A mouse hippocampus labeled for oligodendrocytes 🟡, myelin 🔵, and nuclei ⚪️. You can appreciate how the distribution of myelin and oligodendrocytes is not homogeneous in the overall hippocampal formation.
#FluorescenceFriday
#FluorescenceFriday
December 20, 2024 at 10:36 AM
A mouse hippocampus labeled for oligodendrocytes 🟡, myelin 🔵, and nuclei ⚪️. You can appreciate how the distribution of myelin and oligodendrocytes is not homogeneous in the overall hippocampal formation.
#FluorescenceFriday
#FluorescenceFriday
Super stoked to share that I’m starting my lab at UHN @dkjei-uhn.bsky.social / @kbi-uhn.bsky.social and the University of Toronto!
If you’re interested in neuron-myelin interactions in circuit maturation and cognition, please reach out - we are hiring!
www.oligodendrocyte.org
1/
If you’re interested in neuron-myelin interactions in circuit maturation and cognition, please reach out - we are hiring!
www.oligodendrocyte.org
1/
Xin Lab
Welcome! We study the cellular interactions between neurons and oligodendrocytes, which produce myelin in the central nervous system.
Myelination - the process by which oligodendrocytes ensheath neuro...
www.oligodendrocyte.org
March 13, 2026 at 4:14 PM
Super stoked to share that I’m starting my lab at UHN @dkjei-uhn.bsky.social / @kbi-uhn.bsky.social and the University of Toronto!
If you’re interested in neuron-myelin interactions in circuit maturation and cognition, please reach out - we are hiring!
www.oligodendrocyte.org
1/
If you’re interested in neuron-myelin interactions in circuit maturation and cognition, please reach out - we are hiring!
www.oligodendrocyte.org
1/
A Review on #oligodendrocytes in Alzheimer’s disease pathophysiology from Shreeya Kedia & Mikael Simons 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Oligodendrocytes in Alzheimer’s disease pathophysiology - Nature Neuroscience
Emerging evidence highlights the dual role of oligodendrocytes in Alzheimer’s disease, both providing protective mechanisms against the pathology and contributing to its progression.
www.nature.com
January 30, 2025 at 1:48 PM
A Review on #oligodendrocytes in Alzheimer’s disease pathophysiology from Shreeya Kedia & Mikael Simons 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Testing some new antibodies to identify oligodendrocytes 🟣, for me, the most difficult one to target in brain microscopy! Here I was able to identify its nuclei (oligo2 marker), not the whole cell body like neurons 🟡or microglia 🔵. Still, you can see oligos are everywhere! #Neuroscience #Microscopy
October 22, 2025 at 4:46 AM
Testing some new antibodies to identify oligodendrocytes 🟣, for me, the most difficult one to target in brain microscopy! Here I was able to identify its nuclei (oligo2 marker), not the whole cell body like neurons 🟡or microglia 🔵. Still, you can see oligos are everywhere! #Neuroscience #Microscopy
New work from Yasmine Kamen shows that differentiating oligodendrocytes are filled with the zymogen procaspase-3. This provides a specific marker for new oligodendrocytes and suggests a role for this pathway in oligodendrocyte fate decisions.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 15, 2024 at 2:21 PM
New work from Yasmine Kamen shows that differentiating oligodendrocytes are filled with the zymogen procaspase-3. This provides a specific marker for new oligodendrocytes and suggests a role for this pathway in oligodendrocyte fate decisions.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Happy #FluorescenceFriday from this pair of white-matter oligodendrocytes!
November 15, 2025 at 12:01 AM
Happy #FluorescenceFriday from this pair of white-matter oligodendrocytes!
A new study in @natneuro.nature.com by @gocastelobranco.bsky.social et al explores how oligodendrocytes respond in #MultipleSclerosis. The researchers identified distinct and early disease-related states and gene activity patterns that may help explain how #MS progresses 🧪 news.ki.se/oligodendroc...
Oligodendrocytes show early changes in multiple sclerosis
A new study from Karolinska Institutet, published in Nature Neuroscience, explores how oligodendrocytes, the cells that produce myelin in the brain and spinal cord, respond during the development of m...
news.ki.se
November 17, 2025 at 1:22 PM
A new study in @natneuro.nature.com by @gocastelobranco.bsky.social et al explores how oligodendrocytes respond in #MultipleSclerosis. The researchers identified distinct and early disease-related states and gene activity patterns that may help explain how #MS progresses 🧪 news.ki.se/oligodendroc...
alert! fundamental myelin biology - led by the amazing Yevgeniya Mironova and Dwight Bergles www.science.org/doi/10.1126/...
Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors
Oligodendrocytes form myelin sheaths around axons to enable rapid signaling within neural circuits. The generation of new oligodendrocytes through differentiation of oligodendrocyte precursor cells (O...
www.science.org
January 23, 2026 at 2:48 AM
alert! fundamental myelin biology - led by the amazing Yevgeniya Mironova and Dwight Bergles www.science.org/doi/10.1126/...
#fluorescencefriday takes a look at oligodendrocytes and OPCs in the cleared mouse 🧠 stained for Olig2 and imaged by #lightsheet 🔬 . By @shahrzadbahrampour.bsky.social @kesummers.bsky.social in collaboration with Corey Baron’s lab. @tridentpct.bsky.social @westernubrainscan.bsky.social
May 16, 2025 at 1:51 AM
#fluorescencefriday takes a look at oligodendrocytes and OPCs in the cleared mouse 🧠 stained for Olig2 and imaged by #lightsheet 🔬 . By @shahrzadbahrampour.bsky.social @kesummers.bsky.social in collaboration with Corey Baron’s lab. @tridentpct.bsky.social @westernubrainscan.bsky.social
What role do #oligodendrocytes play in #Parkinson's disease progression? In this Unsolved Mystery, @sjaekel.bsky.social and colleagues highlight what is and isn't known about oligodendrocytes in PD, and discuss whether they are bystanders or drivers of PD pathology.
plos.io/408mdjA
plos.io/408mdjA
January 10, 2025 at 6:01 PM
What role do #oligodendrocytes play in #Parkinson's disease progression? In this Unsolved Mystery, @sjaekel.bsky.social and colleagues highlight what is and isn't known about oligodendrocytes in PD, and discuss whether they are bystanders or drivers of PD pathology.
plos.io/408mdjA
plos.io/408mdjA
We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth.
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry
Dereddi, Djannatian, and colleagues show that oligodendrocytes use mechanical cues
to measure axon size. The stretch-activated channel TMEM63A converts membrane tension
into calcium signals, which cal...
www.cell.com
January 2, 2026 at 3:55 PM
We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth.
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
Cool!! 💥Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson’s disease via the prosaposin-GPR37-IL-6 axis💥
by Qiang Ma and colleagues
#neuroskyence
#neurosky
#oligodendrocytes
#Parkinson’s
www.cell.com/cell-reports...
by Qiang Ma and colleagues
#neuroskyence
#neurosky
#oligodendrocytes
#Parkinson’s
www.cell.com/cell-reports...
Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson’s disease via the prosaposin-GPR37-IL-6 axis
Ma et al. identify that oligodendrocytes drive PD-like neurodegeneration via the prosaposin-GPR37-IL-6
axis. GPR37 is upregulated in oligodendrocytes, and prosaposin secretion is increased
in parkinso...
www.cell.com
February 6, 2025 at 8:47 PM
Cool!! 💥Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson’s disease via the prosaposin-GPR37-IL-6 axis💥
by Qiang Ma and colleagues
#neuroskyence
#neurosky
#oligodendrocytes
#Parkinson’s
www.cell.com/cell-reports...
by Qiang Ma and colleagues
#neuroskyence
#neurosky
#oligodendrocytes
#Parkinson’s
www.cell.com/cell-reports...
We had fun assembling images and describing approaches for imaging oligodendrocytes and myelin in vivo, in organotypic slices, and in fixed tissues. This work started in the lab of @jgrutzendler.bsky.social over 10 years ago and continues to keep us busy.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
July 18, 2025 at 6:15 PM
We had fun assembling images and describing approaches for imaging oligodendrocytes and myelin in vivo, in organotypic slices, and in fixed tissues. This work started in the lab of @jgrutzendler.bsky.social over 10 years ago and continues to keep us busy.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
New preprint from Xhoela Bame et al shows that dying oligodendrocytes stick around for weeks to months without mitochondria! This happens after single cell DNA damage or when mitochondrial Fis1 is deleted in oligodendrocytes.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 23, 2026 at 3:24 PM
New preprint from Xhoela Bame et al shows that dying oligodendrocytes stick around for weeks to months without mitochondria! This happens after single cell DNA damage or when mitochondrial Fis1 is deleted in oligodendrocytes.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Expanding metabolic roles for the GIPR in oligodendrocytes #weightloss www.cell.com/cell-metabol...
Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism
Hansford et al. show that GIPR, a target of new weight-loss drugs, is found in brain
cells called oligodendrocytes. GIPR helps these drugs access the brain and boosts
weight loss. Without GIPR in thes...
www.cell.com
August 14, 2025 at 3:07 PM
Expanding metabolic roles for the GIPR in oligodendrocytes #weightloss www.cell.com/cell-metabol...
Review @cellcellpress.bsky.social
Oligodendrocytes in central nervous system health and disease
www.cell.com/cell/fulltex...
Oligodendrocytes in central nervous system health and disease
www.cell.com/cell/fulltex...
September 21, 2026 at 4:15 PM
Review @cellcellpress.bsky.social
Oligodendrocytes in central nervous system health and disease
www.cell.com/cell/fulltex...
Oligodendrocytes in central nervous system health and disease
www.cell.com/cell/fulltex...
If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system
Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...
www.biorxiv.org
September 3, 2025 at 11:51 AM
If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
When we think #glia & #Alzheimers disease, some think #microglia - some think #astrocytes
But how about #oligodendrocytes ?
Just because something is seemingly quiet & unassuming, doesn’t mean that it is or that it can’t become reactive #neuroskyence
But how about #oligodendrocytes ?
Just because something is seemingly quiet & unassuming, doesn’t mean that it is or that it can’t become reactive #neuroskyence
A Review on #oligodendrocytes in Alzheimer’s disease pathophysiology from Shreeya Kedia & Mikael Simons 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Oligodendrocytes in Alzheimer’s disease pathophysiology - Nature Neuroscience
Emerging evidence highlights the dual role of oligodendrocytes in Alzheimer’s disease, both providing protective mechanisms against the pathology and contributing to its progression.
www.nature.com
January 30, 2025 at 10:54 PM
When we think #glia & #Alzheimers disease, some think #microglia - some think #astrocytes
But how about #oligodendrocytes ?
Just because something is seemingly quiet & unassuming, doesn’t mean that it is or that it can’t become reactive #neuroskyence
But how about #oligodendrocytes ?
Just because something is seemingly quiet & unassuming, doesn’t mean that it is or that it can’t become reactive #neuroskyence
Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article in collaboration with the Burbulla lab! It is quite certain that a lot of work moves in this direction.
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Are oligodendrocytes bystanders or drivers of Parkinson’s disease pathology?
The major pathological feature of Parkinson ‘s disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons...
journals.plos.org
January 8, 2025 at 8:15 PM
Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article in collaboration with the Burbulla lab! It is quite certain that a lot of work moves in this direction.
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Which track do I choose: On #FluorescenceFriday, a pair of newly formed oligodendrocytes encounter a field of neuronal axons. Later in development, they will wrap around and insulate subset of these axons
September 19, 2025 at 8:22 PM
Which track do I choose: On #FluorescenceFriday, a pair of newly formed oligodendrocytes encounter a field of neuronal axons. Later in development, they will wrap around and insulate subset of these axons
Since everyone's doing intros: Hi 👋
I'm a postdoc at UCC 🇮🇪 I did my PhD at MPI-NAT 🇩🇪 where I worked on Alzheimer's disease from a glial POV and now I'm adding sex differences and the gut microbiome on top.
A shameless plug of our recent work on oligodendrocytes contributing to Aβ plaque formation:
I'm a postdoc at UCC 🇮🇪 I did my PhD at MPI-NAT 🇩🇪 where I worked on Alzheimer's disease from a glial POV and now I'm adding sex differences and the gut microbiome on top.
A shameless plug of our recent work on oligodendrocytes contributing to Aβ plaque formation:
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice - Nature Neuroscience
In Alzheimer’s disease, neurons are considered the sole source of amyloid-β (Aβ) peptides that form plaques. Here the authors show that oligodendrocytes, the myelinating glial cells of the brain, also...
www.nature.com
November 13, 2024 at 2:06 PM
Since everyone's doing intros: Hi 👋
I'm a postdoc at UCC 🇮🇪 I did my PhD at MPI-NAT 🇩🇪 where I worked on Alzheimer's disease from a glial POV and now I'm adding sex differences and the gut microbiome on top.
A shameless plug of our recent work on oligodendrocytes contributing to Aβ plaque formation:
I'm a postdoc at UCC 🇮🇪 I did my PhD at MPI-NAT 🇩🇪 where I worked on Alzheimer's disease from a glial POV and now I'm adding sex differences and the gut microbiome on top.
A shameless plug of our recent work on oligodendrocytes contributing to Aβ plaque formation:
Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research? molecularneurodegeneration.biomedcentral.com/articles/10....
November 17, 2024 at 7:49 PM
Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research? molecularneurodegeneration.biomedcentral.com/articles/10....