Intercellular trafficking of latent TGF-β1 converts integrin expressing cells into signaling relays https://www.biorxiv.org/content/10.64898/2026.11.09.765446v1
November 12, 2026 at 12:19 PM
Intercellular trafficking of latent TGF-β1 converts integrin expressing cells into signaling relays https://www.biorxiv.org/content/10.64898/2026.11.09.765446v1
New paper from the Utrecht Virology Lab! 👇
🔗 doi.org/10.1038/s414...
We identified integrin α2β1 as a receptor for equine rhinitis A virus, revealing how protein and glycan interactions contribute to picornavirus entry.
Congrats to Collins, Giann, Rutger et al!
#virology #cryoEM
🔗 doi.org/10.1038/s414...
We identified integrin α2β1 as a receptor for equine rhinitis A virus, revealing how protein and glycan interactions contribute to picornavirus entry.
Congrats to Collins, Giann, Rutger et al!
#virology #cryoEM
November 9, 2026 at 11:35 AM
New paper from the Utrecht Virology Lab! 👇
🔗 doi.org/10.1038/s414...
We identified integrin α2β1 as a receptor for equine rhinitis A virus, revealing how protein and glycan interactions contribute to picornavirus entry.
Congrats to Collins, Giann, Rutger et al!
#virology #cryoEM
🔗 doi.org/10.1038/s414...
We identified integrin α2β1 as a receptor for equine rhinitis A virus, revealing how protein and glycan interactions contribute to picornavirus entry.
Congrats to Collins, Giann, Rutger et al!
#virology #cryoEM
New study from Rega, Perrucci et al. sheds light on Cilengitide as a valuable and exploitable therapeutic strategy for syndromic and sporadic thoracic aortic aneurysm. This selective integrin inhibitor reduces fibrosis and dilation in the aorta. rupress.org/jem/article/...
#CardiovascularBiology
#CardiovascularBiology
November 11, 2026 at 5:01 PM
New study from Rega, Perrucci et al. sheds light on Cilengitide as a valuable and exploitable therapeutic strategy for syndromic and sporadic thoracic aortic aneurysm. This selective integrin inhibitor reduces fibrosis and dilation in the aorta. rupress.org/jem/article/...
#CardiovascularBiology
#CardiovascularBiology
The authors included RRIDs in their in Cellular and Molecular Life Sciences paper! We value the author's support of reproducibility. #OpenResearch #reproducibility #accelerateopenscience
TROP2 promotes bone metastasis of colorectal cancer through interaction with the fibronectin-integrin axis
Read the full paper: TROP2 promotes bone metastasis of colorectal cancer through interaction with the fibronectin-integrin axis
doi.org
November 15, 2026 at 8:01 AM
The authors included RRIDs in their in Cellular and Molecular Life Sciences paper! We value the author's support of reproducibility. #OpenResearch #reproducibility #accelerateopenscience
Intercellular trafficking of latent TGF-β1 converts integrin expressing cells into signaling relays https://www.biorxiv.org/content/10.64898/2026.11.09.765446v1
November 12, 2026 at 12:19 PM
Intercellular trafficking of latent TGF-β1 converts integrin expressing cells into signaling relays https://www.biorxiv.org/content/10.64898/2026.11.09.765446v1
RRIDs were included in this in G3: Genes, Genomes, Genetics paper. RRIDs improve reproducibility in scientific research. #accelerateopenscience #methodsmatter #ReproducibleResearch
Integrin–Talin axis regulates mechanosensory presynaptic development and behavioral habituation to mechanical stimulation
Read the full paper: Integrin–Talin axis regulates mechanosensory presynaptic development and behavioral habituation to mechanical stimulation
doi.org
November 12, 2026 at 8:00 AM
RRIDs were included in this in G3: Genes, Genomes, Genetics paper. RRIDs improve reproducibility in scientific research. #accelerateopenscience #methodsmatter #ReproducibleResearch
[🧪 Venom] ACS Omega
Disintegrin-Derived Cyclic RGD Surfaces Enable Integrin α5β1-Mediated Rapid Cell Adhesion
https://doi.org/10.1021/acsomega.6c09159
Disintegrin-Derived Cyclic RGD Surfaces Enable Integrin α5β1-Mediated Rapid Cell Adhesion
https://doi.org/10.1021/acsomega.6c09159
November 11, 2026 at 6:30 PM
[🧪 Venom] ACS Omega
Disintegrin-Derived Cyclic RGD Surfaces Enable Integrin α5β1-Mediated Rapid Cell Adhesion
https://doi.org/10.1021/acsomega.6c09159
Disintegrin-Derived Cyclic RGD Surfaces Enable Integrin α5β1-Mediated Rapid Cell Adhesion
https://doi.org/10.1021/acsomega.6c09159
(US20260345803A1)
Targinta’s integrin α10-targeted ADC Th-Ab12-PNU-159682 shows marked selectivity over α11, with IC50 0.001 vs 2.791 nM in engineered cells. Bystander killing and BT549 activity support α10 as an ADC target; human tumour/normal-tissue expression will define its therapeutic window.
