Highly cited manuscripts from @nioxjournal.bsky.social
Endocan alters nitric oxide production in endothelial cells by targeting AKT/eNOS and NFkB/iNOS signaling
By Sarwareddy Kartik Kumar and Krishna Priya Mani
Endocan alters nitric oxide production in endothelial cells by targeting AKT/eNOS and NFkB/iNOS signaling
By Sarwareddy Kartik Kumar and Krishna Priya Mani
buff.ly
October 12, 2026 at 12:03 PM
Highly cited manuscripts from @nioxjournal.bsky.social
Endocan alters nitric oxide production in endothelial cells by targeting AKT/eNOS and NFkB/iNOS signaling
By Sarwareddy Kartik Kumar and Krishna Priya Mani
Endocan alters nitric oxide production in endothelial cells by targeting AKT/eNOS and NFkB/iNOS signaling
By Sarwareddy Kartik Kumar and Krishna Priya Mani
Interesting study on Robusta coffee ☕️
Robusta coffee treatment reduced NF-κB expression in the coronary arteries of hyperlipidemic rats, suggesting a potential effect on inflammatory signaling.
🔗 academicstrive.com/DDPJ/article...
#Coffee #NFkB #Inflammation #CardiovascularResearch
Robusta coffee treatment reduced NF-κB expression in the coronary arteries of hyperlipidemic rats, suggesting a potential effect on inflammatory signaling.
🔗 academicstrive.com/DDPJ/article...
#Coffee #NFkB #Inflammation #CardiovascularResearch
academicstrive.com
October 6, 2026 at 6:19 AM
Interesting study on Robusta coffee ☕️
Robusta coffee treatment reduced NF-κB expression in the coronary arteries of hyperlipidemic rats, suggesting a potential effect on inflammatory signaling.
🔗 academicstrive.com/DDPJ/article...
#Coffee #NFkB #Inflammation #CardiovascularResearch
Robusta coffee treatment reduced NF-κB expression in the coronary arteries of hyperlipidemic rats, suggesting a potential effect on inflammatory signaling.
🔗 academicstrive.com/DDPJ/article...
#Coffee #NFkB #Inflammation #CardiovascularResearch
Key word here is "EARLY" - for all types of Interferon (type 1, type 2 and type 3) - any delay - triggers NfKB pathway!
September 28, 2026 at 2:08 PM
Key word here is "EARLY" - for all types of Interferon (type 1, type 2 and type 3) - any delay - triggers NfKB pathway!
Creo que o segredo do TNF (e a razón pola que bloquealo non mellora o prognóstico na sepse) áchase na transcripción (vía NFkb etc) de factores e citoquinas que en xeral manteñen o trofismo das células inmunes, podería ser que protexéndoas da anerxia/apoptose
¿?
¿?
September 28, 2026 at 7:10 PM
Creo que o segredo do TNF (e a razón pola que bloquealo non mellora o prognóstico na sepse) áchase na transcripción (vía NFkb etc) de factores e citoquinas que en xeral manteñen o trofismo das células inmunes, podería ser que protexéndoas da anerxia/apoptose
¿?
¿?
#ChangeTheDogma! #TLRpower! @jkagan1.bsky.social @danielhfisch.bsky.social &co show @nature.com that TRAM, so far believed to control endosomal TLR4 signaling & interferon #IFN production, is essential to release the #myddosome from #TIRAP & the plasma membrane allowing full NFkB signaling!
