New on bioRxiv! 🧠🧬
Our work uncovers how modularity in the DCC-ECD shapes axon guidance and neuronal migration.Using mouse lines with mutations in Netrin-1 and Draxin binding sites, we show how distinct DCC modules drive precise circuit assembly
#Neuroscience #AxonGuidance #DCC #Netrin1 #Draxin
Our work uncovers how modularity in the DCC-ECD shapes axon guidance and neuronal migration.Using mouse lines with mutations in Netrin-1 and Draxin binding sites, we show how distinct DCC modules drive precise circuit assembly
#Neuroscience #AxonGuidance #DCC #Netrin1 #Draxin
Modularity in the DCC extracellular domain elicits distinct effects on axon guidance https://www.biorxiv.org/content/10.64898/2025.12.11.693717v1
December 12, 2025 at 11:12 AM
New on bioRxiv! 🧠🧬
Our work uncovers how modularity in the DCC-ECD shapes axon guidance and neuronal migration.Using mouse lines with mutations in Netrin-1 and Draxin binding sites, we show how distinct DCC modules drive precise circuit assembly
#Neuroscience #AxonGuidance #DCC #Netrin1 #Draxin
Our work uncovers how modularity in the DCC-ECD shapes axon guidance and neuronal migration.Using mouse lines with mutations in Netrin-1 and Draxin binding sites, we show how distinct DCC modules drive precise circuit assembly
#Neuroscience #AxonGuidance #DCC #Netrin1 #Draxin
'In this study, we show that the axon guidance molecule Netrin-1 is expressed in precursor lesions of pancreatic cancer and promotes sympathetic axon growth and branching via the Deleted in Colorectal Cancer (DCC) receptor.'
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neural function of Netrin-1 in precancerous lesions of the pancreas - Nature Communications
The nervous system can influence cancer progression. Here, authors show in mouse models that Netrin-1 promotes sympathetic nerve remodeling in early pancreatic cancer lesions and has a protective effe...
www.nature.com
August 18, 2025 at 4:56 AM
'In this study, we show that the axon guidance molecule Netrin-1 is expressed in precursor lesions of pancreatic cancer and promotes sympathetic axon growth and branching via the Deleted in Colorectal Cancer (DCC) receptor.'
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New antibody release!
Explore axon guidance with confidence using the latest IPI antibodies for Netrin, DCC, and IGDCC3 (PUNC) — now available at Addgene. High-quality tools to support your neuroscience research.
https://twp.ai/4itjtg
Explore axon guidance with confidence using the latest IPI antibodies for Netrin, DCC, and IGDCC3 (PUNC) — now available at Addgene. High-quality tools to support your neuroscience research.
https://twp.ai/4itjtg
January 16, 2026 at 4:00 PM
New antibody release!
Explore axon guidance with confidence using the latest IPI antibodies for Netrin, DCC, and IGDCC3 (PUNC) — now available at Addgene. High-quality tools to support your neuroscience research.
https://twp.ai/4itjtg
Explore axon guidance with confidence using the latest IPI antibodies for Netrin, DCC, and IGDCC3 (PUNC) — now available at Addgene. High-quality tools to support your neuroscience research.
https://twp.ai/4itjtg
Mechanical Netrin-1-DCC Coupling Mediates Netrin-1-induced Axonal Haptotaxis https://www.biorxiv.org/content/10.1101/2023.12.03.569828v1
Mechanical Netrin-1-DCC Coupling Mediates Netrin-1-induced Axonal Haptotaxis https://www.biorxiv.org/content/10.1101/2023.12.03.569828v1
The growth cone, a motile structure located at the tip of growing axons, senses extracellular guidan
www.biorxiv.org
December 4, 2023 at 8:30 PM
Mechanical Netrin-1-DCC Coupling Mediates Netrin-1-induced Axonal Haptotaxis https://www.biorxiv.org/content/10.1101/2023.12.03.569828v1
it's very different. Concerns were raised about one of the papers in 2015, and in 2021 Elisabeth Bik raised more issues. The situation seems much more like "Board finally had to stop ignoring it" than "Tessier-Lavigne lost a fight with the board."
pubpeer.com/publications...
pubpeer.com/publications...
