"Acute COVID-19 results from complex pathophysiological mechanisms beyond the lungs. Viral cytotoxicity injures alveolar and endothelial cells, while inflammation and endothelial dysfunction cause microvascular damage, increasing permeability and leading to pulmonary edema, impaired gas..."
October 30, 2026 at 11:03 PM
"Acute COVID-19 results from complex pathophysiological mechanisms beyond the lungs. Viral cytotoxicity injures alveolar and endothelial cells, while inflammation and endothelial dysfunction cause microvascular damage, increasing permeability and leading to pulmonary edema, impaired gas..."
Endothelial CB1 receptors heighten arterial inflammation and lipid uptake in atherosclerosis. Removing endothelial CB1 or using antagonists reduces these effects. PMID:42414306, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75214-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Endothelial cannabinoid CB1 receptor deficiency reduces shear stress-induced arterial inflammation and lipid uptake | Nature Communications
Peripheral cannabinoid CB1 receptor antagonists that lack central nervous system effects are emerging as promising therapies for metabolic disease, yet the role of endothelial CB1 signaling in atherosclerosis remains unclear. Here, we show that endothelial CB1 is expressed in human atherosclerotic plaques, is induced by oscillatory shear stress in atheroprone flow regions, and promotes vascular inflammation, permeability and lipid uptake. Endothelial-specific Cnr1 deletion or peripheral CB1 antagonism in mice attenuates atherosclerosis, reduces endothelial caveolae–dependent low-density lipoprotein uptake by downregulating caveolin-1 and ALK1 expression, and improves metabolic parameters in brown and white adipose tissue and the liver. The anti-atherogenic and metabolic effects are more pronounced in females, which is possibly linked to estrogen signaling. These findings identify endothelial CB1 as a proatherogenic, sex-biased regulator of vascular lipid transport and plaque developmen
doi.org
October 31, 2026 at 6:00 PM
Sepsis as a disease of endothelial dysfunction: doi.org/10.1172/JCI2...
In this Review, Qin et al. present a framework to understand sepsis as a continuum of vascular manifestations, from endothelial activation to progressive endothelial dysfunction.
In this Review, Qin et al. present a framework to understand sepsis as a continuum of vascular manifestations, from endothelial activation to progressive endothelial dysfunction.
October 31, 2026 at 9:01 PM
Sepsis as a disease of endothelial dysfunction: doi.org/10.1172/JCI2...
In this Review, Qin et al. present a framework to understand sepsis as a continuum of vascular manifestations, from endothelial activation to progressive endothelial dysfunction.
In this Review, Qin et al. present a framework to understand sepsis as a continuum of vascular manifestations, from endothelial activation to progressive endothelial dysfunction.
"...exchange, and multi-organ involvement [17,24]. Immune dysregulation is pivotal in COVID-19 pathogenesis, characterized by a hyperinflammatory cytokine storm leading to systemic injury, ARDS, and multiorgan failure. Concurrent hypercoagulability, driven by endothelial activation,..."
October 30, 2026 at 11:03 PM
"...exchange, and multi-organ involvement [17,24]. Immune dysregulation is pivotal in COVID-19 pathogenesis, characterized by a hyperinflammatory cytokine storm leading to systemic injury, ARDS, and multiorgan failure. Concurrent hypercoagulability, driven by endothelial activation,..."
Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis - Nature Aging
The Human Aging Endothelial Cell Atlas reveals how gene expression patterns of the human endothelium change with age, identifying reduced angiogenesis, altered mechanical signaling and a conserved gen...
www.nature.com
October 29, 2026 at 12:42 PM
Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Older Gut Microbiomes Can Drive Vascular Aging
Microbiomes in older mice pumped out damaging metabolites that drove endothelial cell senescence, offering potential targets for therapeutic intervention.
#Omics #Science
Microbiomes in older mice pumped out damaging metabolites that drove endothelial cell senescence, offering potential targets for therapeutic intervention.
#Omics #Science
Older Gut Microbiomes Can Drive Vascular Aging | The Scientist
Microbiomes in older mice pumped out damaging metabolites that drove endothelial cell senescence, offering potential targets for therapeutic intervention.
www.the-scientist.com
October 31, 2026 at 6:14 PM
"...stimulation, autoimmunity, endothelial dysfunction, mitochondrial impairment or maladaptive repair."
October 28, 2026 at 4:39 PM
"...stimulation, autoimmunity, endothelial dysfunction, mitochondrial impairment or maladaptive repair."
Older Gut Microbiomes Can Drive Vascular Aging
Microbiomes in older mice pumped out damaging metabolites that drove endothelial cell senescence, offering potential targets for therapeutic intervention.