TRAM promotes Toll-like-receptor-free myddosome signal transduction - Nature
TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.
www.nature.com
September 23, 2026 at 4:50 PM
#ChangeTheDogma! #TLRpower! @jkagan1.bsky.social @danielhfisch.bsky.social &co show @nature.com that TRAM, so far believed to control endosomal TLR4 signaling & interferon #IFN production, is essential to release the #myddosome from #TIRAP & the plasma membrane allowing full NFkB signaling!
miR-146, a microRNA involved in the TLR-4/NFkb pathway, is known to regulate proinflammatory signaling, whereas HMGB1 activates inflammatory pathways through TLR2 and TLR4 receptors. (🧵 2/10)
September 2, 2026 at 8:33 AM
miR-146, a microRNA involved in the TLR-4/NFkb pathway, is known to regulate proinflammatory signaling, whereas HMGB1 activates inflammatory pathways through TLR2 and TLR4 receptors. (🧵 2/10)
Building on Tom's previous findings on nfkb and immune suppression in coral-algae symbiosis, we wanted to know if hosting different algal types (Cladocopium/C vs. Durusdinium/D) changes a coral's immune state. (2/16)
August 28, 2026 at 4:59 PM
Building on Tom's previous findings on nfkb and immune suppression in coral-algae symbiosis, we wanted to know if hosting different algal types (Cladocopium/C vs. Durusdinium/D) changes a coral's immune state. (2/16)
Building on Tom's previous findings on nfkb and immune suppression in coral-algae symbiosis, we wanted to know if hosting different algal types (Cladocopium/C vs. Durusdinium/D) changes a coral's immune state. (2/16)
August 28, 2026 at 4:48 PM
Building on Tom's previous findings on nfkb and immune suppression in coral-algae symbiosis, we wanted to know if hosting different algal types (Cladocopium/C vs. Durusdinium/D) changes a coral's immune state. (2/16)
First, we profiled GE patterns of Cladocopium- and Durusdinium-hosting corals and found that genes associated with immunity (including NFkB!) were upregulated in D-hosting corals. This pattern was confirmed via western blotting.
August 26, 2026 at 8:48 PM
First, we profiled GE patterns of Cladocopium- and Durusdinium-hosting corals and found that genes associated with immunity (including NFkB!) were upregulated in D-hosting corals. This pattern was confirmed via western blotting.
Online now!✨Wang et al report a role for CDK4/6 in regulating not only cell cycle progression but also the SASP, via retinoic acid signaling and NFkB. Targeting this pathway reduces inflammation and improves function in aged mice
Boshiwang.bsky.social Marcdema.bsky.social Demarialab.bsky.social
Boshiwang.bsky.social Marcdema.bsky.social Demarialab.bsky.social
Disruption of CDK4/6–RARα–NF-κB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy - Nature Aging
Wang et al. report that the cell cycle regulators CDK4/6 also regulate the inflammatory phenotype of senescent cells, via modulation of retinoic acid signaling and NF-κB. Pharmacologically targeting t...
www.nature.com
August 20, 2026 at 10:56 AM
Online now!✨Wang et al report a role for CDK4/6 in regulating not only cell cycle progression but also the SASP, via retinoic acid signaling and NFkB. Targeting this pathway reduces inflammation and improves function in aged mice
Boshiwang.bsky.social Marcdema.bsky.social Demarialab.bsky.social
Boshiwang.bsky.social Marcdema.bsky.social Demarialab.bsky.social
A heart attack can echo to the brain. Low-density lipoprotein receptor-related protein 5 (LRP5) deficiency worsens cardiac injury and neuronal vulnerability, while TNF-α supports microglial survival via LRP5–NF-κB signaling. #AMI #Neuroinflammation #LRP5 #NFkB.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
August 14, 2026 at 2:41 AM
A heart attack can echo to the brain. Low-density lipoprotein receptor-related protein 5 (LRP5) deficiency worsens cardiac injury and neuronal vulnerability, while TNF-α supports microglial survival via LRP5–NF-κB signaling. #AMI #Neuroinflammation #LRP5 #NFkB.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
wow- NFkB is so pro-inflammatory and if this works - it settles that Long Covid is associated with persistent inflammation.
August 6, 2026 at 4:48 PM
wow- NFkB is so pro-inflammatory and if this works - it settles that Long Covid is associated with persistent inflammation.
QUERO SABER: O QUE É QUE O TSE VAI FAZER?
youtube.com/watch?v=nFKB...
youtube.com/watch?v=nFKB...
QUERO SABER: O QUE É QUE O TSE VAI FAZER?
