Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These invol...

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Tai et al. employed mouse models of skin injury to demonstrate that injury-induced panniculitis stimulates hair regeneration by promoting adipocyte lipolysis via macrophage-adipocyte interactions. Thi...

The hypothalamus is a central regulator of glucose and energy homeostasis, with arcuate nucleus (ARC) neurons orchestrating these processes. Agouti-related peptide (AgRP) and pro-opiomelanocortin (POM...

Nature Metabolism, Published online: 08 January 2026; doi:10.1038/s42255-025-01426-3When the brain detects ongoing fuel depletion, sympathetic nervous system outflow to white adipose tissue induces lipolysis to mobilize fuel. Yet there exists a subset of ‘stable adipocytes’ that resist lipolysis via this mechanism. The discovery of a novel lipolysis mechanism reshapes our understanding of how body energy requirements are met in times of need.

Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These invol...

Nature Metabolism, Published online: 08 January 2026; doi:10.1038/s42255-025-01424-5Stable adipocytes resist lipolysis in healthy states but are highly susceptible to a catecholamine-independent, neurosystemic pathway-driven catabolic state.

Stable adipocytes resist lipolysis in healthy states but are highly susceptible to a catecholamine-independent, neurosystemic pathway-driven catabolic state.

Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

Following skin injury, macrophages infiltrate the adipose tissue, promoting adipocyte lipolysis, and the released fatty acids induce hair regrowth by activating hair follicle stem cells.

Adrenergic stimulation of brown adipocytes induces a robust detachment of mitochondria from lipid droplets (LD), which is followed by lipolysis and lipid catabolism. However, the signals inducing mito...

Nature Metabolism, Published online: 15 April 2025; doi:10.1038/s42255-025-01264-3Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These invol...