#Omics #Science
Microbiomes in older mice pumped out damaging metabolites that drove endothelial cell senescence, offering potential targets for therapeutic intervention.
#Omics #Science
Older Gut Microbiomes Can Drive Vascular Aging | The Scientist
Microbiomes in older mice pumped out damaging metabolites that drove endothelial cell senescence, offering potential targets for therapeutic intervention.
www.the-scientist.com
October 31, 2026 at 6:14 PM
RhoA effectors ROCK and SLK/LOK oppositely regulate VE-cadherin mobility at endothelial junctions https://www.biorxiv.org/content/10.64898/2026.10.28.762575v1
October 30, 2026 at 11:47 PM
RhoA effectors ROCK and SLK/LOK oppositely regulate VE-cadherin mobility at endothelial junctions https://www.biorxiv.org/content/10.64898/2026.10.28.762575v1
I hope doctors finally learn, that if the endothelial layer of your blood vessels are utterly destroyed you can’t improve vasoconstriction through EXERCISE. You can’t “retrain vascular dysfunction.” This is very 1990.
www.medscape.com/viewarticle/...
www.medscape.com/viewarticle/...
A Long-Ignored Syndrome Is Drawing Unprecedented Attention
A sharp rise in POTS has pushed the condition into the spotlight. Now, scientists are learning more than ever about its causes and how to treat it.
www.medscape.com
October 30, 2026 at 3:56 PM
I hope doctors finally learn, that if the endothelial layer of your blood vessels are utterly destroyed you can’t improve vasoconstriction through EXERCISE. You can’t “retrain vascular dysfunction.” This is very 1990.
www.medscape.com/viewarticle/...
www.medscape.com/viewarticle/...
🌙✨📚📚📚🎩📖 right, so
Endothelial Dysfunction: viral fragments or the immune system damage this layer, it triggers endothelial dysfunction, causing the vessel walls to lose their normal function, become "leaky," promote abnormal clotting.
Yeah it’s a bummer. You should have let people heal before work
Endothelial Dysfunction: viral fragments or the immune system damage this layer, it triggers endothelial dysfunction, causing the vessel walls to lose their normal function, become "leaky," promote abnormal clotting.
Yeah it’s a bummer. You should have let people heal before work
November 2, 2026 at 2:39 PM
🌙✨📚📚📚🎩📖 right, so
Endothelial Dysfunction: viral fragments or the immune system damage this layer, it triggers endothelial dysfunction, causing the vessel walls to lose their normal function, become "leaky," promote abnormal clotting.
Yeah it’s a bummer. You should have let people heal before work
Endothelial Dysfunction: viral fragments or the immune system damage this layer, it triggers endothelial dysfunction, causing the vessel walls to lose their normal function, become "leaky," promote abnormal clotting.
Yeah it’s a bummer. You should have let people heal before work
🔥These mechanisms collectively restore endothelial function, normalize blood pressure, improve glucose tolerance, and prevent hepatic lipid accumulation
October 31, 2026 at 6:08 AM
🔥These mechanisms collectively restore endothelial function, normalize blood pressure, improve glucose tolerance, and prevent hepatic lipid accumulation
How do our blood vessels age? 🕰️🩸
Excited to share our new paper in @nataging.nature.com, in which we integrated single-cell data from >375,000 endothelial cells across 12 human tissues to create the Human Aging Endothelial Cell Atlas: www.nature.com/articles/s43...
Excited to share our new paper in @nataging.nature.com, in which we integrated single-cell data from >375,000 endothelial cells across 12 human tissues to create the Human Aging Endothelial Cell Atlas: www.nature.com/articles/s43...
Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis - Nature Aging
The Human Aging Endothelial Cell Atlas reveals how gene expression patterns of the human endothelium change with age, identifying reduced angiogenesis, altered mechanical signaling and a conserved gen...
www.nature.com
October 27, 2026 at 9:37 AM
How do our blood vessels age? 🕰️🩸
Excited to share our new paper in @nataging.nature.com, in which we integrated single-cell data from >375,000 endothelial cells across 12 human tissues to create the Human Aging Endothelial Cell Atlas: www.nature.com/articles/s43...
Excited to share our new paper in @nataging.nature.com, in which we integrated single-cell data from >375,000 endothelial cells across 12 human tissues to create the Human Aging Endothelial Cell Atlas: www.nature.com/articles/s43...
4) For endothelial activation they measure Von Willebrand factor (VWF, helps platelets stick) and thrombomodulin (sheds when the endothelium is damaged).
Measures of platelet activation included P-selectin and sCD40L.