Targinta’s integrin α10-targeted ADC Th-Ab12-PNU-159682 shows marked selectivity over α11, with IC50 0.001 vs 2.791 nM in engineered cells. Bystander killing and BT549 activity support α10 as an ADC target; human tumour/normal-tissue expression will define its therapeutic window.
November 15, 2026 at 8:11 AM
(US20260345803A1)
Targinta’s integrin α10-targeted ADC Th-Ab12-PNU-159682 shows marked selectivity over α11, with IC50 0.001 vs 2.791 nM in engineered cells. Bystander killing and BT549 activity support α10 as an ADC target; human tumour/normal-tissue expression will define its therapeutic window.
Targinta’s integrin α10-targeted ADC Th-Ab12-PNU-159682 shows marked selectivity over α11, with IC50 0.001 vs 2.791 nM in engineered cells. Bystander killing and BT549 activity support α10 as an ADC target; human tumour/normal-tissue expression will define its therapeutic window.
Check how, by linking inflammation, ECM remodeling, integrin-mediated mechanotransduction, and ligand-independent EGFR/HER2 activation, their findings provide a unified framework for understanding how microenvironmental changes initiate metastatic outgrowth after prolonged dormancy.
November 12, 2026 at 8:14 AM
Check how, by linking inflammation, ECM remodeling, integrin-mediated mechanotransduction, and ligand-independent EGFR/HER2 activation, their findings provide a unified framework for understanding how microenvironmental changes initiate metastatic outgrowth after prolonged dormancy.
Embryonic integrin signaling establishes a program of differential cell elongation in a growing proprioceptive organ https://www.biorxiv.org/content/10.64898/2026.11.07.765072v1
November 9, 2026 at 9:30 PM
Embryonic integrin signaling establishes a program of differential cell elongation in a growing proprioceptive organ https://www.biorxiv.org/content/10.64898/2026.11.07.765072v1
Embryonic integrin signaling establishes a program of differential cell elongation in a growing proprioceptive organ https://www.biorxiv.org/content/10.64898/2026.11.07.765072v1
November 9, 2026 at 9:30 PM
Embryonic integrin signaling establishes a program of differential cell elongation in a growing proprioceptive organ https://www.biorxiv.org/content/10.64898/2026.11.07.765072v1
New study @jem.org from Rega, Perrucci et al. sheds light on Cilengitide as a valuable and exploitable therapeutic strategy for syndromic and sporadic thoracic aortic aneurysm. This selective integrin inhibitor reduces fibrosis and dilation in the aorta. rupress.org/jem/article/...
November 11, 2026 at 5:30 PM
New study @jem.org from Rega, Perrucci et al. sheds light on Cilengitide as a valuable and exploitable therapeutic strategy for syndromic and sporadic thoracic aortic aneurysm. This selective integrin inhibitor reduces fibrosis and dilation in the aorta. rupress.org/jem/article/...
A great week for papers from the lab!
Our kindlin-3 paper is out today in Blood!
Just four amino acids added by alternative splicing enhance membrane recruitment, integrin activation and neutrophil adhesion.
Great collaboration with Lai Wen's team, and Klaus Ley!
Paper: doi.org/10.1182/bloo...
Our kindlin-3 paper is out today in Blood!
Just four amino acids added by alternative splicing enhance membrane recruitment, integrin activation and neutrophil adhesion.
Great collaboration with Lai Wen's team, and Klaus Ley!
Paper: doi.org/10.1182/bloo...
FERMT3 alternative splicing enhances kindlin-3 membrane recruitment for neutrophil adhesion during stress myelopoiesis
Key PointsA 4-residue IPRR insertion enhances kindlin-3 membrane recruitment and promotes β2-integrin activation.FERMT3 alternative splicing dynamically re
doi.org
November 5, 2026 at 6:48 PM
A great week for papers from the lab!
