Cool application of in vivo bioorthogonal chemistry from Biogen, imaging biodistribution of ASOs in the brain 🤯
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry
Intrathecally dosed antisense oligonucleotide distribution can be imaged in rat and nonhuman primate brains using a PET tracer and click chemistry.
www.science.org
May 8, 2025 at 10:12 PM
Cool application of in vivo bioorthogonal chemistry from Biogen, imaging biodistribution of ASOs in the brain 🤯
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
'Unlike typical gene therapy, which alters a person’s genes to treat a genetic disease, antisense oligonucleotide [RNA] therapy, uses short strands of genetic material to target RNA produced by the gene and reduce how much protein is made.'
Looking for good news. Advances in RNA science & med.
Looking for good news. Advances in RNA science & med.
First for RNA therapy: man with rare motor-neuron disease improves after treatment
Gene-targeting treatments could be used to treat other people with rare forms of amyotrophic lateral sclerosis (ALS).
www.nature.com
September 19, 2026 at 9:48 AM
'Unlike typical gene therapy, which alters a person’s genes to treat a genetic disease, antisense oligonucleotide [RNA] therapy, uses short strands of genetic material to target RNA produced by the gene and reduce how much protein is made.'
Looking for good news. Advances in RNA science & med.
Looking for good news. Advances in RNA science & med.
Our story with @hobbslabutah.bsky.social discovering CBASS sensing of phage proteases out now in @science.org
New data include CBASS recognition of diverse proteases beyond T4, and verifying CD-NTase activation loop cleavage as the trigger for defense in vivo
www.science.org/doi/10.1126/...
New data include CBASS recognition of diverse proteases beyond T4, and verifying CD-NTase activation loop cleavage as the trigger for defense in vivo
www.science.org/doi/10.1126/...
October 1, 2026 at 7:07 PM
Our story with @hobbslabutah.bsky.social discovering CBASS sensing of phage proteases out now in @science.org
New data include CBASS recognition of diverse proteases beyond T4, and verifying CD-NTase activation loop cleavage as the trigger for defense in vivo
www.science.org/doi/10.1126/...
New data include CBASS recognition of diverse proteases beyond T4, and verifying CD-NTase activation loop cleavage as the trigger for defense in vivo
www.science.org/doi/10.1126/...
Click editing uses DNA polymerases, HUH endonucleases and oligonucleotide templates for genome modification go.nature.com/3zPEIjp
rdcu.be/erfhL
rdcu.be/erfhL
Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases - Nature Biotechnology
Click editing uses DNA polymerases, HUH endonucleases and oligonucleotide templates for genome modification.
go.nature.com
June 24, 2025 at 3:34 AM
Click editing uses DNA polymerases, HUH endonucleases and oligonucleotide templates for genome modification go.nature.com/3zPEIjp
rdcu.be/erfhL
rdcu.be/erfhL
New preprint from the Sternberg lab!
We used pooled oligonucleotide library mutagenesis + high-throughput sequencing to systematically dissect the molecular determinants of IStron transposition, RNA-guided DNA cleavage, and self-splicing.
www.biorxiv.org/content/10.6...
We used pooled oligonucleotide library mutagenesis + high-throughput sequencing to systematically dissect the molecular determinants of IStron transposition, RNA-guided DNA cleavage, and self-splicing.
www.biorxiv.org/content/10.6...
March 16, 2026 at 6:59 PM
New preprint from the Sternberg lab!
We used pooled oligonucleotide library mutagenesis + high-throughput sequencing to systematically dissect the molecular determinants of IStron transposition, RNA-guided DNA cleavage, and self-splicing.
www.biorxiv.org/content/10.6...
We used pooled oligonucleotide library mutagenesis + high-throughput sequencing to systematically dissect the molecular determinants of IStron transposition, RNA-guided DNA cleavage, and self-splicing.
www.biorxiv.org/content/10.6...
We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer 🧬💊!
Preprint led by Disha
#chemsky 🧪 @uclchemistry.bsky.social @oxfordchemistry.bsky.social chemrxiv.org/engage/chemr...
Preprint led by Disha
#chemsky 🧪 @uclchemistry.bsky.social @oxfordchemistry.bsky.social chemrxiv.org/engage/chemr...
Going nuclear: Improved antisense oligonucleotide activity through conjugation with a nuclear importer
Antisense oligonucleotides (ASOs) are a promising class of therapeutics designed to modulate gene expression. Both key mechanisms of action for ASOs operate in the nucleus: splice-switching ASOs modif...
chemrxiv.org
December 5, 2024 at 9:41 AM
We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer 🧬💊!
Preprint led by Disha
#chemsky 🧪 @uclchemistry.bsky.social @oxfordchemistry.bsky.social chemrxiv.org/engage/chemr...
Preprint led by Disha
#chemsky 🧪 @uclchemistry.bsky.social @oxfordchemistry.bsky.social chemrxiv.org/engage/chemr...
Heck, PCR wasn't even invented until 1983, and oligonucleotide synthesis didn't become practical until 1986.
April 20, 2026 at 9:39 PM
Heck, PCR wasn't even invented until 1983, and oligonucleotide synthesis didn't become practical until 1986.