Measures of platelet activation included P-selectin and sCD40L.
October 29, 2026 at 9:22 AM
4) For endothelial activation they measure Von Willebrand factor (VWF, helps platelets stick) and thrombomodulin (sheds when the endothelium is damaged).
Measures of platelet activation included P-selectin and sCD40L.
Measures of platelet activation included P-selectin and sCD40L.
wildDISCO protocol
#SciArt
Whole-mouse immunolabeling at cellular resolution for comprehensive 3D atlases
Validated antibodies in Table 1
Podocalyxin (R&D MAB1556) for endothelial labeling
α-SMA (Abcam ab5694)
@erturklab.bsky.social #NatProtoc 2026
www.nature.com/articles/s41...
#SciArt
Whole-mouse immunolabeling at cellular resolution for comprehensive 3D atlases
Validated antibodies in Table 1
Podocalyxin (R&D MAB1556) for endothelial labeling
α-SMA (Abcam ab5694)
@erturklab.bsky.social #NatProtoc 2026
www.nature.com/articles/s41...
October 30, 2026 at 12:02 PM
wildDISCO protocol
#SciArt
Whole-mouse immunolabeling at cellular resolution for comprehensive 3D atlases
Validated antibodies in Table 1
Podocalyxin (R&D MAB1556) for endothelial labeling
α-SMA (Abcam ab5694)
@erturklab.bsky.social #NatProtoc 2026
www.nature.com/articles/s41...
#SciArt
Whole-mouse immunolabeling at cellular resolution for comprehensive 3D atlases
Validated antibodies in Table 1
Podocalyxin (R&D MAB1556) for endothelial labeling
α-SMA (Abcam ab5694)
@erturklab.bsky.social #NatProtoc 2026
www.nature.com/articles/s41...
What is your initial work-up?
hs-CRP?
Endothelial/thrombotic: P-selectin, vWF, D-dimer
Autoantibody: DN2 B-cell frequency
Autophagy: pATG13, beclin-1
Anemia/iron: heme-metabolism signature
Epigenetic: DNA methylation
Gut-brain: kynurenine/serotonin ratio
#medsky
#LongCOVID
hs-CRP?
Endothelial/thrombotic: P-selectin, vWF, D-dimer
Autoantibody: DN2 B-cell frequency
Autophagy: pATG13, beclin-1
Anemia/iron: heme-metabolism signature
Epigenetic: DNA methylation
Gut-brain: kynurenine/serotonin ratio
#medsky
#LongCOVID
November 1, 2026 at 4:00 PM
What is your initial work-up?
hs-CRP?
Endothelial/thrombotic: P-selectin, vWF, D-dimer
Autoantibody: DN2 B-cell frequency
Autophagy: pATG13, beclin-1
Anemia/iron: heme-metabolism signature
Epigenetic: DNA methylation
Gut-brain: kynurenine/serotonin ratio
#medsky
#LongCOVID
hs-CRP?
Endothelial/thrombotic: P-selectin, vWF, D-dimer
Autoantibody: DN2 B-cell frequency
Autophagy: pATG13, beclin-1
Anemia/iron: heme-metabolism signature
Epigenetic: DNA methylation
Gut-brain: kynurenine/serotonin ratio
#medsky
#LongCOVID
Chromosome positioning is impaired with age
Jemery Morales, Omar Akhtar, Gabriel Quintero Plancarte and Lisa Hua find that mechanisms governing chromosome antipairing decline with aortic endothelial cell age. journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Jemery Morales, Omar Akhtar, Gabriel Quintero Plancarte and Lisa Hua find that mechanisms governing chromosome antipairing decline with aortic endothelial cell age. journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
November 2, 2026 at 4:08 PM
Chromosome positioning is impaired with age
Jemery Morales, Omar Akhtar, Gabriel Quintero Plancarte and Lisa Hua find that mechanisms governing chromosome antipairing decline with aortic endothelial cell age. journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Jemery Morales, Omar Akhtar, Gabriel Quintero Plancarte and Lisa Hua find that mechanisms governing chromosome antipairing decline with aortic endothelial cell age. journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Spatiotemporal mapping of endothelial proliferative response in acute chemical liver injury https://www.biorxiv.org/content/10.64898/2026.10.29.760435v1
November 2, 2026 at 6:30 PM
Spatiotemporal mapping of endothelial proliferative response in acute chemical liver injury https://www.biorxiv.org/content/10.64898/2026.10.29.760435v1
Spatiotemporal mapping of endothelial proliferative response in acute chemical liver injury https://www.biorxiv.org/content/10.64898/2026.10.29.760435v1
November 2, 2026 at 6:30 PM
Spatiotemporal mapping of endothelial proliferative response in acute chemical liver injury https://www.biorxiv.org/content/10.64898/2026.10.29.760435v1
What drives immune-mediated inflammation of the brain’s blood vessels?