PubPeer - Binding of DCC by netrin-1 to mediate axon guidance independ...
There are comments on PubPeer for publication: Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation (2001)
pubpeer.com
January 4, 2024 at 12:20 AM
it's very different. Concerns were raised about one of the papers in 2015, and in 2021 Elisabeth Bik raised more issues. The situation seems much more like "Board finally had to stop ignoring it" than "Tessier-Lavigne lost a fight with the board."
pubpeer.com/publications...
pubpeer.com/publications...
🎉 Excited to share our new publication!
Targeted inhibition of netrin–DCC axis with NP137 reverses netrin-driven survival in vitro & reduces high-grade pancreatic NEN progression in vivo.
Potential therapeutic strategy for aggressive PNENs?
bit.ly/435pKBx
@endocancer.bsky.social
Targeted inhibition of netrin–DCC axis with NP137 reverses netrin-driven survival in vitro & reduces high-grade pancreatic NEN progression in vivo.
Potential therapeutic strategy for aggressive PNENs?
bit.ly/435pKBx
@endocancer.bsky.social
November 1, 2025 at 4:03 PM
🎉 Excited to share our new publication!
Targeted inhibition of netrin–DCC axis with NP137 reverses netrin-driven survival in vitro & reduces high-grade pancreatic NEN progression in vivo.
Potential therapeutic strategy for aggressive PNENs?
bit.ly/435pKBx
@endocancer.bsky.social
Targeted inhibition of netrin–DCC axis with NP137 reverses netrin-driven survival in vitro & reduces high-grade pancreatic NEN progression in vivo.
Potential therapeutic strategy for aggressive PNENs?
bit.ly/435pKBx
@endocancer.bsky.social
IPI has new #recombinant antibodies available against DCC, anti-Netrin-1 and anti-IGDCC3 (PUNC), key players in axon guidance!
Explore the datasheets and order here 👉 buff.ly/KYdEvur
Explore the datasheets and order here 👉 buff.ly/KYdEvur
Axon Guidance Antibody Collection
For neurons to communicate, their axons must navigate precisely to their targets through a complex process known as axon guidance or neuronal migration. This pr
proteininnovation.org
January 14, 2026 at 7:56 PM
IPI has new #recombinant antibodies available against DCC, anti-Netrin-1 and anti-IGDCC3 (PUNC), key players in axon guidance!
Explore the datasheets and order here 👉 buff.ly/KYdEvur
Explore the datasheets and order here 👉 buff.ly/KYdEvur
Good antibodies start with good data.
Our new anti-DCC, anti-Netrin-1, and anti-IGDCC3 (PUNC) #antibodies come with full validation datasets—including demonstrated lack of #crossreactivity.
Take a closer look: buff.ly/LLL78N2
Our new anti-DCC, anti-Netrin-1, and anti-IGDCC3 (PUNC) #antibodies come with full validation datasets—including demonstrated lack of #crossreactivity.
Take a closer look: buff.ly/LLL78N2
January 23, 2026 at 11:12 PM
Good antibodies start with good data.
Our new anti-DCC, anti-Netrin-1, and anti-IGDCC3 (PUNC) #antibodies come with full validation datasets—including demonstrated lack of #crossreactivity.
Take a closer look: buff.ly/LLL78N2
Our new anti-DCC, anti-Netrin-1, and anti-IGDCC3 (PUNC) #antibodies come with full validation datasets—including demonstrated lack of #crossreactivity.
Take a closer look: buff.ly/LLL78N2
Attending the Neuronal Connectivity meeting @cshlnews.bsky.social this week? Check out Nirakar Basnet’s poster to learn about our #axonguidance & #synapticfunction antibodies!