A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins
Abstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz
doi.org
August 1, 2026 at 7:19 PM
A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
Oligonucleotide design meets big data:
We present oligoN-design, a simple, reproducible and versatile open-source tool to design specific primers and probes directly from large environmental DNA datasets.
🔗 DOI: doi.org/10.1101/2025...
👉 github.com/MiguelMSandi...
We present oligoN-design, a simple, reproducible and versatile open-source tool to design specific primers and probes directly from large environmental DNA datasets.
🔗 DOI: doi.org/10.1101/2025...
👉 github.com/MiguelMSandi...
November 7, 2025 at 12:54 PM
Oligonucleotide design meets big data:
We present oligoN-design, a simple, reproducible and versatile open-source tool to design specific primers and probes directly from large environmental DNA datasets.
🔗 DOI: doi.org/10.1101/2025...
👉 github.com/MiguelMSandi...
We present oligoN-design, a simple, reproducible and versatile open-source tool to design specific primers and probes directly from large environmental DNA datasets.
🔗 DOI: doi.org/10.1101/2025...
👉 github.com/MiguelMSandi...
Phage proteases activate CBASS antiphage immunity | Science
Phage proteases activate CBASS antiphage immunity
Cyclic oligonucleotide–based antiphage signaling systems (CBASS) are bacterial immune pathways evolutionarily related to cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes) in humans. ...
www.science.org
October 2, 2026 at 12:06 AM
Phage proteases activate CBASS antiphage immunity | Science
Germany Oligonucleotide Pool Market Size, Share, Report 2035 www.marketresearchfuture.com/reports/germ...
Germany Oligonucleotide Pool Market Size, Share, Report 2035
Germany Oligonucleotide Pool Market share register 204.57 USD Million in 2024, projected to grow 8.35 % CAGR to reach USD Million 494.50 during the forecast period 2025 - 2035.
www.marketresearchfuture.com
October 1, 2026 at 5:48 AM
Germany Oligonucleotide Pool Market Size, Share, Report 2035 www.marketresearchfuture.com/reports/germ...
503 Service Temporarily Unavailable www.wiseguyreports.com/reports/dna-...
DNA Oligonucleotide Synthesis Market Forecasting Growth 2035
The DNA Oligonucleotide Synthesis Market is expected to grow from 4,700 USD Million in 2025 to 10 USD Billion by 2035. The DNA Oligonucleotide Synthesis Market CAGR (growth rate) is expected to be aro...
www.wiseguyreports.com
September 30, 2026 at 6:50 AM
503 Service Temporarily Unavailable www.wiseguyreports.com/reports/dna-...
#apaperaday The @worldmusclesociety.org #WMS2026 special continues with a pick from Stenler et al in @moltherapy.bsky.social nucleic acids on a comparison of antisense oligonucleotide (ASO) treatment in adult and very old mice. DOI 10.1016/j.omtn.2026.103017
October 1, 2026 at 11:02 PM
#apaperaday The @worldmusclesociety.org #WMS2026 special continues with a pick from Stenler et al in @moltherapy.bsky.social nucleic acids on a comparison of antisense oligonucleotide (ASO) treatment in adult and very old mice. DOI 10.1016/j.omtn.2026.103017
Photolabile oligonucleotides with topological light gradients enable spatially resolved single-cell transcriptomics and epigenomics - @ucsantabarbara.bsky.social www.nature.com/articles/s41...
Photolabile oligonucleotides with topological light gradients enable spatially resolved single-cell transcriptomics and epigenomics - Nature Biotechnology
A photolabile oligonucleotide system enables spatially resolved single-cell measurements to show how the epigenome regulates gene expression.
www.nature.com
September 25, 2026 at 7:05 PM
Photolabile oligonucleotides with topological light gradients enable spatially resolved single-cell transcriptomics and epigenomics - @ucsantabarbara.bsky.social www.nature.com/articles/s41...
Iana Fedorova: Acb2 sequesters nearly all known CBASS signaling molecules through two distinct binding pockets and therefore serves as a broad-spectrum “sponge” inhibitor of cGAS based innate immunity #phages2025 🦠
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
Cyclic-oligonucleotide-based anti-phage signaling system (CBASS) is a common immune system that uses cyclic oligonucleotide signals to limit phage rep…
www.sciencedirect.com
August 8, 2025 at 10:02 PM
Iana Fedorova: Acb2 sequesters nearly all known CBASS signaling molecules through two distinct binding pockets and therefore serves as a broad-spectrum “sponge” inhibitor of cGAS based innate immunity #phages2025 🦠
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Happy to share with you the first official photos of our new Omnitrap! Big shootout to the Fasmatech team for this amazing technology! Now let's add lasers and see what it has under the bonnet for oligonucleotide analysis 😊
December 5, 2024 at 2:57 PM
Happy to share with you the first official photos of our new Omnitrap! Big shootout to the Fasmatech team for this amazing technology! Now let's add lasers and see what it has under the bonnet for oligonucleotide analysis 😊
Now with oligos: antibody–oligonucleotide conjugates are the new drug modality to watch doi.org/10.1038/s415...
