Targeted Mutagenesis Reveals Noncanonical Genetic Requirements for Carbon Monoxide Oxidation enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/... #jcampubs
Targeted Mutagenesis Reveals Noncanonical Genetic Requirements for Carbon Monoxide Oxidation
Using targeted mutagenesis, this study shows that form II CODH does not contribute to CO oxidation in the model carboxydovore Paraburkholderia terrae COX and reveals that canonical maturation pathway...
enviromicro-journals.onlinelibrary.wiley.com
November 3, 2026 at 4:06 PM
Targeted Mutagenesis Reveals Noncanonical Genetic Requirements for Carbon Monoxide Oxidation enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/... #jcampubs
Now online! CRISPR mutagenesis of the MYC locus reveals a druggable ultraconserved RNA element
CRISPR mutagenesis of the MYC locus reveals a druggable ultraconserved RNA element
CRISPR tiling mutagenesis of the 10-kb human MYC locus mapped the fitness landscape of an entire human gene at base-pair resolution. This unbiased interrogation revealed that 67% of functionally essential base pairs are noncoding. An ultraconserved RNA regulatory element was identified that controls MYC localization and can be therapeutically targeted to suppress cancer cell growth in patient-derived tumor organoids.
dlvr.it
November 4, 2026 at 3:59 PM
Now online! CRISPR mutagenesis of the MYC locus reveals a druggable ultraconserved RNA element
Targeted Mutagenesis Reveals Noncanonical Genetic Requirements for Carbon Monoxide Oxidation - Dawson - 2026 - Environmental Microbiology - Wiley Online Library
Targeted Mutagenesis Reveals Noncanonical Genetic Requirements for Carbon Monoxide Oxidation
Using targeted mutagenesis, this study shows that form II CODH does not contribute to CO oxidation in the model carboxydovore Paraburkholderia terrae COX and reveals that canonical maturation pathway...
enviromicro-journals.onlinelibrary.wiley.com
November 3, 2026 at 10:50 AM
Targeted Mutagenesis Reveals Noncanonical Genetic Requirements for Carbon Monoxide Oxidation - Dawson - 2026 - Environmental Microbiology - Wiley Online Library
Excited to share that our MYC mutagenesis paper is now online at Cell @cp-cell.bsky.social! Free access link through Dec 24 authors.elsevier.com/a/1o316L7PXy.... Special thanks to our handling editor Dr. Jude Nicholson and the reviewers for their support and feedback throughout the process!
November 4, 2026 at 5:04 PM
Excited to share that our MYC mutagenesis paper is now online at Cell @cp-cell.bsky.social! Free access link through Dec 24 authors.elsevier.com/a/1o316L7PXy.... Special thanks to our handling editor Dr. Jude Nicholson and the reviewers for their support and feedback throughout the process!
🧬New today!
📄Deep #CRISPR mutagenesis predicts cancer risk in Li-Fraumeni syndrome
📄Deep #CRISPR mutagenesis predicts cancer risk in Li-Fraumeni syndrome
Deep CRISPR mutagenesis predicts cancer risk in Li-Fraumeni syndrome
TP53 encodes for the transcription factor TP53, which controls the expression of genes
involved in cell cycle, apoptosis, senescence, stem cell differentiation, metabolism,
and DNA repair.1 ∼50% of al...
www.cell.com
November 2, 2026 at 5:40 PM
🧬New today!
📄Deep #CRISPR mutagenesis predicts cancer risk in Li-Fraumeni syndrome
📄Deep #CRISPR mutagenesis predicts cancer risk in Li-Fraumeni syndrome
Targeted Mutagenesis Reveals Noncanonical Genetic Requirements for Carbon Monoxide Oxidation.
Targeted Mutagenesis Reveals Noncanonical Genetic Requirements for Carbon Monoxide Oxidation.
Published in Environmental microbiology
doi.org
November 3, 2026 at 8:00 AM
Targeted Mutagenesis Reveals Noncanonical Genetic Requirements for Carbon Monoxide Oxidation.
Is there mutagenesis?
November 1, 2026 at 2:00 PM
Is there mutagenesis?