Not going? View all our panels, including #Netrin/DCC, #Slit/Robo, #Semaphorin/Plexin & #Eph/Ephrin ➡️ buff.ly/NshB3AJ
Not going? View all our panels, including #Netrin/DCC, #Slit/Robo, #Semaphorin/Plexin & #Eph/Ephrin ➡️ buff.ly/NshB3AJ
September 7, 2026 at 2:15 PM
Attending the Neuronal Connectivity meeting @cshlnews.bsky.social this week? Check out Nirakar Basnet’s poster to learn about our #axonguidance & #synapticfunction antibodies!
Not going? View all our panels, including #Netrin/DCC, #Slit/Robo, #Semaphorin/Plexin & #Eph/Ephrin ➡️ buff.ly/NshB3AJ
Not going? View all our panels, including #Netrin/DCC, #Slit/Robo, #Semaphorin/Plexin & #Eph/Ephrin ➡️ buff.ly/NshB3AJ
The authors included RRIDs in their in Nature Communications paper! We value the author's support of reproducibility. #OpenResearch #OpenScience #methodsmatter
Frazzled/DCC directs spatial progenitor integration ensuring steady-state intestinal turnover - Nature Communications
The intestinal epithelium is constantly renewed by stem- and progenitor cells. Here, Zipper et al unravel that Netrin-Frazzled/DCC signalling spatially directs progenitor migration and invasion implying their findings in the pathology of metastasis.
doi.org
April 2, 2026 at 7:00 AM
The authors included RRIDs in their in Nature Communications paper! We value the author's support of reproducibility. #OpenResearch #OpenScience #methodsmatter
Did you know @addgene.bsky.social now offers antibodies?
You can find 200+ #antibodies in their catalog — including IPI recombinants targeting #Netrin, #PUNC, #DCC, #Neurexin, #Neuroligin, #Glypican, #Integrin and more.
Browse here:
You can find 200+ #antibodies in their catalog — including IPI recombinants targeting #Netrin, #PUNC, #DCC, #Neurexin, #Neuroligin, #Glypican, #Integrin and more.
Browse here:
Synaptic cleft antibody collection
Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft. Proteins positione
buff.ly
January 30, 2026 at 3:15 PM
Did you know @addgene.bsky.social now offers antibodies?
You can find 200+ #antibodies in their catalog — including IPI recombinants targeting #Netrin, #PUNC, #DCC, #Neurexin, #Neuroligin, #Glypican, #Integrin and more.
Browse here:
You can find 200+ #antibodies in their catalog — including IPI recombinants targeting #Netrin, #PUNC, #DCC, #Neurexin, #Neuroligin, #Glypican, #Integrin and more.
Browse here:
IPI’s antibody collections now includes monoclonals targeted to: #Semaphorin #Neuropilin #Contactin #ROBO #Slit #Netrin #DCC #PUNC #Glypican
All undergo strict biophysical characterization/application validation at IPI, with data available online.
View our collections & order now:
buff.ly/7SE9WnB
All undergo strict biophysical characterization/application validation at IPI, with data available online.
View our collections & order now:
buff.ly/7SE9WnB
Axon Guidance Antibody Collection
For neurons to communicate, their axons must navigate precisely to their targets through a complex process known as axon guidance or neuronal migration. This pr
buff.ly
August 14, 2026 at 3:15 PM
IPI’s antibody collections now includes monoclonals targeted to: #Semaphorin #Neuropilin #Contactin #ROBO #Slit #Netrin #DCC #PUNC #Glypican
All undergo strict biophysical characterization/application validation at IPI, with data available online.
View our collections & order now:
buff.ly/7SE9WnB
All undergo strict biophysical characterization/application validation at IPI, with data available online.
