In Lupus nephritis patients, neutrophils have increased surface LAMP1, which is externalized after activation. Soluble LAMP1 is increased both in the blood and urine of patients, correlating with histological activity. #NephSky 🧪
Our paper in @eurjimmunol.bsky.social
doi.org/10.1002/eji....
Our paper in @eurjimmunol.bsky.social
doi.org/10.1002/eji....
August 7, 2025 at 4:49 PM
In Lupus nephritis patients, neutrophils have increased surface LAMP1, which is externalized after activation. Soluble LAMP1 is increased both in the blood and urine of patients, correlating with histological activity. #NephSky 🧪
Our paper in @eurjimmunol.bsky.social
doi.org/10.1002/eji....
Our paper in @eurjimmunol.bsky.social
doi.org/10.1002/eji....
Reem Abouward, Giampietro Schiavo & team find that LAMP1 and LAMP2A localise to distinct axonal organelles with differential transport dynamics, but share overlapping total protein compositions.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
February 17, 2026 at 10:31 AM
Reem Abouward, Giampietro Schiavo & team find that LAMP1 and LAMP2A localise to distinct axonal organelles with differential transport dynamics, but share overlapping total protein compositions.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Fast and efficient lysosome clustering in patient-derived metastatic melanoma cells (Black= LAMP1, Magenta= LifeActin). Spinning disk imaging @PIC-STRA.
#fluorescencefriday #livecellimaging #lysosomes
Read more here:
rdcu.be/eg6k3
#fluorescencefriday #livecellimaging #lysosomes
Read more here:
rdcu.be/eg6k3
April 11, 2025 at 11:52 AM
Fast and efficient lysosome clustering in patient-derived metastatic melanoma cells (Black= LAMP1, Magenta= LifeActin). Spinning disk imaging @PIC-STRA.
#fluorescencefriday #livecellimaging #lysosomes
Read more here:
rdcu.be/eg6k3
#fluorescencefriday #livecellimaging #lysosomes
Read more here:
rdcu.be/eg6k3
youtu.be/BR8Ad5hMU3U?...
New art video every day at 11am est
#anwahart #traditionalart #artist #houseworkarchives #art
New art video every day at 11am est
#anwahart #traditionalart #artist #houseworkarchives #art
Capsouls Lamp1 S3 EP107
YouTube video by Anwah
youtu.be
September 23, 2026 at 3:15 PM
youtu.be/BR8Ad5hMU3U?...
New art video every day at 11am est
#anwahart #traditionalart #artist #houseworkarchives #art
New art video every day at 11am est
#anwahart #traditionalart #artist #houseworkarchives #art
Mitochondria meet lysosomes 🔬
Fibroblasts: Mic60 (STAR RED), LAMP1 (STAR ORANGE), DAPI
Imaged by Fabian Link @ Fraunhofer ITMP Göttingen.
#Microscopy #CellBiology #STARdyes
Fibroblasts: Mic60 (STAR RED), LAMP1 (STAR ORANGE), DAPI
Imaged by Fabian Link @ Fraunhofer ITMP Göttingen.
#Microscopy #CellBiology #STARdyes
October 1, 2026 at 11:15 AM
Mitochondria meet lysosomes 🔬
Fibroblasts: Mic60 (STAR RED), LAMP1 (STAR ORANGE), DAPI
Imaged by Fabian Link @ Fraunhofer ITMP Göttingen.
#Microscopy #CellBiology #STARdyes
Fibroblasts: Mic60 (STAR RED), LAMP1 (STAR ORANGE), DAPI
Imaged by Fabian Link @ Fraunhofer ITMP Göttingen.
#Microscopy #CellBiology #STARdyes
Chouhan, Phogat et al. of the Mahak Sharma lab report that the small GTP-binding protein Arl8b recruits the Rab11a GAP, TBC1D9B, to inactivate Rab11a-mediated recycling of newly synthesized LAMP1 and mediate its efficient sorting to #lysosomes. rupress.org/jcb/article/...
May 21, 2026 at 6:00 PM
Chouhan, Phogat et al. of the Mahak Sharma lab report that the small GTP-binding protein Arl8b recruits the Rab11a GAP, TBC1D9B, to inactivate Rab11a-mediated recycling of newly synthesized LAMP1 and mediate its efficient sorting to #lysosomes. rupress.org/jcb/article/...
Arl8b inactivates the Rab11a recycling pathway to promote LAMP1 sorting and lysosome biogenesis rupress.org/jcb/article/...
