#NR2F1
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jcellsci.bsky.social
In their Review, Ishani Sharma and Partha Roy examine the cell-intrinsic, niche-specific and #immune controls that govern #cancer dormancy transitions, and the strategies aimed at blocking relapse.
journals.biologists.com/jcs/article/...
Figure showing regulation of dormancy emergence of DTCs in the lung microenvironment. On arrival in the lung, DTCs lodge in the alveolar and perivascular niches. Dormancy is enforced by several converging cues. These include contact with AT1 lung epithelium (which promotes survival and restrains growth), anti-proliferative action of vascular endothelium-derived TSP-1, sequestration of tumor-derived ECM remodeling enzymes (e.g. LOXL2) by endothelial PEAR1, and activation of a NAS1-driven NR2F1-based dormancy transcriptional program by stromal cell-derived BMP. NR2F1 mediates suppression of ΔNp63, the pro-proliferative isoform of p63 (TP63). Reactivation (indicated by the proliferation marker Ki67) occurs when tumor cells interact with AT2 epithelium (which provides pro-proliferative signals). Additional reactivation cues include tumor-derived factors tenascin-C and Coco (which antagonizes BMP to release the dormancy brake via integrin-dependent FAK signaling; phosphorylated FAK is indicated as pFAK), sprouting angiogenesis (which supplies TGF-β1 and periostin), and activation of integrin-dependent ERK–MLCK signaling triggered by alterations in the ECM (e.g. fibrotic ECM and/or remodeling of laminin by NET-derived proteases like MMP9). Together, these opposing endothelial, epithelial, stromal and matrix inputs determine whether DTCs remain dormant or undergo metastatic outgrowth in the lung. Created in BioRender by Sharma, I., 2026. https://BioRender.com/j23rlwk. This figure was sublicensed under CC-BY 4.0 terms.
September 29, 2026 at 9:12 AM
prepub-singlecell.bsky.social
An NR2F1-dependent retinoic acid network controls retinal specialization in mice and reveals foveal hypoplasia in patients with BBSOAS #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.22.753406v1
September 23, 2026 at 10:00 AM
biorxiv-devbio.bsky.social
An NR2F1-dependent retinoic acid network controls retinal specialization in mice and reveals foveal hypoplasia in patients with BBSOAS https://www.biorxiv.org/content/10.64898/2026.09.22.753406v1
September 23, 2026 at 8:33 AM
biorxivpreprint.bsky.social
An NR2F1-dependent retinoic acid network controls retinal specialization in mice and reveals foveal hypoplasia in patients with BBSOAS https://www.biorxiv.org/content/10.64898/2026.09.22.753406v1
September 23, 2026 at 8:33 AM
jcellsci.bsky.social
Also in Issue 17:
- Research Highlights on asymmetric cell division and clathrin-mediated endocytosis
- Review on the cell biology of cancer dormancy
- Plus, four ‘First person’ interviews
journals.biologists.com/jcs/issue/13...
Figure showing regulation of dormancy emergence of DTCs in the lung microenvironment. On arrival in the lung, DTCs lodge in the alveolar and perivascular niches. Dormancy is enforced by several converging cues. These include contact with AT1 lung epithelium (which promotes survival and restrains growth), anti-proliferative action of vascular endothelium-derived TSP-1, sequestration of tumor-derived ECM remodeling enzymes (e.g. LOXL2) by endothelial PEAR1, and activation of a NAS1-driven NR2F1-based dormancy transcriptional program by stromal cell-derived BMP. NR2F1 mediates suppression of ΔNp63, the pro-proliferative isoform of p63 (TP63). Reactivation (indicated by the proliferation marker Ki67) occurs when tumor cells interact with AT2 epithelium (which provides pro-proliferative signals). Additional reactivation cues include tumor-derived factors tenascin-C and Coco (which antagonizes BMP to release the dormancy brake via integrin-dependent FAK signaling; phosphorylated FAK is indicated as pFAK), sprouting angiogenesis (which supplies TGF-β1 and periostin), and activation of integrin-dependent ERK–MLCK signaling triggered by alterations in the ECM (e.g. fibrotic ECM and/or remodeling of laminin by NET-derived proteases like MMP9). Together, these opposing endothelial, epithelial, stromal and matrix inputs determine whether DTCs remain dormant or undergo metastatic outgrowth in the lung. Created in BioRender by Sharma, I., 2026. https://BioRender.com/j23rlwk. This figure was sublicensed under CC-BY 4.0 terms.
September 22, 2026 at 11:39 AM
abbsjournal.bsky.social
✨USP11-mediated deubiquitination regulates the protein stability of NR2F1
www.sciengine.com/ABBS/doi/10....
#USP11
#deubiquitinase
#NR2F1
#tumor_dormancy
#ubiquitination
September 15, 2026 at 4:06 AM
abbsjournal.bsky.social
USP11-mediated deubiquitination regulates the protein stability of NR2F1
www.sciengine.com/ABBS/doi/10....
September 7, 2026 at 7:44 AM
abbsjournal.bsky.social
🎊USP11-mediated deubiquitination regulates the protein stability of NR2F1
www.sciengine.com/ABBS/doi/10....