Have a look at the new study in @JCI introducing BrEndO, a model to investigate CNS vasculitis. Our Hamburg #HertieNetwork fellow @brissiek.bsky.social is one of the authors!
www.jci.org/articles/vie...
Have a look at the new study in @JCI introducing BrEndO, a model to investigate CNS vasculitis. Our Hamburg #HertieNetwork fellow @brissiek.bsky.social is one of the authors!
www.jci.org/articles/vie...
JCI -
Endothelial neo-antigen expression initiates CD8⁺ T cell–driven CNS vasculitis amplified by peripheral immune challenge
www.jci.org
November 2, 2026 at 12:53 PM
What drives immune-mediated inflammation of the brain’s blood vessels?
Have a look at the new study in @JCI introducing BrEndO, a model to investigate CNS vasculitis. Our Hamburg #HertieNetwork fellow @brissiek.bsky.social is one of the authors!
www.jci.org/articles/vie...
Have a look at the new study in @JCI introducing BrEndO, a model to investigate CNS vasculitis. Our Hamburg #HertieNetwork fellow @brissiek.bsky.social is one of the authors!
www.jci.org/articles/vie...
Endothelial protein C receptor is an entry receptor for Langya and related parahenipaviruses https://www.biorxiv.org/content/10.64898/2026.11.01.763137v1
November 2, 2026 at 7:16 PM
Endothelial protein C receptor is an entry receptor for Langya and related parahenipaviruses https://www.biorxiv.org/content/10.64898/2026.11.01.763137v1
Endothelial protein C receptor is an entry receptor for Langya and related parahenipaviruses https://www.biorxiv.org/content/10.64898/2026.11.01.763137v1
November 2, 2026 at 7:16 PM
Endothelial protein C receptor is an entry receptor for Langya and related parahenipaviruses https://www.biorxiv.org/content/10.64898/2026.11.01.763137v1
A Human Aging Endothelial Cell Atlas was created by analyzing #GeneActivity in more than 375,000 #EndothelialCells from the #BloodVessels of 12 healthy human tissues, revealing #MolecularChanges associated with #VascularAging.
#Aging
#Aging
Vascular aging: How our blood vessels age from within – BioNews Central
A Human Aging Endothelial Cell Atlas was created by analyzing gene activity in more than 375,000 endothelial cells from the blood vessels of 12 healthy human tissues, revealing molecular changes associated with vascular aging. ...
sbee.link
November 2, 2026 at 3:15 PM
A Human Aging Endothelial Cell Atlas was created by analyzing #GeneActivity in more than 375,000 #EndothelialCells from the #BloodVessels of 12 healthy human tissues, revealing #MolecularChanges associated with #VascularAging.
#Aging
#Aging
Halloween Highlight💫 : The ghoulish figure in this full spectrum flow cytometry and mass cytometry plot embodies how fibrosis-associated endothelial cells turn nasty during #LiverDisease.
Gkantsinikoudi et al.: doi.org/10.1172/jci....
@neildufton.bsky.social @timkendall.bsky.social
Gkantsinikoudi et al.: doi.org/10.1172/jci....
@neildufton.bsky.social @timkendall.bsky.social
October 31, 2026 at 4:04 PM
Halloween Highlight💫 : The ghoulish figure in this full spectrum flow cytometry and mass cytometry plot embodies how fibrosis-associated endothelial cells turn nasty during #LiverDisease.
Gkantsinikoudi et al.: doi.org/10.1172/jci....
@neildufton.bsky.social @timkendall.bsky.social
Gkantsinikoudi et al.: doi.org/10.1172/jci....
@neildufton.bsky.social @timkendall.bsky.social
More persuasive
pubmed.ncbi.nlm.nih.gov/40459966/
pubmed.ncbi.nlm.nih.gov/40459966/
The non-nutritive sweetener erythritol adversely affects brain microvascular endothelial cell function - PubMed
The experimental aim of this study was to determine, in vitro, the effect of the non-nutritive sweetener erythritol on brain microvascular endothelial cell oxidative stress, nitric oxide (NO) and endo...
pubmed.ncbi.nlm.nih.gov
November 1, 2026 at 9:53 AM
More persuasive
pubmed.ncbi.nlm.nih.gov/40459966/
pubmed.ncbi.nlm.nih.gov/40459966/