Arl8b inactivates the Rab11a recycling pathway to promote LAMP1 sorting and lysosome biogenesis
Lysosomal cargo sorting from the early endosomes should involve mechanisms that prevent their recycling to the plasma membrane. Here, Chouhan P and Phogat
rupress.org
May 22, 2026 at 2:12 PM
Arl8b inactivates the Rab11a recycling pathway to promote LAMP1 sorting and lysosome biogenesis rupress.org/jcb/article/...
Second preprint casting doubt on glycoRNA.
“we further demonstrate that recombinant soluble LAMP1 can be purified following the glycoRNA isolation method… thus representing a considerable source of glycans in samples of glycoRNA”
Still waiting for a journal publication of either preprint.
“we further demonstrate that recombinant soluble LAMP1 can be purified following the glycoRNA isolation method… thus representing a considerable source of glycans in samples of glycoRNA”
Still waiting for a journal publication of either preprint.
March 18, 2025 at 7:04 AM
Second preprint casting doubt on glycoRNA.
“we further demonstrate that recombinant soluble LAMP1 can be purified following the glycoRNA isolation method… thus representing a considerable source of glycans in samples of glycoRNA”
Still waiting for a journal publication of either preprint.
“we further demonstrate that recombinant soluble LAMP1 can be purified following the glycoRNA isolation method… thus representing a considerable source of glycans in samples of glycoRNA”
Still waiting for a journal publication of either preprint.
Issue 3 is complete
Explore our ToC: journals.biologists.com/jcs/issue/13...
On the cover: hiPSC-derived neurons labelled with TUJ1 (blue), LAMP1 (green) & LAMP2 (red). The image highlights the heterogeneity of the neuronal endolysosomal system.
journals.biologists.com/jcs/article/...
Explore our ToC: journals.biologists.com/jcs/issue/13...
On the cover: hiPSC-derived neurons labelled with TUJ1 (blue), LAMP1 (green) & LAMP2 (red). The image highlights the heterogeneity of the neuronal endolysosomal system.
journals.biologists.com/jcs/article/...
February 26, 2026 at 11:12 AM
Issue 3 is complete
Explore our ToC: journals.biologists.com/jcs/issue/13...
On the cover: hiPSC-derived neurons labelled with TUJ1 (blue), LAMP1 (green) & LAMP2 (red). The image highlights the heterogeneity of the neuronal endolysosomal system.
journals.biologists.com/jcs/article/...
Explore our ToC: journals.biologists.com/jcs/issue/13...
On the cover: hiPSC-derived neurons labelled with TUJ1 (blue), LAMP1 (green) & LAMP2 (red). The image highlights the heterogeneity of the neuronal endolysosomal system.
journals.biologists.com/jcs/article/...
Excited to share our latest study " #Rab11a recycling pathway to promote #LAMP1 sorting and #lysosome biogenesis" published in @jcb.org doi.org/10.1083/jcb....
Grateful to the mentors Dr. Amit Tuli and Dr. Mahak Sharma
for their guidance. I would like to thank Yogita and all the co-authors.
Grateful to the mentors Dr. Amit Tuli and Dr. Mahak Sharma
for their guidance. I would like to thank Yogita and all the co-authors.
Arl8b inactivates the Rab11a recycling pathway to promote LAMP1 sorting and lysosome biogenesis
Lysosomal cargo sorting from the early endosomes should involve mechanisms that prevent their recycling to the plasma membrane. Here, Chouhan P and Phogat
doi.org
May 24, 2026 at 7:10 AM
Excited to share our latest study " #Rab11a recycling pathway to promote #LAMP1 sorting and #lysosome biogenesis" published in @jcb.org doi.org/10.1083/jcb....
Grateful to the mentors Dr. Amit Tuli and Dr. Mahak Sharma
for their guidance. I would like to thank Yogita and all the co-authors.
Grateful to the mentors Dr. Amit Tuli and Dr. Mahak Sharma
for their guidance. I would like to thank Yogita and all the co-authors.
Arl8b inactivates the Rab11a recycling pathway to promote LAMP1 sorting and #lysosome biogenesis. New study from Priya Chouhan (@priyachouhan.bsky.social ), Yogita Phogat, Amit Tuli, Mahak Sharma and colleagues (Indian Institute of Science Education and Research Mohali):
rupress.org/jcb/article/...
rupress.org/jcb/article/...
May 28, 2026 at 2:30 PM
Arl8b inactivates the Rab11a recycling pathway to promote LAMP1 sorting and #lysosome biogenesis. New study from Priya Chouhan (@priyachouhan.bsky.social ), Yogita Phogat, Amit Tuli, Mahak Sharma and colleagues (Indian Institute of Science Education and Research Mohali):
rupress.org/jcb/article/...
rupress.org/jcb/article/...
