotection #metabolism
Through closely related receptors, they help coordinate metabolism, growth, development, neuronal survival, and repair... 🧵
#IOCB #IOCBPrague #insulin #IGF1 #neuroprotection #metabolism
August 26, 2026 at 6:13 PM
🧫 Hormones such as insulin and insulin-like growth factors do far more than regulate blood sugar.
Through closely related receptors, they help coordinate metabolism, growth, development, neuronal survival, and repair... 🧵
#IOCB #IOCBPrague #insulin #IGF1 #neuroprotection #metabolism
Through closely related receptors, they help coordinate metabolism, growth, development, neuronal survival, and repair... 🧵
#IOCB #IOCBPrague #insulin #IGF1 #neuroprotection #metabolism
Il y a 17 ans : Avec le Repoxygen, premier exemple de dopage génétique www.cyclisme-dopage.com/dossierdefon... #cyclisme #dopage #Repoxygen #DopageGénétique #EPO #Hormone #IGF1
Avec le Repoxygen, premier exemple de dopage g�n�tique
Tout a commenc� en janvier 2006 au cours du proc�s de l'ancien entra�neur est-allemand Thomas Springstein. Les enqu�teurs ont alors r�v�l� avoir trouv� � son domicile la trace d'un courriel o� l'on…
www.cyclisme-dopage.com
August 25, 2026 at 3:08 PM
Il y a 17 ans : Avec le Repoxygen, premier exemple de dopage génétique www.cyclisme-dopage.com/dossierdefon... #cyclisme #dopage #Repoxygen #DopageGénétique #EPO #Hormone #IGF1
The study also found that insulin-like growth factors (IGF1 and IGF2) work alongside insulin to regulate placental function, trophoblast invasion, and nutrient transport.
August 25, 2026 at 2:07 PM
The study also found that insulin-like growth factors (IGF1 and IGF2) work alongside insulin to regulate placental function, trophoblast invasion, and nutrient transport.
Targeted modulation of IGFBP5/IGF1, THPO, and P38 MAPK signaling are potent therapeutic strategies generalizable for mitochondrial respiratory chain disease and osteosarcoma https://www.biorxiv.org/content/10.64898/2026.07.20.739625v1
July 22, 2026 at 8:38 AM
Targeted modulation of IGFBP5/IGF1, THPO, and P38 MAPK signaling are potent therapeutic strategies generalizable for mitochondrial respiratory chain disease and osteosarcoma https://www.biorxiv.org/content/10.64898/2026.07.20.739625v1
Targeted modulation of IGFBP5/IGF1, THPO, and P38 MAPK signaling are potent therapeutic strategies generalizable for mitochondrial respiratory chain disease and osteosarcoma https://www.biorxiv.org/content/10.64898/2026.07.20.739625v1
July 22, 2026 at 8:38 AM
Targeted modulation of IGFBP5/IGF1, THPO, and P38 MAPK signaling are potent therapeutic strategies generalizable for mitochondrial respiratory chain disease and osteosarcoma https://www.biorxiv.org/content/10.64898/2026.07.20.739625v1
İnme geçirmiş insanlardan alınan beyin dokularını da inceleyen ekip, insanlardaki karşılığı olan ZNF384 geninin yükselmesiyle onarıcı faktörlerin, IGF1, azaldığını teyit ettiler.
July 13, 2026 at 12:05 PM
İnme geçirmiş insanlardan alınan beyin dokularını da inceleyen ekip, insanlardaki karşılığı olan ZNF384 geninin yükselmesiyle onarıcı faktörlerin, IGF1, azaldığını teyit ettiler.
Araştırmacılar, beynin yerleşik bağışıklık hücreleri olan mikrogliaların, hasarın ardından büyüme faktörleri, IGF1 gibi, salgılayarak sinirleri onardığını ancak zamanla beyinde artan ZFP384 adlı bir transkripsiyon faktörünün bu iyileşme genlerini bloke ettiğini tespit ettiler.
July 13, 2026 at 12:03 PM
Araştırmacılar, beynin yerleşik bağışıklık hücreleri olan mikrogliaların, hasarın ardından büyüme faktörleri, IGF1 gibi, salgılayarak sinirleri onardığını ancak zamanla beyinde artan ZFP384 adlı bir transkripsiyon faktörünün bu iyileşme genlerini bloke ettiğini tespit ettiler.
