During navigation, animals continuously sample their environment and plan routes to distant goals. Flexible navigation requires neural dynamics capable of rapidly deploying task-relevant information to direct behavior toward goals. Hippocampal spiking sequences within theta cycles, which sweep along spatial trajectories ahead of the animal, serve as a potential candidate. Previous research identified experience-independent, left–right-alternating theta sweeps as a mechanism for local spatial sampling. However, it remains unclear whether theta sweeps also facilitate trajectory evaluation toward distant, remembered goals. In rats performing goal-directed navigation in an open arena, we identified a distinct form of learning-dependent theta sequences that predicted upcoming goal-directed trajectories. These sequences coordinated with prefrontal cortical activity and were preferentially replayed during sharp-wave ripples. We described a circuit mechanism whereby egocentric goal-direction s

感情ベクトルの解釈とSSM構造の最適化による次世代AIの可能性。

The Department of Psychological and Brain Sciences offers graduate training leading to a doctoral degree in Psychological and Brain Science or Cognitive Neuroscience. Research within the department is...

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