Charlotte Auerbach, «madre de la mutagénesis química»
Charlotte Auerbach, «madre de la mutagénesis química» - Mujeres con ciencia
Charlotte Auerbach. Mutagénesis química. Material genético. Agente tóxico. Madre de la mutagénesis química. Gas mostaza. Biomedicina.
mujeresconciencia.com
October 28, 2026 at 2:31 PM
Charlotte Auerbach, «madre de la mutagénesis química»
RRID:AB_228302 from @thermofishersci.bsky.social was used by authors in their Cell Reports paper. Thanks for making your methods matter! #accelerateopenscience #RRID #BetterScience
Heterogeneous contributions of APOBEC3 deaminases to substitution and indel mutagenesis in lung adenocarcinoma
Read the full paper: Heterogeneous contributions of APOBEC3 deaminases to substitution and indel mutagenesis in lung adenocarcinoma
doi.org
November 4, 2026 at 8:00 AM
RRID:AB_228302 from @thermofishersci.bsky.social was used by authors in their Cell Reports paper. Thanks for making your methods matter! #accelerateopenscience #RRID #BetterScience
Struggling with Q5® site-directed mutagenesis PCR? Primer design, template quality, annealing temperature, and reaction conditions can all make or break your experiment. Here's a practical troubleshooting guide to help scientists identify common pitfalls and improve PCR success. 🧬
November 3, 2026 at 1:30 AM
Struggling with Q5® site-directed mutagenesis PCR? Primer design, template quality, annealing temperature, and reaction conditions can all make or break your experiment. Here's a practical troubleshooting guide to help scientists identify common pitfalls and improve PCR success. 🧬
DMF, DCM, NMP, HBTU. Solid phase peptide synthesis is no fucking joke, and if even a few parts per million of those organic solvents carry over to the DP, people are going to get acute toxicity and long term mutagenesis.
November 2, 2026 at 3:10 PM
DMF, DCM, NMP, HBTU. Solid phase peptide synthesis is no fucking joke, and if even a few parts per million of those organic solvents carry over to the DP, people are going to get acute toxicity and long term mutagenesis.
New CRISPR prime editing targets histone H3, allowing precise changes to Lys sites. PMID:42420522, Nat Genet 2026, @NatureGenet @OTSociety @NAR_Open https://doi.org/10.1038/s41588-026-02675-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing | Nature Genetics
Histone post-translational modifications are fundamental to genome regulation, yet dissecting the functions of individual histone marks in mammals remains challenging due to the presence of multiple histone gene copies. Here we develop a high-throughput clustered regularly interspaced short palindromic repeats (CRISPR) prime editing platform enabling precise, reversible and combinatorial mutagenesis of canonical and noncanonical histone H3 genes within their native genomic context. Using systematic lysine-to-arginine substitutions benchmarked against synonymous controls, we identify key residues, including H3K4, H3K9, H3K14, H3K18 and H3K79, whose mutation compromises fitness in mouse embryonic stem cells. We further show that H3K56, linked to genome stability in yeast and Drosophila, has a conserved role in mammalian cells. Through analysis of selected double mutants, we uncover functional crosstalk across residues, with combinations such as H3K27R + H3K36R impairing stem cell self-re
doi.org
November 4, 2026 at 1:00 AM
Mutagenesis to cover up engineering evidence - it's not new, you also have to remember: these are the same idiots like Peter Thiel who believe in their Transhumanist Immortality Bullshit that won't work - because they themselves don't even have a functional mind to transfer.
November 1, 2026 at 4:25 PM
Mutagenesis to cover up engineering evidence - it's not new, you also have to remember: these are the same idiots like Peter Thiel who believe in their Transhumanist Immortality Bullshit that won't work - because they themselves don't even have a functional mind to transfer.