🌟 It's #FluorescenceFriday and we are proud to share an image we produced using #AploScope: U2OS cells with two #SMLM channels - mitochondrial #Tomm20 in yellow and lysosomal #LAMP1 in red, and two diffraction-limited channels, tubulin in cyan and the plasma membrane (CellMask™ Green) in gray.🔬
January 17, 2025 at 3:34 PM
🌟 It's #FluorescenceFriday and we are proud to share an image we produced using #AploScope: U2OS cells with two #SMLM channels - mitochondrial #Tomm20 in yellow and lysosomal #LAMP1 in red, and two diffraction-limited channels, tubulin in cyan and the plasma membrane (CellMask™ Green) in gray.🔬
Thanks to Yanwei Su from @volkerhaucke-lab.bsky.social, we have a new scientific image of the month: When morphology gets romantic 🫶- this is a U2OS cell overexpressing Sec61b (ER), stained with LAMP1 (lysosome) and DAPI (nuclei), to test lysosome–ER membrane contact sites.
August 12, 2025 at 3:00 PM
Thanks to Yanwei Su from @volkerhaucke-lab.bsky.social, we have a new scientific image of the month: When morphology gets romantic 🫶- this is a U2OS cell overexpressing Sec61b (ER), stained with LAMP1 (lysosome) and DAPI (nuclei), to test lysosome–ER membrane contact sites.
LAMP1 and LAMP2A localise to axonal organelles with distinct motility dynamics and partially overlapping molecular signatures in human neurons url: journals.biologists.com/jcs/article/...
LAMP1 and LAMP2A localise to axonal organelles with distinct motility dynamics and partially overlapping molecular signatures in human neurons
LAMP1 and LAMP2A are abundant proteins of late endosomal/lysosomal compartments that are often used interchangeably to label what is assumed to be the same organelle population, potentially obscuring ...
journals.biologists.com
January 19, 2026 at 3:34 PM
LAMP1 and LAMP2A localise to axonal organelles with distinct motility dynamics and partially overlapping molecular signatures in human neurons url: journals.biologists.com/jcs/article/...
Journal Club Time📰: A new publication from Aging Cell identified LAMP1 as a surface biomarker of senescent cells. LAMP1⁺ cells increased with age and in mouse models of Idiopathic Pulmonary Fibrosis. Use of a dual‐antibody-drug conjugate system selectively eliminated LAMP1⁺ senescent cells in vitro.
Cell‐Surface LAMP1 is a Senescence Marker in Aging and Idiopathic Pulmonary Fibrosis
We have validated the selective upregulation of LAMP1 in SEN in culture, and the percentage of Lamp1+ cells increases in various tissues with age, as well as in fibrotic lungs following BLM instillat...
onlinelibrary.wiley.com
November 24, 2025 at 9:34 AM
Journal Club Time📰: A new publication from Aging Cell identified LAMP1 as a surface biomarker of senescent cells. LAMP1⁺ cells increased with age and in mouse models of Idiopathic Pulmonary Fibrosis. Use of a dual‐antibody-drug conjugate system selectively eliminated LAMP1⁺ senescent cells in vitro.
Die Steckdose als Lichtobjekt: Mit der AVOLT Lamp 1 wird aus einem funktionalen Detail ein atmosphärischer Akzent. 100 LEDs, satiniertes Glas, dimmbares Warmweiß und skandinavisches Design – ganz ohne Installation. #AVOLT #Lamp1 #LightingDesign #InteriorDesign the-luxury-home.guide/avolt-lamp-1...
AVOLT Lamp 1 – Skandinavisches Lichtdesign für die Steckdose | the LUXURY HOME guide
Mit der AVOLT Lamp 1 wird die Wandsteckdose selbst zur Lichtquelle – eine ebenso einfache wie elegante Idee für stimmungsvolle Akzente in anspruchsvoll gestalteten Innenräumen.
the-luxury-home.guide
October 1, 2026 at 10:07 AM
Die Steckdose als Lichtobjekt: Mit der AVOLT Lamp 1 wird aus einem funktionalen Detail ein atmosphärischer Akzent. 100 LEDs, satiniertes Glas, dimmbares Warmweiß und skandinavisches Design – ganz ohne Installation. #AVOLT #Lamp1 #LightingDesign #InteriorDesign the-luxury-home.guide/avolt-lamp-1...
Thanks! That's LAMP1 marker...
February 8, 2025 at 8:36 PM
Thanks! That's LAMP1 marker...
