#IntrinsicallyDisorderedProteins
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sarahrauscher.bsky.social
New preprint from our lab!

Generating Structural Ensembles of Disordered Proteins with Diffusion Models

Preprint: doi.org/10.64898/202...
Code: github.com/rauscher-lab...

#MachineLearning #MolecularDynamics #ComputationalBiophysics #IntrinsicallyDisorderedProteins
October 7, 2026 at 11:02 PM
aureliaball.bsky.social
Check out our paper on how phosphorylation affects the RNA Pol II CTD in the latest issue of Biophysical Journal in Honor of Martin Karplus! @biophysj.bsky.social @weichen2.bsky.social
#OPENACCESS #undergradinthelab #compchem #intrinsicallydisorderedproteins
www.cell.com/biophysj/ful...
RNA polymerase II CTD Ser5 phosphorylation induces competing effects of expansion and compaction
The carboxy-terminal domain (CTD) of RNA polymerase II, composed of tandem heptad repeats with the consensus sequence YSPTSPS, orchestrates the transcription cycle through a dynamic series of posttran...
www.cell.com
August 18, 2026 at 4:40 PM
cp-trendsbiochem.bsky.social
Keep up with the series: www.cell.com/trends/bioch...

#TIBS50 #TIBSCelebrates50 #SLiMs #IntrinsicallyDisorderedProteins #ProteinScience #StructuralBiology
June 24, 2026 at 1:11 PM
aureliaball.bsky.social
Check out my student's posters at the Biophysical Society meeting! Sunday: B110, B111, on the RNA CTD domain, Monday: B112, B114, B115 on ArkA-SH3 binding and B116 on HIV Vif-APOBEC interactions, Tuesday: LB15 on ArkA-SH3 also. #BPS2026 #undergradinthelab #compchem #intrinsicallydisorderedproteins
February 21, 2026 at 6:41 PM
ichikawa-lab.bsky.social
#KANK1 #LC8 #IntrinsicallyDisorderedProteins #AlphaFold #EM
ichikawa-lab.bsky.social Yoshi Ichikawa @ichikawa-lab.bsky.social · Jan 7
New collaborative preprint!
A striking result: a disordered linker in KANK1 binds as many as 15 LC8 dimers, forming a protein rod that bridges cell membranes and microtubules!
www.biorxiv.org/content/10.1...
Disordered linker of Kank1 forms rigid protein rod upon binding to 15 LC8 molecules and bridge the gap between membrane and microtubule.
January 8, 2026 at 3:07 PM
maciejgielnik.bsky.social
Attended #BenzonSymposium no. 69 in Copenhagen 🇩🇰 and presented my poster: De novo engineering of functional #IntrinsicallyDisorderedProteins #IDPs 🧪✨

Great insights on protein design, structure prediction & ML in #ProteinScience 🤖🔬

#ProteinDesign #Research
September 8, 2025 at 1:42 PM
cp-trendsbiochem.bsky.social
Online now - the Spotlight "Sensitivity to #chirality correlates in a continuum with protein disorder" from Lucia Alvarez and Lucia @chemeslab.bsky.social.

#IntrinsicallyDisorderedProteins #IDPs #steroselectivity

authors.elsevier.com/a/1l18y3S6Gf...
May 9, 2025 at 1:31 PM
csbj.org
🧠 How do prediction models perform in recognizing disordered regions with specific binding functions?

🔗 Evaluation of predictions of disordered binding regions in the CAID2 experiment. DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#CAID2 #LigandBinding #IntrinsicallyDisorderedProteins #AI
Evaluation of predictions of disordered binding regions in the CAID2 experiment. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.12.009
April 20, 2025 at 2:30 PM
proseandpassion.mastodon.social.ap.brid.gy
6-Mar-2025
A new algorithm sheds light on ‘disordered’ #proteins

The #intrinsicallydisorderedproteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly change their conformation, making #structureprediction particularly challenging. These proteins although exhibit […]
Original post on mastodon.social
mastodon.social
March 6, 2025 at 4:31 PM
brukercorporation.bsky.social
A recent publication in ChemBioChem details how researchers from Italy used NMR spectroscopy to detect proline residues in Intrinsically Disordered Proteins (IDP): goto.bruker.com/40IYWq2

@chemistryeurope.bsky.social

#NMR #Pharma #Pharmaceutical #PharmaIndustry #IntrinsicallyDisorderedProteins
Sequence-Specific Assignments for Intrinsically Disordered Proteins
A recent publication in ChemBioChem details how researchers from Italy used NMR spectroscopy to detect proline residues in IDPs. Their NMR spectra were acquired on a Bruker AVANCE NEO spectrometer.
goto.bruker.com
January 22, 2025 at 12:05 PM
idw-online.de
Reliable analysis of #IntrinsicallyDisorderedProteins: Researchers of #MainzUniversity and EMBL Hamburg present new approach to determine form of disordered proteins by using two different methods simultaneously in a single sample https://press...
weiterlesen
Examining an intrinsically disordered protein: "Re" is the end-to-end distance or height, "Rg" is the radius of gyration or overall size. - Copyright ill./©: Miao Yu
January 20, 2025 at 12:32 PM
mainzuniversity.bsky.social
Reliable analysis of #IntrinsicallyDisorderedProteins: Researchers of #MainzUniversity and @embl.org Hamburg present new approach to determine the form of disordered proteins by using two different methods simultaneously in a single sample 👉 press.uni-mainz.de/reliable-ana... @imbmainz.bsky.social
Artistic illustration of a researcher examining an intrinsically disordered protein
January 20, 2025 at 12:06 PM
mainzuniversity.bsky.social
#IntrinsicallyDisorderedProteins in the center of the pore of the nuclear envelope can form spaghetti-like barrier permeable for cellular factors but blocking viruses and pathogens https://press.uni-mainz.de/how-wiggly-spaghetti-guard-the-genome/ #biophysics @LemkeLab @imbmainz...
December 12, 2024 at 12:17 PM