🆕️🔥 #CPK
Drug–Drug Interaction Management with the Novel Anti-Cytomegalovirus Agents Letermovir & Maribavir: Guidance for Clinicians #idsky
✨️tables✨️ #bookmark
link.springer.com/article/10.1...
🆕️🔥 #CPK
Drug–Drug Interaction Management with the Novel Anti-Cytomegalovirus Agents Letermovir & Maribavir: Guidance for Clinicians #idsky
✨️tables✨️ #bookmark
link.springer.com/article/10.1...
Maribavir shows high real-world effectiveness and good tolerability for CMV in HCT.
⚠️ But resistance, relapse, and data gaps remain
👉 Likely role beyond current indications—needs clearer positioning
Maribavir shows high real-world effectiveness and good tolerability for CMV in HCT.
⚠️ But resistance, relapse, and data gaps remain
👉 Likely role beyond current indications—needs clearer positioning
📊 Mostly used as 2nd/3rd line for CMV
⚠️ Common triggers: refractory infection, cytopenias, renal impairment
🧬 High-risk population: frequent GvHD, varied prophylaxis strategies
🔁 Majority received a single MBV course
📊 Mostly used as 2nd/3rd line for CMV
⚠️ Common triggers: refractory infection, cytopenias, renal impairment
🧬 High-risk population: frequent GvHD, varied prophylaxis strategies
🔁 Majority received a single MBV course
📌 Primary: CMV resolution at 12 weeks after starting maribavir
📊 Secondary: discontinuation, OS & NRM
⚠️ Failure = viremia progression, rebound, CMV disease, or toxicity
Clear definitions → clearer real-world interpretation of MBV effectiveness 🧬
📌 Primary: CMV resolution at 12 weeks after starting maribavir
📊 Secondary: discontinuation, OS & NRM
⚠️ Failure = viremia progression, rebound, CMV disease, or toxicity
Clear definitions → clearer real-world interpretation of MBV effectiveness 🧬
📊 ~81% response in PET courses
⚠️ ~17% failure; small proportion with progression/rebound
🧬 Used across complex CMV disease, including end-organ involvement
Promising effectiveness in high-risk patients, but failure& rebound remain key challenges
📊 ~81% response in PET courses
⚠️ ~17% failure; small proportion with progression/rebound
🧬 Used across complex CMV disease, including end-organ involvement
Promising effectiveness in high-risk patients, but failure& rebound remain key challenges
🆕️🔥 #CPK
Drug–Drug Interaction Management with the Novel Anti-Cytomegalovirus Agents Letermovir & Maribavir: Guidance for Clinicians #idsky
✨️tables✨️ #bookmark
link.springer.com/article/10.1...
Comparison of on-treatment antiviral resistance rates betw MBV (10%; median 35 d) vs (Val)GCV (2.5%; median 90 days) for CMV infection in HSCT
Treatment response rate was 69.6% (MBV) and 77.4% (V/GCV)
academic.oup.com/jid/article/...
Comparison of on-treatment antiviral resistance rates betw MBV (10%; median 35 d) vs (Val)GCV (2.5%; median 90 days) for CMV infection in HSCT
Treatment response rate was 69.6% (MBV) and 77.4% (V/GCV)
academic.oup.com/jid/article/...
💊 Oral UL97 inhibitor for R/R CMV post-transplant (EMA approved)
✅ Favorable toxicity profile
⚠️ Resistance in ~7–10%
📉 Still limited real-world data
An important option—but gaps remain in how it performs outside trials 🧬
💊 Oral UL97 inhibitor for R/R CMV post-transplant (EMA approved)
✅ Favorable toxicity profile
⚠️ Resistance in ~7–10%
📉 Still limited real-world data
An important option—but gaps remain in how it performs outside trials 🧬
Maribavir for clinically significant cytomegalovirus infection in haematopoietic cell transplant recipients in Europe: a real-world multicentre retrospective registry study
www.thelancet.com/journals/lan...
Maribavir for clinically significant cytomegalovirus infection in haematopoietic cell transplant recipients in Europe: a real-world multicentre retrospective registry study
www.thelancet.com/journals/lan...
pubmed.ncbi.nlm.nih.gov/23449792/
pubmed.ncbi.nlm.nih.gov/23449792/
« …A further review by the expert panel shortlisted four drugs (famciclovir, tenofovir alafenamide, maribavir and spironolactone) deemed to have the best balance of efficacy, safety and tolerability for use in MS…. »
"Repurposing Licensed Drugs with Activity Against Epstein-Barr Virus for Treatment of Multiple Sclerosis: A Systematic Approach" pubmed.ncbi.nlm.nih.gov/39792343/
« …A further review by the expert panel shortlisted four drugs (famciclovir, tenofovir alafenamide, maribavir and spironolactone) deemed to have the best balance of efficacy, safety and tolerability for use in MS…. »
20 April, 1:30pm, Hall A3-1
#ESCMIDGlobal2026
20 April, 1:30pm, Hall A3-1
#ESCMIDGlobal2026
pubmed.ncbi.nlm.nih.gov/39792343/
"expert panel shortlisted four drugs (famciclovir, tenofovir alafenamide, maribavir and spironolactone) ... for use in MS."
pubmed.ncbi.nlm.nih.gov/39792343/
"expert panel shortlisted four drugs (famciclovir, tenofovir alafenamide, maribavir and spironolactone) ... for use in MS."
Looking for a trusted source of Maribavir API for antiviral pharmaceutical formulation development, cytomegalovirus (CMV) pharmaceutical research, transplant medicine formulations, pharmaceutical process development, analytical pharmaceutica
Looking for a trusted source of Maribavir API for antiviral pharmaceutical formulation development, cytomegalovirus (CMV) pharmaceutical research, transplant medicine formulations, pharmaceutical process development, analytical pharmaceutica
#TransplantSky #IDSky #MedSky
#TransplantSky #IDSky #MedSky
💊 Maribavir for Refractory CMV in SOT
Spotify: open.spotify.com/episode/6xgn...
Apple Podcast: podcasts.apple.com/us/podcast/0...
YouTube: youtu.be/3LhGnw2mEcY
💊 Maribavir for Refractory CMV in SOT
Spotify: open.spotify.com/episode/6xgn...
Apple Podcast: podcasts.apple.com/us/podcast/0...
YouTube: youtu.be/3LhGnw2mEcY
🆓https://doi.org/10.53855/bjt.v28i1.711_ENG
@scielo.org #BJT #transplant
🆓https://doi.org/10.53855/bjt.v28i1.711_ENG
@scielo.org #BJT #transplant
Jonathan C Tsui et al. Retin Cases Brief Rep. 2024
I have a patient on this for different end organ disease. Takeda fairly easy to work with, May have better safety profile than the rest
Jonathan C Tsui et al. Retin Cases Brief Rep. 2024
I have a patient on this for different end organ disease. Takeda fairly easy to work with, May have better safety profile than the rest
Make your own at meducationai.com
Make your own at meducationai.com