Our kindlin-3 paper is out today in Blood!
Just four amino acids added by alternative splicing enhance membrane recruitment, integrin activation and neutrophil adhesion.
Great collaboration with Lai Wen's team, and Klaus Ley!
Paper: doi.org/10.1182/bloo...
Our kindlin-3 paper is out today in Blood!
Just four amino acids added by alternative splicing enhance membrane recruitment, integrin activation and neutrophil adhesion.
Great collaboration with Lai Wen's team, and Klaus Ley!
Paper: doi.org/10.1182/bloo...
Two distinct α2β1 integrin glycan interactions mediate cell entry of a picornavirus
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com
November 6, 2026 at 2:41 PM
Two distinct α2β1 integrin glycan interactions mediate cell entry of a picornavirus
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mechano-chemical Pericyte-to-Endothelial cell communication
R-Ras acts as a pro-wrapping & pro-contractile factor in Pericyte
R-Ras activation in pericyte
⏫Cell contractility
⏫αv integrin- & Myosin (MYL9/MLCK)-dependent active TGFβ1 secretion
⏫EC quiescence
#PNAS 2026
www.pnas.org/doi/10.1073/...
R-Ras acts as a pro-wrapping & pro-contractile factor in Pericyte
R-Ras activation in pericyte
⏫Cell contractility
⏫αv integrin- & Myosin (MYL9/MLCK)-dependent active TGFβ1 secretion
⏫EC quiescence
#PNAS 2026
www.pnas.org/doi/10.1073/...
November 10, 2026 at 1:04 PM
Mechano-chemical Pericyte-to-Endothelial cell communication
R-Ras acts as a pro-wrapping & pro-contractile factor in Pericyte
R-Ras activation in pericyte
⏫Cell contractility
⏫αv integrin- & Myosin (MYL9/MLCK)-dependent active TGFβ1 secretion
⏫EC quiescence
#PNAS 2026
www.pnas.org/doi/10.1073/...
R-Ras acts as a pro-wrapping & pro-contractile factor in Pericyte
R-Ras activation in pericyte
⏫Cell contractility
⏫αv integrin- & Myosin (MYL9/MLCK)-dependent active TGFβ1 secretion
⏫EC quiescence
#PNAS 2026
www.pnas.org/doi/10.1073/...
CRV Science Wiki
🧬 Integrin — Integrins (named by Richard O. Hynes in 1987 for their role in integrating the extracellular matrix with the intracellular cytoskeleton) are a superfamily of obligate α/β heterodimeric transmembrane glycoprotein receptors that se…
https://crvscience.com/wiki/integrin
🧬 Integrin — Integrins (named by Richard O. Hynes in 1987 for their role in integrating the extracellular matrix with the intracellular cytoskeleton) are a superfamily of obligate α/β heterodimeric transmembrane glycoprotein receptors that se…
https://crvscience.com/wiki/integrin
CRV Science Wiki
🧬 Integrin — Integrins (named by Richard O. Hynes in 1987 for their role in integrating the extracellular matrix with the intracellular cytoskeleton) are a superfamily of obligate α/β heterodimeric transmembrane glycoprotein receptors that serve as the primary biomechanical and s…
crvscience.com
November 7, 2026 at 8:05 AM
CRV Science Wiki
🧬 Integrin — Integrins (named by Richard O. Hynes in 1987 for their role in integrating the extracellular matrix with the intracellular cytoskeleton) are a superfamily of obligate α/β heterodimeric transmembrane glycoprotein receptors that se…
https://crvscience.com/wiki/integrin
🧬 Integrin — Integrins (named by Richard O. Hynes in 1987 for their role in integrating the extracellular matrix with the intracellular cytoskeleton) are a superfamily of obligate α/β heterodimeric transmembrane glycoprotein receptors that se…
https://crvscience.com/wiki/integrin
A paper using RRID:AB_1272189 from @thermofishersci.bsky.social was just published in iScience. We value the author's support of reproducibility. #reproducibility #OpenScience #methodsmatter
β7-Integrin worsens diet-induced metabolic syndrome in mice by altering intestinal lipid handling and colonic inflammatory monocyte infiltration
Read the full paper: β7-Integrin worsens diet-induced metabolic syndrome in mice by altering intestinal lipid handling and colonic inflammatory monocyte infiltration
doi.org
November 7, 2026 at 8:00 AM
A paper using RRID:AB_1272189 from @thermofishersci.bsky.social was just published in iScience. We value the author's support of reproducibility. #reproducibility #OpenScience #methodsmatter
New paper out today in PNAS! 🎉
We've finally resolved a 40-year-old mystery in talin that's bugged me for years.
