Our data suggest that climatic factors are major drivers of OROV spread and were potentially exacerbated during 2024 by extreme weather events. OROV glycoprotein reassortants, but not individual OROV ...

Our data suggest that climatic factors are major drivers of OROV spread and were potentially exacerbated during 2024 by extreme weather events. OROV glycoprotein reassortants, but not individual OROV ...

Our data suggest that climatic factors are major drivers of OROV spread and were potentially exacerbated during 2024 by extreme weather events. OROV glycoprotein reassortants, but not individual OROV ...

Oropouche virus (OROV) is an emerging virus in Latin America. Here the authors show in a mouse model that OROV infects the placenta and can reach the fetus during pregnancy, a conserved feature across...

We detected OROV IgM in six of 68 newborns with microcephaly of unknown cause. One infant who died had OROV RNA and antigen in several tissues, including the brain. The possibility of OROV vertical tr...

Oropouche virus (OROV) is an emerging arbovirus with increasing outbreaks in South America, yet its environmental drivers and potential range remain poorly understood. Using ecological niche modeling ...

We detected OROV IgM in six of 68 newborns with microcephaly of unknown cause. One infant who died had OROV RNA and antigen in several tissues, including the brain. The possibility of OROV vertical tr...

Oropouche virus (OROV) is an emerging orthobunyavirus responsible for widespread outbreaks across South and Central America. Recent reports of congenital disease have raised urgent concerns regarding the potential risk of OROV infection during pregnancy. Here, we establish an in vivo murine model of OROV vertical transmission using the ancestral (prototype) strain BeAn19991 in immunocompetent C57BL/6 J mice. We demonstrate that OROV robustly replicates in maternal tissues and efficiently infects the placenta. Complementary studies in human trophoblast-derived cell lines demonstrate conserved placental tropism across both the ancestral strain and a contemporary (outbreak) isolate, supporting the translational relevance of our findings. Notably, comparison of ancestral and contemporary viruses indicates that placental infection is not a recently acquired property of OROV. Further, offspring born to infected dams exhibit maternally derived neutralizing antibodies and transient protec

Oropouche virus has recently become an urgent threat to public health in Central and South America. OROV is mainly transmitted by biting midges; however, some public health agencies and scientific sou...

Oropouche virus (OROV) is an emerging arbovirus with rapidly increasing incidence and recent reports of severe disease outcomes. While gastrointestinal symptoms have been described, the intestinal tropism of OROV has not been experimentally explored. By combining meta-analysis of clinical data with human intestinal organoid infection models, we demonstrate that OROV can replicate in intestinal epithelial cells. We further show that, in a human intestinal organoid model, endogenous interferon responses are insufficient to restrict replication, while treatment with interferons exerts potent antiviral activity. These findings highlight the susceptibility of intestinal epithelial cells to OROV infection and the therapeutic potential of interferons.

Currently, the largest outbreak of Oropouche virus (OROV) in Latin America and the Caribbean, has also spread across the globe to Italy, Spain, and Germany, bringing this virus into the public domain....

Clinical and epidemiologic evidence from the recent outbreak of Oropouche virus (OROV) has demonstrated increased severity in clinical disease and adverse pregnancy outcomes including miscarriage, sti...

Oropouche virus (OROV) is an orthobunyavirus mainly transmitted by the bites of Culicoides paraensis. OROV is endemic to the north region of Brazil and is also found in other countries, including Peru...

Oropouche virus (OROV) is an orthobunyavirus undergoing dramatic re-emergence and rapid geographic expansion across Central and South America, coinciding wit...

Our data suggest that climatic factors are major drivers of OROV spread and were potentially exacerbated during 2024 by extreme weather events. OROV glycoprotein reassortants, but not individual OROV ...

Loving him was Fed(orov)

Oropouche virus (OROV) is a re-emerging arbovirus that poses a yet undetermined degree of threat to the United States (US), with outbreaks reported in the Caribbean and South America, including new areas of spread, since the end of 2023.

Oropouche fever is a neglected tropical viral disease endemic to Latin America and the Caribbean. Oropouche fever is caused by Oropouche virus (OROV), an orthobunyavirus with a tri-segmented (-)ssRNA ...

La maladie à virus Oropouche est causée par le virus Oropouche (OROV) qui peut provoquer de la fièvre, des maux de tête, des douleurs articulaires, des douleurs musculaires, des frissons, des nausées,...