January 8, 2026 at 3:05 PM
Now with oligos: antibody–oligonucleotide conjugates are the new drug modality to watch doi.org/10.1038/s415...
(JASMS) [ASAP] Increasing Oligonucleotide Sequencing Information and Throughput with Ion Mobility Spectrometry–Mass Spectrometry: Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00083 (RSS) #MassSpecRSS #JASMS
[ASAP] Increasing Oligonucleotide Sequencing Information and Throughput with Ion Mobility Spectrometry–Mass Spectrometry
Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00083
dlvr.it
June 10, 2025 at 4:06 PM
(JASMS) [ASAP] Increasing Oligonucleotide Sequencing Information and Throughput with Ion Mobility Spectrometry–Mass Spectrometry: Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00083 (RSS) #MassSpecRSS #JASMS
US clinics continue to sell unproven oligonucleotide therapy "supportive oligonucleotide therapy (SOT)" or rebranded as Q-REstrain including for cancer. Any hope the FDA CBER might look into this? #stemcells #genetherapy ipscell.com/2024/03/us-c...
US clinics widely selling supportive oligonucleotide therapy (SOT) or Q-REstrain therapy, from Greek firm RGCC - The Niche
Professor investigates clinics selling unproven RNA therapy including supportive oligonucleotide therapy or SOT from RGCC.
ipscell.com
May 13, 2025 at 7:58 PM
US clinics continue to sell unproven oligonucleotide therapy "supportive oligonucleotide therapy (SOT)" or rebranded as Q-REstrain including for cancer. Any hope the FDA CBER might look into this? #stemcells #genetherapy ipscell.com/2024/03/us-c...
Great organoids paper. If you want to freeze and recover viable organoids, without them exploding on thaw, there is a way. DM me. 🧪
Rapid and scalable personalized ASO screening in patient-derived organoids - Nature
A scalable platform for generating patient-specific organoids for testing personalized oligonucleotide therapeutics is described.
www.nature.com
January 24, 2025 at 9:49 PM
Great organoids paper. If you want to freeze and recover viable organoids, without them exploding on thaw, there is a way. DM me. 🧪
About ELI-002
ELI-002 is composed of AMP-modified mutant KRAS peptide antigens and ELI-004- an AMP-modified immune-stimulatory oligonucleotide CpG adjuvant available as an off-the-shelf subcutaneous administration. Researchers explained that what distinguishes ELI-002
ELI-002 is composed of AMP-modified mutant KRAS peptide antigens and ELI-004- an AMP-modified immune-stimulatory oligonucleotide CpG adjuvant available as an off-the-shelf subcutaneous administration. Researchers explained that what distinguishes ELI-002
January 18, 2024 at 5:01 PM
About ELI-002
ELI-002 is composed of AMP-modified mutant KRAS peptide antigens and ELI-004- an AMP-modified immune-stimulatory oligonucleotide CpG adjuvant available as an off-the-shelf subcutaneous administration. Researchers explained that what distinguishes ELI-002
ELI-002 is composed of AMP-modified mutant KRAS peptide antigens and ELI-004- an AMP-modified immune-stimulatory oligonucleotide CpG adjuvant available as an off-the-shelf subcutaneous administration. Researchers explained that what distinguishes ELI-002
Just out! Our manuscript (led by Pauline Lanting and @robertwarmerdam.bsky.social) on the generation of pharmacogenetic passports from low-cost GSA oligonucleotide array data.
📣New from Lanting et al.
📄Low-cost generation of clinical-grade, layperson-friendly pharmacogenetic passports using oligonucleotide arrays
#PGx
📄Low-cost generation of clinical-grade, layperson-friendly pharmacogenetic passports using oligonucleotide arrays
#PGx
Low-cost generation of clinical-grade, layperson-friendly pharmacogenetic passports using oligonucleotide arrays
Almost all individuals will carry a genetic marker that affects their drug response
and warrants therapy adjustments. This study demonstrates the feasibility of a low-cost,
pre-emptive pharmacogenetic...
www.cell.com
April 4, 2025 at 10:08 AM
Just out! Our manuscript (led by Pauline Lanting and @robertwarmerdam.bsky.social) on the generation of pharmacogenetic passports from low-cost GSA oligonucleotide array data.
(CEJ) Synthesis of Oligonucleotide Conjugates Employing a Diselenide Linker: Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026. (/CEJ)
Synthesis of Oligonucleotide Conjugates Employing a Diselenide Linker
Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026.
dlvr.it
October 2, 2026 at 10:03 AM
(CEJ) Synthesis of Oligonucleotide Conjugates Employing a Diselenide Linker: Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026. (/CEJ)
New #CommsMed paper: FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models. #DM1 #MyoBlue tinyurl.com/z4jrmaxk
FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models - Communications Medicine
Weeden et al. use a method called FORCE to deliver oligonucleotides to muscle and evaluate the platform’s utility in models of myotonic dystrophy. An antisense oligonucleotide targeting DMPK is guided...
tinyurl.com
January 18, 2025 at 6:12 PM
New #CommsMed paper: FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models. #DM1 #MyoBlue tinyurl.com/z4jrmaxk