View our collections & order now:
buff.ly/7SE9WnB
Metastasierungsmechanismen verstehen
Metastasen, also die Tochtergeschwülste von Krebszellen, stellen bei vielen Krebsformen ein zentrales Problem dar. Als Abkömmlinge des Primärtumors können sie in entfernten Organen wachsen und sind oft sc...
weiterlesen
Metastasen, also die Tochtergeschwülste von Krebszellen, stellen bei vielen Krebsformen ein zentrales Problem dar. Als Abkömmlinge des Primärtumors können sie in entfernten Organen wachsen und sind oft sc...
weiterlesen
April 2, 2026 at 11:41 AM
Metastasierungsmechanismen verstehen
Metastasen, also die Tochtergeschwülste von Krebszellen, stellen bei vielen Krebsformen ein zentrales Problem dar. Als Abkömmlinge des Primärtumors können sie in entfernten Organen wachsen und sind oft sc...
weiterlesen
Metastasen, also die Tochtergeschwülste von Krebszellen, stellen bei vielen Krebsformen ein zentrales Problem dar. Als Abkömmlinge des Primärtumors können sie in entfernten Organen wachsen und sind oft sc...
weiterlesen
タイトル: NLRP3/DCCシグナル経路を介したPinocembrinがマウスにおけるLPS誘発性うつ病様行動を軽減する
要点1: PinocembrinとMCC950は、うつ病様行動を改善し、NLRP3およびNetrin-1/DCC経路を調整する。
要点2: Pinocembrinは、LPSによって誘発されたうつ病様行動を改善し、神経可塑性を向上させる。
要点1: PinocembrinとMCC950は、うつ病様行動を改善し、NLRP3およびNetrin-1/DCC経路を調整する。
要点2: Pinocembrinは、LPSによって誘発されたうつ病様行動を改善し、神経可塑性を向上させる。
Pinocembrin alleviates LPS-induced depressive-like behavior in mice via the NLRP3/DCC signaling pathway.
【Biochem Biophys Res Commun】<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Depression, a prevalent and severe mental d...
pubmed.ncbi.nlm.nih.gov
November 13, 2024 at 11:49 PM
タイトル: NLRP3/DCCシグナル経路を介したPinocembrinがマウスにおけるLPS誘発性うつ病様行動を軽減する
要点1: PinocembrinとMCC950は、うつ病様行動を改善し、NLRP3およびNetrin-1/DCC経路を調整する。
要点2: Pinocembrinは、LPSによって誘発されたうつ病様行動を改善し、神経可塑性を向上させる。
要点1: PinocembrinとMCC950は、うつ病様行動を改善し、NLRP3およびNetrin-1/DCC経路を調整する。
要点2: Pinocembrinは、LPSによって誘発されたうつ病様行動を改善し、神経可塑性を向上させる。
We released new Neurexin, Neuroligin, Netrin, DCC and PUNC antibodies with lots of characterization work & data to assess their performance — shout out to our partner @addgene.bsky.social.
(You can find all our Abs here: buff.ly/TsqcTVF)
(You can find all our Abs here: buff.ly/TsqcTVF)
March 2, 2026 at 6:04 PM
We released new Neurexin, Neuroligin, Netrin, DCC and PUNC antibodies with lots of characterization work & data to assess their performance — shout out to our partner @addgene.bsky.social.
(You can find all our Abs here: buff.ly/TsqcTVF)
(You can find all our Abs here: buff.ly/TsqcTVF)
Axon guidance shapes how #neurons connect—and proteins like #Netrin-1, #DCC and #PUNC sit at the center of this process 🧠
IPI now offers #recombinantantibodies to all three targets, backed by solid validation data.
Explore our reagents: buff.ly/T1CktaD
IPI now offers #recombinantantibodies to all three targets, backed by solid validation data.
Explore our reagents: buff.ly/T1CktaD
Axon Guidance Antibody Collection
For neurons to communicate, their axons must navigate precisely to their targets through a complex process known as axon guidance or neuronal migration. This pr
proteininnovation.org
February 13, 2026 at 3:20 PM
Axon guidance shapes how #neurons connect—and proteins like #Netrin-1, #DCC and #PUNC sit at the center of this process 🧠
IPI now offers #recombinantantibodies to all three targets, backed by solid validation data.