#USP11
#deubiquitinase
#NR2F1
#tumor_dormancy
#ubiquitination
September 7, 2026 at 7:41 AM
abbsjournal.bsky.social
🌈USP11-mediated deubiquitination regulates the protein stability of NR2F1
www.sciengine.com/ABBS/doi/10....
#USP11
#deubiquitinase
#NR2F1
#tumor dormancy
#ubiquitination
September 2, 2026 at 3:43 AM
olmeda-lab.bsky.social
Crucially, we found that combining an NR2F1 agonist with an MDK inhibitor could be a potential therapeutic strategy to prolong the dormancy phase of melanoma DCCs, preventing metastasis formation! Big implications for future treatments. #Science #CancerTreatment
June 18, 2025 at 6:36 AM
olmeda-lab.bsky.social
This study reveals the growth factor Midkine (MDK) triggers a potent autocrine mechanism that deactivates NR2F1-dependent dormancy in DCCs, favoring metastatic outgrowth. This means MDK essentially "wakes up" dormant melanoma cells! #MIDKINE #NR2F1 #DDCs
June 18, 2025 at 6:36 AM
olmeda-lab.bsky.social
Why is this important? Melanoma recurrence often comes from dormant cancer cells (DCCs) "waking up" to form metastases, sometime years after primary tumor was removed. We've known NR2F1 drives dormancy , but how DCCs reactivate has been puzzling. #Dormancy
June 18, 2025 at 6:36 AM
annikadbs.bsky.social
I am so glad that I was given the opportunity to contribute to this great paper during my time in Italy!

doi.org/10.1242/bio....
SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus
Summary: The transcriptional regulators SOX2 and NR2F1 drive the development of the visual thalamus. Mutations in these genes cause visual impairment in humans.
doi.org
August 18, 2025 at 6:07 PM
uniquecharity.bsky.social
Our BBSOAS Guide is Now Available in Spanish! 🇪🇸✨

Thank you to Dr. Álvaro López, HGU Santa Lucía, Cartagena for his incredible support in translating these vital resources! Find the guide here: bit.ly/SíndromeBBSOAS

#BBSOAS #GenéticaRara #NR2F1 #ConcienciaciónGenética
April 1, 2025 at 10:06 AM
rridrobot.bsky.social
RRIDs were included in this in bioRxiv paper. Thanks for making your methods matter! #OpenScience #RRID #accelerateopenscience
Cycling persister clones with elevated NR2F1-mediated cholesterol biosynthesis cause chemotherapy resistance
Read the full paper: Cycling persister clones with elevated NR2F1-mediated cholesterol biosynthesis cause chemotherapy resistance
doi.org
June 17, 2026 at 7:01 AM
rridrobot.bsky.social
@thermofishersci.bsky.social's resource, RRID:AB_2576217, was just reported to be used in the paper. Thanks for making your methods matter! #methodsmatter #BetterScience #ReproducibleResearch
Generation of BBSOAS patient-specific induced pluripotent stem cell lines harboring six NR2F1 pathogenic variants
Read the full paper: Generation of BBSOAS patient-specific induced pluripotent stem cell lines harboring six NR2F1 pathogenic variants
doi.org
March 25, 2026 at 7:01 AM
rridrobot.bsky.social
A paper using RRID:AB_528084 from @dshb-antibodies.bsky.social was just published. Thanks for making your methods matter! #ReproducibleResearch #accelerateopenscience #methodsmatter
Cranial neural crest shortage leads to extensive craniofacial anomalies in mice mutant for the NR2F1/2 nuclear receptors
doi.org
January 6, 2026 at 8:00 AM
rridrobot.bsky.social
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #methodsmatter #reproducibility #accelerateopenscience
Transcriptional activation of MACF1 by NR2F1 drives WNT-mediated focal adhesion and metastasis in lung adenocarcinoma
doi.org
November 27, 2025 at 8:02 AM
rridrobot.bsky.social
RRIDs were included in this Communications Biology paper. RRIDs improve reproducibility in scientific research. #OpenScience #accelerateopenscience #RRID
Unravelling the conundrum of nucleolar NR2F1 localization using antibody-based approaches in vitro and in vivo
doi.org
May 25, 2025 at 7:01 AM
btbsunimib.bsky.social
SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus. The publication was realized by colleagues at #BtBsUNIMIB together with other authors. #BtBsPub journals.biologists.com/bio/article/...
SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus
Summary: The transcriptional regulators SOX2 and NR2F1 drive the development of the visual thalamus. Mutations in these genes cause visual impairment in humans.
journals.biologists.com
October 29, 2025 at 4:10 PM
transpread.bsky.social
The findings, published on January 28, 2025, in Genes & Diseases, reveal that NR2F1 promotes fibrosis by directly activating the STAT3 signaling pathway.
#JAK1/STAT3 pathway #Apoptosis
Details: doi.org/10.1016/j.ge...
July 29, 2025 at 12:54 PM
longtail-news.bsky.social
Feed: "The Brighter Side of News"
By: Mac Oliveau and Joseph Shavit on Sunday, March 22, 2026
Why do many patients develop scarring after cataract surgery?
New research reveals how NR2F1 triggers lens scarring and cataracts, opening the door to non-surgical treatments.
www.thebrighterside.news
March 23, 2026 at 8:36 AM
haoyin.bsky.social
#FGF9 ➡️Mechanosensitive Osteocyte-to-Osteoblast/Osteoclast signaling in Maxillary Bone formation

#CyclicStretch ➡️⏬FGF9 in MC3T3 preosteoblasts (😆)

FGF9⏫ in underdeveloped🧍‍♂️Maxilla

FGF9 ⏬osteogenesis &⏫osteoclastogenesis
ATF4/5/6 NR2F1

#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
September 10, 2025 at 6:54 PM
hefanmiao.bsky.social
Remarkable! looks like NR2F1/2 play too many roles in head…
January 27, 2026 at 10:26 AM
michaelokun.bsky.social
A new gene locus for Tourette on GWAS? 'This large study group identified a genome-wide significant locus on chromosome 5q15. Integration of eQTL, Hi-C and GWAS data implicated the NR2F1 gene and associated lncRNAs within the 5q15 locus.'...
December 1, 2024 at 4:24 AM