#MuscleStemCells
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narjournal.bsky.social
New research in #NARMolecularMedicine shows that #musclestemcells retain intrinsic #inflammatory changes, with aberrant #TNFα signaling and reduced #H3.3 impairing muscle regeneration, pointing to #newtherapeutic opportunities in #dermatomyositis beyond #interferon. 🧬 doi.org/10.1093/narm...
July 16, 2026 at 3:53 PM
epigenometech.bsky.social
Epigenetics Update - Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength bit.ly/3HGmRiH

#Epigenetics #MuscleStemCells

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Perfect for cancer, immunology, and aging research; epigenometech.com
June 20, 2025 at 8:00 AM
epigenometech.bsky.social
Epigenetics Update - Epigenetic dysregulation in aged muscle stem cells drives mesenchymal progenitor expansion via IL-6 and Spp1 signaling go.nature.com/3JshDZ8

#Epigenetics #StemCells #MuscleStemCells #Aging
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Perfect for cancer, immunology, and aging research; epigenometech.com
October 31, 2025 at 12:18 PM
mspacealliance.bsky.social
🚨 Join the Muscle Mini-Symposium! 💪
Exploring skeletal muscle communication—from tissues to molecules!
9 Apr 2025, 1–5 PM
COS HD (INF 230)
Organised by J Bageritz
Supported by @hlsalliance.bsky.social
Featuring Fanny Sage on Spatial Multi-Omics in Muscle Architecture
#SpatialOmics, #MuscleStemCells
April 1, 2025 at 12:48 PM
stemcellnetwork.ca
SCN researchers are working to better understand #MuscleStemCells and develop treatments for #MuscularDystrophy and other muscle diseases. From restoring muscle stem cell function to developing anti-fibrotic treatments that reduce scarring and support #TissueRegeneration,
September 11, 2026 at 4:00 PM
alicefrolov.bsky.social
New visualization: Satellite Cell Reserve Declines with Age Across Muscle Groups

I am sharing a figure summarizing the age-associated contraction of the muscle satellite cell (MuSC)

#SatelliteCells #MuscleStemCells #Sarcopenia #Myogenesis #AgingBiology #Pax7 #SkeletalMuscle
New visualization: Satellite Cell Reserve Declines with Age Across Muscle Groups I am sharing a figure summarizing the age-associated contraction of the muscle satellite cell (MuSC) pool across distinct skeletal muscle groups. The dumbbell-style plot contrasts simulated Pax7+ satellite cell density per myofiber in young versus aged conditions, with each pair of points connected to emphasize the magnitude of decline within a given muscle. Important methodological note: the data plotted here are simulated. They do not derive from a single empirical dataset. Rather, the values were constructed to reflect the direction and approximate magnitude of trends consistently reported in the literature on satellite cell aging. The figure is intended as an illustrative synthesis for pedagogical and discussion purposes, not as a substitute for primary quantification. Rationale and mechanistic context: The satellite cell compartment, resident in the sublaminar niche between the sarcolemma and basal lamina, constitutes the principal source of myogenic progenitors for postnatal growth, hypertrophy, and regeneration. Quiescence is maintained through Pax7 expression alongside Notch signaling and niche-derived cues. With advancing age, the reserve pool undergoes progressive numerical depletion, a decline that is neither uniform nor stochastic across the musculature. Several convergent mechanisms are implicated. A partial shift from reversible quiescence toward an irreversible pre-senescent or senescent state, driven in part by derepression of the p16INK4a (Cdkn2a) locus, reduces the fraction of cells capable of reentering the cell cycle. Concurrent alterations in the systemic and local milieu, including elevated FGF2, dysregulated Notch-Delta signaling, and Wnt-driven fibrogenic conversion, compromise self-renewal and bias asymmetric division outcomes.
July 18, 2026 at 5:09 PM
bionewscentral.com
Study reveals how #MuscleStemCells "flip a switch" to initiate #MuscleRepair and rebuild damaged tissue, which could help address #MuscleLoss linked to #aging, injury, and the use of widely prescribed #WeightLossMedications.
Scientists uncover cellular mechanism behind muscle repair – BioNews Central
Study discovers how muscle stem cells “flip a switch” to initiate muscle repair and rebuild damaged muscle—a finding that could help address muscle loss linked to aging, injury, and the use of widely prescribed weight-loss medications. ...
sbee.link
March 1, 2026 at 1:38 AM