YouTube video by Hevelin Agostinelli
youtube.com
July 30, 2026 at 3:42 AM
QUERO SABER: O QUE É QUE O TSE VAI FAZER?
youtube.com/watch?v=nFKB...
youtube.com/watch?v=nFKB...
And either by HDAC3i or overexpression on PCAF, we were able to reactivate some of these genes (e.g., NFkB pathway) in cells expressing the truncated BRCA2 variant /5
May 31, 2026 at 12:10 PM
And either by HDAC3i or overexpression on PCAF, we were able to reactivate some of these genes (e.g., NFkB pathway) in cells expressing the truncated BRCA2 variant /5
🩸Facts about Myelofibrosis:
Combination & Emerging Therapies
#Myelofibrosis #HemeOnc #Hematology #MedEd #ClinicalTrials #Epigenetics #Pelabresib #Ruxolitinib #JAKInhibitors #Selinexor #NFkB #Cytokines #HemeHub #HematologyEducation #MedicalEducation
Combination & Emerging Therapies
#Myelofibrosis #HemeOnc #Hematology #MedEd #ClinicalTrials #Epigenetics #Pelabresib #Ruxolitinib #JAKInhibitors #Selinexor #NFkB #Cytokines #HemeHub #HematologyEducation #MedicalEducation
March 16, 2026 at 5:52 PM
🩸Facts about Myelofibrosis:
Combination & Emerging Therapies
#Myelofibrosis #HemeOnc #Hematology #MedEd #ClinicalTrials #Epigenetics #Pelabresib #Ruxolitinib #JAKInhibitors #Selinexor #NFkB #Cytokines #HemeHub #HematologyEducation #MedicalEducation
Combination & Emerging Therapies
#Myelofibrosis #HemeOnc #Hematology #MedEd #ClinicalTrials #Epigenetics #Pelabresib #Ruxolitinib #JAKInhibitors #Selinexor #NFkB #Cytokines #HemeHub #HematologyEducation #MedicalEducation
🩸Facts about Multiple Myeloma:
Myeloma Biology and Microenvironment
#MultipleMyeloma #Hematology #NKcells #Cytogenetics #HEMEHUB #TP53 #NFkB #Hyperdiploidy #t1114 #del17p #HemOnc #MedEd
Myeloma Biology and Microenvironment
#MultipleMyeloma #Hematology #NKcells #Cytogenetics #HEMEHUB #TP53 #NFkB #Hyperdiploidy #t1114 #del17p #HemOnc #MedEd
February 24, 2026 at 6:08 PM
🩸Facts about Multiple Myeloma:
Myeloma Biology and Microenvironment
#MultipleMyeloma #Hematology #NKcells #Cytogenetics #HEMEHUB #TP53 #NFkB #Hyperdiploidy #t1114 #del17p #HemOnc #MedEd
Myeloma Biology and Microenvironment
#MultipleMyeloma #Hematology #NKcells #Cytogenetics #HEMEHUB #TP53 #NFkB #Hyperdiploidy #t1114 #del17p #HemOnc #MedEd
#ESM1 or #Endocan or #endothelial cell specific molecule 1: a key knot (with #HomoCysteine & #NFKB) of the #metabolic #pathway for #human #health.
Public Open Question .. www.researchgate.net/post/Homocys...
Paper TEXT .. www.researchgate.net/post/Homocys... ........
Public Open Question .. www.researchgate.net/post/Homocys...
Paper TEXT .. www.researchgate.net/post/Homocys... ........
August 30, 2025 at 10:25 AM
#ESM1 or #Endocan or #endothelial cell specific molecule 1: a key knot (with #HomoCysteine & #NFKB) of the #metabolic #pathway for #human #health.
Public Open Question .. www.researchgate.net/post/Homocys...
Paper TEXT .. www.researchgate.net/post/Homocys... ........
Public Open Question .. www.researchgate.net/post/Homocys...
Paper TEXT .. www.researchgate.net/post/Homocys... ........