Since 1986, IBS2 has been considered an integrin-binding site, but direct evidence has remained elusive.
Turns out, it's a talin-binding site!
www.pnas.org/doi/10.1073/...
We've finally resolved a 40-year-old mystery in talin that's bugged me for years.
Since 1986, IBS2 has been considered an integrin-binding site, but direct evidence has remained elusive.
Turns out, it's a talin-binding site!
www.pnas.org/doi/10.1073/...
November 4, 2026 at 5:39 PM
New paper out today in PNAS! 🎉
We've finally resolved a 40-year-old mystery in talin that's bugged me for years.
Since 1986, IBS2 has been considered an integrin-binding site, but direct evidence has remained elusive.
Turns out, it's a talin-binding site!
www.pnas.org/doi/10.1073/...
We've finally resolved a 40-year-old mystery in talin that's bugged me for years.
Since 1986, IBS2 has been considered an integrin-binding site, but direct evidence has remained elusive.
Turns out, it's a talin-binding site!
www.pnas.org/doi/10.1073/...
An aggregation-prone region in talin controls talin self-interactions and regulates integrin adhesion complex dynamics
PNAS
doi.org/10.1073/pnas...
PNAS
doi.org/10.1073/pnas...
An aggregation-prone region in talin controls talin self-interactions and regulates integrin adhesion complex dynamics | PNAS
Talin is a mechanosensitive scaffold that couples integrins to the actin cytoskeleton
and coordinates signaling at integrin adhesion complexes. A s...
doi.org
November 6, 2026 at 6:26 AM
An aggregation-prone region in talin controls talin self-interactions and regulates integrin adhesion complex dynamics
PNAS
doi.org/10.1073/pnas...
PNAS
doi.org/10.1073/pnas...
Receptor-proximal phosphoform organization precedes β2 integrin activation https://www.biorxiv.org/content/10.64898/2026.11.04.762546v1
November 6, 2026 at 2:30 AM
Receptor-proximal phosphoform organization precedes β2 integrin activation https://www.biorxiv.org/content/10.64898/2026.11.04.762546v1
Receptor-proximal phosphoform organization precedes β2 integrin activation https://www.biorxiv.org/content/10.64898/2026.11.04.762546v1
November 6, 2026 at 2:30 AM
Receptor-proximal phosphoform organization precedes β2 integrin activation https://www.biorxiv.org/content/10.64898/2026.11.04.762546v1
Ball NJ, ... Goult BT.
An aggregation-prone region in talin controls talin self-interactions and regulates integrin adhesion complex dynamics.
Proc Natl Acad Sci U S A. (2026) 123: e2602326123
PMID: 42981030
An aggregation-prone region in talin controls talin self-interactions and regulates integrin adhesion complex dynamics.
Proc Natl Acad Sci U S A. (2026) 123: e2602326123
PMID: 42981030
November 6, 2026 at 11:26 AM
Ball NJ, ... Goult BT.
An aggregation-prone region in talin controls talin self-interactions and regulates integrin adhesion complex dynamics.
Proc Natl Acad Sci U S A. (2026) 123: e2602326123
PMID: 42981030
An aggregation-prone region in talin controls talin self-interactions and regulates integrin adhesion complex dynamics.
Proc Natl Acad Sci U S A. (2026) 123: e2602326123
PMID: 42981030
Chen, T., Fernandez-Espartero, C. H., Giannone, G. (2025). Single-Molecule Tracking and Super-Resolution Microscopy Unveil Actin-Driven Membrane Nanotopography Shaping Stable Integrin Adhesions in Developing Tissue. Cytoskeleton, 82(7):471-474 onlinelibrary.wiley.com/doi/10.1002/...
November 6, 2026 at 6:57 PM
Chen, T., Fernandez-Espartero, C. H., Giannone, G. (2025). Single-Molecule Tracking and Super-Resolution Microscopy Unveil Actin-Driven Membrane Nanotopography Shaping Stable Integrin Adhesions in Developing Tissue. Cytoskeleton, 82(7):471-474 onlinelibrary.wiley.com/doi/10.1002/...