Explore our reagents: buff.ly/T1CktaD
IPI now offers #recombinantantibodies to all three targets, backed by solid validation data.
Explore our reagents: buff.ly/T1CktaD
Interactions of netrin-1 through its glycosylation sites immobilize Deleted in Colorectal Cancer (DCC) by favoring its constitutive clustering https://www.biorxiv.org/content/10.1101/2023.10.26.563740v1
Interactions of netrin-1 through its glycosylation sites immobilize Deleted in Colorectal Cancer (DCC) by favoring its constitutive clustering https://www.biorxiv.org/content/10.1101/2023.10.26.563740v1
Netrin-1 is a secreted protein that attracts neurons expressing the membrane receptor Deleted in Col
www.biorxiv.org
October 26, 2023 at 8:32 PM
Interactions of netrin-1 through its glycosylation sites immobilize Deleted in Colorectal Cancer (DCC) by favoring its constitutive clustering https://www.biorxiv.org/content/10.1101/2023.10.26.563740v1
TRIM9 controls growth cone responses to netrin through DCC and UNC5C https://www.biorxiv.org/content/10.1101/2024.05.08.593135v1
TRIM9 controls growth cone responses to netrin through DCC and UNC5C https://www.biorxiv.org/content/10.1101/2024.05.08.593135v1
The guidance cue netrin-1 promotes both growth cone attraction and growth cone repulsion. How netrin
www.biorxiv.org
May 9, 2024 at 1:20 AM
TRIM9 controls growth cone responses to netrin through DCC and UNC5C https://www.biorxiv.org/content/10.1101/2024.05.08.593135v1
Mechanical Netrin-1-DCC Coupling Mediates Netrin-1-induced Axonal Haptotaxis https://www.biorxiv.org/content/10.1101/2023.12.03.569828v1
Mechanical Netrin-1-DCC Coupling Mediates Netrin-1-induced Axonal Haptotaxis https://www.biorxiv.org/content/10.1101/2023.12.03.569828v1
The growth cone, a motile structure located at the tip of growing axons, senses extracellular guidan
www.biorxiv.org
December 4, 2023 at 8:30 PM
Mechanical Netrin-1-DCC Coupling Mediates Netrin-1-induced Axonal Haptotaxis https://www.biorxiv.org/content/10.1101/2023.12.03.569828v1
Interactions of netrin-1 through its glycosylation sites immobilize Deleted in Colorectal Cancer (DCC) by favoring its constitutive clustering https://www.biorxiv.org/content/10.1101/2023.10.26.563740v1
Interactions of netrin-1 through its glycosylation sites immobilize Deleted in Colorectal Cancer (DCC) by favoring its constitutive clustering https://www.biorxiv.org/content/10.1101/2023.10.26.563740v1
Netrin-1 is a secreted protein that attracts neurons expressing the membrane receptor Deleted in Col
www.biorxiv.org
October 26, 2023 at 8:32 PM
Interactions of netrin-1 through its glycosylation sites immobilize Deleted in Colorectal Cancer (DCC) by favoring its constitutive clustering https://www.biorxiv.org/content/10.1101/2023.10.26.563740v1
TRIM9 controls growth cone responses to netrin through DCC and UNC5C https://www.biorxiv.org/content/10.1101/2024.05.08.593135v1
TRIM9 controls growth cone responses to netrin through DCC and UNC5C https://www.biorxiv.org/content/10.1101/2024.05.08.593135v1
The guidance cue netrin-1 promotes both growth cone attraction and growth cone repulsion. How netrin
www.biorxiv.org
May 9, 2024 at 1:20 AM
TRIM9 controls growth cone responses to netrin through DCC and UNC5C https://www.biorxiv.org/content/10.1101/2024.05.08.593135v1
Retraction Notice to: A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion
Retraction Notice to: A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion
(Cell 97, 927–941; June 25, 1999)
www.cell.com
September 14, 2023 at 2:50 PM
Retraction Notice to: A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion