#MIDKINE
🎉 Our review on how adult neural stem cells are kept quiescent in the zebrafish telencephalon is finally out in GLIA! We summarize established mechanisms and propose an integrative hypothesis.

doi.org/10.1002/glia...

#Zebrafish #NeuralStemCells #Neuroscience
Molecular Control of Neural Stem Cell Quiescence in the Adult Zebrafish Telencephalon: Established Mechanisms and an Integrative Hypothesis
Adult zebrafish radial glia quiescence is controlled by at least four mechanisms: Notch3, BMP-Id1, Nr2f1b and Midkine-a. We propose these act as partially redundant inputs, biased along the anter...
doi.org
October 6, 2026 at 2:19 PM
In damaged pig hearts, transplanted cardiovascular progenitor cells switched on genes for heart-muscle function and reduced scar-related gene activity. They also produced Midkine, which promoted blood-vessel development. doi.org/hcj9r8
Gene map reveals how transplanted stem cells repair damaged heart muscle
Researchers led by Assistant Professor Lynn Yap of the Lee Kong Chian School of Medicine at Nanyang Technological University, Singapore, have uncovered new insights into how unspecialized cells, also known as stem cells, develop and mature into heart muscle cells.
medicalxpress.com
September 21, 2026 at 5:00 PM
Context-Dependent Effects of Midkine on Plexiform Neurofibroma Growth and Drug Response in 3D Coculture Models
Context-Dependent Effects of Midkine on Plexiform Neurofibroma Growth and Drug Response in 3D Coculture Models
News update via NF Bot
doi.org
September 13, 2026 at 4:06 PM
Scientists at St. Jude Children’s Research Hospital have discovered that the protein midkine can prevent the toxic clumping of amyloid beta, a key driver of Alzheimer’s disease. www.goodnewsnetwork.org/tiny-protein...
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease
Scientists at St. Jude Children’s Research Hospital have demonstrated for the first time that the protein midkine plays a preventative role in Alzheimer’s disease. Midkine is known to accumulate in Al...
www.goodnewsnetwork.org
September 10, 2025 at 11:52 AM
Midkine Dependency Defines a Therapeutically Actionable Vulnerability in Medulloblastoma #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.04.11.717918v1
April 15, 2026 at 7:01 AM
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease - Good News Network www.goodnewsnetwork.org/tiny-protein...
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease
Scientists at St. Jude Children’s Research Hospital have demonstrated for the first time that the protein midkine plays a preventative role in Alzheimer’s disease. Midkine is known to accumulate in Al...
www.goodnewsnetwork.org
September 8, 2025 at 10:37 PM
Researchers led by @msmelanoma.bsky.social from 🇪🇸 @cniostopcancer.bsky.social discovered a key mechanism by which #melanomas and other aggressive #tumours prevent the #immune system from detecting and attacking them – one of the greatest challenges in #oncology today.
How midkine helps tumours evade immunotherapy
Cutaneous melanoma, the most aggressive form of skin cancer, is characterised by its accumulation of a large number of mutations.
dlvr.it
April 5, 2025 at 6:31 AM
And it's not just melanoma! Midkine has been implicated in metastasis for other cancers too, like breast cancer, lung cancer, colorectal cancer, and hepatocellular carcinoma. This work, therefore, has broader implications beyond just melanoma! #CancerResearch #MetastasisPrevention
June 18, 2025 at 6:36 AM
This study reveals the growth factor Midkine (MDK) triggers a potent autocrine mechanism that deactivates NR2F1-dependent dormancy in DCCs, favoring metastatic outgrowth. This means MDK essentially "wakes up" dormant melanoma cells! #MIDKINE #NR2F1 #DDCs
June 18, 2025 at 6:36 AM
So excited and proud to be a co-author on our new preprint: "Midkine inhibits dormancy of disseminated melanoma cells." Huge congrats to Carolina Rodriguez-Tirado & Maria Soledad Sosa for leading this fantastic work! 🎉 #MelanomaResearch #CancerDormancy #Midkine
June 18, 2025 at 6:36 AM
Midkine is known to accumulate in Alzheimer’s patients, but rather than accelerate the disease, it seems to prevent a second, sticky protein from clumping together—the chief hallmark in this form of dementia.

www.goodnewsnetwork.org/tiny-protein...
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease
Scientists at St. Jude Children’s Research Hospital have demonstrated for the first time that the protein midkine plays a preventative role in Alzheimer’s disease. Midkine is known to accumulate in Al...
www.goodnewsnetwork.org
September 10, 2025 at 11:52 PM
🏹Las células de melanoma producen una proteína, llamada Midkine, que convierte al sistema inmunitario en su aliado.

Trabajo dirigido por Marisol Soengas @msmelanoma.bsky.social, con Xavier Catena como primer autor, en 'Nature Cancer' @natureportfolio.nature.com

➡️bit.ly/3Y5BPEa 👇🏻
April 22, 2026 at 3:13 PM
These findings add new information to previous studies by the CNIO Melanoma Group, which had already shown that the Midkine protein can promote melanoma metastasis and alter the function of other components of the immune system.

https://bit.ly/426Pufj
March 28, 2025 at 3:48 PM