Genomic Correlates of APOBEC-Associated Mutagenesis in Esophageal Squamous Cell Carcinoma https://www.biorxiv.org/content/10.64898/2026.10.27.762354v1
November 1, 2026 at 2:33 AM
Genomic Correlates of APOBEC-Associated Mutagenesis in Esophageal Squamous Cell Carcinoma https://www.biorxiv.org/content/10.64898/2026.10.27.762354v1
Genomic Correlates of APOBEC-Associated Mutagenesis in Esophageal Squamous Cell Carcinoma https://www.biorxiv.org/content/10.64898/2026.10.27.762354v1
November 1, 2026 at 2:33 AM
Genomic Correlates of APOBEC-Associated Mutagenesis in Esophageal Squamous Cell Carcinoma https://www.biorxiv.org/content/10.64898/2026.10.27.762354v1
modalities, reducing latency for 1 MB track predictions. Supports concurrent multi-variant evaluation for in silico saturation mutagenesis ( score_ism_variants ) without HTTP gateway timeouts. Supports model fold selection ( ALL_FOLDS, FOLD_0, FOLD_1, FOLD_2, and FOLD_3 )
November 5, 2026 at 12:20 AM
modalities, reducing latency for 1 MB track predictions. Supports concurrent multi-variant evaluation for in silico saturation mutagenesis ( score_ism_variants ) without HTTP gateway timeouts. Supports model fold selection ( ALL_FOLDS, FOLD_0, FOLD_1, FOLD_2, and FOLD_3 )
🎓 Congratulations to Noé Seija on successfully defending his PhD thesis entitled: “Epigenetic and transcriptional determinants of AID mutagenesis in B cells” 👏
He was supervised by Dr. Javier Di Noia, Director of the Molecular biology of the B cell Research Unit.
He was supervised by Dr. Javier Di Noia, Director of the Molecular biology of the B cell Research Unit.
November 3, 2026 at 5:27 PM
🎓 Congratulations to Noé Seija on successfully defending his PhD thesis entitled: “Epigenetic and transcriptional determinants of AID mutagenesis in B cells” 👏
He was supervised by Dr. Javier Di Noia, Director of the Molecular biology of the B cell Research Unit.
He was supervised by Dr. Javier Di Noia, Director of the Molecular biology of the B cell Research Unit.
Deep scanning mutagenesis of membrane-bound rhodopsin reveals precise design of rhodopsin for light detection and demonstrates an unbiased screening technique applicable to personalized medicine. doi.org/10.1073/pnas...
Deep mutational scanning of the GPCR rhodopsin reveals pleiotropic mutational effects and their roles in modulating receptor signaling | PNAS
Biophysical pleiotropy, the phenomenon in which a mutation affects multiple protein
properties, underlies many genetic diseases and shapes protein ...
doi.org
November 2, 2026 at 4:29 PM
Deep scanning mutagenesis of membrane-bound rhodopsin reveals precise design of rhodopsin for light detection and demonstrates an unbiased screening technique applicable to personalized medicine. doi.org/10.1073/pnas...
A study reveals that prion-based switches in DNA repair proteins enhance mutagenesis in S. cerevisiae, enabling rapid evolution under selective pressure. PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5
No description available
www.cell.com
October 30, 2026 at 8:00 AM
Excited to share our new paper on error-prone DNA polymerase Pol η! Pol η preferentially contributes to lagging strand synthesis and late-replicating regions. Its usage pattern is also linked to mutagenesis in cancer genomes. Great work by Lewis Bainbridge and teams!
rdcu.be/uRWTMpCG6wba
rdcu.be/uRWTMpCG6wba
October 29, 2026 at 6:50 AM
Excited to share our new paper on error-prone DNA polymerase Pol η! Pol η preferentially contributes to lagging strand synthesis and late-replicating regions. Its usage pattern is also linked to mutagenesis in cancer genomes. Great work by Lewis Bainbridge and teams!
rdcu.be/uRWTMpCG6wba
rdcu.be/uRWTMpCG6wba
“To explore the potential for new genetic pathways or components in glomerular development, we generated a transcriptome of… larval pronephric glomeruli and conducted a CRISPR-Cas9 G0 mutagenesis screen [which] identified eight potential new causes of proteinuria…”
New from Drummond Lab @mdibl.org
New from Drummond Lab @mdibl.org
Novel regulators of zebrafish glomerular development https://www.biorxiv.org/content/10.64898/2026.10.27.762292v1
October 30, 2026 at 6:43 PM
“To explore the potential for new genetic pathways or components in glomerular development, we generated a transcriptome of… larval pronephric glomeruli and conducted a CRISPR-Cas9 G0 mutagenesis screen [which] identified eight potential new causes of proteinuria…”
New from Drummond Lab @mdibl.org
New from Drummond Lab @mdibl.org
Charlotte Auerbach, «madre de la mutagénesis química»
Charlotte Auerbach, «madre de la mutagénesis química» - Mujeres con ciencia
Charlotte Auerbach. Mutagénesis química. Material genético. Agente tóxico. Madre de la mutagénesis química. Gas mostaza. Biomedicina.
mujeresconciencia.com
October 28, 2026 at 2:31 PM
Charlotte Auerbach, «madre de la mutagénesis química»