Kawa zamiast śniadania, a potem batonik? Dietetycy grzmią, że trzeba zjeść odżywcze śniadanie, żeby mieć energię i nie podjadać między posiłkami. Dzięki regularnym posiłkom i jedzeniu śniadań metaboli...

Mechanisms by which primary tumor cells acquire metastatic capability through metabolic and signaling adaptations are currently poorly understood. We demonstrate that tumor-intrinsic ceramide metaboli...

Mechanisms by which primary tumor cells acquire metastatic capability through metabolic and signaling adaptations are currently poorly understood. We demonstrate that tumor-intrinsic ceramide metaboli...

Metabolic acidosis is common in critically ill patients and is associated with organ dysfunction and death. Sodium bicarbonate is used to correct acidemia, but its benefit in patients with metaboli...

AbstractAs legislative regulations on traditional plasticizers have been tightened globally, diisononyl cyclohexane-1,2-dicarboxylate (DINCH) gains widespread use owing to its environmental safety claims. Nevertheless, the emerging toxicological evidence raises concerns about its health and ecological risks. In soil earthworms, the dynamic bioaccumulation, biotransformation, and tissue-specific distribution of DINCH were first characterized using mass spectrometry imaging, and the major metabolites of monoisononyl cyclohexane-1,2-dicarboxylate (MINCH) and hydroxylated derivatives were primarily distributed in the earthworm coelom. Noticeably, the multilevel toxicological responses including growth inhibition, tissue damage, and oxidative stress were shown with a cascade of physiological and biochemical perturbations, particularly in endocrine and metabolic homeostasis. Disruption of peroxisome proliferator-activated receptor (PPARγ) signaling with downstream lipid biosynthesis and endocrine-metabolic homeostasis was further confirmed via integration of transcriptomics and metabolomics, while PPARγ was prioritized as a candidate biomarker for apparent exposure. Due to the stronger binding interactions of MINCH by in vitro/in silico studies, a metabolite-mediated mechanism whereby MINCH may mimic endogenous fatty acid-like ligands to regulate PPARγ was rationalized for lipid metabolism and endocrine disturbances. These findings provide early warnings of the ecological relevance and potential risks of DINCH to soil ecosystems and underscore the essentiality of incorporating bioactive metabolites into full environmental risk assessments.

Metabolic syndrome (MetS) is a cluster of metabolic abnormalities including central obesity, hypertension, dyslipidemia, and impaired glucose metaboli…

Gjumia ka rol të rëndësishëm në kontrollin e peshës trupore, sipas një hulumtimi të cituar nga Ekonomia Online. Shkencëtarët vërejtën se njerëzit që shtojnë orët e gjumit përballë me rutininë e tyre zakonisht humbasin peshë. Kjo ndodh sepse gjumia shtesë redukton dëshirën dhe konrimin e sheqerit. Në anën tjetër, fjetja më pak se të nevojshme lidhet me rritjen e peshës. Studimi përfshoi një grup të rriturish që u vënë të flinin më shumë orë se zakonisht, duke tregoi ndryshime pozitive në metabolizëm. **Burimet:** Ekonomia Online (klaster 1 outlets).

The hyphae-to-yeast morphological transition promotes dissemination of the pathogen Candida albicans, but the mechanisms underlying this process are poorly defined. By identifying a bacterial metaboli...

The hyphae-to-yeast morphological transition promotes dissemination of the pathogen Candida albicans, but the mechanisms underlying this process are poorly defined. By identifying a bacterial metaboli...

The hyphae-to-yeast morphological transition promotes dissemination of the pathogen Candida albicans, but the mechanisms underlying this process are poorly defined. By identifying a bacterial metaboli...

Plastics that can metabolize in oceans are highly sought for a sustainable future. In this work, we report the noncovalent synthesis of unprecedented plastics that are mechanically strong yet metaboli...

Un estudio internacional ha descubierto que las nuevas definiciones de obesidad propuestas ofrecen una visión más completa del estado de salud de los candidatos a cirugía bariátrica metabóli ...

Your body makes creatine naturally in the kidneys & liver, storing 95% in muscle as a rapid-fire energy buffer. During intense activity, phosphocreatine instantly regenerates ATP—y… #ATP #Bioenergetics #Creatine #Kidneyfunction #Metabolism

Un estudio internacional ha descubierto que las nuevas definiciones de obesidad propuestas ofrecen una visión más completa del estado de salud de los candidatos a cirugía bariátrica metabóli ...

Elizabeth C. Hoots, Luis L. Kuchenmüller, Michael R. Skeeles, Timothy D. Clark This is a plain language summary of a Functional Ecology research article which can be found here. Growth and metaboli…

Angelica gigas NAKAI (AG) is a popular traditional medicinal herb widely used to treat dyslipidemia owing to its antioxidant activity. Vascular disease is intimately linked to obesity-induced metaboli

Lemon-garlic baked salmon with quinoa & asparagus: a low-sodium, heart-healthy dinner backed by real research. Save it for the weeknight that needs it most.

Metabolic acidosis is common in critically ill patients and is associated with organ dysfunction and death. Sodium bicarbonate is used to correct acidemia, but its benefit in patients with metaboli...

Every thought, habit, and experience is physically reshaping your brain. The question is not whether your brain is changing — it is whether you are consciously directing the process.

Iron is a key micronutrient that constrains microbial growth and productivity in many aquatic and terrestrial environments due to its limited bioavailability. Microorganisms evolved sophisticated acquisition strategies, including the production of siderophores, high-affinity iron-chelating molecules that facilitate iron solubilisation and uptake. Cyanobacteria, photosynthetic prokaryotes and major contributors to global primary production, also depend on iron as a cofactor to their core metabolic enzymes. However, very few cyanobacterial siderophores were described so far, and cyanobacteria remain an underxplored source of possibly novel siderophores. Here we report a novel cyanobacterial siderophore, cyanochelin C, that employs two {beta}-hydroxyaspartate residues for iron chelation. We provide extensive nuclear magnetic resonance (NMR) and mass spectrometry (MS) evidence on the molecular structure and identify the corresponding biosynthetic gene cluster (BGC). Bioinformatic analysis of the BGC further revealed the presence of an acylase CcsQ clustering with a broader cyanobacteria-specific family of acylases associated with predicted siderophore-encoding BGCs. Discovery of cyanochelin C and its deacylation by CcsQ expands the known structural diversity of cyanobacterial siderophores and improves the understanding of important enzymatic reactions.

Most people misunderstand ATP. Actually, ~90% of cellular ATP exists bound to magnesium ions (Mg²⁺), not as free ATP. Without magnesium coordination, ATP cannot dock into enzyme ac… #ATP #Biochemistry #Cellularenergy #Magnesium #Metabolism

Breath sensor detects fat burning

Highlighted Article: Rescue behaviour in the ant Cataglyphis nigra is associated with mushroom body neuronal gene activity rather than workers' physical traits. Rescuers upregulate immune and metaboli...

Highlighted Article: Rescue behaviour in the ant Cataglyphis nigra is associated with mushroom body neuronal gene activity rather than workers' physical traits. Rescuers upregulate immune and metaboli...