𝗜𝗻𝘁𝗿𝗼𝗱𝘂𝗰𝗶𝗻𝗴 𝗼𝘂𝗿 𝗺𝗼𝘀𝘁 𝘃𝗲𝗿𝘀𝗮𝘁𝗶𝗹𝗲 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗺𝘂𝗹𝘁𝗶𝗽𝗹𝗲𝘅𝗶𝗻𝗴 𝗸𝗶𝘁 𝘆𝗲𝘁! MASSIVE-sdAB-FAST 1 - 6-Plex kits enable users to create a 𝗰𝘂𝘀𝘁𝗼𝗺𝗶𝘇𝗲𝗱 𝗸𝗶𝘁 𝗳𝗼𝗿 𝟭 – 𝟲 𝘁𝗮𝗿𝗴𝗲𝘁 𝗶𝗺𝗮𝗴𝗶𝗻𝗴!
#DNAPAINT #SuperResolution #Microscopy #MassivePhotonics #PreMixing #SMLM
#DNAPAINT #SuperResolution #Microscopy #MassivePhotonics #PreMixing #SMLM
June 27, 2025 at 8:24 AM
𝗜𝗻𝘁𝗿𝗼𝗱𝘂𝗰𝗶𝗻𝗴 𝗼𝘂𝗿 𝗺𝗼𝘀𝘁 𝘃𝗲𝗿𝘀𝗮𝘁𝗶𝗹𝗲 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗺𝘂𝗹𝘁𝗶𝗽𝗹𝗲𝘅𝗶𝗻𝗴 𝗸𝗶𝘁 𝘆𝗲𝘁! MASSIVE-sdAB-FAST 1 - 6-Plex kits enable users to create a 𝗰𝘂𝘀𝘁𝗼𝗺𝗶𝘇𝗲𝗱 𝗸𝗶𝘁 𝗳𝗼𝗿 𝟭 – 𝟲 𝘁𝗮𝗿𝗴𝗲𝘁 𝗶𝗺𝗮𝗴𝗶𝗻𝗴!
#DNAPAINT #SuperResolution #Microscopy #MassivePhotonics #PreMixing #SMLM
#DNAPAINT #SuperResolution #Microscopy #MassivePhotonics #PreMixing #SMLM
My project at @i-med.ac.at focused on lysosomal proteins which show an uneven distribution between perinuclear and peripheral pools (www.biorxiv.org/content/10.6...)
Here's one identified perinuclear lysosomal protein, EPDR1-mCherry (magenta), expressed in U2OS cells alongside LAMP1 (green).
Here's one identified perinuclear lysosomal protein, EPDR1-mCherry (magenta), expressed in U2OS cells alongside LAMP1 (green).
June 17, 2026 at 10:50 AM
My project at @i-med.ac.at focused on lysosomal proteins which show an uneven distribution between perinuclear and peripheral pools (www.biorxiv.org/content/10.6...)
Here's one identified perinuclear lysosomal protein, EPDR1-mCherry (magenta), expressed in U2OS cells alongside LAMP1 (green).
Here's one identified perinuclear lysosomal protein, EPDR1-mCherry (magenta), expressed in U2OS cells alongside LAMP1 (green).
lamp1 western blot/ imaging??
January 27, 2025 at 1:51 PM
lamp1 western blot/ imaging??
It's #FluorescenceFriday and we are happy to share a 5-color image taken with the #AploScope. Here we have a #SuperResolution #SMLM (#SingleMolecule Localization #Microscopy) image of the mitochondrial protein #Tomm20 in yellow, and the following diffraction-limited targets:
March 21, 2025 at 10:52 AM
It's #FluorescenceFriday and we are happy to share a 5-color image taken with the #AploScope. Here we have a #SuperResolution #SMLM (#SingleMolecule Localization #Microscopy) image of the mitochondrial protein #Tomm20 in yellow, and the following diffraction-limited targets:
Nearly all of these proteins are known to be glycosylated and/or possess RNA-binding properties. One particularly intriguing hit was LAMP1, which we used as a model to explore glycoprotein co-purification. (6/9)
March 19, 2025 at 10:43 AM
Nearly all of these proteins are known to be glycosylated and/or possess RNA-binding properties. One particularly intriguing hit was LAMP1, which we used as a model to explore glycoprotein co-purification. (6/9)
RNA-seq flagged the lysosomal pathway as the top OM-89-induced signature. Imaging and experiments confirmed it: expanded Rab7+/Lamp1+ compartments, lower intraorganellar pH, more cathepsin L activity, and UPEC enriched near protease-active autolysosomes.
September 26, 2026 at 7:27 AM
RNA-seq flagged the lysosomal pathway as the top OM-89-induced signature. Imaging and experiments confirmed it: expanded Rab7+/Lamp1+ compartments, lower intraorganellar pH, more cathepsin L activity, and UPEC enriched near protease-active autolysosomes.
Thanks 🫶, this is Lamp1 staining
April 21, 2025 at 7:35 PM
Thanks 🫶, this is Lamp1 staining