✅ ID new citrullination site in NF-kB p65
✅ Show macrophage polarization is decreased when citrullination enzyme PAD2 is gone
✅ Develop a nanomedicine: gold nanoparticles + PAD2 inhibitor + ICAM-1
✅ Show reduction of inflammation in acute lung injury syndrome
🧪 pubmed.ncbi.nlm.nih.gov/40087815/
✅ Show macrophage polarization is decreased when citrullination enzyme PAD2 is gone
✅ Develop a nanomedicine: gold nanoparticles + PAD2 inhibitor + ICAM-1
✅ Show reduction of inflammation in acute lung injury syndrome
🧪 pubmed.ncbi.nlm.nih.gov/40087815/
March 17, 2025 at 6:20 PM
✅ ID new citrullination site in NF-kB p65
✅ Show macrophage polarization is decreased when citrullination enzyme PAD2 is gone
✅ Develop a nanomedicine: gold nanoparticles + PAD2 inhibitor + ICAM-1
✅ Show reduction of inflammation in acute lung injury syndrome
🧪 pubmed.ncbi.nlm.nih.gov/40087815/
✅ Show macrophage polarization is decreased when citrullination enzyme PAD2 is gone
✅ Develop a nanomedicine: gold nanoparticles + PAD2 inhibitor + ICAM-1
✅ Show reduction of inflammation in acute lung injury syndrome
🧪 pubmed.ncbi.nlm.nih.gov/40087815/
Influenza a virus NS2 suppresses NFKB/NF-κB signaling to facilitate viral replication by mediating the autophagic-degradation of IKBKG/NEMO
www.tandfonline.com/doi/10.1080/...
www.tandfonline.com/doi/10.1080/...
Influenza a virus NS2 suppresses NFKB/NF-κB signaling to facilitate viral replication by mediating the autophagic-degradation of IKBKG/NEMO
Influenza A virus (IAV) is an important zoonotic pathogen responsible for substantial respiratory morbidity and mortality. Elucidating the mechanisms by which IAV evades host innate immunity is cri...
www.tandfonline.com
May 28, 2026 at 6:27 PM
Influenza a virus NS2 suppresses NFKB/NF-κB signaling to facilitate viral replication by mediating the autophagic-degradation of IKBKG/NEMO
www.tandfonline.com/doi/10.1080/...
www.tandfonline.com/doi/10.1080/...
PTCL NOS - molecular 🧬
GATA3 expression:
poor prognosis
Cell of origin Th2
PI3K-mTOR activation
Possible roll for PI3K inhibitors
TBX21 expression:
better prognosis (than GATA3)
Cell of origin Th1
NFKB activation
NFKBi (Bortezomib)
#hemesky #PTCL
ashpublications.org/blood/articl...
GATA3 expression:
poor prognosis
Cell of origin Th2
PI3K-mTOR activation
Possible roll for PI3K inhibitors
TBX21 expression:
better prognosis (than GATA3)
Cell of origin Th1
NFKB activation
NFKBi (Bortezomib)
#hemesky #PTCL
ashpublications.org/blood/articl...
Subclassifying peripheral T-cell lymphoma NOS
In this issue of Blood, Amador et al identified 2 distinct subtypes of peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS) using gene expression
ashpublications.org
November 23, 2024 at 4:12 PM
PTCL NOS - molecular 🧬
GATA3 expression:
poor prognosis
Cell of origin Th2
PI3K-mTOR activation
Possible roll for PI3K inhibitors
TBX21 expression:
better prognosis (than GATA3)
Cell of origin Th1
NFKB activation
NFKBi (Bortezomib)
#hemesky #PTCL
ashpublications.org/blood/articl...
GATA3 expression:
poor prognosis
Cell of origin Th2
PI3K-mTOR activation
Possible roll for PI3K inhibitors
TBX21 expression:
better prognosis (than GATA3)
Cell of origin Th1
NFKB activation
NFKBi (Bortezomib)
#hemesky #PTCL
ashpublications.org/blood/articl...
LOL what happened here, let's try again
December 1, 2024 at 2:30 PM
LOL what happened here, let's try again